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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PICK1
Full Name:
PRKCA-binding protein
Alias:
DJ1039K5; MGC15204; PRKCABP; Protein interacting with C kinase 1; Protein interacting with PRKCA 1; Protein kinase C-alpha-binding protein
Type:
Ligand, receptor tyrosine kinase; Cell development/differentiation; Adaptor/scaffold
Mass (Da):
46600
Number AA:
415
UniProt ID:
Q9NRD5
International Prot ID:
IPI00160369
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030054
GO:0030666
Uniprot
OncoNet
Molecular Function:
GO:0016887
GO:0008022
GO:0005080
PhosphoSite+
KinaseNET
Biological Process:
GO:0043045
GO:0043046
GO:0007205
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
F
A
D
L
D
Y
D
I
E
E
D
K
L
Site 2
T18
E
D
K
L
G
I
P
T
V
P
G
K
V
T
L
Site 3
Y101
K
G
E
V
T
I
H
Y
N
K
L
Q
A
D
P
Site 4
S113
A
D
P
K
Q
G
M
S
L
D
I
V
L
K
K
Site 5
S131
R
L
V
E
N
M
S
S
G
T
A
D
A
L
G
Site 6
T159
R
L
E
E
L
E
R
T
A
E
L
Y
K
G
M
Site 7
Y163
L
E
R
T
A
E
L
Y
K
G
M
T
E
H
T
Site 8
Y178
K
N
L
L
R
A
F
Y
E
L
S
Q
T
H
R
Site 9
S181
L
R
A
F
Y
E
L
S
Q
T
H
R
A
F
G
Site 10
T183
A
F
Y
E
L
S
Q
T
H
R
A
F
G
D
V
Site 11
S216
K
F
A
D
A
H
R
S
I
E
K
F
G
I
R
Site 12
T237
P
M
L
T
D
L
N
T
Y
L
N
K
A
I
P
Site 13
T249
A
I
P
D
T
R
L
T
I
K
K
Y
L
D
V
Site 14
Y253
T
R
L
T
I
K
K
Y
L
D
V
K
F
E
Y
Site 15
S262
D
V
K
F
E
Y
L
S
Y
C
L
K
V
K
E
Site 16
Y263
V
K
F
E
Y
L
S
Y
C
L
K
V
K
E
M
Site 17
Y275
K
E
M
D
D
E
E
Y
S
C
I
A
L
G
E
Site 18
Y285
I
A
L
G
E
P
L
Y
R
V
S
T
G
N
Y
Site 19
S288
G
E
P
L
Y
R
V
S
T
G
N
Y
E
Y
R
Site 20
T289
E
P
L
Y
R
V
S
T
G
N
Y
E
Y
R
L
Site 21
Y292
Y
R
V
S
T
G
N
Y
E
Y
R
L
I
L
R
Site 22
S309
Q
E
A
R
A
R
F
S
Q
M
R
K
D
V
L
Site 23
S339
F
Q
L
Q
R
L
V
S
T
M
S
K
Y
Y
N
Site 24
Y344
L
V
S
T
M
S
K
Y
Y
N
D
C
Y
A
V
Site 25
Y349
S
K
Y
Y
N
D
C
Y
A
V
L
R
D
A
D
Site 26
T368
E
V
D
L
A
H
T
T
L
A
Y
G
L
N
Q
Site 27
T390
E
E
E
E
E
E
D
T
A
A
G
E
P
S
R
Site 28
T399
A
G
E
P
S
R
D
T
R
G
A
A
G
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation