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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCB1
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
Alias:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1; KIAA0581; Phosphoinositide phospholipase C; Phosphoinositide-specific; Phospholipase C, beta 1; Phospholipase C-beta-1; PIB1; PLC154; PLC-154; PLC-beta1; PLC-beta-1; PLC-I
Type:
Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate
Mass (Da):
138567
Number AA:
1216
UniProt ID:
Q9NQ66
International Prot ID:
IPI00219563
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0019899
GO:0004435
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
K
P
V
C
V
S
D
S
L
K
K
G
T
K
F
Site 2
T26
S
D
S
L
K
K
G
T
K
F
V
K
W
D
D
Site 3
T39
D
D
D
S
T
I
V
T
P
I
I
L
R
T
D
Site 4
T55
Q
G
F
F
F
Y
W
T
D
Q
N
K
E
T
E
Site 5
S67
E
T
E
L
L
D
L
S
L
V
K
D
A
R
C
Site 6
T104
R
L
E
Q
R
M
I
T
V
V
Y
G
P
D
L
Site 7
Y107
Q
R
M
I
T
V
V
Y
G
P
D
L
V
N
I
Site 8
T131
E
E
V
A
K
E
W
T
N
E
V
F
S
L
A
Site 9
S136
E
W
T
N
E
V
F
S
L
A
T
N
L
L
A
Site 10
T139
N
E
V
F
S
L
A
T
N
L
L
A
Q
N
M
Site 11
S147
N
L
L
A
Q
N
M
S
R
D
A
F
L
E
K
Site 12
T164
T
K
L
K
L
Q
V
T
P
E
G
R
I
P
L
Site 13
Y175
R
I
P
L
K
N
I
Y
R
L
F
S
A
D
R
Site 14
S179
K
N
I
Y
R
L
F
S
A
D
R
K
R
V
E
Site 15
T187
A
D
R
K
R
V
E
T
A
L
E
A
C
S
L
Site 16
S193
E
T
A
L
E
A
C
S
L
P
S
S
R
N
D
Site 17
S196
L
E
A
C
S
L
P
S
S
R
N
D
S
I
P
Site 18
S197
E
A
C
S
L
P
S
S
R
N
D
S
I
P
Q
Site 19
S201
L
P
S
S
R
N
D
S
I
P
Q
E
D
F
T
Site 20
T208
S
I
P
Q
E
D
F
T
P
E
V
Y
R
V
F
Site 21
S236
F
S
E
F
G
A
K
S
K
P
Y
L
T
V
D
Site 22
Y239
F
G
A
K
S
K
P
Y
L
T
V
D
Q
M
M
Site 23
T241
A
K
S
K
P
Y
L
T
V
D
Q
M
M
D
F
Site 24
Y263
P
R
L
N
E
I
L
Y
P
P
L
K
Q
E
Q
Site 25
Y278
V
Q
V
L
I
E
K
Y
E
P
N
N
S
L
A
Site 26
S283
E
K
Y
E
P
N
N
S
L
A
R
K
G
Q
I
Site 27
S291
L
A
R
K
G
Q
I
S
V
D
G
F
M
R
Y
Site 28
Y298
S
V
D
G
F
M
R
Y
L
S
G
E
E
N
G
Site 29
S300
D
G
F
M
R
Y
L
S
G
E
E
N
G
V
V
Site 30
S308
G
E
E
N
G
V
V
S
P
E
K
L
D
L
N
Site 31
S319
L
D
L
N
E
D
M
S
Q
P
L
S
H
Y
F
Site 32
S323
E
D
M
S
Q
P
L
S
H
Y
F
I
N
S
S
Site 33
Y325
M
S
Q
P
L
S
H
Y
F
I
N
S
S
H
N
Site 34
T333
F
I
N
S
S
H
N
T
Y
L
T
A
G
Q
L
Site 35
Y334
I
N
S
S
H
N
T
Y
L
T
A
G
Q
L
A
Site 36
T336
S
S
H
N
T
Y
L
T
A
G
Q
L
A
G
N
Site 37
S345
G
Q
L
A
G
N
S
S
V
E
M
Y
R
Q
V
Site 38
Y349
G
N
S
S
V
E
M
Y
R
Q
V
L
L
S
G
Site 39
T377
A
E
E
E
P
V
I
T
H
G
F
T
M
T
T
Site 40
S410
S
P
F
P
I
L
L
S
F
E
N
H
V
D
S
Site 41
S417
S
F
E
N
H
V
D
S
P
K
Q
Q
A
K
M
Site 42
Y427
Q
Q
A
K
M
A
E
Y
C
R
L
I
F
G
D
Site 43
Y444
L
M
E
P
L
E
K
Y
P
L
E
S
G
V
P
Site 44
S448
L
E
K
Y
P
L
E
S
G
V
P
L
P
S
P
Site 45
S454
E
S
G
V
P
L
P
S
P
M
D
L
M
Y
K
Site 46
Y460
P
S
P
M
D
L
M
Y
K
I
L
V
K
N
K
Site 47
S470
L
V
K
N
K
K
K
S
H
K
S
S
E
G
S
Site 48
S473
N
K
K
K
S
H
K
S
S
E
G
S
G
K
K
Site 49
S474
K
K
K
S
H
K
S
S
E
G
S
G
K
K
K
Site 50
S477
S
H
K
S
S
E
G
S
G
K
K
K
L
S
E
Site 51
S483
G
S
G
K
K
K
L
S
E
Q
A
S
N
T
Y
Site 52
S487
K
K
L
S
E
Q
A
S
N
T
Y
S
D
S
S
Site 53
T489
L
S
E
Q
A
S
N
T
Y
S
D
S
S
S
M
Site 54
Y490
S
E
Q
A
S
N
T
Y
S
D
S
S
S
M
F
Site 55
S491
E
Q
A
S
N
T
Y
S
D
S
S
S
M
F
E
Site 56
S493
A
S
N
T
Y
S
D
S
S
S
M
F
E
P
S
Site 57
S494
S
N
T
Y
S
D
S
S
S
M
F
E
P
S
S
Site 58
S495
N
T
Y
S
D
S
S
S
M
F
E
P
S
S
P
Site 59
S500
S
S
S
M
F
E
P
S
S
P
G
A
G
E
A
Site 60
S501
S
S
M
F
E
P
S
S
P
G
A
G
E
A
D
Site 61
T509
P
G
A
G
E
A
D
T
E
S
D
D
D
D
D
Site 62
S511
A
G
E
A
D
T
E
S
D
D
D
D
D
D
D
Site 63
S523
D
D
D
D
C
K
K
S
S
M
D
E
G
T
A
Site 64
S524
D
D
D
C
K
K
S
S
M
D
E
G
T
A
G
Site 65
T537
A
G
S
E
A
M
A
T
E
E
M
S
N
L
V
Site 66
Y546
E
M
S
N
L
V
N
Y
I
Q
P
V
K
F
E
Site 67
S554
I
Q
P
V
K
F
E
S
F
E
I
S
K
K
R
Site 68
S558
K
F
E
S
F
E
I
S
K
K
R
N
K
S
F
Site 69
S564
I
S
K
K
R
N
K
S
F
E
M
S
S
F
V
Site 70
S568
R
N
K
S
F
E
M
S
S
F
V
E
T
K
G
Site 71
S569
N
K
S
F
E
M
S
S
F
V
E
T
K
G
L
Site 72
T580
T
K
G
L
E
Q
L
T
K
S
P
V
E
F
V
Site 73
S582
G
L
E
Q
L
T
K
S
P
V
E
F
V
E
Y
Site 74
Y589
S
P
V
E
F
V
E
Y
N
K
M
Q
L
S
R
Site 75
S595
E
Y
N
K
M
Q
L
S
R
I
Y
P
K
G
T
Site 76
Y598
K
M
Q
L
S
R
I
Y
P
K
G
T
R
V
D
Site 77
T602
S
R
I
Y
P
K
G
T
R
V
D
S
S
N
Y
Site 78
S606
P
K
G
T
R
V
D
S
S
N
Y
M
P
Q
L
Site 79
S607
K
G
T
R
V
D
S
S
N
Y
M
P
Q
L
F
Site 80
Y640
M
Q
I
N
M
G
M
Y
E
Y
N
G
K
S
G
Site 81
Y642
I
N
M
G
M
Y
E
Y
N
G
K
S
G
Y
R
Site 82
S646
M
Y
E
Y
N
G
K
S
G
Y
R
L
K
P
E
Site 83
T666
D
K
H
F
D
P
F
T
E
G
I
V
D
G
I
Site 84
S689
I
I
S
G
Q
F
L
S
D
K
K
V
G
T
Y
Site 85
Y696
S
D
K
K
V
G
T
Y
V
E
V
D
M
F
G
Site 86
T715
T
R
R
K
A
F
K
T
K
T
S
Q
G
N
A
Site 87
Y771
V
Q
A
I
R
P
G
Y
H
Y
I
C
L
R
N
Site 88
Y773
A
I
R
P
G
Y
H
Y
I
C
L
R
N
E
R
Site 89
T785
N
E
R
N
Q
P
L
T
L
P
A
V
F
V
Y
Site 90
Y798
V
Y
I
E
V
K
D
Y
V
P
D
T
Y
A
D
Site 91
T802
V
K
D
Y
V
P
D
T
Y
A
D
V
I
E
A
Site 92
Y803
K
D
Y
V
P
D
T
Y
A
D
V
I
E
A
L
Site 93
Y816
A
L
S
N
P
I
R
Y
V
N
L
M
E
Q
R
Site 94
T847
K
E
A
D
P
G
E
T
P
S
E
A
P
S
E
Site 95
S849
A
D
P
G
E
T
P
S
E
A
P
S
E
A
R
Site 96
S853
E
T
P
S
E
A
P
S
E
A
R
T
T
P
A
Site 97
T857
E
A
P
S
E
A
R
T
T
P
A
E
N
G
V
Site 98
T858
A
P
S
E
A
R
T
T
P
A
E
N
G
V
N
Site 99
T869
N
G
V
N
H
T
T
T
L
T
P
K
P
P
S
Site 100
T871
V
N
H
T
T
T
L
T
P
K
P
P
S
Q
A
Site 101
S876
T
L
T
P
K
P
P
S
Q
A
L
H
S
Q
P
Site 102
S881
P
P
S
Q
A
L
H
S
Q
P
A
P
G
S
V
Site 103
S887
H
S
Q
P
A
P
G
S
V
K
A
P
A
K
T
Site 104
S918
E
E
L
K
Q
Q
K
S
F
V
K
L
Q
K
K
Site 105
T941
V
K
R
H
H
K
K
T
T
D
L
I
K
E
H
Site 106
Y952
I
K
E
H
T
T
K
Y
N
E
I
Q
N
D
Y
Site 107
Y959
Y
N
E
I
Q
N
D
Y
L
R
R
R
A
A
L
Site 108
S969
R
R
A
A
L
E
K
S
A
K
K
D
S
K
K
Site 109
S974
E
K
S
A
K
K
D
S
K
K
K
S
E
P
S
Site 110
S978
K
K
D
S
K
K
K
S
E
P
S
S
P
D
H
Site 111
S981
S
K
K
K
S
E
P
S
S
P
D
H
G
S
S
Site 112
S982
K
K
K
S
E
P
S
S
P
D
H
G
S
S
T
Site 113
S987
P
S
S
P
D
H
G
S
S
T
I
E
Q
D
L
Site 114
S988
S
S
P
D
H
G
S
S
T
I
E
Q
D
L
A
Site 115
T989
S
P
D
H
G
S
S
T
I
E
Q
D
L
A
A
Site 116
Y1024
L
N
L
R
Q
E
Q
Y
Y
S
E
K
Y
Q
K
Site 117
Y1025
N
L
R
Q
E
Q
Y
Y
S
E
K
Y
Q
K
R
Site 118
Y1029
E
Q
Y
Y
S
E
K
Y
Q
K
R
E
H
I
K
Site 119
T1043
K
L
L
I
Q
K
L
T
D
V
A
E
E
C
Q
Site 120
T1081
K
K
R
Q
E
K
I
T
E
A
K
S
K
D
K
Site 121
S1085
E
K
I
T
E
A
K
S
K
D
K
S
Q
M
E
Site 122
S1089
E
A
K
S
K
D
K
S
Q
M
E
E
E
K
T
Site 123
T1096
S
Q
M
E
E
E
K
T
E
M
I
R
S
Y
I
Site 124
S1101
E
K
T
E
M
I
R
S
Y
I
Q
E
V
V
Q
Site 125
Y1102
K
T
E
M
I
R
S
Y
I
Q
E
V
V
Q
Y
Site 126
Y1109
Y
I
Q
E
V
V
Q
Y
I
K
R
L
E
E
A
Site 127
S1118
K
R
L
E
E
A
Q
S
K
R
Q
E
K
L
V
Site 128
S1177
K
G
K
I
S
E
D
S
N
H
G
S
A
P
L
Site 129
S1181
S
E
D
S
N
H
G
S
A
P
L
S
L
S
S
Site 130
S1185
N
H
G
S
A
P
L
S
L
S
S
D
P
G
K
Site 131
S1187
G
S
A
P
L
S
L
S
S
D
P
G
K
V
N
Site 132
S1188
S
A
P
L
S
L
S
S
D
P
G
K
V
N
H
Site 133
T1197
P
G
K
V
N
H
K
T
P
S
S
E
E
L
G
Site 134
S1199
K
V
N
H
K
T
P
S
S
E
E
L
G
G
D
Site 135
S1200
V
N
H
K
T
P
S
S
E
E
L
G
G
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation