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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACF
Full Name:
APOBEC1 complementation factor
Alias:
A1CF; ACF64; ACF65; Apo-B RNA editing; APOBEC-1 stimulating; APOBEC1CF; APOBEC1-stimulating protein; ASP
Type:
RNA binding protein
Mass (Da):
65202
Number AA:
594
UniProt ID:
Q9NQ94
International Prot ID:
IPI00071360
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030895
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005515
GO:0003727
PhosphoSite+
KinaseNET
Biological Process:
GO:0006397
GO:0050821
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
S
N
H
K
S
G
D
G
L
S
G
T
Site 2
S12
H
K
S
G
D
G
L
S
G
T
Q
K
E
A
A
Site 3
T14
S
G
D
G
L
S
G
T
Q
K
E
A
A
L
R
Site 4
Y29
A
L
V
Q
R
T
G
Y
S
L
V
Q
E
N
G
Site 5
Y40
Q
E
N
G
Q
R
K
Y
G
G
P
P
P
G
W
Site 6
Y83
C
E
K
I
G
K
I
Y
E
M
R
M
M
M
D
Site 7
Y98
F
N
G
N
N
R
G
Y
A
F
V
T
F
S
N
Site 8
T102
N
R
G
Y
A
F
V
T
F
S
N
K
V
E
A
Site 9
Y119
A
I
K
Q
L
N
N
Y
E
I
R
N
G
R
L
Site 10
T146
F
V
G
G
I
P
K
T
K
K
R
E
E
I
L
Site 11
S154
K
K
R
E
E
I
L
S
E
M
K
K
V
T
E
Site 12
T176
Y
P
S
A
A
D
K
T
K
N
R
G
F
A
F
Site 13
Y186
R
G
F
A
F
V
E
Y
E
S
H
R
A
A
A
Site 14
T226
E
V
E
V
D
E
D
T
M
S
S
V
K
I
L
Site 15
S228
E
V
D
E
D
T
M
S
S
V
K
I
L
Y
V
Site 16
S241
Y
V
R
N
L
M
L
S
T
S
E
E
M
I
E
Site 17
S243
R
N
L
M
L
S
T
S
E
E
M
I
E
K
E
Site 18
Y268
R
V
K
K
I
R
D
Y
A
F
V
H
F
S
N
Site 19
S274
D
Y
A
F
V
H
F
S
N
R
E
D
A
V
E
Site 20
S308
A
K
P
V
D
K
D
S
Y
V
R
Y
T
R
G
Site 21
Y309
K
P
V
D
K
D
S
Y
V
R
Y
T
R
G
T
Site 22
Y312
D
K
D
S
Y
V
R
Y
T
R
G
T
G
G
R
Site 23
T313
K
D
S
Y
V
R
Y
T
R
G
T
G
G
R
G
Site 24
T316
Y
V
R
Y
T
R
G
T
G
G
R
G
T
M
L
Site 25
T321
R
G
T
G
G
R
G
T
M
L
Q
G
E
Y
T
Site 26
Y327
G
T
M
L
Q
G
E
Y
T
Y
S
L
G
Q
V
Site 27
T328
T
M
L
Q
G
E
Y
T
Y
S
L
G
Q
V
Y
Site 28
S330
L
Q
G
E
Y
T
Y
S
L
G
Q
V
Y
D
P
Site 29
Y335
T
Y
S
L
G
Q
V
Y
D
P
T
T
T
Y
L
Site 30
T338
L
G
Q
V
Y
D
P
T
T
T
Y
L
G
A
P
Site 31
T339
G
Q
V
Y
D
P
T
T
T
Y
L
G
A
P
V
Site 32
T364
P
S
L
H
F
P
A
T
K
G
H
L
S
N
R
Site 33
S369
P
A
T
K
G
H
L
S
N
R
A
I
I
R
A
Site 34
S378
R
A
I
I
R
A
P
S
V
R
E
I
Y
M
N
Site 35
Y401
R
G
L
G
G
R
G
Y
L
A
Y
T
G
L
G
Site 36
Y404
G
G
R
G
Y
L
A
Y
T
G
L
G
R
G
Y
Site 37
Y411
Y
T
G
L
G
R
G
Y
Q
V
K
G
D
K
R
Site 38
Y423
D
K
R
E
D
K
L
Y
D
I
L
P
G
M
E
Site 39
T438
L
T
P
M
N
P
V
T
L
K
P
Q
G
I
K
Site 40
Y465
N
N
W
G
Q
P
V
Y
Q
L
H
S
A
I
G
Site 41
T499
N
P
A
I
H
P
F
T
P
P
K
L
S
A
F
Site 42
S504
P
F
T
P
P
K
L
S
A
F
V
D
E
A
K
Site 43
Y513
F
V
D
E
A
K
T
Y
A
A
E
Y
T
L
Q
Site 44
T532
P
T
D
G
G
D
G
T
M
A
T
A
A
A
A
Site 45
S556
P
N
A
T
A
P
V
S
A
A
Q
L
K
Q
A
Site 46
Y573
L
G
Q
D
L
A
A
Y
T
T
Y
E
V
Y
P
Site 47
T575
Q
D
L
A
A
Y
T
T
Y
E
V
Y
P
T
F
Site 48
T581
T
T
Y
E
V
Y
P
T
F
A
V
T
A
R
G
Site 49
T585
V
Y
P
T
F
A
V
T
A
R
G
D
G
Y
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation