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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv7.5
Full Name:
Potassium voltage-gated channel subfamily KQT member 5
Alias:
KCNQ5; KQT-like 6; Potassium channel alpha subunit KvLQT5
Type:
Channel protein, potassium
Mass (Da):
102179
Number AA:
932
UniProt ID:
Q9NR82
International Prot ID:
IPI00396336
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0005242
GO:0030955
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0006461
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
A
G
G
G
R
L
G
S
G
M
K
D
V
E
S
Site 2
S41
S
G
M
K
D
V
E
S
G
R
G
R
V
L
L
Site 3
S50
R
G
R
V
L
L
N
S
A
A
A
R
G
D
G
Site 4
S78
G
G
G
G
L
R
E
S
R
R
G
K
Q
G
A
Site 5
S88
G
K
Q
G
A
R
M
S
L
L
G
K
P
L
S
Site 6
S95
S
L
L
G
K
P
L
S
Y
T
S
S
Q
S
C
Site 7
Y96
L
L
G
K
P
L
S
Y
T
S
S
Q
S
C
R
Site 8
T97
L
G
K
P
L
S
Y
T
S
S
Q
S
C
R
R
Site 9
S98
G
K
P
L
S
Y
T
S
S
Q
S
C
R
R
N
Site 10
S99
K
P
L
S
Y
T
S
S
Q
S
C
R
R
N
V
Site 11
S101
L
S
Y
T
S
S
Q
S
C
R
R
N
V
K
Y
Site 12
Y108
S
C
R
R
N
V
K
Y
R
R
V
Q
N
Y
L
Site 13
Y114
K
Y
R
R
V
Q
N
Y
L
Y
N
V
L
E
R
Site 14
Y116
R
R
V
Q
N
Y
L
Y
N
V
L
E
R
P
R
Site 15
Y188
S
A
G
C
C
C
R
Y
R
G
W
Q
G
R
L
Site 16
T251
R
M
D
R
R
G
G
T
W
K
L
L
G
S
V
Site 17
S257
G
T
W
K
L
L
G
S
V
V
Y
A
H
S
K
Site 18
S263
G
S
V
V
Y
A
H
S
K
E
L
I
T
A
W
Site 19
Y298
A
N
K
E
F
S
T
Y
A
D
A
L
W
W
G
Site 20
T318
T
I
G
Y
G
D
K
T
P
L
T
W
L
G
R
Site 21
T321
Y
G
D
K
T
P
L
T
W
L
G
R
L
L
S
Site 22
Y381
I
Q
C
V
W
R
S
Y
A
A
D
E
K
S
V
Site 23
S387
S
Y
A
A
D
E
K
S
V
S
I
A
T
W
K
Site 24
S389
A
A
D
E
K
S
V
S
I
A
T
W
K
P
H
Site 25
T402
P
H
L
K
A
L
H
T
C
S
P
T
K
K
E
Site 26
S404
L
K
A
L
H
T
C
S
P
T
K
K
E
Q
G
Site 27
S414
K
K
E
Q
G
E
A
S
S
S
Q
K
L
S
F
Site 28
S415
K
E
Q
G
E
A
S
S
S
Q
K
L
S
F
K
Site 29
S416
E
Q
G
E
A
S
S
S
Q
K
L
S
F
K
E
Site 30
S420
A
S
S
S
Q
K
L
S
F
K
E
R
V
R
M
Site 31
S429
K
E
R
V
R
M
A
S
P
R
G
Q
S
I
K
Site 32
S434
M
A
S
P
R
G
Q
S
I
K
S
R
Q
A
S
Site 33
S437
P
R
G
Q
S
I
K
S
R
Q
A
S
V
G
D
Site 34
S441
S
I
K
S
R
Q
A
S
V
G
D
R
R
S
P
Site 35
S447
A
S
V
G
D
R
R
S
P
S
T
D
I
T
A
Site 36
S449
V
G
D
R
R
S
P
S
T
D
I
T
A
E
G
Site 37
T450
G
D
R
R
S
P
S
T
D
I
T
A
E
G
S
Site 38
T453
R
S
P
S
T
D
I
T
A
E
G
S
P
T
K
Site 39
S457
T
D
I
T
A
E
G
S
P
T
K
V
Q
K
S
Site 40
T459
I
T
A
E
G
S
P
T
K
V
Q
K
S
W
S
Site 41
S464
S
P
T
K
V
Q
K
S
W
S
F
N
D
R
T
Site 42
S466
T
K
V
Q
K
S
W
S
F
N
D
R
T
R
F
Site 43
T471
S
W
S
F
N
D
R
T
R
F
R
P
S
L
R
Site 44
S476
D
R
T
R
F
R
P
S
L
R
L
K
S
S
Q
Site 45
S481
R
P
S
L
R
L
K
S
S
Q
P
K
P
V
I
Site 46
S482
P
S
L
R
L
K
S
S
Q
P
K
P
V
I
D
Site 47
T492
K
P
V
I
D
A
D
T
A
L
G
T
D
D
V
Site 48
T496
D
A
D
T
A
L
G
T
D
D
V
Y
D
E
K
Site 49
Y500
A
L
G
T
D
D
V
Y
D
E
K
G
C
Q
C
Site 50
S510
K
G
C
Q
C
D
V
S
V
E
D
L
T
P
P
Site 51
T540
A
K
R
K
F
K
E
T
L
R
P
Y
D
V
K
Site 52
Y544
F
K
E
T
L
R
P
Y
D
V
K
D
V
I
E
Site 53
S566
D
M
L
C
R
I
K
S
L
Q
T
R
V
D
Q
Site 54
S582
L
G
K
G
Q
I
T
S
D
K
K
S
R
E
K
Site 55
S586
Q
I
T
S
D
K
K
S
R
E
K
I
T
A
E
Site 56
T597
I
T
A
E
H
E
T
T
D
D
L
S
M
L
G
Site 57
S601
H
E
T
T
D
D
L
S
M
L
G
R
V
V
K
Site 58
S618
K
Q
V
Q
S
I
E
S
K
L
D
C
L
L
D
Site 59
T654
P
P
F
E
C
E
Q
T
S
D
Y
Q
S
P
V
Site 60
S655
P
F
E
C
E
Q
T
S
D
Y
Q
S
P
V
D
Site 61
Y657
E
C
E
Q
T
S
D
Y
Q
S
P
V
D
S
K
Site 62
S659
E
Q
T
S
D
Y
Q
S
P
V
D
S
K
D
L
Site 63
S663
D
Y
Q
S
P
V
D
S
K
D
L
S
G
S
A
Site 64
S667
P
V
D
S
K
D
L
S
G
S
A
Q
N
S
G
Site 65
S669
D
S
K
D
L
S
G
S
A
Q
N
S
G
C
L
Site 66
S673
L
S
G
S
A
Q
N
S
G
C
L
S
R
S
T
Site 67
S677
A
Q
N
S
G
C
L
S
R
S
T
S
A
N
I
Site 68
S679
N
S
G
C
L
S
R
S
T
S
A
N
I
S
R
Site 69
T680
S
G
C
L
S
R
S
T
S
A
N
I
S
R
G
Site 70
S681
G
C
L
S
R
S
T
S
A
N
I
S
R
G
L
Site 71
S685
R
S
T
S
A
N
I
S
R
G
L
Q
F
I
L
Site 72
T693
R
G
L
Q
F
I
L
T
P
N
E
F
S
A
Q
Site 73
T701
P
N
E
F
S
A
Q
T
F
Y
A
L
S
P
T
Site 74
S706
A
Q
T
F
Y
A
L
S
P
T
M
H
S
Q
A
Site 75
S711
A
L
S
P
T
M
H
S
Q
A
T
Q
V
P
I
Site 76
T714
P
T
M
H
S
Q
A
T
Q
V
P
I
S
Q
S
Site 77
S719
Q
A
T
Q
V
P
I
S
Q
S
D
G
S
A
V
Site 78
S721
T
Q
V
P
I
S
Q
S
D
G
S
A
V
A
A
Site 79
T747
P
K
P
A
A
P
T
T
L
Q
I
P
P
P
L
Site 80
T765
K
H
L
P
R
P
E
T
L
H
P
N
P
A
G
Site 81
S776
N
P
A
G
L
Q
E
S
I
S
D
V
T
T
C
Site 82
T781
Q
E
S
I
S
D
V
T
T
C
L
V
A
S
K
Site 83
T782
E
S
I
S
D
V
T
T
C
L
V
A
S
K
E
Site 84
T799
Q
V
A
Q
S
N
L
T
K
D
R
S
M
R
K
Site 85
S803
S
N
L
T
K
D
R
S
M
R
K
S
F
D
M
Site 86
S807
K
D
R
S
M
R
K
S
F
D
M
G
G
E
T
Site 87
S831
K
D
L
G
K
S
L
S
V
Q
N
L
I
R
S
Site 88
S838
S
V
Q
N
L
I
R
S
T
E
E
L
N
I
Q
Site 89
T839
V
Q
N
L
I
R
S
T
E
E
L
N
I
Q
L
Site 90
S847
E
E
L
N
I
Q
L
S
G
S
E
S
S
G
S
Site 91
S849
L
N
I
Q
L
S
G
S
E
S
S
G
S
R
G
Site 92
S851
I
Q
L
S
G
S
E
S
S
G
S
R
G
S
Q
Site 93
S852
Q
L
S
G
S
E
S
S
G
S
R
G
S
Q
D
Site 94
S854
S
G
S
E
S
S
G
S
R
G
S
Q
D
F
Y
Site 95
S857
E
S
S
G
S
R
G
S
Q
D
F
Y
P
K
W
Site 96
Y861
S
R
G
S
Q
D
F
Y
P
K
W
R
E
S
K
Site 97
T883
V
G
P
E
E
T
E
T
D
T
F
D
A
A
P
Site 98
T885
P
E
E
T
E
T
D
T
F
D
A
A
P
Q
P
Site 99
S900
A
R
E
A
A
F
A
S
D
S
L
R
T
G
R
Site 100
S902
E
A
A
F
A
S
D
S
L
R
T
G
R
S
R
Site 101
T905
F
A
S
D
S
L
R
T
G
R
S
R
S
S
Q
Site 102
S908
D
S
L
R
T
G
R
S
R
S
S
Q
S
I
C
Site 103
S910
L
R
T
G
R
S
R
S
S
Q
S
I
C
K
A
Site 104
S911
R
T
G
R
S
R
S
S
Q
S
I
C
K
A
G
Site 105
S913
G
R
S
R
S
S
Q
S
I
C
K
A
G
E
S
Site 106
T921
I
C
K
A
G
E
S
T
D
A
L
S
L
P
H
Site 107
S925
G
E
S
T
D
A
L
S
L
P
H
V
K
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation