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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INCENP
Full Name:
Inner centromere protein
Alias:
AURKB; EC 2.7.11.1; FLJ31633; INCE; Inner centromere protein antigens 135/155kDa
Type:
EC 2.7.11.1; Cell cycle regulation
Mass (Da):
105429
Number AA:
918
UniProt ID:
Q9NQS7
International Prot ID:
IPI00024970
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005721
GO:0005874
GO:0005819
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007059
GO:0000910
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T46
E
E
A
E
R
M
F
T
R
E
F
S
K
E
P
Site 2
S50
R
M
F
T
R
E
F
S
K
E
P
E
L
M
P
Site 3
T59
E
P
E
L
M
P
K
T
P
S
Q
K
N
R
R
Site 4
S61
E
L
M
P
K
T
P
S
Q
K
N
R
R
K
K
Site 5
S72
R
R
K
K
R
R
I
S
Y
V
Q
D
E
N
R
Site 6
Y73
R
K
K
R
R
I
S
Y
V
Q
D
E
N
R
D
Site 7
S87
D
P
I
R
R
R
L
S
R
R
K
S
R
S
S
Site 8
S91
R
R
L
S
R
R
K
S
R
S
S
Q
L
S
S
Site 9
S93
L
S
R
R
K
S
R
S
S
Q
L
S
S
R
R
Site 10
S94
S
R
R
K
S
R
S
S
Q
L
S
S
R
R
L
Site 11
S97
K
S
R
S
S
Q
L
S
S
R
R
L
R
S
K
Site 12
S98
S
R
S
S
Q
L
S
S
R
R
L
R
S
K
D
Site 13
S103
L
S
S
R
R
L
R
S
K
D
S
V
E
K
L
Site 14
S106
R
R
L
R
S
K
D
S
V
E
K
L
A
T
V
Site 15
T112
D
S
V
E
K
L
A
T
V
V
G
E
N
G
S
Site 16
S119
T
V
V
G
E
N
G
S
V
L
R
R
V
T
R
Site 17
S142
T
M
A
L
A
A
P
S
S
P
T
P
E
S
P
Site 18
S143
M
A
L
A
A
P
S
S
P
T
P
E
S
P
T
Site 19
T145
L
A
A
P
S
S
P
T
P
E
S
P
T
M
L
Site 20
S148
P
S
S
P
T
P
E
S
P
T
M
L
T
K
K
Site 21
T150
S
P
T
P
E
S
P
T
M
L
T
K
K
P
E
Site 22
T153
P
E
S
P
T
M
L
T
K
K
P
E
D
N
H
Site 23
T161
K
K
P
E
D
N
H
T
Q
C
Q
L
V
P
V
Site 24
S174
P
V
V
E
I
G
I
S
E
R
Q
N
A
E
Q
Site 25
T184
Q
N
A
E
Q
H
V
T
Q
L
M
S
T
E
P
Site 26
T195
S
T
E
P
L
P
R
T
L
S
P
T
P
A
S
Site 27
S197
E
P
L
P
R
T
L
S
P
T
P
A
S
A
T
Site 28
T199
L
P
R
T
L
S
P
T
P
A
S
A
T
A
P
Site 29
S202
T
L
S
P
T
P
A
S
A
T
A
P
T
S
Q
Site 30
T204
S
P
T
P
A
S
A
T
A
P
T
S
Q
G
I
Site 31
T207
P
A
S
A
T
A
P
T
S
Q
G
I
P
T
S
Site 32
S208
A
S
A
T
A
P
T
S
Q
G
I
P
T
S
D
Site 33
T213
P
T
S
Q
G
I
P
T
S
D
E
E
S
T
P
Site 34
S214
T
S
Q
G
I
P
T
S
D
E
E
S
T
P
K
Site 35
S218
I
P
T
S
D
E
E
S
T
P
K
K
S
K
A
Site 36
T219
P
T
S
D
E
E
S
T
P
K
K
S
K
A
R
Site 37
S223
E
E
S
T
P
K
K
S
K
A
R
I
L
E
S
Site 38
S230
S
K
A
R
I
L
E
S
I
T
V
S
S
L
M
Site 39
T232
A
R
I
L
E
S
I
T
V
S
S
L
M
A
T
Site 40
S234
I
L
E
S
I
T
V
S
S
L
M
A
T
P
Q
Site 41
S235
L
E
S
I
T
V
S
S
L
M
A
T
P
Q
D
Site 42
T239
T
V
S
S
L
M
A
T
P
Q
D
P
K
G
Q
Site 43
T250
P
K
G
Q
G
V
G
T
G
R
S
A
S
K
L
Site 44
S253
Q
G
V
G
T
G
R
S
A
S
K
L
R
I
A
Site 45
S255
V
G
T
G
R
S
A
S
K
L
R
I
A
Q
V
Site 46
S263
K
L
R
I
A
Q
V
S
P
G
P
R
D
S
P
Site 47
S269
V
S
P
G
P
R
D
S
P
A
F
P
D
S
P
Site 48
S275
D
S
P
A
F
P
D
S
P
W
R
E
R
V
L
Site 49
S291
P
I
L
P
D
N
F
S
T
P
T
G
S
R
T
Site 50
T292
I
L
P
D
N
F
S
T
P
T
G
S
R
T
D
Site 51
T294
P
D
N
F
S
T
P
T
G
S
R
T
D
S
Q
Site 52
S296
N
F
S
T
P
T
G
S
R
T
D
S
Q
S
V
Site 53
T298
S
T
P
T
G
S
R
T
D
S
Q
S
V
R
H
Site 54
S300
P
T
G
S
R
T
D
S
Q
S
V
R
H
S
P
Site 55
S302
G
S
R
T
D
S
Q
S
V
R
H
S
P
I
A
Site 56
S306
D
S
Q
S
V
R
H
S
P
I
A
P
S
S
P
Site 57
S311
R
H
S
P
I
A
P
S
S
P
S
P
Q
V
L
Site 58
S312
H
S
P
I
A
P
S
S
P
S
P
Q
V
L
A
Site 59
S314
P
I
A
P
S
S
P
S
P
Q
V
L
A
Q
K
Site 60
Y322
P
Q
V
L
A
Q
K
Y
S
L
V
A
K
Q
E
Site 61
S323
Q
V
L
A
Q
K
Y
S
L
V
A
K
Q
E
S
Site 62
S330
S
L
V
A
K
Q
E
S
V
V
R
R
A
S
R
Site 63
S336
E
S
V
V
R
R
A
S
R
R
L
A
K
K
T
Site 64
T343
S
R
R
L
A
K
K
T
A
E
E
P
A
A
S
Site 65
S350
T
A
E
E
P
A
A
S
G
R
I
I
C
H
S
Site 66
S357
S
G
R
I
I
C
H
S
Y
L
E
R
L
L
N
Site 67
S373
E
V
P
Q
K
V
G
S
E
Q
K
E
P
P
E
Site 68
S400
P
E
N
N
G
N
N
S
W
P
H
N
D
T
E
Site 69
T406
N
S
W
P
H
N
D
T
E
I
A
N
S
T
P
Site 70
S411
N
D
T
E
I
A
N
S
T
P
N
P
K
P
A
Site 71
T412
D
T
E
I
A
N
S
T
P
N
P
K
P
A
A
Site 72
S420
P
N
P
K
P
A
A
S
S
P
E
T
P
S
A
Site 73
S421
N
P
K
P
A
A
S
S
P
E
T
P
S
A
G
Site 74
T424
P
A
A
S
S
P
E
T
P
S
A
G
Q
Q
E
Site 75
S426
A
S
S
P
E
T
P
S
A
G
Q
Q
E
A
K
Site 76
T434
A
G
Q
Q
E
A
K
T
D
Q
A
D
G
P
R
Site 77
S446
G
P
R
E
P
P
Q
S
A
R
R
K
R
S
Y
Site 78
S452
Q
S
A
R
R
K
R
S
Y
K
Q
A
V
S
E
Site 79
Y453
S
A
R
R
K
R
S
Y
K
Q
A
V
S
E
L
Site 80
S458
R
S
Y
K
Q
A
V
S
E
L
D
E
E
Q
H
Site 81
S476
E
E
L
Q
P
P
R
S
K
T
P
S
S
P
C
Site 82
T478
L
Q
P
P
R
S
K
T
P
S
S
P
C
P
A
Site 83
S480
P
P
R
S
K
T
P
S
S
P
C
P
A
S
K
Site 84
S481
P
R
S
K
T
P
S
S
P
C
P
A
S
K
V
Site 85
S486
P
S
S
P
C
P
A
S
K
V
V
R
P
L
R
Site 86
T494
K
V
V
R
P
L
R
T
F
L
H
T
V
Q
R
Site 87
T498
P
L
R
T
F
L
H
T
V
Q
R
N
Q
M
L
Site 88
T507
Q
R
N
Q
M
L
M
T
P
T
S
A
P
R
S
Site 89
T509
N
Q
M
L
M
T
P
T
S
A
P
R
S
V
M
Site 90
S510
Q
M
L
M
T
P
T
S
A
P
R
S
V
M
K
Site 91
S514
T
P
T
S
A
P
R
S
V
M
K
S
F
I
K
Site 92
S518
A
P
R
S
V
M
K
S
F
I
K
R
N
T
P
Site 93
T524
K
S
F
I
K
R
N
T
P
L
R
M
D
P
K
Site 94
S533
L
R
M
D
P
K
C
S
F
V
E
K
E
R
Q
Site 95
T610
F
A
Q
I
D
E
K
T
E
K
A
K
E
E
R
Site 96
T793
A
S
K
A
L
N
V
T
V
D
V
Q
S
P
A
Site 97
S798
N
V
T
V
D
V
Q
S
P
A
C
T
S
Y
Q
Site 98
T802
D
V
Q
S
P
A
C
T
S
Y
Q
M
T
P
Q
Site 99
S803
N
V
T
V
D
V
Q
S
P
A
C
T
S
Y
Q
Site 100
T807
A
C
T
S
Y
Q
M
T
P
Q
G
H
R
A
P
Site 101
Y822
P
K
I
N
P
D
N
Y
G
M
D
L
N
S
D
Site 102
S828
N
Y
G
M
D
L
N
S
D
D
S
T
D
D
E
Site 103
S831
M
D
L
N
S
D
D
S
T
D
D
E
A
H
P
Site 104
T832
D
L
N
S
D
D
S
T
D
D
E
A
H
P
R
Site 105
T844
H
P
R
K
P
I
P
T
W
A
R
G
T
P
L
Site 106
Y859
S
Q
A
I
I
H
Q
Y
Y
H
P
P
N
L
L
Site 107
Y860
Q
A
I
I
H
Q
Y
Y
H
P
P
N
L
L
E
Site 108
S884
L
E
D
I
F
K
K
S
K
P
R
Y
H
K
R
Site 109
Y888
F
K
K
S
K
P
R
Y
H
K
R
T
S
S
A
Site 110
T892
K
P
R
Y
H
K
R
T
S
S
A
V
W
N
S
Site 111
S893
P
R
Y
H
K
R
T
S
S
A
V
W
N
S
P
Site 112
S894
R
Y
H
K
R
T
S
S
A
V
W
N
S
P
P
Site 113
S899
R
Y
H
K
R
T
S
S
A
V
W
N
S
P
P
Site 114
S909
L
Q
G
A
R
V
P
S
S
L
A
Y
S
L
K
Site 115
S910
V
P
S
S
L
A
Y
S
L
K
K
H
_
_
_
Site 116
Y913
R
V
P
S
S
L
A
Y
S
L
K
K
H
_
_
Site 117
S914
V
P
S
S
L
A
Y
S
L
K
K
H
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation