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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HPS4
Full Name:
Hermansky-Pudlak syndrome 4 protein
Alias:
Hermansky-Pudlak syndrome 4; KIAA1667; LE; light-ear
Type:
Mass (Da):
76920
Number AA:
UniProt ID:
Q9NQG7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
GO:0042470
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0007599
GO:0007040
GO:0048075
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
T
S
T
S
T
E
A
K
S
A
S
Site 2
Y17
K
S
A
S
W
W
N
Y
F
F
L
Y
D
G
S
Site 3
S24
Y
F
F
L
Y
D
G
S
K
V
K
E
E
G
D
Site 4
T33
V
K
E
E
G
D
P
T
R
A
G
I
C
Y
F
Site 5
Y39
P
T
R
A
G
I
C
Y
F
Y
P
S
Q
T
L
Site 6
T73
D
I
S
D
S
P
P
T
L
V
R
L
R
K
L
Site 7
S104
A
V
E
L
P
D
V
S
C
K
R
F
L
D
Q
Site 8
Y127
N
G
P
V
S
L
A
Y
E
N
C
S
Q
E
E
Site 9
S131
S
L
A
Y
E
N
C
S
Q
E
E
L
S
T
E
Site 10
T137
C
S
Q
E
E
L
S
T
E
W
D
T
F
I
E
Site 11
T141
E
L
S
T
E
W
D
T
F
I
E
Q
I
L
K
Site 12
T182
K
A
A
R
I
L
Q
T
C
Q
R
S
P
H
I
Site 13
T210
T
Q
L
P
P
S
L
T
A
K
V
L
L
H
R
Site 14
T227
P
Q
E
Q
R
L
P
T
G
E
D
A
P
Q
E
Site 15
S257
V
T
K
E
E
A
I
S
L
H
E
F
P
V
E
Site 16
S269
P
V
E
Q
M
T
R
S
L
A
S
P
A
G
L
Site 17
S272
Q
M
T
R
S
L
A
S
P
A
G
L
Q
D
G
Site 18
S280
P
A
G
L
Q
D
G
S
A
Q
H
H
P
K
G
Site 19
T298
S
A
L
K
E
N
A
T
G
H
V
E
S
M
A
Site 20
T307
H
V
E
S
M
A
W
T
T
P
D
P
T
S
P
Site 21
T308
V
E
S
M
A
W
T
T
P
D
P
T
S
P
D
Site 22
S313
W
T
T
P
D
P
T
S
P
D
E
A
C
P
D
Site 23
S329
R
K
E
N
G
C
L
S
G
H
D
L
E
S
I
Site 24
S335
L
S
G
H
D
L
E
S
I
R
P
A
G
L
H
Site 25
S344
R
P
A
G
L
H
N
S
A
R
G
E
V
L
G
Site 26
S353
R
G
E
V
L
G
L
S
S
S
L
G
K
E
L
Site 27
S355
E
V
L
G
L
S
S
S
L
G
K
E
L
V
F
Site 28
S370
L
Q
E
E
L
D
L
S
E
I
H
I
P
E
A
Site 29
Y401
V
P
D
G
R
A
P
Y
C
K
A
S
L
S
A
Site 30
S405
R
A
P
Y
C
K
A
S
L
S
A
S
S
S
L
Site 31
S407
P
Y
C
K
A
S
L
S
A
S
S
S
L
E
P
Site 32
S409
C
K
A
S
L
S
A
S
S
S
L
E
P
T
P
Site 33
S411
A
S
L
S
A
S
S
S
L
E
P
T
P
P
E
Site 34
T415
A
S
S
S
L
E
P
T
P
P
E
D
T
A
I
Site 35
T420
E
P
T
P
P
E
D
T
A
I
S
S
L
R
P
Site 36
S423
P
P
E
D
T
A
I
S
S
L
R
P
P
S
A
Site 37
S424
P
E
D
T
A
I
S
S
L
R
P
P
S
A
P
Site 38
S429
I
S
S
L
R
P
P
S
A
P
E
M
L
T
Q
Site 39
S451
E
D
H
P
G
H
S
S
Q
A
P
I
P
R
A
Site 40
T465
A
D
P
L
P
R
R
T
R
R
P
L
L
L
P
Site 41
S500
D
V
D
G
V
C
E
S
H
A
A
P
G
L
E
Site 42
S512
G
L
E
C
S
S
G
S
A
N
C
Q
G
A
G
Site 43
S521
N
C
Q
G
A
G
P
S
A
D
G
I
S
S
R
Site 44
S526
G
P
S
A
D
G
I
S
S
R
L
T
P
A
E
Site 45
T530
D
G
I
S
S
R
L
T
P
A
E
S
C
M
G
Site 46
Y544
G
L
V
R
M
N
L
Y
T
H
C
V
K
G
L
Site 47
T545
L
V
R
M
N
L
Y
T
H
C
V
K
G
L
V
Site 48
S565
E
E
P
L
L
G
D
S
A
A
I
E
E
V
Y
Site 49
S574
A
I
E
E
V
Y
H
S
S
L
A
S
L
N
G
Site 50
S597
L
P
R
D
E
A
A
S
T
S
S
T
Y
N
F
Site 51
T598
P
R
D
E
A
A
S
T
S
S
T
Y
N
F
T
Site 52
S600
D
E
A
A
S
T
S
S
T
Y
N
F
T
H
Y
Site 53
T601
E
A
A
S
T
S
S
T
Y
N
F
T
H
Y
D
Site 54
Y607
S
T
Y
N
F
T
H
Y
D
R
I
Q
S
L
L
Site 55
S612
T
H
Y
D
R
I
Q
S
L
L
M
A
N
L
P
Site 56
T623
A
N
L
P
Q
V
A
T
P
Q
D
R
R
F
L
Site 57
S634
R
R
F
L
Q
A
V
S
L
M
H
S
E
F
A
Site 58
Y659
R
N
A
S
T
A
V
Y
A
C
C
N
P
I
Q
Site 59
Y669
C
N
P
I
Q
E
T
Y
F
Q
Q
L
A
P
A
Site 60
S680
L
A
P
A
A
R
S
S
G
F
P
N
P
Q
D
Site 61
S691
N
P
Q
D
G
A
F
S
L
S
G
K
A
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation