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Updated November 2019
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Protein Info
Short Name:
RTN4
Full Name:
Reticulon-4
Alias:
ASY; Foocen; KIAA0886; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NOGO; Nogo protein; NSP; NSP-CL; Reticulon 4; Reticulon-4; Reticulon-5; RTN-x
Type:
Inhibitor protein
Mass (Da):
129931
Number AA:
1192
UniProt ID:
Q9NQC3
International Prot ID:
IPI00021766
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030176
GO:0005635
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0019987
GO:0030517
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
D
L
D
Q
S
P
L
V
S
S
S
D
Site 2
S11
L
D
Q
S
P
L
V
S
S
S
D
S
P
P
R
Site 3
S12
D
Q
S
P
L
V
S
S
S
D
S
P
P
R
P
Site 4
S13
Q
S
P
L
V
S
S
S
D
S
P
P
R
P
Q
Site 5
S15
P
L
V
S
S
S
D
S
P
P
R
P
Q
P
A
Site 6
Y25
R
P
Q
P
A
F
K
Y
Q
F
V
R
E
P
E
Site 7
S107
V
A
P
E
R
Q
P
S
W
D
P
S
P
V
S
Site 8
S111
R
Q
P
S
W
D
P
S
P
V
S
S
T
V
P
Site 9
S114
S
W
D
P
S
P
V
S
S
T
V
P
A
P
S
Site 10
S115
W
D
P
S
P
V
S
S
T
V
P
A
P
S
P
Site 11
T116
D
P
S
P
V
S
S
T
V
P
A
P
S
P
L
Site 12
S121
S
S
T
V
P
A
P
S
P
L
S
A
A
A
V
Site 13
S129
P
L
S
A
A
A
V
S
P
S
K
L
P
E
D
Site 14
S150
P
P
P
P
P
P
A
S
V
S
P
Q
A
E
P
Site 15
S152
P
P
P
P
A
S
V
S
P
Q
A
E
P
V
W
Site 16
T160
P
Q
A
E
P
V
W
T
P
P
A
P
A
P
A
Site 17
S171
P
A
P
A
A
P
P
S
T
P
A
A
P
K
R
Site 18
T172
A
P
A
A
P
P
S
T
P
A
A
P
K
R
R
Site 19
S181
A
A
P
K
R
R
G
S
S
G
S
V
D
E
T
Site 20
S182
A
P
K
R
R
G
S
S
G
S
V
D
E
T
L
Site 21
S184
K
R
R
G
S
S
G
S
V
D
E
T
L
F
A
Site 22
T188
S
S
G
S
V
D
E
T
L
F
A
L
P
A
A
Site 23
S196
L
F
A
L
P
A
A
S
E
P
V
I
R
S
S
Site 24
S202
A
S
E
P
V
I
R
S
S
A
E
N
M
D
L
Site 25
S203
S
E
P
V
I
R
S
S
A
E
N
M
D
L
K
Site 26
S218
E
Q
P
G
N
T
I
S
A
G
Q
E
D
F
P
Site 27
S242
L
P
S
L
S
P
L
S
A
A
S
F
K
E
H
Site 28
S245
L
S
P
L
S
A
A
S
F
K
E
H
E
Y
L
Site 29
Y251
A
S
F
K
E
H
E
Y
L
G
N
L
S
T
V
Site 30
S256
H
E
Y
L
G
N
L
S
T
V
L
P
T
E
G
Site 31
T257
E
Y
L
G
N
L
S
T
V
L
P
T
E
G
T
Site 32
S270
G
T
L
Q
E
N
V
S
E
A
S
K
E
V
S
Site 33
S277
S
E
A
S
K
E
V
S
E
K
A
K
T
L
L
Site 34
T282
E
V
S
E
K
A
K
T
L
L
I
D
R
D
L
Site 35
T290
L
L
I
D
R
D
L
T
E
F
S
E
L
E
Y
Site 36
S293
D
R
D
L
T
E
F
S
E
L
E
Y
S
E
M
Site 37
Y297
T
E
F
S
E
L
E
Y
S
E
M
G
S
S
F
Site 38
S298
E
F
S
E
L
E
Y
S
E
M
G
S
S
F
S
Site 39
S302
L
E
Y
S
E
M
G
S
S
F
S
V
S
P
K
Site 40
S303
E
Y
S
E
M
G
S
S
F
S
V
S
P
K
A
Site 41
S305
S
E
M
G
S
S
F
S
V
S
P
K
A
E
S
Site 42
S307
M
G
S
S
F
S
V
S
P
K
A
E
S
A
V
Site 43
S336
D
E
E
E
K
L
V
S
N
N
I
L
H
N
Q
Site 44
S361
V
K
E
D
E
V
V
S
S
E
K
A
K
D
S
Site 45
S362
K
E
D
E
V
V
S
S
E
K
A
K
D
S
F
Site 46
S368
S
S
E
K
A
K
D
S
F
N
E
K
R
V
A
Site 47
Y384
E
A
P
M
R
E
E
Y
A
D
F
K
P
F
E
Site 48
S399
R
V
W
E
V
K
D
S
K
E
D
S
D
M
L
Site 49
S403
V
K
D
S
K
E
D
S
D
M
L
A
A
G
G
Site 50
S418
K
I
E
S
N
L
E
S
K
V
D
K
K
C
F
Site 51
S428
D
K
K
C
F
A
D
S
L
E
Q
T
N
H
E
Site 52
T432
F
A
D
S
L
E
Q
T
N
H
E
K
D
S
E
Site 53
S438
Q
T
N
H
E
K
D
S
E
S
S
N
D
D
T
Site 54
S440
N
H
E
K
D
S
E
S
S
N
D
D
T
S
F
Site 55
T445
S
E
S
S
N
D
D
T
S
F
P
S
T
P
E
Site 56
S446
E
S
S
N
D
D
T
S
F
P
S
T
P
E
G
Site 57
T450
D
D
T
S
F
P
S
T
P
E
G
I
K
D
R
Site 58
S458
P
E
G
I
K
D
R
S
G
A
Y
I
T
C
A
Site 59
T463
D
R
S
G
A
Y
I
T
C
A
P
F
N
P
A
Site 60
T487
F
P
L
L
G
D
P
T
S
E
N
K
T
D
E
Site 61
S488
P
L
L
G
D
P
T
S
E
N
K
T
D
E
K
Site 62
T492
D
P
T
S
E
N
K
T
D
E
K
K
I
E
E
Site 63
T510
Q
I
V
T
E
K
N
T
S
T
K
T
S
N
P
Site 64
S511
I
V
T
E
K
N
T
S
T
K
T
S
N
P
F
Site 65
T514
E
K
N
T
S
T
K
T
S
N
P
F
L
V
A
Site 66
S515
K
N
T
S
T
K
T
S
N
P
F
L
V
A
A
Site 67
S525
F
L
V
A
A
Q
D
S
E
T
D
Y
V
T
T
Site 68
T527
V
A
A
Q
D
S
E
T
D
Y
V
T
T
D
N
Site 69
Y529
A
Q
D
S
E
T
D
Y
V
T
T
D
N
L
T
Site 70
T551
A
N
M
P
E
G
L
T
P
D
L
V
Q
E
A
Site 71
S561
L
V
Q
E
A
C
E
S
E
L
N
E
V
T
G
Site 72
T569
E
L
N
E
V
T
G
T
K
I
A
Y
E
T
K
Site 73
S589
T
S
E
V
M
Q
E
S
L
Y
P
A
A
Q
L
Site 74
Y591
E
V
M
Q
E
S
L
Y
P
A
A
Q
L
C
P
Site 75
S599
P
A
A
Q
L
C
P
S
F
E
E
S
E
A
T
Site 76
S603
L
C
P
S
F
E
E
S
E
A
T
P
S
P
V
Site 77
T606
S
F
E
E
S
E
A
T
P
S
P
V
L
P
D
Site 78
S608
E
E
S
E
A
T
P
S
P
V
L
P
D
I
V
Site 79
S635
G
A
S
V
I
Q
P
S
S
S
P
L
E
A
S
Site 80
S636
A
S
V
I
Q
P
S
S
S
P
L
E
A
S
S
Site 81
S637
S
V
I
Q
P
S
S
S
P
L
E
A
S
S
V
Site 82
S642
S
S
S
P
L
E
A
S
S
V
N
Y
E
S
I
Site 83
S643
S
S
P
L
E
A
S
S
V
N
Y
E
S
I
K
Site 84
Y646
L
E
A
S
S
V
N
Y
E
S
I
K
H
E
P
Site 85
S648
A
S
S
V
N
Y
E
S
I
K
H
E
P
E
N
Site 86
Y659
E
P
E
N
P
P
P
Y
E
E
A
M
S
V
S
Site 87
S664
P
P
Y
E
E
A
M
S
V
S
L
K
K
V
S
Site 88
S666
Y
E
E
A
M
S
V
S
L
K
K
V
S
G
I
Site 89
Y694
L
Q
E
T
E
A
P
Y
I
S
I
A
C
D
L
Site 90
S708
L
I
K
E
T
K
L
S
A
E
P
A
P
D
F
Site 91
S716
A
E
P
A
P
D
F
S
D
Y
S
E
M
A
K
Site 92
Y718
P
A
P
D
F
S
D
Y
S
E
M
A
K
V
E
Site 93
S732
E
Q
P
V
P
D
H
S
E
L
V
E
D
S
S
Site 94
S738
H
S
E
L
V
E
D
S
S
P
D
S
E
P
V
Site 95
S739
S
E
L
V
E
D
S
S
P
D
S
E
P
V
D
Site 96
S742
V
E
D
S
S
P
D
S
E
P
V
D
L
F
S
Site 97
S749
S
E
P
V
D
L
F
S
D
D
S
I
P
D
V
Site 98
S752
V
D
L
F
S
D
D
S
I
P
D
V
P
Q
K
Site 99
T763
V
P
Q
K
Q
D
E
T
V
M
L
V
K
E
S
Site 100
T772
M
L
V
K
E
S
L
T
E
T
S
F
E
S
M
Site 101
T774
V
K
E
S
L
T
E
T
S
F
E
S
M
I
E
Site 102
S775
K
E
S
L
T
E
T
S
F
E
S
M
I
E
Y
Site 103
S778
L
T
E
T
S
F
E
S
M
I
E
Y
E
N
K
Site 104
Y782
S
F
E
S
M
I
E
Y
E
N
K
E
K
L
S
Site 105
S789
Y
E
N
K
E
K
L
S
A
L
P
P
E
G
G
Site 106
Y799
P
P
E
G
G
K
P
Y
L
E
S
F
K
L
S
Site 107
S802
G
G
K
P
Y
L
E
S
F
K
L
S
L
D
N
Site 108
S806
Y
L
E
S
F
K
L
S
L
D
N
T
K
D
T
Site 109
T810
F
K
L
S
L
D
N
T
K
D
T
L
L
P
D
Site 110
T813
S
L
D
N
T
K
D
T
L
L
P
D
E
V
S
Site 111
S820
T
L
L
P
D
E
V
S
T
L
S
K
K
E
K
Site 112
S823
P
D
E
V
S
T
L
S
K
K
E
K
I
P
L
Site 113
S836
P
L
Q
M
E
E
L
S
T
A
V
Y
S
N
D
Site 114
T837
L
Q
M
E
E
L
S
T
A
V
Y
S
N
D
D
Site 115
Y840
E
E
L
S
T
A
V
Y
S
N
D
D
L
F
I
Site 116
S848
S
N
D
D
L
F
I
S
K
E
A
Q
I
R
E
Site 117
T856
K
E
A
Q
I
R
E
T
E
T
F
S
D
S
S
Site 118
T858
A
Q
I
R
E
T
E
T
F
S
D
S
S
P
I
Site 119
S860
I
R
E
T
E
T
F
S
D
S
S
P
I
E
I
Site 120
S862
E
T
E
T
F
S
D
S
S
P
I
E
I
I
D
Site 121
S863
T
E
T
F
S
D
S
S
P
I
E
I
I
D
E
Site 122
T873
E
I
I
D
E
F
P
T
L
I
S
S
K
T
D
Site 123
S876
D
E
F
P
T
L
I
S
S
K
T
D
S
F
S
Site 124
S877
E
F
P
T
L
I
S
S
K
T
D
S
F
S
K
Site 125
T879
P
T
L
I
S
S
K
T
D
S
F
S
K
L
A
Site 126
S881
L
I
S
S
K
T
D
S
F
S
K
L
A
R
E
Site 127
S883
S
S
K
T
D
S
F
S
K
L
A
R
E
Y
T
Site 128
Y889
F
S
K
L
A
R
E
Y
T
D
L
E
V
S
H
Site 129
T890
S
K
L
A
R
E
Y
T
D
L
E
V
S
H
K
Site 130
S898
D
L
E
V
S
H
K
S
E
I
A
N
A
P
D
Site 131
S909
N
A
P
D
G
A
G
S
L
P
C
T
E
L
P
Site 132
T913
G
A
G
S
L
P
C
T
E
L
P
H
D
L
S
Site 133
S920
T
E
L
P
H
D
L
S
L
K
N
I
Q
P
K
Site 134
S933
P
K
V
E
E
K
I
S
F
S
D
D
F
S
K
Site 135
S935
V
E
E
K
I
S
F
S
D
D
F
S
K
N
G
Site 136
S939
I
S
F
S
D
D
F
S
K
N
G
S
A
T
S
Site 137
S943
D
D
F
S
K
N
G
S
A
T
S
K
V
L
L
Site 138
T945
F
S
K
N
G
S
A
T
S
K
V
L
L
L
P
Site 139
S946
S
K
N
G
S
A
T
S
K
V
L
L
L
P
P
Site 140
S983
E
A
E
K
K
L
P
S
D
T
E
K
E
D
R
Site 141
T985
E
K
K
L
P
S
D
T
E
K
E
D
R
S
P
Site 142
S991
D
T
E
K
E
D
R
S
P
S
A
I
F
S
A
Site 143
S993
E
K
E
D
R
S
P
S
A
I
F
S
A
E
L
Site 144
S997
R
S
P
S
A
I
F
S
A
E
L
S
K
T
S
Site 145
Y1010
T
S
V
V
D
L
L
Y
W
R
D
I
K
K
T
Site 146
T1017
Y
W
R
D
I
K
K
T
G
V
V
F
G
A
S
Site 147
S1067
V
I
Q
A
I
Q
K
S
D
E
G
H
P
F
R
Site 148
Y1076
E
G
H
P
F
R
A
Y
L
E
S
E
V
A
I
Site 149
S1079
P
F
R
A
Y
L
E
S
E
V
A
I
S
E
E
Site 150
S1084
L
E
S
E
V
A
I
S
E
E
L
V
Q
K
Y
Site 151
Y1091
S
E
E
L
V
Q
K
Y
S
N
S
A
L
G
H
Site 152
S1092
E
E
L
V
Q
K
Y
S
N
S
A
L
G
H
V
Site 153
Y1165
H
Q
A
Q
I
D
H
Y
L
G
L
A
N
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation