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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRC4
Full Name:
NLR family CARD domain-containing protein 4
Alias:
CARD, LRR, and NACHT-containing protein;Caspase recruitment domain-containing protein 12;Ice protease-activating factor
Type:
Mass (Da):
116159
Number AA:
1024
UniProt ID:
Q9NPP4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S65
I
L
K
K
G
S
E
S
C
N
L
F
L
K
S
Site 2
Y78
K
S
L
K
E
W
N
Y
P
L
F
Q
D
L
N
Site 3
S88
F
Q
D
L
N
G
Q
S
L
F
H
Q
T
S
E
Site 4
S94
Q
S
L
F
H
Q
T
S
E
G
D
L
D
D
L
Site 5
Y109
A
Q
D
L
K
D
L
Y
H
T
P
S
F
L
N
Site 6
T111
D
L
K
D
L
Y
H
T
P
S
F
L
N
F
Y
Site 7
S113
K
D
L
Y
H
T
P
S
F
L
N
F
Y
P
L
Site 8
Y118
T
P
S
F
L
N
F
Y
P
L
G
E
D
I
D
Site 9
T153
H
H
R
V
E
Q
L
T
L
N
G
L
L
Q
A
Site 10
S176
G
E
S
G
K
G
K
S
T
L
L
Q
R
I
A
Site 11
T226
Q
L
L
D
I
P
G
T
I
R
K
Q
T
F
M
Site 12
Y250
V
L
F
L
L
D
G
Y
N
E
F
K
P
Q
N
Site 13
T301
T
A
E
V
G
D
M
T
E
D
S
A
Q
A
L
Site 14
S304
V
G
D
M
T
E
D
S
A
Q
A
L
I
R
E
Site 15
S356
M
G
E
S
E
F
H
S
H
T
Q
T
T
L
F
Site 16
T358
E
S
E
F
H
S
H
T
Q
T
T
L
F
H
T
Site 17
T360
E
F
H
S
H
T
Q
T
T
L
F
H
T
F
Y
Site 18
Y367
T
T
L
F
H
T
F
Y
D
L
L
I
Q
K
N
Site 19
S384
K
H
K
G
V
A
A
S
D
F
I
R
S
L
D
Site 20
S414
D
F
E
L
Q
D
V
S
S
V
N
E
D
V
L
Site 21
Y430
T
T
G
L
L
C
K
Y
T
A
Q
R
F
K
P
Site 22
T431
T
G
L
L
C
K
Y
T
A
Q
R
F
K
P
K
Site 23
Y439
A
Q
R
F
K
P
K
Y
K
F
F
H
K
S
F
Site 24
Y449
F
H
K
S
F
Q
E
Y
T
A
G
R
R
L
S
Site 25
T450
H
K
S
F
Q
E
Y
T
A
G
R
R
L
S
S
Site 26
S456
Y
T
A
G
R
R
L
S
S
L
L
T
S
H
E
Site 27
S457
T
A
G
R
R
L
S
S
L
L
T
S
H
E
P
Site 28
T460
R
R
L
S
S
L
L
T
S
H
E
P
E
E
V
Site 29
S461
R
L
S
S
L
L
T
S
H
E
P
E
E
V
T
Site 30
Y473
E
V
T
K
G
N
G
Y
L
Q
K
M
V
S
I
Site 31
S479
G
Y
L
Q
K
M
V
S
I
S
D
I
T
S
T
Site 32
S481
L
Q
K
M
V
S
I
S
D
I
T
S
T
Y
S
Site 33
T486
S
I
S
D
I
T
S
T
Y
S
S
L
L
R
Y
Site 34
S489
D
I
T
S
T
Y
S
S
L
L
R
Y
T
C
G
Site 35
Y493
T
Y
S
S
L
L
R
Y
T
C
G
S
S
V
E
Site 36
T494
Y
S
S
L
L
R
Y
T
C
G
S
S
V
E
A
Site 37
S497
L
L
R
Y
T
C
G
S
S
V
E
A
T
R
A
Site 38
S498
L
R
Y
T
C
G
S
S
V
E
A
T
R
A
V
Site 39
S533
R
P
L
W
R
Q
E
S
L
Q
S
V
K
N
T
Site 40
S536
W
R
Q
E
S
L
Q
S
V
K
N
T
T
E
Q
Site 41
Y562
V
E
C
G
I
H
L
Y
Q
E
S
T
S
K
S
Site 42
S565
G
I
H
L
Y
Q
E
S
T
S
K
S
A
L
S
Site 43
S567
H
L
Y
Q
E
S
T
S
K
S
A
L
S
Q
E
Site 44
S569
Y
Q
E
S
T
S
K
S
A
L
S
Q
E
F
E
Site 45
S572
S
T
S
K
S
A
L
S
Q
E
F
E
A
F
F
Site 46
S583
E
A
F
F
Q
G
K
S
L
Y
I
N
S
G
N
Site 47
Y585
F
F
Q
G
K
S
L
Y
I
N
S
G
N
I
P
Site 48
S588
G
K
S
L
Y
I
N
S
G
N
I
P
D
Y
L
Site 49
Y594
N
S
G
N
I
P
D
Y
L
F
D
F
F
E
H
Site 50
S623
F
Y
G
G
A
M
A
S
W
E
K
A
A
E
D
Site 51
T642
H
M
E
E
A
P
E
T
Y
I
P
S
R
A
V
Site 52
S650
Y
I
P
S
R
A
V
S
L
F
F
N
W
K
Q
Site 53
T661
N
W
K
Q
E
F
R
T
L
E
V
T
L
R
D
Site 54
T665
E
F
R
T
L
E
V
T
L
R
D
F
S
K
L
Site 55
S670
E
V
T
L
R
D
F
S
K
L
N
K
Q
D
I
Site 56
Y679
L
N
K
Q
D
I
R
Y
L
G
K
I
F
S
S
Site 57
S685
R
Y
L
G
K
I
F
S
S
A
T
S
L
R
L
Site 58
S689
K
I
F
S
S
A
T
S
L
R
L
Q
I
K
R
Site 59
S716
S
T
C
K
N
I
Y
S
L
M
V
E
A
S
P
Site 60
S722
Y
S
L
M
V
E
A
S
P
L
T
I
E
D
E
Site 61
T725
M
V
E
A
S
P
L
T
I
E
D
E
R
H
I
Site 62
T733
I
E
D
E
R
H
I
T
S
V
T
N
L
K
T
Site 63
S734
E
D
E
R
H
I
T
S
V
T
N
L
K
T
L
Site 64
T736
E
R
H
I
T
S
V
T
N
L
K
T
L
S
I
Site 65
T740
T
S
V
T
N
L
K
T
L
S
I
H
D
L
Q
Site 66
S742
V
T
N
L
K
T
L
S
I
H
D
L
Q
N
Q
Site 67
T756
Q
R
L
P
G
G
L
T
D
S
L
G
N
L
K
Site 68
S758
L
P
G
G
L
T
D
S
L
G
N
L
K
N
L
Site 69
Y810
D
I
G
E
G
M
D
Y
I
V
K
S
L
S
S
Site 70
S814
G
M
D
Y
I
V
K
S
L
S
S
E
P
C
D
Site 71
S816
D
Y
I
V
K
S
L
S
S
E
P
C
D
L
E
Site 72
S817
Y
I
V
K
S
L
S
S
E
P
C
D
L
E
E
Site 73
S856
K
L
S
I
L
D
L
S
E
N
Y
L
E
K
D
Site 74
Y859
I
L
D
L
S
E
N
Y
L
E
K
D
G
N
E
Site 75
S895
W
G
C
D
V
Q
G
S
L
S
S
L
L
K
H
Site 76
S898
D
V
Q
G
S
L
S
S
L
L
K
H
L
E
E
Site 77
T920
G
L
K
N
W
R
L
T
D
T
E
I
R
I
L
Site 78
T922
K
N
W
R
L
T
D
T
E
I
R
I
L
G
A
Site 79
S950
N
L
A
G
N
R
V
S
S
D
G
W
L
A
F
Site 80
S992
R
K
L
S
Q
V
L
S
K
L
T
F
L
Q
E
Site 81
S1013
Q
F
D
D
D
D
L
S
V
I
T
G
A
F
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation