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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRDM9
Full Name:
Histone-lysine N-methyltransferase PRDM9
Alias:
PR domain zinc finger protein 9;PR domain-containing protein 9
Type:
Mass (Da):
103376
Number AA:
894
UniProt ID:
Q9NQV7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
P
E
K
S
Q
E
E
S
P
E
E
Site 2
S10
P
E
K
S
Q
E
E
S
P
E
E
D
T
E
R
Site 3
T15
E
E
S
P
E
E
D
T
E
R
T
E
R
K
P
Site 4
S32
K
D
A
F
K
D
I
S
I
Y
F
T
K
E
E
Site 5
Y34
A
F
K
D
I
S
I
Y
F
T
K
E
E
W
A
Site 6
T36
K
D
I
S
I
Y
F
T
K
E
E
W
A
E
M
Site 7
Y51
G
D
W
E
K
T
R
Y
R
N
V
K
R
N
Y
Site 8
Y58
Y
R
N
V
K
R
N
Y
N
A
L
I
T
I
G
Site 9
T69
I
T
I
G
L
R
A
T
R
P
A
F
M
C
H
Site 10
T88
I
K
L
Q
V
D
D
T
E
D
S
D
E
E
W
Site 11
S91
Q
V
D
D
T
E
D
S
D
E
E
W
T
P
R
Site 12
T96
E
D
S
D
E
E
W
T
P
R
Q
Q
V
K
P
Site 13
S123
Q
K
G
M
P
K
A
S
F
S
N
E
S
S
L
Site 14
S125
G
M
P
K
A
S
F
S
N
E
S
S
L
K
E
Site 15
S128
K
A
S
F
S
N
E
S
S
L
K
E
L
S
R
Site 16
S129
A
S
F
S
N
E
S
S
L
K
E
L
S
R
T
Site 17
S134
E
S
S
L
K
E
L
S
R
T
A
N
L
L
N
Site 18
T136
S
L
K
E
L
S
R
T
A
N
L
L
N
A
S
Site 19
S145
N
L
L
N
A
S
G
S
E
Q
A
Q
K
P
V
Site 20
S153
E
Q
A
Q
K
P
V
S
P
S
G
E
A
S
T
Site 21
S155
A
Q
K
P
V
S
P
S
G
E
A
S
T
S
G
Site 22
S159
V
S
P
S
G
E
A
S
T
S
G
Q
H
S
R
Site 23
S161
P
S
G
E
A
S
T
S
G
Q
H
S
R
L
K
Site 24
S165
A
S
T
S
G
Q
H
S
R
L
K
L
E
L
R
Site 25
T176
L
E
L
R
K
K
E
T
E
R
K
M
Y
S
L
Site 26
Y181
K
E
T
E
R
K
M
Y
S
L
R
E
R
K
G
Site 27
S182
E
T
E
R
K
M
Y
S
L
R
E
R
K
G
H
Site 28
Y191
R
E
R
K
G
H
A
Y
K
E
V
S
E
P
Q
Site 29
S195
G
H
A
Y
K
E
V
S
E
P
Q
D
D
D
Y
Site 30
Y202
S
E
P
Q
D
D
D
Y
L
Y
C
E
M
C
Q
Site 31
Y204
P
Q
D
D
D
Y
L
Y
C
E
M
C
Q
N
F
Site 32
S228
P
P
T
F
V
K
D
S
A
V
D
K
G
H
P
Site 33
S238
D
K
G
H
P
N
R
S
A
L
S
L
P
P
G
Site 34
S241
H
P
N
R
S
A
L
S
L
P
P
G
L
R
I
Site 35
Y276
L
G
L
H
F
G
P
Y
E
G
R
I
T
E
D
Site 36
T281
G
P
Y
E
G
R
I
T
E
D
E
E
A
A
N
Site 37
Y302
I
T
K
G
R
N
C
Y
E
Y
V
D
G
K
D
Site 38
Y304
K
G
R
N
C
Y
E
Y
V
D
G
K
D
K
S
Site 39
Y335
Q
N
L
V
A
F
Q
Y
H
R
Q
I
F
Y
R
Site 40
Y357
G
C
E
L
L
V
W
Y
G
D
E
Y
G
Q
E
Site 41
Y361
L
V
W
Y
G
D
E
Y
G
Q
E
L
G
I
K
Site 42
S399
S
C
C
L
A
F
S
S
Q
K
F
L
S
Q
H
Site 43
S404
F
S
S
Q
K
F
L
S
Q
H
V
E
R
N
H
Site 44
S412
Q
H
V
E
R
N
H
S
S
Q
N
F
P
G
P
Site 45
S413
H
V
E
R
N
H
S
S
Q
N
F
P
G
P
S
Site 46
S420
S
Q
N
F
P
G
P
S
A
R
K
L
L
Q
P
Site 47
Y441
D
Q
N
Q
E
Q
Q
Y
P
D
P
H
S
R
N
Site 48
S446
Q
Q
Y
P
D
P
H
S
R
N
D
K
T
K
G
Site 49
T451
P
H
S
R
N
D
K
T
K
G
Q
E
I
K
E
Site 50
T467
S
K
L
L
N
K
R
T
W
Q
R
E
I
S
R
Site 51
S473
R
T
W
Q
R
E
I
S
R
A
F
S
S
P
P
Site 52
S477
R
E
I
S
R
A
F
S
S
P
P
K
G
Q
M
Site 53
S478
E
I
S
R
A
F
S
S
P
P
K
G
Q
M
G
Site 54
S486
P
P
K
G
Q
M
G
S
C
R
V
G
K
R
I
Site 55
T500
I
M
E
E
E
S
R
T
G
Q
K
V
N
P
G
Site 56
Y526
S
R
I
A
K
V
K
Y
G
E
C
G
Q
G
F
Site 57
S534
G
E
C
G
Q
G
F
S
V
K
S
D
V
I
T
Site 58
S537
G
Q
G
F
S
V
K
S
D
V
I
T
H
Q
R
Site 59
T541
S
V
K
S
D
V
I
T
H
Q
R
T
H
T
G
Site 60
T545
D
V
I
T
H
Q
R
T
H
T
G
E
K
L
Y
Site 61
T547
I
T
H
Q
R
T
H
T
G
E
K
L
Y
V
C
Site 62
Y552
T
H
T
G
E
K
L
Y
V
C
R
E
C
G
R
Site 63
S562
R
E
C
G
R
G
F
S
W
K
S
H
L
L
I
Site 64
S565
G
R
G
F
S
W
K
S
H
L
L
I
H
Q
R
Site 65
T575
L
I
H
Q
R
I
H
T
G
E
K
P
Y
V
C
Site 66
Y580
I
H
T
G
E
K
P
Y
V
C
R
E
C
G
R
Site 67
S590
R
E
C
G
R
G
F
S
W
Q
S
V
L
L
T
Site 68
S593
G
R
G
F
S
W
Q
S
V
L
L
T
H
Q
R
Site 69
T597
S
W
Q
S
V
L
L
T
H
Q
R
T
H
T
G
Site 70
T601
V
L
L
T
H
Q
R
T
H
T
G
E
K
P
Y
Site 71
T603
L
T
H
Q
R
T
H
T
G
E
K
P
Y
V
C
Site 72
Y608
T
H
T
G
E
K
P
Y
V
C
R
E
C
G
R
Site 73
S618
R
E
C
G
R
G
F
S
R
Q
S
V
L
L
T
Site 74
S621
G
R
G
F
S
R
Q
S
V
L
L
T
H
Q
R
Site 75
T625
S
R
Q
S
V
L
L
T
H
Q
R
R
H
T
G
Site 76
T631
L
T
H
Q
R
R
H
T
G
E
K
P
Y
V
C
Site 77
Y636
R
H
T
G
E
K
P
Y
V
C
R
E
C
G
R
Site 78
S730
R
E
C
G
R
G
F
S
N
K
S
H
L
L
R
Site 79
S733
G
R
G
F
S
N
K
S
H
L
L
R
H
Q
R
Site 80
T741
H
L
L
R
H
Q
R
T
H
T
G
E
K
P
Y
Site 81
T743
L
R
H
Q
R
T
H
T
G
E
K
P
Y
V
C
Site 82
S761
G
R
G
F
R
D
K
S
H
L
L
R
H
Q
R
Site 83
S789
G
R
G
F
R
D
K
S
N
L
L
S
H
Q
R
Site 84
S793
R
D
K
S
N
L
L
S
H
Q
R
T
H
T
G
Site 85
T797
N
L
L
S
H
Q
R
T
H
T
G
E
K
P
Y
Site 86
T799
L
S
H
Q
R
T
H
T
G
E
K
P
Y
V
C
Site 87
S845
G
R
G
F
R
N
K
S
H
L
L
R
H
Q
R
Site 88
S870
R
E
C
G
R
G
F
S
D
R
S
S
L
C
Y
Site 89
S873
G
R
G
F
S
D
R
S
S
L
C
Y
H
Q
R
Site 90
S874
R
G
F
S
D
R
S
S
L
C
Y
H
Q
R
T
Site 91
Y877
S
D
R
S
S
L
C
Y
H
Q
R
T
H
T
G
Site 92
T881
S
L
C
Y
H
Q
R
T
H
T
G
E
K
P
Y
Site 93
T883
C
Y
H
Q
R
T
H
T
G
E
K
P
Y
V
C
Site 94
Y888
T
H
T
G
E
K
P
Y
V
C
R
E
D
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation