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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL1
Full Name:
Kelch-like protein 1
Alias:
Type:
Mass (Da):
82680
Number AA:
748
UniProt ID:
Q9NR64
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
R
L
R
W
K
L
F
S
H
P
S
P
S
T
G
Site 2
S26
W
K
L
F
S
H
P
S
P
S
T
G
G
P
A
Site 3
S28
L
F
S
H
P
S
P
S
T
G
G
P
A
G
G
Site 4
T29
F
S
H
P
S
P
S
T
G
G
P
A
G
G
G
Site 5
S43
G
C
L
Q
Q
D
G
S
G
S
F
E
H
W
G
Site 6
S45
L
Q
Q
D
G
S
G
S
F
E
H
W
G
P
S
Site 7
S52
S
F
E
H
W
G
P
S
Q
S
R
L
L
K
S
Site 8
S54
E
H
W
G
P
S
Q
S
R
L
L
K
S
Q
E
Site 9
S59
S
Q
S
R
L
L
K
S
Q
E
R
S
G
V
S
Site 10
S63
L
L
K
S
Q
E
R
S
G
V
S
T
F
W
K
Site 11
T67
Q
E
R
S
G
V
S
T
F
W
K
K
P
S
S
Site 12
S73
S
T
F
W
K
K
P
S
S
S
S
S
S
S
S
Site 13
S74
T
F
W
K
K
P
S
S
S
S
S
S
S
S
S
Site 14
S75
F
W
K
K
P
S
S
S
S
S
S
S
S
S
P
Site 15
S76
W
K
K
P
S
S
S
S
S
S
S
S
S
P
S
Site 16
S77
K
K
P
S
S
S
S
S
S
S
S
S
P
S
S
Site 17
S78
K
P
S
S
S
S
S
S
S
S
S
P
S
S
S
Site 18
S79
P
S
S
S
S
S
S
S
S
S
P
S
S
S
S
Site 19
S80
S
S
S
S
S
S
S
S
S
P
S
S
S
S
S
Site 20
S81
S
S
S
S
S
S
S
S
P
S
S
S
S
S
S
Site 21
S83
S
S
S
S
S
S
P
S
S
S
S
S
S
F
N
Site 22
S84
S
S
S
S
S
P
S
S
S
S
S
S
F
N
P
Site 23
S85
S
S
S
S
P
S
S
S
S
S
S
F
N
P
L
Site 24
S86
S
S
S
P
S
S
S
S
S
S
F
N
P
L
N
Site 25
S87
S
S
P
S
S
S
S
S
S
F
N
P
L
N
G
Site 26
S88
S
P
S
S
S
S
S
S
F
N
P
L
N
G
T
Site 27
T112
Q
G
A
P
G
Q
G
T
Q
Q
P
A
R
T
L
Site 28
Y121
Q
P
A
R
T
L
F
Y
V
E
S
L
E
E
E
Site 29
S124
R
T
L
F
Y
V
E
S
L
E
E
E
V
V
P
Site 30
S155
L
K
V
E
P
D
N
S
S
Q
A
T
G
E
G
Site 31
S156
K
V
E
P
D
N
S
S
Q
A
T
G
E
G
C
Site 32
T159
P
D
N
S
S
Q
A
T
G
E
G
C
G
H
R
Site 33
S168
E
G
C
G
H
R
L
S
S
T
G
H
S
M
T
Site 34
S169
G
C
G
H
R
L
S
S
T
G
H
S
M
T
P
Site 35
T170
C
G
H
R
L
S
S
T
G
H
S
M
T
P
Q
Site 36
S173
R
L
S
S
T
G
H
S
M
T
P
Q
S
D
L
Site 37
T175
S
S
T
G
H
S
M
T
P
Q
S
D
L
D
S
Site 38
S178
G
H
S
M
T
P
Q
S
D
L
D
S
S
S
S
Site 39
S182
T
P
Q
S
D
L
D
S
S
S
S
E
E
F
Y
Site 40
S183
P
Q
S
D
L
D
S
S
S
S
E
E
F
Y
Q
Site 41
S184
Q
S
D
L
D
S
S
S
S
E
E
F
Y
Q
A
Site 42
S185
S
D
L
D
S
S
S
S
E
E
F
Y
Q
A
V
Site 43
Y189
S
S
S
S
E
E
F
Y
Q
A
V
H
H
A
E
Site 44
T198
A
V
H
H
A
E
Q
T
F
R
K
M
E
S
Y
Site 45
Y205
T
F
R
K
M
E
S
Y
L
K
Q
Q
Q
L
C
Site 46
S364
E
L
H
K
L
L
A
S
D
D
V
N
V
P
D
Site 47
Y436
L
I
L
E
A
M
K
Y
H
L
L
P
E
R
R
Site 48
T444
H
L
L
P
E
R
R
T
L
M
Q
S
P
R
T
Site 49
S448
E
R
R
T
L
M
Q
S
P
R
T
K
P
R
K
Site 50
T451
T
L
M
Q
S
P
R
T
K
P
R
K
S
T
V
Site 51
S456
P
R
T
K
P
R
K
S
T
V
G
T
L
Y
A
Site 52
T457
R
T
K
P
R
K
S
T
V
G
T
L
Y
A
V
Site 53
T460
P
R
K
S
T
V
G
T
L
Y
A
V
G
G
M
Site 54
Y462
K
S
T
V
G
T
L
Y
A
V
G
G
M
D
N
Site 55
Y479
G
A
T
T
I
E
K
Y
D
L
R
T
N
L
W
Site 56
T519
G
G
R
D
G
L
K
T
L
N
T
V
E
C
Y
Site 57
T522
D
G
L
K
T
L
N
T
V
E
C
Y
N
P
K
Site 58
T530
V
E
C
Y
N
P
K
T
K
T
W
T
V
L
P
Site 59
T534
N
P
K
T
K
T
W
T
V
L
P
P
M
S
T
Site 60
T541
T
V
L
P
P
M
S
T
H
R
H
G
L
G
V
Site 61
Y566
G
G
H
D
G
W
S
Y
L
N
T
V
E
R
W
Site 62
T581
D
P
Q
S
Q
Q
W
T
F
V
A
S
M
S
I
Site 63
Y603
A
A
L
N
G
K
L
Y
S
V
G
G
R
D
G
Site 64
S604
A
L
N
G
K
L
Y
S
V
G
G
R
D
G
S
Site 65
S611
S
V
G
G
R
D
G
S
S
C
L
S
S
M
E
Site 66
S612
V
G
G
R
D
G
S
S
C
L
S
S
M
E
Y
Site 67
S615
R
D
G
S
S
C
L
S
S
M
E
Y
Y
D
P
Site 68
S616
D
G
S
S
C
L
S
S
M
E
Y
Y
D
P
H
Site 69
Y619
S
C
L
S
S
M
E
Y
Y
D
P
H
T
N
K
Site 70
Y620
C
L
S
S
M
E
Y
Y
D
P
H
T
N
K
W
Site 71
T624
M
E
Y
Y
D
P
H
T
N
K
W
N
M
C
A
Site 72
S660
G
G
H
D
A
P
A
S
N
H
C
S
R
L
L
Site 73
S664
A
P
A
S
N
H
C
S
R
L
L
D
Y
V
E
Site 74
Y669
H
C
S
R
L
L
D
Y
V
E
R
Y
D
P
K
Site 75
Y673
L
L
D
Y
V
E
R
Y
D
P
K
T
D
T
W
Site 76
T677
V
E
R
Y
D
P
K
T
D
T
W
T
M
V
A
Site 77
T679
R
Y
D
P
K
T
D
T
W
T
M
V
A
P
L
Site 78
T681
D
P
K
T
D
T
W
T
M
V
A
P
L
S
M
Site 79
T712
V
G
G
Y
D
G
Q
T
Y
L
N
T
M
E
S
Site 80
Y713
G
G
Y
D
G
Q
T
Y
L
N
T
M
E
S
Y
Site 81
S719
T
Y
L
N
T
M
E
S
Y
D
P
Q
T
N
E
Site 82
S732
N
E
W
T
Q
M
A
S
L
N
I
G
R
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation