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Updated November 2019
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Protein Info
Short Name:
EIF4ENIF1
Full Name:
Eukaryotic translation initiation factor 4E transporter
Alias:
2610509L04Rik; 4ET; 4E-T; Clast4; EIF4E transporter; EIF4E-transporter; Eukaryotic translation initiation factor 4E nuclear import factor 1; Eukaryotic translation initiation factor 4E transporter; FLJ21601
Type:
Transport protein, facilitator
Mass (Da):
108201
Number AA:
985
UniProt ID:
Q9NRA8
International Prot ID:
IPI00291800
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
D
R
R
S
M
G
E
T
E
S
G
Site 2
T9
D
R
R
S
M
G
E
T
E
S
G
D
A
F
L
Site 3
S11
R
S
M
G
E
T
E
S
G
D
A
F
L
D
L
Site 4
S24
D
L
K
K
P
P
A
S
K
C
P
H
R
Y
T
Site 5
T31
S
K
C
P
H
R
Y
T
K
E
E
L
L
D
I
Site 6
S44
D
I
K
E
L
P
H
S
K
Q
R
P
S
C
L
Site 7
S49
P
H
S
K
Q
R
P
S
C
L
S
E
K
Y
D
Site 8
S52
K
Q
R
P
S
C
L
S
E
K
Y
D
S
D
G
Site 9
Y55
P
S
C
L
S
E
K
Y
D
S
D
G
V
W
D
Site 10
S57
C
L
S
E
K
Y
D
S
D
G
V
W
D
P
E
Site 11
S69
D
P
E
K
W
H
A
S
L
Y
P
A
S
G
R
Site 12
Y71
E
K
W
H
A
S
L
Y
P
A
S
G
R
S
S
Site 13
S74
H
A
S
L
Y
P
A
S
G
R
S
S
P
V
E
Site 14
S77
L
Y
P
A
S
G
R
S
S
P
V
E
S
L
K
Site 15
S78
Y
P
A
S
G
R
S
S
P
V
E
S
L
K
K
Site 16
S82
G
R
S
S
P
V
E
S
L
K
K
E
L
D
T
Site 17
T89
S
L
K
K
E
L
D
T
D
R
P
S
L
V
R
Site 18
S93
E
L
D
T
D
R
P
S
L
V
R
R
I
V
D
Site 19
S115
D
D
L
D
V
V
L
S
P
Q
R
R
S
F
G
Site 20
S120
V
L
S
P
Q
R
R
S
F
G
G
G
C
H
V
Site 21
T128
F
G
G
G
C
H
V
T
A
A
V
S
S
R
R
Site 22
S132
C
H
V
T
A
A
V
S
S
R
R
S
G
S
P
Site 23
S133
H
V
T
A
A
V
S
S
R
R
S
G
S
P
L
Site 24
S136
A
A
V
S
S
R
R
S
G
S
P
L
E
K
D
Site 25
S138
V
S
S
R
R
S
G
S
P
L
E
K
D
S
D
Site 26
S144
G
S
P
L
E
K
D
S
D
G
L
R
L
L
G
Site 27
S157
L
G
G
R
R
I
G
S
G
R
I
I
S
A
R
Site 28
S162
I
G
S
G
R
I
I
S
A
R
T
F
E
K
D
Site 29
T165
G
R
I
I
S
A
R
T
F
E
K
D
H
R
L
Site 30
S173
F
E
K
D
H
R
L
S
D
K
D
L
R
D
L
Site 31
S201
F
R
R
E
F
G
D
S
K
R
V
F
G
E
R
Site 32
S213
G
E
R
R
R
N
D
S
Y
T
E
E
E
P
E
Site 33
Y214
E
R
R
R
N
D
S
Y
T
E
E
E
P
E
W
Site 34
T215
R
R
R
N
D
S
Y
T
E
E
E
P
E
W
F
Site 35
S223
E
E
E
P
E
W
F
S
A
G
P
T
S
Q
S
Site 36
T227
E
W
F
S
A
G
P
T
S
Q
S
E
T
I
E
Site 37
S228
W
F
S
A
G
P
T
S
Q
S
E
T
I
E
L
Site 38
S230
S
A
G
P
T
S
Q
S
E
T
I
E
L
T
G
Site 39
T232
G
P
T
S
Q
S
E
T
I
E
L
T
G
F
D
Site 40
T253
D
H
K
G
R
K
R
T
R
R
R
T
A
S
V
Site 41
T257
R
K
R
T
R
R
R
T
A
S
V
K
E
G
I
Site 42
S259
R
T
R
R
R
T
A
S
V
K
E
G
I
V
E
Site 43
S301
D
A
V
L
P
E
Q
S
P
G
D
F
D
F
N
Site 44
S331
E
D
V
L
G
E
G
S
V
S
A
S
R
F
S
Site 45
S333
V
L
G
E
G
S
V
S
A
S
R
F
S
R
W
Site 46
S335
G
E
G
S
V
S
A
S
R
F
S
R
W
F
S
Site 47
S338
S
V
S
A
S
R
F
S
R
W
F
S
N
P
S
Site 48
S342
S
R
F
S
R
W
F
S
N
P
S
R
S
G
S
Site 49
S345
S
R
W
F
S
N
P
S
R
S
G
S
R
S
S
Site 50
S347
W
F
S
N
P
S
R
S
G
S
R
S
S
S
L
Site 51
S349
S
N
P
S
R
S
G
S
R
S
S
S
L
G
S
Site 52
S351
P
S
R
S
G
S
R
S
S
S
L
G
S
T
P
Site 53
S352
S
R
S
G
S
R
S
S
S
L
G
S
T
P
H
Site 54
S353
R
S
G
S
R
S
S
S
L
G
S
T
P
H
E
Site 55
S356
S
R
S
S
S
L
G
S
T
P
H
E
E
L
E
Site 56
T357
R
S
S
S
L
G
S
T
P
H
E
E
L
E
R
Site 57
S374
G
L
E
Q
A
I
L
S
P
G
Q
N
S
G
N
Site 58
S379
I
L
S
P
G
Q
N
S
G
N
Y
F
A
P
I
Site 59
Y382
P
G
Q
N
S
G
N
Y
F
A
P
I
P
L
E
Site 60
S414
V
D
L
K
P
L
L
S
S
L
S
A
N
K
E
Site 61
S415
D
L
K
P
L
L
S
S
L
S
A
N
K
E
K
Site 62
S417
K
P
L
L
S
S
L
S
A
N
K
E
K
L
K
Site 63
S429
K
L
K
E
S
S
H
S
G
V
V
L
S
V
E
Site 64
S454
V
D
Q
Q
V
K
N
S
T
P
F
M
A
E
H
Site 65
T455
D
Q
Q
V
K
N
S
T
P
F
M
A
E
H
L
Site 66
T465
M
A
E
H
L
E
E
T
L
S
A
V
T
N
N
Site 67
S467
E
H
L
E
E
T
L
S
A
V
T
N
N
R
Q
Site 68
T482
L
K
K
D
G
D
M
T
A
F
N
K
L
V
S
Site 69
S494
L
V
S
T
M
K
A
S
G
T
L
P
S
Q
P
Site 70
T496
S
T
M
K
A
S
G
T
L
P
S
Q
P
K
V
Site 71
S499
K
A
S
G
T
L
P
S
Q
P
K
V
S
R
N
Site 72
S504
L
P
S
Q
P
K
V
S
R
N
L
E
S
H
L
Site 73
S509
K
V
S
R
N
L
E
S
H
L
M
S
P
A
E
Site 74
S513
N
L
E
S
H
L
M
S
P
A
E
I
P
G
Q
Site 75
S540
Q
P
V
Q
R
P
A
S
S
N
L
L
S
G
L
Site 76
S541
P
V
Q
R
P
A
S
S
N
L
L
S
G
L
M
Site 77
T554
L
M
G
S
L
E
P
T
T
S
L
L
G
Q
R
Site 78
S556
G
S
L
E
P
T
T
S
L
L
G
Q
R
A
P
Site 79
S564
L
L
G
Q
R
A
P
S
P
P
L
S
Q
V
F
Site 80
S568
R
A
P
S
P
P
L
S
Q
V
F
Q
T
R
A
Site 81
S577
V
F
Q
T
R
A
A
S
A
D
Y
L
R
P
R
Site 82
Y580
T
R
A
A
S
A
D
Y
L
R
P
R
I
P
S
Site 83
S587
Y
L
R
P
R
I
P
S
P
I
G
F
T
P
G
Site 84
T592
I
P
S
P
I
G
F
T
P
G
P
Q
Q
L
L
Site 85
S611
Q
G
M
R
K
P
M
S
P
I
T
A
Q
M
S
Site 86
T614
R
K
P
M
S
P
I
T
A
Q
M
S
Q
L
E
Site 87
S618
S
P
I
T
A
Q
M
S
Q
L
E
L
Q
Q
A
Site 88
Y644
A
V
Q
A
A
N
F
Y
Q
P
G
F
G
K
P
Site 89
T668
R
N
R
Q
Q
R
V
T
K
S
P
A
P
V
H
Site 90
S670
R
Q
Q
R
V
T
K
S
P
A
P
V
H
R
G
Site 91
S679
A
P
V
H
R
G
N
S
S
S
P
A
P
A
A
Site 92
S680
P
V
H
R
G
N
S
S
S
P
A
P
A
A
S
Site 93
S681
V
H
R
G
N
S
S
S
P
A
P
A
A
S
I
Site 94
S693
A
S
I
T
S
M
L
S
P
S
F
T
P
T
S
Site 95
T697
S
M
L
S
P
S
F
T
P
T
S
V
I
R
K
Site 96
T699
L
S
P
S
F
T
P
T
S
V
I
R
K
M
Y
Site 97
S700
S
P
S
F
T
P
T
S
V
I
R
K
M
Y
E
Site 98
Y706
T
S
V
I
R
K
M
Y
E
S
K
E
K
S
K
Site 99
S708
V
I
R
K
M
Y
E
S
K
E
K
S
K
E
E
Site 100
S712
M
Y
E
S
K
E
K
S
K
E
E
P
A
S
G
Site 101
S718
K
S
K
E
E
P
A
S
G
K
A
A
L
G
D
Site 102
S726
G
K
A
A
L
G
D
S
K
E
D
T
Q
K
A
Site 103
T730
L
G
D
S
K
E
D
T
Q
K
A
S
E
E
N
Site 104
S740
A
S
E
E
N
L
L
S
S
S
S
V
P
S
A
Site 105
S741
S
E
E
N
L
L
S
S
S
S
V
P
S
A
D
Site 106
S742
E
E
N
L
L
S
S
S
S
V
P
S
A
D
R
Site 107
S743
E
N
L
L
S
S
S
S
V
P
S
A
D
R
D
Site 108
S746
L
S
S
S
S
V
P
S
A
D
R
D
S
S
P
Site 109
S751
V
P
S
A
D
R
D
S
S
P
T
T
N
S
K
Site 110
S752
P
S
A
D
R
D
S
S
P
T
T
N
S
K
L
Site 111
T754
A
D
R
D
S
S
P
T
T
N
S
K
L
S
A
Site 112
T755
D
R
D
S
S
P
T
T
N
S
K
L
S
A
L
Site 113
S757
D
S
S
P
T
T
N
S
K
L
S
A
L
Q
R
Site 114
S760
P
T
T
N
S
K
L
S
A
L
Q
R
S
S
C
Site 115
S765
K
L
S
A
L
Q
R
S
S
C
S
T
P
L
S
Site 116
S766
L
S
A
L
Q
R
S
S
C
S
T
P
L
S
Q
Site 117
S768
A
L
Q
R
S
S
C
S
T
P
L
S
Q
A
N
Site 118
T769
L
Q
R
S
S
C
S
T
P
L
S
Q
A
N
R
Site 119
S772
S
S
C
S
T
P
L
S
Q
A
N
R
Y
T
K
Site 120
T778
L
S
Q
A
N
R
Y
T
K
E
Q
D
Y
R
P
Site 121
Y783
R
Y
T
K
E
Q
D
Y
R
P
K
A
T
G
R
Site 122
T788
Q
D
Y
R
P
K
A
T
G
R
K
T
P
T
L
Site 123
T792
P
K
A
T
G
R
K
T
P
T
L
A
S
P
V
Site 124
S797
R
K
T
P
T
L
A
S
P
V
P
T
T
P
F
Site 125
T801
T
L
A
S
P
V
P
T
T
P
F
L
R
P
V
Site 126
S860
L
P
P
G
M
D
L
S
H
L
Q
G
I
S
G
Site 127
S881
F
Y
P
L
P
A
A
S
H
P
L
L
N
P
R
Site 128
S905
V
Q
Q
Q
L
Q
R
S
V
L
H
P
P
G
S
Site 129
S914
L
H
P
P
G
S
G
S
H
A
A
A
V
S
V
Site 130
S920
G
S
H
A
A
A
V
S
V
Q
T
T
P
Q
N
Site 131
T924
A
A
V
S
V
Q
T
T
P
Q
N
V
P
S
R
Site 132
S930
T
T
P
Q
N
V
P
S
R
S
G
L
P
H
M
Site 133
S932
P
Q
N
V
P
S
R
S
G
L
P
H
M
H
S
Site 134
S939
S
G
L
P
H
M
H
S
Q
L
E
H
R
P
S
Site 135
S946
S
Q
L
E
H
R
P
S
Q
R
S
S
S
P
V
Site 136
S949
E
H
R
P
S
Q
R
S
S
S
P
V
G
L
A
Site 137
S950
H
R
P
S
Q
R
S
S
S
P
V
G
L
A
K
Site 138
S951
R
P
S
Q
R
S
S
S
P
V
G
L
A
K
W
Site 139
S977
S
M
P
A
K
V
I
S
V
D
E
L
E
Y
R
Site 140
Y983
I
S
V
D
E
L
E
Y
R
Q
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation