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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EXOSC5
Full Name:
Exosome complex exonuclease RRP46
Alias:
Chronic myelogenous leukemia tumor antigen 28; CML28; EXOS5; Exosome component 5; Exosome component Rrp46; HRrp46p; MGC12901; P12B; Ribosomal RNA-processing protein 46; RRP41B; RRP46; Rrp46p
Type:
Ribonuclease; EC 3.1.13.-
Mass (Da):
25249
Number AA:
235
UniProt ID:
Q9NQT4
International Prot ID:
IPI00015955
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000178
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0000175
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006364
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
E
E
E
T
H
T
D
A
K
I
R
A
E
Site 2
T17
K
I
R
A
E
N
G
T
G
S
S
P
R
G
P
Site 3
S19
R
A
E
N
G
T
G
S
S
P
R
G
P
G
C
Site 4
S20
A
E
N
G
T
G
S
S
P
R
G
P
G
C
S
Site 5
S27
S
P
R
G
P
G
C
S
L
R
H
F
A
C
E
Site 6
S39
A
C
E
Q
N
L
L
S
R
P
D
G
S
A
S
Site 7
S44
L
L
S
R
P
D
G
S
A
S
F
L
Q
G
D
Site 8
S46
S
R
P
D
G
S
A
S
F
L
Q
G
D
T
S
Site 9
S67
G
P
A
E
V
K
V
S
K
E
I
F
N
K
A
Site 10
S93
L
P
G
V
A
E
K
S
R
E
R
L
I
R
N
Site 11
T101
R
E
R
L
I
R
N
T
C
E
A
V
V
L
G
Site 12
S171
T
L
V
L
D
P
T
S
K
Q
E
K
E
A
R
Site 13
S195
V
E
R
K
L
L
M
S
S
T
K
G
L
Y
S
Site 14
T197
R
K
L
L
M
S
S
T
K
G
L
Y
S
D
T
Site 15
S202
S
S
T
K
G
L
Y
S
D
T
E
L
Q
Q
C
Site 16
Y224
S
Q
H
V
F
R
F
Y
R
E
S
L
Q
R
R
Site 17
S227
V
F
R
F
Y
R
E
S
L
Q
R
R
Y
S
K
Site 18
Y232
R
E
S
L
Q
R
R
Y
S
K
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation