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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCUBE2
Full Name:
Signal peptide, CUB and EGF-like domain-containing protein 2
Alias:
Protein CEGP1
Type:
Mass (Da):
109957
Number AA:
999
UniProt ID:
Q9NQ36
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T65
A
D
A
L
C
Q
N
T
P
T
S
Y
K
C
S
Site 2
Y77
K
C
S
C
K
P
G
Y
Q
G
E
G
R
Q
C
Site 3
S149
T
C
V
N
V
M
G
S
Y
E
C
C
C
K
E
Site 4
S176
H
R
S
E
E
G
L
S
C
M
N
K
D
H
G
Site 5
S195
C
K
E
A
P
R
G
S
V
A
C
E
C
R
P
Site 6
S227
G
N
G
G
C
Q
H
S
C
D
D
T
A
D
G
Site 7
T231
C
Q
H
S
C
D
D
T
A
D
G
P
E
C
S
Site 8
T247
H
P
Q
Y
K
M
H
T
D
G
R
S
C
L
E
Site 9
T258
S
C
L
E
R
E
D
T
V
L
E
V
T
E
S
Site 10
T268
E
V
T
E
S
N
T
T
S
V
V
D
G
D
K
Site 11
S269
V
T
E
S
N
T
T
S
V
V
D
G
D
K
R
Site 12
T285
K
R
R
L
L
M
E
T
C
A
V
N
N
G
G
Site 13
T296
N
N
G
G
C
D
R
T
C
K
D
T
S
T
G
Site 14
T302
R
T
C
K
D
T
S
T
G
V
H
C
S
C
P
Site 15
T320
T
L
Q
L
D
G
K
T
C
K
D
I
D
E
C
Site 16
T357
K
K
G
F
K
L
L
T
D
E
K
S
C
Q
D
Site 17
S361
K
L
L
T
D
E
K
S
C
Q
D
V
D
E
C
Site 18
Y393
A
C
A
C
N
R
G
Y
T
L
Y
G
F
T
H
Site 19
Y396
C
N
R
G
Y
T
L
Y
G
F
T
H
C
G
D
Site 20
S458
T
S
V
S
P
R
V
S
L
H
C
G
K
S
G
Site 21
S464
V
S
L
H
C
G
K
S
G
G
G
D
G
C
F
Site 22
S476
G
C
F
L
R
C
H
S
G
I
H
L
S
S
D
Site 23
S481
C
H
S
G
I
H
L
S
S
D
V
T
T
I
R
Site 24
S482
H
S
G
I
H
L
S
S
D
V
T
T
I
R
T
Site 25
T489
S
D
V
T
T
I
R
T
S
V
T
F
K
L
N
Site 26
S490
D
V
T
T
I
R
T
S
V
T
F
K
L
N
E
Site 27
T492
T
T
I
R
T
S
V
T
F
K
L
N
E
G
K
Site 28
S501
K
L
N
E
G
K
C
S
L
K
N
A
E
L
F
Site 29
S521
P
A
L
P
E
K
H
S
S
V
K
E
S
F
R
Site 30
S522
A
L
P
E
K
H
S
S
V
K
E
S
F
R
Y
Site 31
S526
K
H
S
S
V
K
E
S
F
R
Y
V
N
L
T
Site 32
Y529
S
V
K
E
S
F
R
Y
V
N
L
T
C
S
S
Site 33
T533
S
F
R
Y
V
N
L
T
C
S
S
G
K
Q
V
Site 34
S535
R
Y
V
N
L
T
C
S
S
G
K
Q
V
P
G
Site 35
S548
P
G
A
P
G
R
P
S
T
P
K
E
M
F
I
Site 36
T549
G
A
P
G
R
P
S
T
P
K
E
M
F
I
T
Site 37
T556
T
P
K
E
M
F
I
T
V
E
F
E
L
E
T
Site 38
T591
R
L
R
K
A
I
R
T
L
R
K
A
V
H
R
Site 39
S620
A
K
K
P
P
R
T
S
E
R
Q
A
E
S
C
Site 40
S626
T
S
E
R
Q
A
E
S
C
G
V
G
Q
G
H
Site 41
T645
C
V
S
C
R
A
G
T
Y
Y
D
G
A
R
E
Site 42
Y647
S
C
R
A
G
T
Y
Y
D
G
A
R
E
R
C
Site 43
T670
Q
N
E
E
G
Q
M
T
C
E
P
C
P
R
P
Site 44
T685
G
N
S
G
A
L
K
T
P
E
A
W
N
M
S
Site 45
S704
L
C
Q
P
G
E
Y
S
A
D
G
F
A
P
C
Site 46
T726
F
Q
P
E
A
G
R
T
S
C
F
P
C
G
G
Site 47
S727
Q
P
E
A
G
R
T
S
C
F
P
C
G
G
G
Site 48
S744
T
K
H
Q
G
A
T
S
F
Q
D
C
E
T
R
Site 49
T750
T
S
F
Q
D
C
E
T
R
V
Q
C
S
P
G
Site 50
T774
C
I
R
C
P
V
G
T
Y
Q
P
E
F
G
K
Site 51
Y775
I
R
C
P
V
G
T
Y
Q
P
E
F
G
K
N
Site 52
T793
S
C
P
G
N
T
T
T
D
F
D
G
S
T
N
Site 53
T802
F
D
G
S
T
N
I
T
Q
C
K
N
R
R
C
Site 54
T817
G
G
E
L
G
D
F
T
G
Y
I
E
S
P
N
Site 55
Y819
E
L
G
D
F
T
G
Y
I
E
S
P
N
Y
P
Site 56
Y825
G
Y
I
E
S
P
N
Y
P
G
N
Y
P
A
N
Site 57
Y829
S
P
N
Y
P
G
N
Y
P
A
N
T
E
C
T
Site 58
T838
A
N
T
E
C
T
W
T
I
N
P
P
P
K
R
Site 59
Y865
I
E
D
D
C
G
D
Y
L
V
M
R
K
T
S
Site 60
T871
D
Y
L
V
M
R
K
T
S
S
S
N
S
V
T
Site 61
S872
Y
L
V
M
R
K
T
S
S
S
N
S
V
T
T
Site 62
S873
L
V
M
R
K
T
S
S
S
N
S
V
T
T
Y
Site 63
S874
V
M
R
K
T
S
S
S
N
S
V
T
T
Y
E
Site 64
S876
R
K
T
S
S
S
N
S
V
T
T
Y
E
T
C
Site 65
T878
T
S
S
S
N
S
V
T
T
Y
E
T
C
Q
T
Site 66
Y880
S
S
N
S
V
T
T
Y
E
T
C
Q
T
Y
E
Site 67
T885
T
T
Y
E
T
C
Q
T
Y
E
R
P
I
A
F
Site 68
Y886
T
Y
E
T
C
Q
T
Y
E
R
P
I
A
F
T
Site 69
T893
Y
E
R
P
I
A
F
T
S
R
S
K
K
L
W
Site 70
S894
E
R
P
I
A
F
T
S
R
S
K
K
L
W
I
Site 71
S905
K
L
W
I
Q
F
K
S
N
E
G
N
S
A
R
Site 72
S910
F
K
S
N
E
G
N
S
A
R
G
F
Q
V
P
Site 73
Y918
A
R
G
F
Q
V
P
Y
V
T
Y
D
E
D
Y
Site 74
Y925
Y
V
T
Y
D
E
D
Y
Q
E
L
I
E
D
I
Site 75
Y939
I
V
R
D
G
R
L
Y
A
S
E
N
H
Q
E
Site 76
S941
R
D
G
R
L
Y
A
S
E
N
H
Q
E
I
L
Site 77
Y967
V
L
A
H
P
Q
N
Y
F
K
Y
T
A
Q
E
Site 78
Y970
H
P
Q
N
Y
F
K
Y
T
A
Q
E
S
R
E
Site 79
S975
F
K
Y
T
A
Q
E
S
R
E
M
F
P
R
S
Site 80
S982
S
R
E
M
F
P
R
S
F
I
R
L
L
R
S
Site 81
S989
S
F
I
R
L
L
R
S
K
V
S
R
F
L
R
Site 82
S992
R
L
L
R
S
K
V
S
R
F
L
R
P
Y
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation