KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MMP25
Full Name:
Matrix metalloproteinase-25
Alias:
Leukolysin;Membrane-type matrix metalloproteinase 6;Membrane-type-6 matrix metalloproteinase
Type:
Mass (Da):
62554
Number AA:
562
UniProt ID:
Q9NPA2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
P
A
R
A
P
K
P
S
A
Q
D
V
S
L
G
Site 2
T37
S
L
G
V
D
W
L
T
R
Y
G
Y
L
P
P
Site 3
Y39
G
V
D
W
L
T
R
Y
G
Y
L
P
P
P
H
Site 4
Y41
D
W
L
T
R
Y
G
Y
L
P
P
P
H
P
A
Site 5
S54
P
A
Q
A
Q
L
Q
S
P
E
K
L
R
D
A
Site 6
T74
R
F
A
G
L
P
E
T
G
R
M
D
P
G
T
Site 7
T81
T
G
R
M
D
P
G
T
V
A
T
M
R
K
P
Site 8
T84
M
D
P
G
T
V
A
T
M
R
K
P
R
C
S
Site 9
S91
T
M
R
K
P
R
C
S
L
P
D
V
L
G
V
Site 10
Y108
L
V
R
R
R
R
R
Y
A
L
S
G
S
V
W
Site 11
S111
R
R
R
R
Y
A
L
S
G
S
V
W
K
K
R
Site 12
S113
R
R
Y
A
L
S
G
S
V
W
K
K
R
T
L
Site 13
T121
V
W
K
K
R
T
L
T
W
R
V
R
S
F
P
Site 14
S126
T
L
T
W
R
V
R
S
F
P
Q
S
S
Q
L
Site 15
S130
R
V
R
S
F
P
Q
S
S
Q
L
S
Q
E
T
Site 16
S131
V
R
S
F
P
Q
S
S
Q
L
S
Q
E
T
V
Site 17
S134
F
P
Q
S
S
Q
L
S
Q
E
T
V
R
V
L
Site 18
T137
S
S
Q
L
S
Q
E
T
V
R
V
L
M
S
Y
Site 19
T156
W
G
M
E
S
G
L
T
F
H
E
V
D
S
P
Site 20
S162
L
T
F
H
E
V
D
S
P
Q
G
Q
E
P
D
Site 21
S182
A
R
A
F
H
Q
D
S
Y
P
F
D
G
L
G
Site 22
Y183
R
A
F
H
Q
D
S
Y
P
F
D
G
L
G
G
Site 23
S204
F
P
G
E
H
P
I
S
G
D
T
H
F
D
D
Site 24
T214
T
H
F
D
D
E
E
T
W
T
F
G
S
K
D
Site 25
T216
F
D
D
E
E
T
W
T
F
G
S
K
D
G
E
Site 26
S219
E
E
T
W
T
F
G
S
K
D
G
E
G
T
D
Site 27
S244
H
A
L
G
L
G
H
S
S
A
P
N
S
I
M
Site 28
S245
A
L
G
L
G
H
S
S
A
P
N
S
I
M
R
Site 29
S249
G
H
S
S
A
P
N
S
I
M
R
P
F
Y
Q
Site 30
Y255
N
S
I
M
R
P
F
Y
Q
G
P
V
G
D
P
Site 31
Y265
P
V
G
D
P
D
K
Y
R
L
S
Q
D
D
R
Site 32
S268
D
P
D
K
Y
R
L
S
Q
D
D
R
D
G
L
Site 33
T285
L
Y
G
K
A
P
Q
T
P
Y
D
K
P
T
R
Site 34
Y287
G
K
A
P
Q
T
P
Y
D
K
P
T
R
K
P
Site 35
T291
Q
T
P
Y
D
K
P
T
R
K
P
L
A
P
P
Site 36
S304
P
P
P
Q
P
P
A
S
P
T
H
S
P
S
F
Site 37
T306
P
Q
P
P
A
S
P
T
H
S
P
S
F
P
I
Site 38
S308
P
P
A
S
P
T
H
S
P
S
F
P
I
P
D
Site 39
S310
A
S
P
T
H
S
P
S
F
P
I
P
D
R
C
Site 40
S345
W
F
W
R
L
Q
P
S
G
Q
L
V
S
P
R
Site 41
S350
Q
P
S
G
Q
L
V
S
P
R
P
A
R
L
H
Site 42
Y374
V
R
V
V
Q
A
A
Y
A
R
H
R
D
G
R
Site 43
T406
E
G
G
A
R
P
L
T
E
L
G
L
P
P
G
Site 44
T428
S
W
P
Q
N
G
K
T
Y
L
V
R
G
R
Q
Site 45
Y429
W
P
Q
N
G
K
T
Y
L
V
R
G
R
Q
Y
Site 46
Y436
Y
L
V
R
G
R
Q
Y
W
R
Y
D
E
A
A
Site 47
Y439
R
G
R
Q
Y
W
R
Y
D
E
A
A
A
R
P
Site 48
Y450
A
A
R
P
D
P
G
Y
P
R
D
L
S
L
W
Site 49
S455
P
G
Y
P
R
D
L
S
L
W
E
G
A
P
P
Site 50
S463
L
W
E
G
A
P
P
S
P
D
D
V
T
V
S
Site 51
T468
P
P
S
P
D
D
V
T
V
S
N
A
G
D
T
Site 52
S470
S
P
D
D
V
T
V
S
N
A
G
D
T
Y
F
Site 53
T475
T
V
S
N
A
G
D
T
Y
F
F
K
G
A
H
Site 54
Y476
V
S
N
A
G
D
T
Y
F
F
K
G
A
H
Y
Site 55
Y483
Y
F
F
K
G
A
H
Y
W
R
F
P
K
N
S
Site 56
S490
Y
W
R
F
P
K
N
S
I
K
T
E
P
D
A
Site 57
S513
L
D
C
P
A
P
S
S
G
P
R
A
P
R
P
Site 58
T524
A
P
R
P
P
K
A
T
P
V
S
E
T
C
D
Site 59
S527
P
P
K
A
T
P
V
S
E
T
C
D
C
Q
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation