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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ASAH2
Full Name:
Neutral ceramidase
Alias:
Acylsphingosine deacylase 2;BCDase;LCDase;N-acylsphingosine amidohydrolase 2;Non-lysosomal ceramidase
Type:
Mass (Da):
85516
Number AA:
780
UniProt ID:
Q9NR71
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S50
D
L
G
G
H
F
F
S
T
T
Q
S
P
P
A
Site 2
T51
L
G
G
H
F
F
S
T
T
Q
S
P
P
A
T
Site 3
T52
G
G
H
F
F
S
T
T
Q
S
P
P
A
T
Q
Site 4
S54
H
F
F
S
T
T
Q
S
P
P
A
T
Q
G
S
Site 5
T58
T
T
Q
S
P
P
A
T
Q
G
S
T
A
A
Q
Site 6
S61
S
P
P
A
T
Q
G
S
T
A
A
Q
R
S
T
Site 7
S67
G
S
T
A
A
Q
R
S
T
A
T
Q
H
S
T
Site 8
T68
S
T
A
A
Q
R
S
T
A
T
Q
H
S
T
A
Site 9
S73
R
S
T
A
T
Q
H
S
T
A
T
Q
S
S
T
Site 10
T74
S
T
A
T
Q
H
S
T
A
T
Q
S
S
T
A
Site 11
S79
H
S
T
A
T
Q
S
S
T
A
T
Q
T
S
P
Site 12
T82
A
T
Q
S
S
T
A
T
Q
T
S
P
V
P
L
Site 13
S85
S
S
T
A
T
Q
T
S
P
V
P
L
T
P
E
Site 14
T90
Q
T
S
P
V
P
L
T
P
E
S
P
L
F
Q
Site 15
S93
P
V
P
L
T
P
E
S
P
L
F
Q
N
F
S
Site 16
S100
S
P
L
F
Q
N
F
S
G
Y
H
I
G
V
G
Site 17
T112
G
V
G
R
A
D
C
T
G
Q
V
A
D
I
N
Site 18
Y123
A
D
I
N
L
M
G
Y
G
K
S
G
Q
N
A
Site 19
S126
N
L
M
G
Y
G
K
S
G
Q
N
A
Q
G
I
Site 20
T135
Q
N
A
Q
G
I
L
T
R
L
Y
S
R
A
F
Site 21
S150
I
M
A
E
P
D
G
S
N
R
T
V
F
V
S
Site 22
T153
E
P
D
G
S
N
R
T
V
F
V
S
I
D
I
Site 23
S177
E
V
L
N
R
L
Q
S
K
Y
G
S
L
Y
R
Site 24
Y179
L
N
R
L
Q
S
K
Y
G
S
L
Y
R
R
D
Site 25
S181
R
L
Q
S
K
Y
G
S
L
Y
R
R
D
N
V
Site 26
Y183
Q
S
K
Y
G
S
L
Y
R
R
D
N
V
I
L
Site 27
S191
R
R
D
N
V
I
L
S
G
T
H
T
H
S
G
Site 28
T193
D
N
V
I
L
S
G
T
H
T
H
S
G
P
A
Site 29
T195
V
I
L
S
G
T
H
T
H
S
G
P
A
G
Y
Site 30
T219
S
E
G
F
S
N
Q
T
F
Q
H
M
V
T
G
Site 31
S258
D
G
V
Q
I
N
R
S
P
Y
S
Y
L
Q
N
Site 32
Y260
V
Q
I
N
R
S
P
Y
S
Y
L
Q
N
P
Q
Site 33
S261
Q
I
N
R
S
P
Y
S
Y
L
Q
N
P
Q
S
Site 34
Y262
I
N
R
S
P
Y
S
Y
L
Q
N
P
Q
S
E
Site 35
S268
S
Y
L
Q
N
P
Q
S
E
R
A
R
Y
S
S
Site 36
Y273
P
Q
S
E
R
A
R
Y
S
S
N
T
D
K
E
Site 37
S274
Q
S
E
R
A
R
Y
S
S
N
T
D
K
E
M
Site 38
S275
S
E
R
A
R
Y
S
S
N
T
D
K
E
M
I
Site 39
T277
R
A
R
Y
S
S
N
T
D
K
E
M
I
V
L
Site 40
S310
H
P
V
S
M
N
N
S
N
H
L
V
N
S
D
Site 41
S316
N
S
N
H
L
V
N
S
D
N
V
G
Y
A
S
Site 42
Y334
E
Q
E
K
N
K
G
Y
L
P
G
Q
G
P
F
Site 43
S354
S
S
N
L
G
D
V
S
P
N
I
L
G
P
R
Site 44
S374
E
S
C
D
N
A
N
S
T
C
P
I
G
G
P
Site 45
T375
S
C
D
N
A
N
S
T
C
P
I
G
G
P
S
Site 46
S396
P
G
Q
D
M
F
D
S
T
Q
I
I
G
R
A
Site 47
Y405
Q
I
I
G
R
A
M
Y
Q
R
A
K
E
L
Y
Site 48
Y412
Y
Q
R
A
K
E
L
Y
A
S
A
S
Q
E
V
Site 49
S414
R
A
K
E
L
Y
A
S
A
S
Q
E
V
T
G
Site 50
S416
K
E
L
Y
A
S
A
S
Q
E
V
T
G
P
L
Site 51
T420
A
S
A
S
Q
E
V
T
G
P
L
A
S
A
H
Site 52
S445
W
L
N
S
T
H
A
S
K
T
C
K
P
A
L
Site 53
T447
N
S
T
H
A
S
K
T
C
K
P
A
L
G
Y
Site 54
T470
G
V
G
G
L
N
F
T
Q
G
K
T
E
G
D
Site 55
T482
E
G
D
P
F
W
D
T
I
R
D
Q
I
L
G
Site 56
S492
D
Q
I
L
G
K
P
S
E
E
I
K
E
C
H
Site 57
T508
P
K
P
I
L
L
H
T
G
E
L
S
K
P
H
Site 58
S512
L
L
H
T
G
E
L
S
K
P
H
P
W
H
P
Site 59
S545
P
G
E
F
T
T
M
S
G
R
R
L
R
E
A
Site 60
Y579
L
C
N
V
Y
T
H
Y
I
T
T
Y
E
E
Y
Site 61
Y583
Y
T
H
Y
I
T
T
Y
E
E
Y
Q
A
Q
R
Site 62
Y591
E
E
Y
Q
A
Q
R
Y
E
A
A
S
T
I
Y
Site 63
S595
A
Q
R
Y
E
A
A
S
T
I
Y
G
P
H
T
Site 64
T596
Q
R
Y
E
A
A
S
T
I
Y
G
P
H
T
L
Site 65
Y606
G
P
H
T
L
S
A
Y
I
Q
L
F
R
N
L
Site 66
S626
T
D
T
V
A
N
L
S
R
G
P
E
P
P
F
Site 67
T654
D
R
A
P
K
G
R
T
F
G
D
V
L
Q
P
Site 68
Y666
L
Q
P
A
K
P
E
Y
R
V
G
E
V
A
E
Site 69
S684
V
G
A
N
P
K
N
S
V
Q
N
Q
T
H
Q
Site 70
T692
V
Q
N
Q
T
H
Q
T
F
L
T
V
E
K
Y
Site 71
T695
Q
T
H
Q
T
F
L
T
V
E
K
Y
E
A
T
Site 72
Y699
T
F
L
T
V
E
K
Y
E
A
T
S
T
S
W
Site 73
Y720
A
S
W
E
T
R
F
Y
W
H
K
G
L
L
G
Site 74
S729
H
K
G
L
L
G
L
S
N
A
T
V
E
W
H
Site 75
Y750
P
G
I
Y
R
I
R
Y
F
G
H
N
R
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation