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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TCF7L2
Full Name:
Transcription factor 7-like 2
Alias:
HMG box transcription factor 4; T-cell-specific transcription factor 4; TCF4; TCF-4; TF7L2; Transcription factor 7-like 2 (T-cell specific, HMG-box)
Type:
Nucleus protein
Mass (Da):
67919
Number AA:
619
UniProt ID:
Q9NQB0
International Prot ID:
IPI00164708
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070369
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0008013
GO:0019901
PhosphoSite+
KinaseNET
Biological Process:
GO:0060070
GO:0006916
GO:0001568
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
G
A
N
D
E
L
I
S
F
K
D
E
G
E
Q
Site 2
S31
E
G
E
Q
E
E
K
S
S
E
N
S
S
A
E
Site 3
S32
G
E
Q
E
E
K
S
S
E
N
S
S
A
E
R
Site 4
S35
E
E
K
S
S
E
N
S
S
A
E
R
D
L
A
Site 5
S36
E
K
S
S
E
N
S
S
A
E
R
D
L
A
D
Site 6
S46
R
D
L
A
D
V
K
S
S
L
V
N
E
S
E
Site 7
S47
D
L
A
D
V
K
S
S
L
V
N
E
S
E
T
Site 8
S52
K
S
S
L
V
N
E
S
E
T
N
Q
N
S
S
Site 9
T54
S
L
V
N
E
S
E
T
N
Q
N
S
S
S
D
Site 10
S58
E
S
E
T
N
Q
N
S
S
S
D
S
E
A
E
Site 11
S59
S
E
T
N
Q
N
S
S
S
D
S
E
A
E
R
Site 12
S60
E
T
N
Q
N
S
S
S
D
S
E
A
E
R
R
Site 13
S62
N
Q
N
S
S
S
D
S
E
A
E
R
R
P
P
Site 14
S72
E
R
R
P
P
P
R
S
E
S
F
R
D
K
S
Site 15
S74
R
P
P
P
R
S
E
S
F
R
D
K
S
R
E
Site 16
S79
S
E
S
F
R
D
K
S
R
E
S
L
E
E
A
Site 17
S82
F
R
D
K
S
R
E
S
L
E
E
A
A
K
R
Site 18
Y103
K
G
P
P
Y
P
G
Y
P
F
I
M
I
P
D
Site 19
Y115
I
P
D
L
T
S
P
Y
L
P
N
G
S
L
S
Site 20
S120
S
P
Y
L
P
N
G
S
L
S
P
T
A
R
T
Site 21
S122
Y
L
P
N
G
S
L
S
P
T
A
R
T
L
H
Site 22
T124
P
N
G
S
L
S
P
T
A
R
T
L
H
F
Q
Site 23
S134
T
L
H
F
Q
S
G
S
T
H
Y
S
A
Y
K
Site 24
S138
Q
S
G
S
T
H
Y
S
A
Y
K
T
I
E
H
Site 25
T142
T
H
Y
S
A
Y
K
T
I
E
H
Q
I
A
V
Site 26
Y151
E
H
Q
I
A
V
Q
Y
L
Q
M
K
W
P
L
Site 27
S177
Q
A
L
K
D
A
R
S
P
S
P
A
H
I
V
Site 28
S179
L
K
D
A
R
S
P
S
P
A
H
I
V
S
N
Site 29
S185
P
S
P
A
H
I
V
S
N
K
V
P
V
V
Q
Site 30
T201
P
H
H
V
H
P
L
T
P
L
I
T
Y
S
N
Site 31
T205
H
P
L
T
P
L
I
T
Y
S
N
E
H
F
T
Site 32
S207
L
T
P
L
I
T
Y
S
N
E
H
F
T
P
G
Site 33
T212
T
Y
S
N
E
H
F
T
P
G
N
P
P
P
H
Site 34
T228
P
A
D
V
D
P
K
T
G
I
P
R
P
P
H
Site 35
S240
P
P
H
P
P
D
I
S
P
Y
Y
P
L
S
P
Site 36
Y242
H
P
P
D
I
S
P
Y
Y
P
L
S
P
G
T
Site 37
Y243
P
P
D
I
S
P
Y
Y
P
L
S
P
G
T
V
Site 38
T249
Y
Y
P
L
S
P
G
T
V
G
Q
I
P
H
P
Site 39
Y269
P
Q
Q
G
Q
P
V
Y
P
I
T
T
G
G
F
Site 40
T272
G
Q
P
V
Y
P
I
T
T
G
G
F
R
H
P
Site 41
Y280
T
G
G
F
R
H
P
Y
P
T
A
L
T
V
N
Site 42
T282
G
F
R
H
P
Y
P
T
A
L
T
V
N
A
S
Site 43
T285
H
P
Y
P
T
A
L
T
V
N
A
S
M
S
R
Site 44
S289
T
A
L
T
V
N
A
S
M
S
R
F
P
P
H
Site 45
T307
P
H
H
T
L
H
T
T
G
I
P
H
P
A
I
Site 46
T316
I
P
H
P
A
I
V
T
P
T
V
K
Q
E
S
Site 47
T318
H
P
A
I
V
T
P
T
V
K
Q
E
S
S
Q
Site 48
S324
P
T
V
K
Q
E
S
S
Q
S
D
V
G
S
L
Site 49
S326
V
K
Q
E
S
S
Q
S
D
V
G
S
L
H
S
Site 50
S330
S
S
Q
S
D
V
G
S
L
H
S
S
K
H
Q
Site 51
S334
D
V
G
S
L
H
S
S
K
H
Q
D
S
K
K
Site 52
S339
H
S
S
K
H
Q
D
S
K
K
E
E
E
K
K
Site 53
Y360
P
L
N
A
F
M
L
Y
M
K
E
M
R
A
K
Site 54
S392
G
R
R
W
H
A
L
S
R
E
E
Q
A
K
Y
Site 55
Y399
S
R
E
E
Q
A
K
Y
Y
E
L
A
R
K
E
Site 56
Y400
R
E
E
Q
A
K
Y
Y
E
L
A
R
K
E
R
Site 57
Y414
R
Q
L
H
M
Q
L
Y
P
G
W
S
A
R
D
Site 58
Y423
G
W
S
A
R
D
N
Y
G
K
K
K
K
R
K
Site 59
S459
L
P
P
I
T
D
L
S
A
P
K
K
C
R
A
Site 60
Y489
R
K
K
K
C
V
R
Y
I
Q
G
E
G
S
C
Site 61
S495
R
Y
I
Q
G
E
G
S
C
L
S
P
P
S
S
Site 62
S498
Q
G
E
G
S
C
L
S
P
P
S
S
D
G
S
Site 63
S501
G
S
C
L
S
P
P
S
S
D
G
S
L
L
D
Site 64
S502
S
C
L
S
P
P
S
S
D
G
S
L
L
D
S
Site 65
S505
S
P
P
S
S
D
G
S
L
L
D
S
P
P
P
Site 66
S509
S
D
G
S
L
L
D
S
P
P
P
S
P
N
L
Site 67
S513
L
L
D
S
P
P
P
S
P
N
L
L
G
S
P
Site 68
S519
P
S
P
N
L
L
G
S
P
P
R
D
A
K
S
Site 69
S526
S
P
P
R
D
A
K
S
Q
T
E
Q
T
Q
P
Site 70
T531
A
K
S
Q
T
E
Q
T
Q
P
L
S
L
S
L
Site 71
S535
T
E
Q
T
Q
P
L
S
L
S
L
K
P
D
P
Site 72
S537
Q
T
Q
P
L
S
L
S
L
K
P
D
P
L
A
Site 73
S547
P
D
P
L
A
H
L
S
M
M
P
P
P
P
A
Site 74
S587
L
Q
P
A
A
P
S
S
S
I
A
Q
P
S
T
Site 75
S588
Q
P
A
A
P
S
S
S
I
A
Q
P
S
T
S
Site 76
S593
S
S
S
I
A
Q
P
S
T
S
S
L
H
S
H
Site 77
T594
S
S
I
A
Q
P
S
T
S
S
L
H
S
H
S
Site 78
S595
S
I
A
Q
P
S
T
S
S
L
H
S
H
S
S
Site 79
S596
I
A
Q
P
S
T
S
S
L
H
S
H
S
S
L
Site 80
S599
P
S
T
S
S
L
H
S
H
S
S
L
A
G
T
Site 81
S602
S
S
L
H
S
H
S
S
L
A
G
T
Q
P
Q
Site 82
T606
S
H
S
S
L
A
G
T
Q
P
Q
P
L
S
L
Site 83
S612
G
T
Q
P
Q
P
L
S
L
V
T
K
S
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation