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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AFAF
Full Name:
Acrosome formation-associated factor
Alias:
Type:
Mass (Da):
32840
Number AA:
294
UniProt ID:
Q9NQ60
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
G
V
F
S
L
K
S
S
T
L
K
P
T
I
E
Site 2
T48
E
E
K
N
E
D
H
T
P
N
Y
A
P
A
N
Site 3
Y51
N
E
D
H
T
P
N
Y
A
P
A
N
E
K
N
Site 4
Y61
A
N
E
K
N
G
N
Y
Y
K
D
I
K
Q
Y
Site 5
Y62
N
E
K
N
G
N
Y
Y
K
D
I
K
Q
Y
V
Site 6
Y68
Y
Y
K
D
I
K
Q
Y
V
F
T
T
Q
N
P
Site 7
T72
I
K
Q
Y
V
F
T
T
Q
N
P
N
G
T
E
Site 8
S80
Q
N
P
N
G
T
E
S
E
I
S
V
R
A
T
Site 9
S83
N
G
T
E
S
E
I
S
V
R
A
T
T
D
L
Site 10
T99
F
A
L
K
N
D
K
T
V
N
A
T
T
Y
E
Site 11
T115
S
T
I
E
E
E
T
T
T
S
E
P
S
H
K
Site 12
T116
T
I
E
E
E
T
T
T
S
E
P
S
H
K
N
Site 13
S117
I
E
E
E
T
T
T
S
E
P
S
H
K
N
I
Site 14
S127
S
H
K
N
I
Q
R
S
T
P
N
V
P
A
F
Site 15
T128
H
K
N
I
Q
R
S
T
P
N
V
P
A
F
W
Site 16
S162
L
F
H
P
I
P
E
S
D
V
N
A
T
Q
G
Site 17
S212
L
Y
K
L
R
H
L
S
Y
K
S
C
E
S
Q
Site 18
S215
L
R
H
L
S
Y
K
S
C
E
S
Q
Y
S
V
Site 19
S218
L
S
Y
K
S
C
E
S
Q
Y
S
V
N
P
E
Site 20
S221
K
S
C
E
S
Q
Y
S
V
N
P
E
L
A
T
Site 21
T228
S
V
N
P
E
L
A
T
M
S
Y
F
H
P
S
Site 22
Y231
P
E
L
A
T
M
S
Y
F
H
P
S
E
G
V
Site 23
S235
T
M
S
Y
F
H
P
S
E
G
V
S
D
T
S
Site 24
S239
F
H
P
S
E
G
V
S
D
T
S
F
S
K
S
Site 25
T241
P
S
E
G
V
S
D
T
S
F
S
K
S
A
E
Site 26
S242
S
E
G
V
S
D
T
S
F
S
K
S
A
E
S
Site 27
S244
G
V
S
D
T
S
F
S
K
S
A
E
S
S
T
Site 28
S246
S
D
T
S
F
S
K
S
A
E
S
S
T
F
L
Site 29
S250
F
S
K
S
A
E
S
S
T
F
L
G
T
T
S
Site 30
T251
S
K
S
A
E
S
S
T
F
L
G
T
T
S
S
Site 31
S258
T
F
L
G
T
T
S
S
D
M
R
R
S
G
T
Site 32
S263
T
S
S
D
M
R
R
S
G
T
R
T
S
E
S
Site 33
T265
S
D
M
R
R
S
G
T
R
T
S
E
S
K
I
Site 34
T267
M
R
R
S
G
T
R
T
S
E
S
K
I
M
T
Site 35
S268
R
R
S
G
T
R
T
S
E
S
K
I
M
T
D
Site 36
S278
K
I
M
T
D
I
I
S
I
G
S
D
N
E
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation