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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLCO1B3
Full Name:
Solute carrier organic anion transporter family member 1B3
Alias:
Liver-specific organic anion transporter 2; LST3; LST-3TM13; OATP1B3; OATP8; Organic anion transporter 8; Organic anion-transporting polypeptide 8; SLC21A8; SO1B2; SO1B3; Solute carrier family 21 member 8; Solute carrier organic anion transporter family, member 1B3
Type:
Transporter; Membrane protein, integral
Mass (Da):
77384
Number AA:
702
UniProt ID:
Q9NPD5
International Prot ID:
IPI00022873
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0015125
GO:0008514
PhosphoSite+
KinaseNET
Biological Process:
GO:0015711
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
Q
H
Q
H
L
N
K
T
A
E
S
A
S
S
E
Site 2
S16
K
T
A
E
S
A
S
S
E
K
K
K
T
R
R
Site 3
T21
A
S
S
E
K
K
K
T
R
R
C
N
G
F
K
Site 4
Y38
L
A
A
L
S
F
S
Y
I
A
K
A
L
G
G
Site 5
S63
E
R
R
F
D
I
S
S
S
L
A
G
L
I
D
Site 6
S64
R
R
F
D
I
S
S
S
L
A
G
L
I
D
G
Site 7
S89
V
F
V
S
Y
F
G
S
K
L
H
R
P
K
L
Site 8
Y120
L
P
H
F
F
M
G
Y
Y
R
Y
S
K
E
T
Site 9
Y121
P
H
F
F
M
G
Y
Y
R
Y
S
K
E
T
H
Site 10
T127
Y
Y
R
Y
S
K
E
T
H
I
N
P
S
E
N
Site 11
S132
K
E
T
H
I
N
P
S
E
N
S
T
S
S
L
Site 12
S135
H
I
N
P
S
E
N
S
T
S
S
L
S
T
C
Site 13
T136
I
N
P
S
E
N
S
T
S
S
L
S
T
C
L
Site 14
S137
N
P
S
E
N
S
T
S
S
L
S
T
C
L
I
Site 15
S138
P
S
E
N
S
T
S
S
L
S
T
C
L
I
N
Site 16
S140
E
N
S
T
S
S
L
S
T
C
L
I
N
Q
T
Site 17
T147
S
T
C
L
I
N
Q
T
L
S
F
N
G
T
S
Site 18
S149
C
L
I
N
Q
T
L
S
F
N
G
T
S
P
E
Site 19
T153
Q
T
L
S
F
N
G
T
S
P
E
I
V
E
K
Site 20
S154
T
L
S
F
N
G
T
S
P
E
I
V
E
K
D
Site 21
S206
F
A
K
E
G
H
S
S
L
Y
L
G
S
L
N
Site 22
Y208
K
E
G
H
S
S
L
Y
L
G
S
L
N
A
I
Site 23
S243
D
I
G
Y
V
D
L
S
T
I
R
I
T
P
K
Site 24
T244
I
G
Y
V
D
L
S
T
I
R
I
T
P
K
D
Site 25
T248
D
L
S
T
I
R
I
T
P
K
D
S
R
W
V
Site 26
S293
P
Q
K
E
R
K
I
S
L
S
L
H
V
L
K
Site 27
S295
K
E
R
K
I
S
L
S
L
H
V
L
K
T
N
Site 28
T301
L
S
L
H
V
L
K
T
N
D
D
R
N
Q
T
Site 29
T308
T
N
D
D
R
N
Q
T
A
N
L
T
N
Q
G
Site 30
Y362
S
F
T
Y
V
F
K
Y
M
E
Q
Q
Y
G
Q
Site 31
Y367
F
K
Y
M
E
Q
Q
Y
G
Q
S
A
S
H
A
Site 32
S372
Q
Q
Y
G
Q
S
A
S
H
A
N
F
L
L
G
Site 33
Y458
H
V
D
V
P
L
S
Y
C
N
S
E
C
N
C
Site 34
S491
P
C
L
A
G
C
K
S
S
S
G
I
K
K
H
Site 35
S493
L
A
G
C
K
S
S
S
G
I
K
K
H
T
V
Site 36
T499
S
S
G
I
K
K
H
T
V
F
Y
N
C
S
C
Site 37
Y517
T
G
L
Q
N
R
N
Y
S
A
H
L
G
E
C
Site 38
S518
G
L
Q
N
R
N
Y
S
A
H
L
G
E
C
P
Site 39
Y537
C
T
R
K
F
F
I
Y
V
A
I
Q
V
I
N
Site 40
S659
Q
G
K
D
T
K
A
S
D
N
E
R
K
V
M
Site 41
S688
V
P
S
A
G
T
D
S
K
T
C
N
L
D
M
Site 42
T690
S
A
G
T
D
S
K
T
C
N
L
D
M
Q
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation