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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SETD8
Full Name:
Histone-lysine N-methyltransferase SETD8
Alias:
H4-K20-HMTase; H4-K20-specific histone methyltransferase; KMT5A; PR/SET domain containing protein 8; PR/SET domain-containing; PR-Set7; SET domain containing (lysine methyltransferase) 8; SET07; SET8
Type:
EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase
Mass (Da):
42890
Number AA:
393
UniProt ID:
Q9NQR1
International Prot ID:
IPI00288890
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0018024
GO:0003714
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0016568
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T83
R
G
P
G
R
P
R
T
D
G
E
N
V
F
T
Site 2
T90
T
D
G
E
N
V
F
T
G
Q
S
K
I
Y
S
Site 3
Y96
F
T
G
Q
S
K
I
Y
S
Y
M
S
P
N
K
Site 4
Y98
G
Q
S
K
I
Y
S
Y
M
S
P
N
K
C
S
Site 5
S100
S
K
I
Y
S
Y
M
S
P
N
K
C
S
G
M
Site 6
S116
F
P
L
Q
E
E
N
S
V
T
H
H
E
V
K
Site 7
T118
L
Q
E
E
N
S
V
T
H
H
E
V
K
C
Q
Site 8
S152
A
V
R
S
A
M
K
S
E
E
Q
K
I
K
D
Site 9
S173
V
P
F
P
N
Q
K
S
E
A
A
E
P
P
K
Site 10
T181
E
A
A
E
P
P
K
T
P
P
S
S
C
D
S
Site 11
S184
E
P
P
K
T
P
P
S
S
C
D
S
T
N
A
Site 12
S185
P
P
K
T
P
P
S
S
C
D
S
T
N
A
A
Site 13
S188
T
P
P
S
S
C
D
S
T
N
A
A
I
A
K
Site 14
T189
P
P
S
S
C
D
S
T
N
A
A
I
A
K
Q
Site 15
T223
T
Q
Q
N
R
K
L
T
D
F
Y
P
V
R
R
Site 16
Y226
N
R
K
L
T
D
F
Y
P
V
R
R
S
S
R
Site 17
S231
D
F
Y
P
V
R
R
S
S
R
K
S
K
A
E
Site 18
S232
F
Y
P
V
R
R
S
S
R
K
S
K
A
E
L
Site 19
S235
V
R
R
S
S
R
K
S
K
A
E
L
Q
S
E
Site 20
S253
R
I
D
E
L
I
E
S
G
K
E
E
G
M
K
Site 21
T274
K
G
R
G
V
I
A
T
K
Q
F
S
R
G
D
Site 22
Y286
R
G
D
F
V
V
E
Y
H
G
D
L
I
E
I
Site 23
Y303
A
K
K
R
E
A
L
Y
A
Q
D
P
S
T
G
Site 24
Y312
Q
D
P
S
T
G
C
Y
M
Y
Y
F
Q
Y
L
Site 25
Y314
P
S
T
G
C
Y
M
Y
Y
F
Q
Y
L
S
K
Site 26
Y315
S
T
G
C
Y
M
Y
Y
F
Q
Y
L
S
K
T
Site 27
T331
C
V
D
A
T
R
E
T
N
R
L
G
R
L
I
Site 28
Y375
A
A
G
E
E
L
L
Y
D
Y
G
D
R
S
K
Site 29
Y377
G
E
E
L
L
Y
D
Y
G
D
R
S
K
A
S
Site 30
S381
L
Y
D
Y
G
D
R
S
K
A
S
I
E
A
H
Site 31
S384
Y
G
D
R
S
K
A
S
I
E
A
H
P
W
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation