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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRMT8
Full Name:
Protein arginine N-methyltransferase 8
Alias:
EC 2.1.1.-; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4; Hmt1 hnrnp methyltransferase-like 4; Hrmt1l3; Hrmt1l4; Prmt8
Type:
Enzyme - Methytransferase
Mass (Da):
45291
Number AA:
394
UniProt ID:
Q9NR22
International Prot ID:
IPI00549813
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005886
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006325
GO:0006464
GO:0006479
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
G
M
K
H
S
S
R
C
L
L
L
R
R
Site 2
T24
A
E
N
A
A
E
S
T
E
V
N
S
P
P
S
Site 3
S28
A
E
S
T
E
V
N
S
P
P
S
Q
P
P
Q
Site 4
S31
T
E
V
N
S
P
P
S
Q
P
P
Q
P
V
V
Site 5
T51
Q
C
V
H
H
V
S
T
Q
P
S
C
P
G
R
Site 6
S54
H
H
V
S
T
Q
P
S
C
P
G
R
G
K
M
Site 7
Y75
E
E
M
T
S
R
D
Y
Y
F
D
S
Y
A
H
Site 8
Y76
E
M
T
S
R
D
Y
Y
F
D
S
Y
A
H
F
Site 9
Y80
R
D
Y
Y
F
D
S
Y
A
H
F
G
I
H
E
Site 10
T98
K
D
E
V
R
T
L
T
Y
R
N
S
M
Y
H
Site 11
Y104
L
T
Y
R
N
S
M
Y
H
N
K
H
V
F
K
Site 12
T122
V
L
D
V
G
S
G
T
G
I
L
S
M
F
A
Site 13
S126
G
S
G
T
G
I
L
S
M
F
A
A
K
A
G
Site 14
S144
V
F
G
I
E
C
S
S
I
S
D
Y
S
E
K
Site 15
S146
G
I
E
C
S
S
I
S
D
Y
S
E
K
I
I
Site 16
Y148
E
C
S
S
I
S
D
Y
S
E
K
I
I
K
A
Site 17
S149
C
S
S
I
S
D
Y
S
E
K
I
I
K
A
N
Site 18
Y189
I
I
S
E
W
M
G
Y
C
L
F
Y
E
S
M
Site 19
Y193
W
M
G
Y
C
L
F
Y
E
S
M
L
N
T
V
Site 20
T199
F
Y
E
S
M
L
N
T
V
I
F
A
R
D
K
Site 21
Y222
F
P
D
R
A
A
L
Y
V
V
A
I
E
D
R
Site 22
Y231
V
A
I
E
D
R
Q
Y
K
D
F
K
I
H
W
Site 23
Y281
L
I
K
E
V
D
I
Y
T
V
K
T
E
E
L
Site 24
T282
I
K
E
V
D
I
Y
T
V
K
T
E
E
L
S
Site 25
T285
V
D
I
Y
T
V
K
T
E
E
L
S
F
T
S
Site 26
Y303
L
Q
I
Q
R
N
D
Y
V
H
A
L
V
T
Y
Site 27
Y332
S
T
A
P
D
A
P
Y
T
H
W
K
Q
T
V
Site 28
T333
T
A
P
D
A
P
Y
T
H
W
K
Q
T
V
F
Site 29
Y341
H
W
K
Q
T
V
F
Y
L
E
D
Y
L
T
V
Site 30
Y345
T
V
F
Y
L
E
D
Y
L
T
V
R
R
G
E
Site 31
T347
F
Y
L
E
D
Y
L
T
V
R
R
G
E
E
I
Site 32
Y355
V
R
R
G
E
E
I
Y
G
T
I
S
M
K
P
Site 33
T357
R
G
E
E
I
Y
G
T
I
S
M
K
P
N
A
Site 34
T373
N
V
R
D
L
D
F
T
V
D
L
D
F
K
G
Site 35
S386
K
G
Q
L
C
E
T
S
V
S
N
D
Y
K
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation