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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX21
Full Name:
Nucleolar RNA helicase 2
Alias:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21; DEAD-box protein 21; GURDB; Nucleolar RNA helicase Gu; Nucleolar RNA helicase II; RH II/Gu; RH-II/GU; RNA helicase II/Gu
Type:
EC 3.6.1.-; Helicase; RNA processing
Mass (Da):
87344
Number AA:
783
UniProt ID:
Q9NR30
International Prot ID:
IPI00015953
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005730
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004004
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
P
G
K
L
R
S
D
A
G
L
E
S
D
Site 2
S13
R
S
D
A
G
L
E
S
D
T
A
M
K
K
G
Site 3
T15
D
A
G
L
E
S
D
T
A
M
K
K
G
E
T
Site 4
T27
G
E
T
L
R
K
Q
T
E
E
K
E
K
K
E
Site 5
S38
E
K
K
E
K
P
K
S
D
K
T
E
E
I
A
Site 6
T41
E
K
P
K
S
D
K
T
E
E
I
A
E
E
E
Site 7
T50
E
I
A
E
E
E
E
T
V
F
P
K
A
K
Q
Site 8
S65
V
K
K
K
A
E
P
S
E
V
D
M
N
S
P
Site 9
S71
P
S
E
V
D
M
N
S
P
K
S
K
K
A
K
Site 10
S74
V
D
M
N
S
P
K
S
K
K
A
K
K
K
E
Site 11
S84
A
K
K
K
E
E
P
S
Q
N
D
I
S
P
K
Site 12
S89
E
P
S
Q
N
D
I
S
P
K
T
K
S
L
R
Site 13
T92
Q
N
D
I
S
P
K
T
K
S
L
R
K
K
K
Site 14
S94
D
I
S
P
K
T
K
S
L
R
K
K
K
E
P
Site 15
S121
V
T
K
N
E
E
P
S
E
E
E
I
D
A
P
Site 16
S147
N
G
E
T
R
E
K
S
P
K
L
K
N
G
F
Site 17
S164
P
E
P
D
C
N
P
S
E
A
A
S
E
E
S
Site 18
S168
C
N
P
S
E
A
A
S
E
E
S
N
S
E
I
Site 19
S171
S
E
A
A
S
E
E
S
N
S
E
I
E
Q
E
Site 20
S173
A
A
S
E
E
S
N
S
E
I
E
Q
E
I
P
Site 21
S189
E
Q
K
E
G
A
F
S
N
F
P
I
S
E
E
Site 22
T216
L
F
P
I
Q
A
K
T
F
H
H
V
Y
S
G
Site 23
Y221
A
K
T
F
H
H
V
Y
S
G
K
D
L
I
A
Site 24
S222
K
T
F
H
H
V
Y
S
G
K
D
L
I
A
Q
Site 25
T234
I
A
Q
A
R
T
G
T
G
K
T
F
S
F
A
Site 26
S277
R
E
L
A
N
Q
V
S
K
D
F
S
D
I
T
Site 27
S281
N
Q
V
S
K
D
F
S
D
I
T
K
K
L
S
Site 28
T284
S
K
D
F
S
D
I
T
K
K
L
S
V
A
C
Site 29
T296
V
A
C
F
Y
G
G
T
P
Y
G
G
Q
F
E
Site 30
Y298
C
F
Y
G
G
T
P
Y
G
G
Q
F
E
R
M
Site 31
T315
G
I
D
I
L
V
G
T
P
G
R
I
K
D
H
Site 32
T331
Q
N
G
K
L
D
L
T
K
L
K
H
V
V
L
Site 33
S358
D
Q
V
E
E
I
L
S
V
A
Y
K
K
D
S
Site 34
T371
D
S
E
D
N
P
Q
T
L
L
F
S
A
T
C
Site 35
Y389
V
F
N
V
A
K
K
Y
M
K
S
T
Y
E
Q
Site 36
S392
V
A
K
K
Y
M
K
S
T
Y
E
Q
V
D
L
Site 37
Y394
K
K
Y
M
K
S
T
Y
E
Q
V
D
L
I
G
Site 38
T407
I
G
K
K
T
Q
K
T
A
I
T
V
E
H
L
Site 39
Y434
I
G
D
V
I
R
V
Y
S
G
H
Q
G
R
T
Site 40
S435
G
D
V
I
R
V
Y
S
G
H
Q
G
R
T
I
Site 41
S455
K
K
E
A
Q
E
L
S
Q
N
S
A
I
K
Q
Site 42
S466
A
I
K
Q
D
A
Q
S
L
H
G
D
I
P
Q
Site 43
T479
P
Q
K
Q
R
E
I
T
L
K
G
F
R
N
G
Site 44
S513
V
D
L
V
I
Q
S
S
P
P
K
D
V
E
S
Site 45
S520
S
P
P
K
D
V
E
S
Y
I
H
R
S
G
R
Site 46
Y521
P
P
K
D
V
E
S
Y
I
H
R
S
G
R
T
Site 47
S525
V
E
S
Y
I
H
R
S
G
R
T
G
R
A
G
Site 48
S567
F
K
R
I
G
V
P
S
A
T
E
I
I
K
A
Site 49
T569
R
I
G
V
P
S
A
T
E
I
I
K
A
S
S
Site 50
T589
L
L
D
S
V
P
P
T
A
I
S
H
F
K
Q
Site 51
S592
S
V
P
P
T
A
I
S
H
F
K
Q
S
A
E
Site 52
S623
A
H
I
S
G
A
T
S
V
D
Q
R
S
L
I
Site 53
S628
A
T
S
V
D
Q
R
S
L
I
N
S
N
V
G
Site 54
S632
D
Q
R
S
L
I
N
S
N
V
G
F
V
T
M
Site 55
S667
Q
L
G
E
E
I
D
S
K
V
K
G
M
V
F
Site 56
S689
C
F
D
V
P
T
A
S
V
T
E
I
Q
E
K
Site 57
S706
D
S
R
R
W
Q
L
S
V
A
T
E
Q
P
E
Site 58
Y721
L
E
G
P
R
E
G
Y
G
G
F
R
G
Q
R
Site 59
S731
F
R
G
Q
R
E
G
S
R
G
F
R
G
Q
R
Site 60
S751
F
R
G
Q
R
E
G
S
R
G
P
R
G
Q
R
Site 61
S759
R
G
P
R
G
Q
R
S
G
G
G
N
K
S
N
Site 62
S765
R
S
G
G
G
N
K
S
N
R
S
Q
N
K
G
Site 63
S768
G
G
N
K
S
N
R
S
Q
N
K
G
Q
K
R
Site 64
S776
Q
N
K
G
Q
K
R
S
F
S
K
A
F
G
Q
Site 65
S778
K
G
Q
K
R
S
F
S
K
A
F
G
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation