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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRDM6
Full Name:
Putative histone-lysine N-methyltransferase PRDM6
Alias:
PR domain zinc finger protein 6;PR domain-containing protein 6
Type:
Mass (Da):
64452
Number AA:
595
UniProt ID:
Q9NQX0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
K
P
G
D
P
G
G
S
A
F
L
K
V
D
P
Site 2
Y19
F
L
K
V
D
P
A
Y
L
Q
H
W
Q
Q
L
Site 3
S45
S
G
A
A
G
L
L
S
A
P
Q
P
L
Q
P
Site 4
S68
R
A
E
P
P
P
D
S
L
R
P
R
P
A
S
Site 5
S75
S
L
R
P
R
P
A
S
L
S
S
A
S
S
T
Site 6
S77
R
P
R
P
A
S
L
S
S
A
S
S
T
P
A
Site 7
S78
P
R
P
A
S
L
S
S
A
S
S
T
P
A
S
Site 8
S80
P
A
S
L
S
S
A
S
S
T
P
A
S
S
S
Site 9
S81
A
S
L
S
S
A
S
S
T
P
A
S
S
S
T
Site 10
T82
S
L
S
S
A
S
S
T
P
A
S
S
S
T
S
Site 11
S85
S
A
S
S
T
P
A
S
S
S
T
S
A
S
S
Site 12
S86
A
S
S
T
P
A
S
S
S
T
S
A
S
S
A
Site 13
S87
S
S
T
P
A
S
S
S
T
S
A
S
S
A
S
Site 14
T88
S
T
P
A
S
S
S
T
S
A
S
S
A
S
S
Site 15
S89
T
P
A
S
S
S
T
S
A
S
S
A
S
S
C
Site 16
S91
A
S
S
S
T
S
A
S
S
A
S
S
C
A
A
Site 17
S92
S
S
S
T
S
A
S
S
A
S
S
C
A
A
A
Site 18
T142
K
E
L
C
L
G
A
T
S
G
P
G
P
V
K
Site 19
S169
G
A
P
R
F
R
C
S
A
E
E
L
D
Y
Y
Site 20
Y175
C
S
A
E
E
L
D
Y
Y
L
Y
G
Q
Q
R
Site 21
Y176
S
A
E
E
L
D
Y
Y
L
Y
G
Q
Q
R
M
Site 22
Y178
E
E
L
D
Y
Y
L
Y
G
Q
Q
R
M
E
I
Site 23
S218
P
M
H
G
P
L
H
S
L
R
R
L
V
G
T
Site 24
S227
R
R
L
V
G
T
S
S
A
A
A
A
A
P
P
Site 25
T272
A
Q
R
I
Q
Q
G
T
W
I
G
P
F
Q
G
Site 26
Y302
T
Q
H
L
W
E
I
Y
D
Q
D
G
T
L
Q
Site 27
S318
F
I
D
G
G
E
P
S
K
S
S
W
M
R
Y
Site 28
S320
D
G
G
E
P
S
K
S
S
W
M
R
Y
I
R
Site 29
S321
G
G
E
P
S
K
S
S
W
M
R
Y
I
R
C
Site 30
T338
H
C
G
E
Q
N
L
T
V
V
Q
Y
R
S
N
Site 31
Y342
Q
N
L
T
V
V
Q
Y
R
S
N
I
F
Y
R
Site 32
Y348
Q
Y
R
S
N
I
F
Y
R
A
C
I
D
I
P
Site 33
Y364
G
T
E
L
L
V
W
Y
N
D
S
Y
T
S
F
Site 34
T390
E
N
L
N
V
P
S
T
V
M
E
A
M
C
R
Site 35
T414
S
S
K
L
A
P
T
T
Q
Q
R
S
V
V
F
Site 36
T424
R
S
V
V
F
P
Q
T
P
C
S
R
N
F
S
Site 37
S427
V
F
P
Q
T
P
C
S
R
N
F
S
L
L
D
Site 38
S431
T
P
C
S
R
N
F
S
L
L
D
K
S
G
P
Site 39
S436
N
F
S
L
L
D
K
S
G
P
I
E
S
G
F
Site 40
S456
K
N
Q
R
V
L
A
S
P
T
S
T
S
Q
L
Site 41
S459
R
V
L
A
S
P
T
S
T
S
Q
L
H
S
E
Site 42
T460
V
L
A
S
P
T
S
T
S
Q
L
H
S
E
F
Site 43
S461
L
A
S
P
T
S
T
S
Q
L
H
S
E
F
S
Site 44
S465
T
S
T
S
Q
L
H
S
E
F
S
D
W
H
L
Site 45
T494
L
L
Q
M
H
V
C
T
Q
N
P
D
R
P
Y
Site 46
Y501
T
Q
N
P
D
R
P
Y
Q
C
G
H
C
S
Q
Site 47
S507
P
Y
Q
C
G
H
C
S
Q
S
F
S
Q
P
S
Site 48
S509
Q
C
G
H
C
S
Q
S
F
S
Q
P
S
E
L
Site 49
S511
G
H
C
S
Q
S
F
S
Q
P
S
E
L
R
N
Site 50
T522
E
L
R
N
H
V
V
T
H
S
S
D
R
P
F
Site 51
Y533
D
R
P
F
K
C
G
Y
C
G
R
A
F
A
G
Site 52
T550
T
L
N
N
H
I
R
T
H
T
G
E
K
P
F
Site 53
T552
N
N
H
I
R
T
H
T
G
E
K
P
F
K
C
Site 54
S565
K
C
E
R
C
E
R
S
F
T
Q
A
T
Q
L
Site 55
T567
E
R
C
E
R
S
F
T
Q
A
T
Q
L
S
R
Site 56
T586
P
N
E
C
K
P
I
T
E
S
P
E
S
I
E
Site 57
S588
E
C
K
P
I
T
E
S
P
E
S
I
E
V
D
Site 58
S591
P
I
T
E
S
P
E
S
I
E
V
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation