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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOX4
Full Name:
NADPH oxidase 4
Alias:
Kidney oxidase-1;Kidney superoxide-producing NADPH oxidase;Renal NAD(P)H-oxidase
Type:
Mass (Da):
66932
Number AA:
578
UniProt ID:
Q9NPH5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
F
W
K
T
F
L
L
Y
N
Q
G
P
E
Y
H
Site 2
Y43
L
Y
N
Q
G
P
E
Y
H
Y
L
H
Q
M
L
Site 3
Y45
N
Q
G
P
E
Y
H
Y
L
H
Q
M
L
G
L
Site 4
S86
L
L
A
Y
L
R
G
S
Q
K
V
P
S
R
R
Site 5
S91
R
G
S
Q
K
V
P
S
R
R
T
R
R
L
L
Site 6
T94
Q
K
V
P
S
R
R
T
R
R
L
L
D
K
S
Site 7
S101
T
R
R
L
L
D
K
S
R
T
F
H
I
T
C
Site 8
T103
R
L
L
D
K
S
R
T
F
H
I
T
C
G
V
Site 9
S135
L
N
F
S
V
N
Y
S
E
D
F
V
E
L
N
Site 10
T157
D
P
R
K
L
L
F
T
T
V
P
G
L
T
G
Site 11
Y215
V
S
G
G
L
L
K
Y
Q
T
N
L
D
T
H
Site 12
T217
G
G
L
L
K
Y
Q
T
N
L
D
T
H
P
P
Site 13
T221
K
Y
Q
T
N
L
D
T
H
P
P
G
C
I
S
Site 14
S228
T
H
P
P
G
C
I
S
L
N
R
T
S
S
Q
Site 15
T232
G
C
I
S
L
N
R
T
S
S
Q
N
I
S
L
Site 16
S233
C
I
S
L
N
R
T
S
S
Q
N
I
S
L
P
Site 17
S234
I
S
L
N
R
T
S
S
Q
N
I
S
L
P
E
Site 18
S238
R
T
S
S
Q
N
I
S
L
P
E
Y
F
S
E
Site 19
Y242
Q
N
I
S
L
P
E
Y
F
S
E
H
F
H
E
Site 20
S244
I
S
L
P
E
Y
F
S
E
H
F
H
E
P
F
Site 21
Y300
L
Y
C
A
E
R
L
Y
R
Y
I
R
S
N
K
Site 22
Y302
C
A
E
R
L
Y
R
Y
I
R
S
N
K
P
V
Site 23
S313
N
K
P
V
T
I
I
S
V
M
S
H
P
S
D
Site 24
T340
A
R
P
G
Q
Y
I
T
L
H
C
P
S
V
S
Site 25
S345
Y
I
T
L
H
C
P
S
V
S
A
L
E
N
H
Site 26
T355
A
L
E
N
H
P
F
T
L
T
M
C
P
T
E
Site 27
T357
E
N
H
P
F
T
L
T
M
C
P
T
E
T
K
Site 28
T378
L
K
I
V
G
D
W
T
E
R
F
R
D
L
L
Site 29
S389
R
D
L
L
L
P
P
S
S
Q
D
S
E
I
L
Site 30
S390
D
L
L
L
P
P
S
S
Q
D
S
E
I
L
P
Site 31
S393
L
P
P
S
S
Q
D
S
E
I
L
P
F
I
Q
Site 32
S401
E
I
L
P
F
I
Q
S
R
N
Y
P
K
L
Y
Site 33
Y404
P
F
I
Q
S
R
N
Y
P
K
L
Y
I
D
G
Site 34
Y408
S
R
N
Y
P
K
L
Y
I
D
G
P
F
G
S
Site 35
S415
Y
I
D
G
P
F
G
S
P
F
E
E
S
L
N
Site 36
S420
F
G
S
P
F
E
E
S
L
N
Y
E
V
S
L
Site 37
T444
P
F
A
S
I
L
N
T
L
L
D
D
W
K
P
Site 38
Y452
L
L
D
D
W
K
P
Y
K
L
R
R
L
Y
F
Site 39
Y458
P
Y
K
L
R
R
L
Y
F
I
W
V
C
R
D
Site 40
Y491
W
Q
E
N
R
P
D
Y
V
N
I
Q
L
Y
L
Site 41
Y497
D
Y
V
N
I
Q
L
Y
L
S
Q
T
D
G
I
Site 42
S499
V
N
I
Q
L
Y
L
S
Q
T
D
G
I
Q
K
Site 43
Y512
Q
K
I
I
G
E
K
Y
H
A
L
N
S
R
L
Site 44
Y536
L
F
D
E
I
A
K
Y
N
R
G
K
T
V
G
Site 45
S551
V
F
C
C
G
P
N
S
L
S
K
T
L
H
K
Site 46
S553
C
C
G
P
N
S
L
S
K
T
L
H
K
L
S
Site 47
T555
G
P
N
S
L
S
K
T
L
H
K
L
S
N
Q
Site 48
S560
S
K
T
L
H
K
L
S
N
Q
N
N
S
Y
G
Site 49
Y566
L
S
N
Q
N
N
S
Y
G
T
R
F
E
Y
N
Site 50
Y572
S
Y
G
T
R
F
E
Y
N
K
E
S
F
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation