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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYLD
Full Name:
Ubiquitin carboxyl-terminal hydrolase CYLD
Alias:
CDMT; CYLD1; CYLDI; Cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; EAC; EC 3.1.2.15; Familial cylindromatosis gene; HSPC057; KIAA0849; Ubiquitin carboxyl-terminal hydrolase CYLD; Ubiquitin specific peptidase like 2; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD; USPL2
Type:
Protease; EC 3.1.2.15; Ubiquitin conjugating system
Mass (Da):
107316
Number AA:
956
UniProt ID:
Q9NQC7
International Prot ID:
IPI00106663
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0048471
GO:0005840
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0003735
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006412
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
S
G
L
W
S
Q
E
K
V
T
S
P
Site 2
S13
W
S
Q
E
K
V
T
S
P
Y
W
E
E
R
I
Site 3
Y15
Q
E
K
V
T
S
P
Y
W
E
E
R
I
F
Y
Site 4
Y22
Y
W
E
E
R
I
F
Y
L
L
L
Q
E
C
S
Site 5
S29
Y
L
L
L
Q
E
C
S
V
T
D
K
Q
T
Q
Site 6
T31
L
L
Q
E
C
S
V
T
D
K
Q
T
Q
K
L
Site 7
T35
C
S
V
T
D
K
Q
T
Q
K
L
L
K
V
P
Site 8
S45
L
L
K
V
P
K
G
S
I
G
Q
Y
I
Q
D
Site 9
Y49
P
K
G
S
I
G
Q
Y
I
Q
D
R
S
V
G
Site 10
S54
G
Q
Y
I
Q
D
R
S
V
G
H
S
R
I
P
Site 11
S58
Q
D
R
S
V
G
H
S
R
I
P
S
A
K
G
Site 12
S62
V
G
H
S
R
I
P
S
A
K
G
K
K
N
Q
Site 13
S111
T
N
C
E
E
R
F
S
L
F
K
N
R
N
R
Site 14
S120
F
K
N
R
N
R
L
S
K
G
L
Q
I
D
V
Site 15
T177
E
G
R
G
Q
G
F
T
D
G
V
Y
Q
G
K
Site 16
Y181
Q
G
F
T
D
G
V
Y
Q
G
K
Q
L
F
Q
Site 17
T210
E
L
I
E
D
D
D
T
A
L
E
S
D
Y
A
Site 18
S214
D
D
D
T
A
L
E
S
D
Y
A
G
P
G
D
Site 19
Y216
D
T
A
L
E
S
D
Y
A
G
P
G
D
T
M
Site 20
T222
D
Y
A
G
P
G
D
T
M
Q
V
E
L
P
P
Site 21
Y263
P
G
K
E
S
L
G
Y
F
V
G
V
D
M
D
Site 22
S307
N
D
I
I
P
A
L
S
E
S
V
T
Q
E
R
Site 23
S309
I
I
P
A
L
S
E
S
V
T
Q
E
R
R
P
Site 24
T311
P
A
L
S
E
S
V
T
Q
E
R
R
P
P
K
Site 25
S323
P
P
K
L
A
F
M
S
R
G
V
G
D
K
G
Site 26
S331
R
G
V
G
D
K
G
S
S
S
H
N
K
P
K
Site 27
S333
V
G
D
K
G
S
S
S
H
N
K
P
K
A
T
Site 28
T340
S
H
N
K
P
K
A
T
G
S
T
S
D
P
G
Site 29
S342
N
K
P
K
A
T
G
S
T
S
D
P
G
N
R
Site 30
T343
K
P
K
A
T
G
S
T
S
D
P
G
N
R
N
Site 31
S344
P
K
A
T
G
S
T
S
D
P
G
N
R
N
R
Site 32
S352
D
P
G
N
R
N
R
S
E
L
F
Y
T
L
N
Site 33
Y356
R
N
R
S
E
L
F
Y
T
L
N
G
S
S
V
Site 34
T357
N
R
S
E
L
F
Y
T
L
N
G
S
S
V
D
Site 35
S361
L
F
Y
T
L
N
G
S
S
V
D
S
Q
P
Q
Site 36
S362
F
Y
T
L
N
G
S
S
V
D
S
Q
P
Q
S
Site 37
S365
L
N
G
S
S
V
D
S
Q
P
Q
S
K
S
K
Site 38
S369
S
V
D
S
Q
P
Q
S
K
S
K
N
T
W
Y
Site 39
S371
D
S
Q
P
Q
S
K
S
K
N
T
W
Y
I
D
Site 40
Y376
S
K
S
K
N
T
W
Y
I
D
E
V
A
E
D
Site 41
S387
V
A
E
D
P
A
K
S
L
T
E
I
S
T
D
Site 42
T389
E
D
P
A
K
S
L
T
E
I
S
T
D
F
D
Site 43
T393
K
S
L
T
E
I
S
T
D
F
D
R
S
S
P
Site 44
S398
I
S
T
D
F
D
R
S
S
P
P
L
Q
P
P
Site 45
S399
S
T
D
F
D
R
S
S
P
P
L
Q
P
P
P
Site 46
S409
L
Q
P
P
P
V
N
S
L
T
T
E
N
R
F
Site 47
T411
P
P
P
V
N
S
L
T
T
E
N
R
F
H
S
Site 48
T412
P
P
V
N
S
L
T
T
E
N
R
F
H
S
L
Site 49
S418
T
T
E
N
R
F
H
S
L
P
F
S
L
T
K
Site 50
S422
R
F
H
S
L
P
F
S
L
T
K
M
P
N
T
Site 51
T424
H
S
L
P
F
S
L
T
K
M
P
N
T
N
G
Site 52
T429
S
L
T
K
M
P
N
T
N
G
S
I
G
H
S
Site 53
S432
K
M
P
N
T
N
G
S
I
G
H
S
P
L
S
Site 54
S436
T
N
G
S
I
G
H
S
P
L
S
L
S
A
Q
Site 55
S439
S
I
G
H
S
P
L
S
L
S
A
Q
S
V
M
Site 56
S441
G
H
S
P
L
S
L
S
A
Q
S
V
M
E
E
Site 57
S444
P
L
S
L
S
A
Q
S
V
M
E
E
L
N
T
Site 58
T451
S
V
M
E
E
L
N
T
A
P
V
Q
E
S
P
Site 59
S457
N
T
A
P
V
Q
E
S
P
P
L
A
M
P
P
Site 60
S474
S
H
G
L
E
V
G
S
L
A
E
V
K
E
N
Site 61
Y485
V
K
E
N
P
P
F
Y
G
V
I
R
W
I
G
Site 62
T521
T
D
G
T
F
R
G
T
R
Y
F
T
C
A
L
Site 63
Y523
G
T
F
R
G
T
R
Y
F
T
C
A
L
K
K
Site 64
T525
F
R
G
T
R
Y
F
T
C
A
L
K
K
A
L
Site 65
S538
A
L
F
V
K
L
K
S
C
R
P
D
S
R
F
Site 66
S543
L
K
S
C
R
P
D
S
R
F
A
S
L
Q
P
Site 67
S547
R
P
D
S
R
F
A
S
L
Q
P
V
S
N
Q
Site 68
S552
F
A
S
L
Q
P
V
S
N
Q
I
E
R
C
N
Site 69
S560
N
Q
I
E
R
C
N
S
L
A
F
G
G
Y
L
Site 70
T575
S
E
V
V
E
E
N
T
P
P
K
M
E
K
E
Site 71
Y598
K
K
G
I
Q
G
H
Y
N
S
C
Y
L
D
S
Site 72
Y602
Q
G
H
Y
N
S
C
Y
L
D
S
T
L
F
C
Site 73
Y632
K
E
K
N
D
V
E
Y
Y
S
E
T
Q
E
L
Site 74
T642
E
T
Q
E
L
L
R
T
E
I
V
N
P
L
R
Site 75
S677
E
A
A
S
G
F
T
S
E
E
K
D
P
E
E
Site 76
S704
E
P
L
L
K
I
R
S
A
G
Q
K
V
Q
D
Site 77
Y713
G
Q
K
V
Q
D
C
Y
F
Y
Q
I
F
M
E
Site 78
Y715
K
V
Q
D
C
Y
F
Y
Q
I
F
M
E
K
N
Site 79
S737
I
Q
Q
L
L
E
W
S
F
I
N
S
N
L
K
Site 80
S741
L
E
W
S
F
I
N
S
N
L
K
F
A
E
A
Site 81
T778
P
S
L
E
L
N
I
T
D
L
L
E
D
T
P
Site 82
T784
I
T
D
L
L
E
D
T
P
R
Q
C
R
I
C
Site 83
Y803
M
Y
E
C
R
E
C
Y
D
D
P
D
I
S
A
Site 84
Y835
P
K
R
L
N
H
K
Y
N
P
V
S
L
P
K
Site 85
S839
N
H
K
Y
N
P
V
S
L
P
K
D
L
P
D
Site 86
Y878
H
Y
V
A
F
V
K
Y
G
K
D
D
S
A
W
Site 87
S890
S
A
W
L
F
F
D
S
M
A
D
R
D
G
G
Site 88
T907
G
F
N
I
P
Q
V
T
P
C
P
E
V
G
E
Site 89
Y915
P
C
P
E
V
G
E
Y
L
K
M
S
L
E
D
Site 90
S919
V
G
E
Y
L
K
M
S
L
E
D
L
H
S
L
Site 91
S925
M
S
L
E
D
L
H
S
L
D
S
R
R
I
Q
Site 92
S928
E
D
L
H
S
L
D
S
R
R
I
Q
G
C
A
Site 93
Y943
R
R
L
L
C
D
A
Y
M
C
M
Y
Q
S
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation