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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF3
Full Name:
Rho guanine nucleotide exchange factor 3
Alias:
ARHG3; DKFZP434F2429; Exchange factor found in platelets and leukemic and neuronal tissues; GEF3; MGC118905; STA3; XPLN
Type:
Intracellular, Cytoplasm protein
Mass (Da):
59783
Number AA:
526
UniProt ID:
Q9NR81
International Prot ID:
IPI00020949
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0007266
GO:0006915
GO:0008624
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
V
A
K
D
Y
P
F
Y
L
T
V
K
R
A
N
Site 2
T11
K
D
Y
P
F
Y
L
T
V
K
R
A
N
C
S
Site 3
S18
T
V
K
R
A
N
C
S
L
E
L
P
P
A
S
Site 4
S25
S
L
E
L
P
P
A
S
G
P
A
K
D
A
E
Site 5
S35
A
K
D
A
E
E
P
S
N
K
R
V
K
P
L
Site 6
S43
N
K
R
V
K
P
L
S
R
V
T
S
L
A
N
Site 7
T58
L
I
P
P
V
K
A
T
P
L
K
R
F
S
Q
Site 8
S64
A
T
P
L
K
R
F
S
Q
T
L
Q
R
S
I
Site 9
T66
P
L
K
R
F
S
Q
T
L
Q
R
S
I
S
F
Site 10
S70
F
S
Q
T
L
Q
R
S
I
S
F
R
S
E
S
Site 11
S72
Q
T
L
Q
R
S
I
S
F
R
S
E
S
R
P
Site 12
S75
Q
R
S
I
S
F
R
S
E
S
R
P
D
I
L
Site 13
S77
S
I
S
F
R
S
E
S
R
P
D
I
L
A
P
Site 14
S88
I
L
A
P
R
P
W
S
R
N
A
A
P
S
S
Site 15
S94
W
S
R
N
A
A
P
S
S
T
K
R
R
D
S
Site 16
S95
S
R
N
A
A
P
S
S
T
K
R
R
D
S
K
Site 17
T96
R
N
A
A
P
S
S
T
K
R
R
D
S
K
L
Site 18
S101
S
S
T
K
R
R
D
S
K
L
W
S
E
T
F
Site 19
S105
R
R
D
S
K
L
W
S
E
T
F
D
V
C
V
Site 20
S131
Q
E
A
I
F
E
L
S
Q
G
E
E
D
L
I
Site 21
Y148
L
K
L
A
K
K
A
Y
H
D
P
M
L
K
L
Site 22
S156
H
D
P
M
L
K
L
S
I
M
T
E
Q
E
L
Site 23
S182
P
L
H
E
E
L
L
S
Q
L
R
D
V
R
K
Site 24
S193
D
V
R
K
P
D
G
S
T
E
H
V
G
P
I
Site 25
T194
V
R
K
P
D
G
S
T
E
H
V
G
P
I
L
Site 26
Y211
W
L
P
C
L
S
S
Y
D
S
Y
C
S
N
Q
Site 27
S213
P
C
L
S
S
Y
D
S
Y
C
S
N
Q
V
A
Site 28
Y214
C
L
S
S
Y
D
S
Y
C
S
N
Q
V
A
A
Site 29
S244
F
L
Q
R
C
L
E
S
P
F
S
R
K
L
D
Site 30
S247
R
C
L
E
S
P
F
S
R
K
L
D
L
W
N
Site 31
S261
N
F
L
D
I
P
R
S
R
L
V
K
Y
P
L
Site 32
Y266
P
R
S
R
L
V
K
Y
P
L
L
L
R
E
I
Site 33
T277
L
R
E
I
L
R
H
T
P
N
D
N
P
D
Q
Site 34
T305
V
A
E
I
N
T
K
T
G
E
S
E
C
R
Y
Site 35
Y312
T
G
E
S
E
C
R
Y
Y
K
E
R
L
L
Y
Site 36
Y313
G
E
S
E
C
R
Y
Y
K
E
R
L
L
Y
L
Site 37
Y319
Y
Y
K
E
R
L
L
Y
L
E
E
G
Q
K
D
Site 38
S327
L
E
E
G
Q
K
D
S
L
I
D
S
S
R
V
Site 39
S331
Q
K
D
S
L
I
D
S
S
R
V
L
C
C
H
Site 40
S332
K
D
S
L
I
D
S
S
R
V
L
C
C
H
G
Site 41
Y372
T
H
N
E
Q
L
C
Y
Q
L
Y
R
Q
P
I
Site 42
Y375
E
Q
L
C
Y
Q
L
Y
R
Q
P
I
P
V
K
Site 43
S399
G
E
V
R
L
G
G
S
L
R
G
A
F
S
N
Site 44
S405
G
S
L
R
G
A
F
S
N
N
E
R
I
K
N
Site 45
S417
I
K
N
F
F
R
V
S
F
K
N
G
S
Q
S
Site 46
S422
R
V
S
F
K
N
G
S
Q
S
Q
T
H
S
L
Site 47
S424
S
F
K
N
G
S
Q
S
Q
T
H
S
L
Q
A
Site 48
T426
K
N
G
S
Q
S
Q
T
H
S
L
Q
A
N
D
Site 49
S428
G
S
Q
S
Q
T
H
S
L
Q
A
N
D
T
F
Site 50
T434
H
S
L
Q
A
N
D
T
F
N
K
Q
Q
W
L
Site 51
S463
G
Q
A
G
V
L
D
S
E
G
S
F
L
N
P
Site 52
S466
G
V
L
D
S
E
G
S
F
L
N
P
T
T
G
Site 53
T472
G
S
F
L
N
P
T
T
G
S
R
E
L
Q
G
Site 54
S489
K
L
E
Q
M
D
Q
S
D
S
E
S
D
C
S
Site 55
S491
E
Q
M
D
Q
S
D
S
E
S
D
C
S
M
D
Site 56
S493
M
D
Q
S
D
S
E
S
D
C
S
M
D
T
S
Site 57
S496
S
D
S
E
S
D
C
S
M
D
T
S
E
V
S
Site 58
T499
E
S
D
C
S
M
D
T
S
E
V
S
L
D
C
Site 59
S500
S
D
C
S
M
D
T
S
E
V
S
L
D
C
E
Site 60
S503
S
M
D
T
S
E
V
S
L
D
C
E
R
M
E
Site 61
T512
D
C
E
R
M
E
Q
T
D
S
S
C
G
N
S
Site 62
S514
E
R
M
E
Q
T
D
S
S
C
G
N
S
R
H
Site 63
S515
R
M
E
Q
T
D
S
S
C
G
N
S
R
H
G
Site 64
S519
T
D
S
S
C
G
N
S
R
H
G
E
S
N
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation