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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAK6
Full Name:
Serine/threonine-protein kinase PAK 6
Alias:
EC 2.7.11.1; PAK5
Type:
Protein-serine kinase, STE group, STE20 family, PAKB subfamily
Mass (Da):
74869
Number AA:
681
UniProt ID:
Q9NQU5
International Prot ID:
IPI00024584
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein-serine/threonine kinase PAK 6 pan-specific antibody AB-NK124-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK124-2#Protein-serine/threonine kinase PAK 6 (G73-K91, human) peptide - Powder PE-01BEH90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BEH90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
N
F
Q
H
R
V
H
T
S
F
D
P
K
E
G
Site 2
S25
F
Q
H
R
V
H
T
S
F
D
P
K
E
G
K
Site 3
T46
Q
W
Q
N
I
L
D
T
L
R
R
P
K
P
V
Site 4
T60
V
V
D
P
S
R
I
T
R
V
Q
L
Q
P
M
Site 5
S74
M
K
T
V
V
R
G
S
A
M
P
V
D
G
Y
Site 6
Y81
S
A
M
P
V
D
G
Y
I
S
G
L
L
N
D
Site 7
S83
M
P
V
D
G
Y
I
S
G
L
L
N
D
I
Q
Site 8
S97
Q
K
L
S
V
I
S
S
N
T
L
R
G
R
S
Site 9
T99
L
S
V
I
S
S
N
T
L
R
G
R
S
P
T
Site 10
S104
S
N
T
L
R
G
R
S
P
T
S
R
R
R
A
Site 11
T106
T
L
R
G
R
S
P
T
S
R
R
R
A
Q
S
Site 12
S107
L
R
G
R
S
P
T
S
R
R
R
A
Q
S
L
Site 13
S113
T
S
R
R
R
A
Q
S
L
G
L
L
G
D
E
Site 14
T124
L
G
D
E
H
W
A
T
D
P
D
M
Y
L
Q
Site 15
Y129
W
A
T
D
P
D
M
Y
L
Q
S
P
Q
S
E
Site 16
S132
D
P
D
M
Y
L
Q
S
P
Q
S
E
R
T
D
Site 17
S135
M
Y
L
Q
S
P
Q
S
E
R
T
D
P
H
G
Site 18
Y144
R
T
D
P
H
G
L
Y
L
S
C
N
G
G
T
Site 19
S146
D
P
H
G
L
Y
L
S
C
N
G
G
T
P
A
Site 20
T151
Y
L
S
C
N
G
G
T
P
A
G
H
K
Q
M
Site 21
S165
M
P
W
P
E
P
Q
S
P
R
V
L
P
N
G
Site 22
S179
G
L
A
A
K
A
Q
S
L
G
P
A
E
F
Q
Site 23
S189
P
A
E
F
Q
G
A
S
Q
R
C
L
Q
L
G
Site 24
S201
Q
L
G
A
C
L
Q
S
S
P
P
G
A
S
P
Site 25
S202
L
G
A
C
L
Q
S
S
P
P
G
A
S
P
P
Site 26
S207
Q
S
S
P
P
G
A
S
P
P
T
G
T
N
R
Site 27
T212
G
A
S
P
P
T
G
T
N
R
H
G
M
K
A
Site 28
S224
M
K
A
A
K
H
G
S
E
E
A
R
P
Q
S
Site 29
S231
S
E
E
A
R
P
Q
S
C
L
V
G
S
A
T
Site 30
S236
P
Q
S
C
L
V
G
S
A
T
G
R
P
G
G
Site 31
T238
S
C
L
V
G
S
A
T
G
R
P
G
G
E
G
Site 32
S246
G
R
P
G
G
E
G
S
P
S
P
K
T
R
E
Site 33
S248
P
G
G
E
G
S
P
S
P
K
T
R
E
S
S
Site 34
T251
E
G
S
P
S
P
K
T
R
E
S
S
L
K
R
Site 35
S254
P
S
P
K
T
R
E
S
S
L
K
R
R
L
F
Site 36
S255
S
P
K
T
R
E
S
S
L
K
R
R
L
F
R
Site 37
T271
M
F
L
S
T
A
A
T
A
P
P
S
S
S
K
Site 38
S275
T
A
A
T
A
P
P
S
S
S
K
P
G
P
P
Site 39
S276
A
A
T
A
P
P
S
S
S
K
P
G
P
P
P
Site 40
S277
A
T
A
P
P
S
S
S
K
P
G
P
P
P
Q
Site 41
S285
K
P
G
P
P
P
Q
S
K
P
N
S
S
F
R
Site 42
S289
P
P
Q
S
K
P
N
S
S
F
R
P
P
Q
K
Site 43
S290
P
Q
S
K
P
N
S
S
F
R
P
P
Q
K
D
Site 44
S301
P
Q
K
D
N
P
P
S
L
V
A
K
A
Q
S
Site 45
S308
S
L
V
A
K
A
Q
S
L
P
S
D
Q
P
V
Site 46
S311
A
K
A
Q
S
L
P
S
D
Q
P
V
G
T
F
Site 47
T317
P
S
D
Q
P
V
G
T
F
S
P
L
T
T
S
Site 48
S319
D
Q
P
V
G
T
F
S
P
L
T
T
S
D
T
Site 49
T322
V
G
T
F
S
P
L
T
T
S
D
T
S
S
P
Site 50
T323
G
T
F
S
P
L
T
T
S
D
T
S
S
P
Q
Site 51
S324
T
F
S
P
L
T
T
S
D
T
S
S
P
Q
K
Site 52
T326
S
P
L
T
T
S
D
T
S
S
P
Q
K
S
L
Site 53
S327
P
L
T
T
S
D
T
S
S
P
Q
K
S
L
R
Site 54
S328
L
T
T
S
D
T
S
S
P
Q
K
S
L
R
T
Site 55
S332
D
T
S
S
P
Q
K
S
L
R
T
A
P
A
T
Site 56
T339
S
L
R
T
A
P
A
T
G
Q
L
P
G
R
S
Site 57
S346
T
G
Q
L
P
G
R
S
S
P
A
G
S
P
R
Site 58
S347
G
Q
L
P
G
R
S
S
P
A
G
S
P
R
T
Site 59
S351
G
R
S
S
P
A
G
S
P
R
T
W
H
A
Q
Site 60
T354
S
P
A
G
S
P
R
T
W
H
A
Q
I
S
T
Site 61
Y365
Q
I
S
T
S
N
L
Y
L
P
Q
D
P
T
V
Site 62
T382
G
A
L
A
G
E
D
T
G
V
V
T
H
E
Q
Site 63
S409
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
Site 64
Y410
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
Site 65
S429
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
Site 66
Y459
E
V
V
I
M
R
D
Y
Q
H
F
N
V
V
E
Site 67
S470
N
V
V
E
M
Y
K
S
Y
L
V
G
E
E
L
Site 68
S494
G
A
L
T
D
I
V
S
Q
V
R
L
N
E
E
Site 69
S531
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
Site 70
T535
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
Site 71
S543
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
Site 72
S560
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
Site 73
T564
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
Site 74
Y566
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
Site 75
Y601
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
Site 76
S603
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
Site 77
S605
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
Site 78
S616
A
M
K
R
L
R
D
S
P
P
P
K
L
K
N
Site 79
S624
P
P
P
K
L
K
N
S
H
K
V
S
P
V
L
Site 80
S628
L
K
N
S
H
K
V
S
P
V
L
R
D
F
L
Site 81
T648
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation