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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEPE
Full Name:
Matrix extracellular phosphoglycoprotein
Alias:
Osteoblast/osteocyte factor 45
Type:
Mass (Da):
58419
Number AA:
525
UniProt ID:
Q9NQ76
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
S
V
T
W
A
A
P
T
F
Q
P
Q
T
E
K
Site 2
T24
A
P
T
F
Q
P
Q
T
E
K
T
K
Q
S
C
Site 3
S30
Q
T
E
K
T
K
Q
S
C
V
E
E
Q
R
Q
Site 4
S73
Q
E
R
K
K
D
L
S
L
S
E
A
S
E
N
Site 5
S75
R
K
K
D
L
S
L
S
E
A
S
E
N
K
G
Site 6
S78
D
L
S
L
S
E
A
S
E
N
K
G
S
S
K
Site 7
S86
E
N
K
G
S
S
K
S
Q
N
Y
F
T
N
R
Site 8
Y89
G
S
S
K
S
Q
N
Y
F
T
N
R
Q
R
L
Site 9
T91
S
K
S
Q
N
Y
F
T
N
R
Q
R
L
N
K
Site 10
Y100
R
Q
R
L
N
K
E
Y
S
I
S
N
K
E
N
Site 11
S101
Q
R
L
N
K
E
Y
S
I
S
N
K
E
N
T
Site 12
S103
L
N
K
E
Y
S
I
S
N
K
E
N
T
H
N
Site 13
S115
T
H
N
G
L
R
M
S
I
Y
P
K
S
T
G
Site 14
Y117
N
G
L
R
M
S
I
Y
P
K
S
T
G
N
K
Site 15
S120
R
M
S
I
Y
P
K
S
T
G
N
K
G
F
E
Site 16
T121
M
S
I
Y
P
K
S
T
G
N
K
G
F
E
D
Site 17
T172
G
E
E
N
K
E
N
T
P
R
N
V
L
N
I
Site 18
S201
K
K
K
P
Q
R
D
S
Q
A
Q
K
S
P
V
Site 19
S206
R
D
S
Q
A
Q
K
S
P
V
K
S
K
S
T
Site 20
S210
A
Q
K
S
P
V
K
S
K
S
T
H
R
I
Q
Site 21
S212
K
S
P
V
K
S
K
S
T
H
R
I
Q
H
N
Site 22
Y222
R
I
Q
H
N
I
D
Y
L
K
H
L
S
K
V
Site 23
S227
I
D
Y
L
K
H
L
S
K
V
K
K
I
P
S
Site 24
S234
S
K
V
K
K
I
P
S
D
F
E
G
S
G
Y
Site 25
Y241
S
D
F
E
G
S
G
Y
T
D
L
Q
E
R
G
Site 26
S253
E
R
G
D
N
D
I
S
P
F
S
G
D
G
Q
Site 27
S256
D
N
D
I
S
P
F
S
G
D
G
Q
P
F
K
Site 28
T283
L
E
G
K
D
I
Q
T
G
F
A
G
P
S
E
Site 29
S289
Q
T
G
F
A
G
P
S
E
A
E
S
T
H
L
Site 30
S293
A
G
P
S
E
A
E
S
T
H
L
D
T
K
K
Site 31
T294
G
P
S
E
A
E
S
T
H
L
D
T
K
K
P
Site 32
T298
A
E
S
T
H
L
D
T
K
K
P
G
Y
N
E
Site 33
Y303
L
D
T
K
K
P
G
Y
N
E
I
P
E
R
E
Site 34
T323
T
I
G
T
R
D
E
T
A
K
E
A
D
A
V
Site 35
S333
E
A
D
A
V
D
V
S
L
V
E
G
S
N
D
Site 36
S362
G
N
R
V
D
A
G
S
Q
N
A
H
Q
G
K
Site 37
Y374
Q
G
K
V
E
F
H
Y
P
P
A
P
S
K
E
Site 38
S388
E
K
R
K
E
G
S
S
D
A
A
E
S
T
N
Site 39
Y396
D
A
A
E
S
T
N
Y
N
E
I
P
K
N
G
Site 40
S406
I
P
K
N
G
K
G
S
T
R
K
G
V
D
H
Site 41
S414
T
R
K
G
V
D
H
S
N
R
N
Q
A
T
L
Site 42
S429
N
E
K
Q
R
F
P
S
K
G
K
S
Q
G
L
Site 43
S433
R
F
P
S
K
G
K
S
Q
G
L
P
I
P
S
Site 44
S453
E
I
K
N
E
M
D
S
F
N
G
P
S
H
E
Site 45
T464
P
S
H
E
N
I
I
T
H
G
R
K
Y
H
Y
Site 46
Y469
I
I
T
H
G
R
K
Y
H
Y
V
P
H
R
Q
Site 47
Y471
T
H
G
R
K
Y
H
Y
V
P
H
R
Q
N
N
Site 48
S479
V
P
H
R
Q
N
N
S
T
R
N
K
G
M
P
Site 49
T480
P
H
R
Q
N
N
S
T
R
N
K
G
M
P
Q
Site 50
S491
G
M
P
Q
G
K
G
S
W
G
R
Q
P
H
S
Site 51
S498
S
W
G
R
Q
P
H
S
N
R
R
F
S
S
R
Site 52
S503
P
H
S
N
R
R
F
S
S
R
R
R
D
D
S
Site 53
S504
H
S
N
R
R
F
S
S
R
R
R
D
D
S
S
Site 54
S510
S
S
R
R
R
D
D
S
S
E
S
S
D
S
G
Site 55
S511
S
R
R
R
D
D
S
S
E
S
S
D
S
G
S
Site 56
S513
R
R
D
D
S
S
E
S
S
D
S
G
S
S
S
Site 57
S514
R
D
D
S
S
E
S
S
D
S
G
S
S
S
E
Site 58
S516
D
S
S
E
S
S
D
S
G
S
S
S
E
S
D
Site 59
S518
S
E
S
S
D
S
G
S
S
S
E
S
D
G
D
Site 60
S520
S
S
D
S
G
S
S
S
E
S
D
G
D
_
_
Site 61
S522
D
S
G
S
S
S
E
S
D
G
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation