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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NANS
Full Name:
Sialic acid synthase
Alias:
N-acetylneuraminic acid synthase; SAS; Sialic acid phosphate synthase; SIAS
Type:
EC 2.5.1.57; EC 2.5.1.56; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Transferase
Mass (Da):
40308
Number AA:
359
UniProt ID:
Q9NR45
International Prot ID:
IPI00147874
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0050462
GO:0008781
GO:0047444
PhosphoSite+
KinaseNET
Biological Process:
GO:0009103
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S56
D
C
A
K
F
Q
K
S
E
L
E
F
K
F
N
Site 2
Y71
R
K
A
L
E
R
P
Y
T
S
K
H
S
W
G
Site 3
T72
K
A
L
E
R
P
Y
T
S
K
H
S
W
G
K
Site 4
S73
A
L
E
R
P
Y
T
S
K
H
S
W
G
K
T
Site 5
S76
R
P
Y
T
S
K
H
S
W
G
K
T
Y
G
E
Site 6
T80
S
K
H
S
W
G
K
T
Y
G
E
H
K
R
H
Site 7
Y81
K
H
S
W
G
K
T
Y
G
E
H
K
R
H
L
Site 8
S91
H
K
R
H
L
E
F
S
H
D
Q
Y
R
E
L
Site 9
Y95
L
E
F
S
H
D
Q
Y
R
E
L
Q
R
Y
A
Site 10
Y101
Q
Y
R
E
L
Q
R
Y
A
E
E
V
G
I
F
Site 11
Y142
G
D
T
N
N
F
P
Y
L
E
K
T
A
K
K
Site 12
S156
K
G
R
P
M
V
I
S
S
G
M
Q
S
M
D
Site 13
S157
G
R
P
M
V
I
S
S
G
M
Q
S
M
D
T
Site 14
S161
V
I
S
S
G
M
Q
S
M
D
T
M
K
Q
V
Site 15
T164
S
G
M
Q
S
M
D
T
M
K
Q
V
Y
Q
I
Site 16
Y169
M
D
T
M
K
Q
V
Y
Q
I
V
K
P
L
N
Site 17
Y188
F
L
Q
C
T
S
A
Y
P
L
Q
P
E
D
V
Site 18
S201
D
V
N
L
R
V
I
S
E
Y
Q
K
L
F
P
Site 19
Y203
N
L
R
V
I
S
E
Y
Q
K
L
F
P
D
I
Site 20
T240
K
V
L
E
R
H
I
T
L
D
K
T
W
K
G
Site 21
T244
R
H
I
T
L
D
K
T
W
K
G
S
D
H
S
Site 22
S251
T
W
K
G
S
D
H
S
A
S
L
E
P
G
E
Site 23
S253
K
G
S
D
H
S
A
S
L
E
P
G
E
L
A
Site 24
S275
L
V
E
R
A
L
G
S
P
T
K
Q
L
L
P
Site 25
T305
K
V
K
I
P
E
G
T
I
L
T
M
D
M
L
Site 26
Y322
K
V
G
E
P
K
G
Y
P
P
E
D
I
F
N
Site 27
T344
V
T
V
E
E
D
D
T
I
M
E
E
L
V
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation