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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DUOX1
Full Name:
Dual oxidase 1
Alias:
dual oxidase 1; DUOX; flavoprotein NADPH oxidase; large NOX 1; LNOX1; long NOX 1; NADPH thyroid oxidase 1; nicotinamide adenine dinucleotide phosphate oxidase; NOXEF1; THOX1; thyroid oxidase 1
Type:
EC 1.11.1.-; EC 1.6.3.1; Oxidoreductase
Mass (Da):
177240
Number AA:
UniProt ID:
Q9NRD9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016324
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0016174
GO:0050661
PhosphoSite+
KinaseNET
Biological Process:
GO:0042335
GO:0019221
GO:0042446
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
L
G
A
Q
N
P
I
S
W
E
V
Q
R
F
D
Site 2
Y36
V
Q
R
F
D
G
W
Y
N
N
L
M
E
H
R
Site 3
S46
L
M
E
H
R
W
G
S
K
G
S
R
L
Q
R
Site 4
S58
L
Q
R
L
V
P
A
S
Y
A
D
G
V
Y
Q
Site 5
Y64
A
S
Y
A
D
G
V
Y
Q
P
L
G
E
P
H
Site 6
S79
L
P
N
P
R
D
L
S
N
T
I
S
R
G
P
Site 7
T81
N
P
R
D
L
S
N
T
I
S
R
G
P
A
G
Site 8
S83
R
D
L
S
N
T
I
S
R
G
P
A
G
L
A
Site 9
S91
R
G
P
A
G
L
A
S
L
R
N
R
T
V
L
Site 10
S149
V
V
L
P
F
Q
R
S
R
W
D
P
E
T
G
Site 11
T155
R
S
R
W
D
P
E
T
G
R
S
P
S
N
P
Site 12
S158
W
D
P
E
T
G
R
S
P
S
N
P
R
D
P
Site 13
S160
P
E
T
G
R
S
P
S
N
P
R
D
P
A
N
Site 14
S176
V
T
G
W
L
D
G
S
A
I
Y
G
S
S
H
Site 15
Y179
W
L
D
G
S
A
I
Y
G
S
S
H
S
W
S
Site 16
S181
D
G
S
A
I
Y
G
S
S
H
S
W
S
D
A
Site 17
S182
G
S
A
I
Y
G
S
S
H
S
W
S
D
A
L
Site 18
S184
A
I
Y
G
S
S
H
S
W
S
D
A
L
R
S
Site 19
S186
Y
G
S
S
H
S
W
S
D
A
L
R
S
F
S
Site 20
S191
S
W
S
D
A
L
R
S
F
S
R
G
Q
L
A
Site 21
S193
S
D
A
L
R
S
F
S
R
G
Q
L
A
S
G
Site 22
S199
F
S
R
G
Q
L
A
S
G
P
D
P
A
F
P
Site 23
S209
D
P
A
F
P
R
D
S
Q
N
P
L
L
M
W
Site 24
T223
W
A
A
P
D
P
A
T
G
Q
N
G
P
R
G
Site 25
Y232
Q
N
G
P
R
G
L
Y
A
F
G
A
E
R
G
Site 26
Y255
L
G
L
L
W
F
R
Y
H
N
L
W
A
Q
R
Site 27
Y287
R
K
R
V
I
A
T
Y
Q
N
I
A
V
Y
E
Site 28
T303
L
P
S
F
L
Q
K
T
L
P
E
Y
T
G
Y
Site 29
Y307
L
Q
K
T
L
P
E
Y
T
G
Y
R
P
F
L
Site 30
Y310
T
L
P
E
Y
T
G
Y
R
P
F
L
D
P
S
Site 31
S317
Y
R
P
F
L
D
P
S
I
S
S
E
F
V
A
Site 32
Y339
T
M
V
P
P
G
V
Y
M
R
N
A
S
C
H
Site 33
S355
Q
G
V
I
N
R
N
S
S
V
S
R
A
L
R
Site 34
S356
G
V
I
N
R
N
S
S
V
S
R
A
L
R
V
Site 35
S358
I
N
R
N
S
S
V
S
R
A
L
R
V
C
N
Site 36
Y367
A
L
R
V
C
N
S
Y
W
S
R
E
H
P
S
Site 37
S374
Y
W
S
R
E
H
P
S
L
Q
S
A
E
D
V
Site 38
S415
W
P
G
P
L
K
F
S
R
T
D
H
L
A
S
Site 39
T417
G
P
L
K
F
S
R
T
D
H
L
A
S
C
L
Site 40
S434
G
R
D
L
G
L
P
S
Y
T
K
A
R
A
A
Site 41
Y435
R
D
L
G
L
P
S
Y
T
K
A
R
A
A
L
Site 42
S445
A
R
A
A
L
G
L
S
P
I
T
R
W
Q
D
Site 43
S458
Q
D
I
N
P
A
L
S
R
S
N
D
T
V
L
Site 44
T463
A
L
S
R
S
N
D
T
V
L
E
A
T
A
A
Site 45
S489
L
P
G
G
L
L
E
S
H
R
D
P
G
P
L
Site 46
Y514
R
L
R
D
G
D
R
Y
W
F
E
N
T
R
N
Site 47
S525
N
T
R
N
G
L
F
S
K
K
E
I
E
E
I
Site 48
T535
E
I
E
E
I
R
N
T
T
L
Q
D
V
L
V
Site 49
S572
C
P
Q
P
R
Q
L
S
T
E
G
L
P
A
C
Site 50
Y587
A
P
S
V
V
R
D
Y
F
E
G
S
G
F
G
Site 51
S591
V
R
D
Y
F
E
G
S
G
F
G
F
G
V
T
Site 52
S634
L
Q
G
Q
D
R
Q
S
I
V
S
E
K
L
V
Site 53
S637
Q
D
R
Q
S
I
V
S
E
K
L
V
G
G
M
Site 54
Y662
P
C
R
P
V
L
V
Y
L
Q
P
G
Q
I
R
Site 55
T680
G
R
L
T
V
L
R
T
I
Q
L
Q
P
P
Q
Site 56
S694
Q
K
V
N
F
V
L
S
S
N
R
G
R
R
T
Site 57
S695
K
V
N
F
V
L
S
S
N
R
G
R
R
T
L
Site 58
T701
S
S
N
R
G
R
R
T
L
L
L
K
I
P
K
Site 59
S739
A
L
K
E
S
G
L
S
I
Q
E
W
E
L
R
Site 60
T766
Q
R
R
H
L
L
E
T
F
F
R
H
L
F
S
Site 61
T785
I
N
Q
A
D
A
G
T
L
P
L
D
S
S
Q
Site 62
S791
G
T
L
P
L
D
S
S
Q
K
V
R
E
A
L
Site 63
S803
E
A
L
T
C
E
L
S
R
A
E
F
A
E
S
Site 64
S810
S
R
A
E
F
A
E
S
L
G
L
K
P
Q
D
Site 65
S825
M
F
V
E
S
M
F
S
L
A
D
K
D
G
N
Site 66
Y834
A
D
K
D
G
N
G
Y
L
S
F
R
E
F
L
Site 67
S836
K
D
G
N
G
Y
L
S
F
R
E
F
L
D
I
Site 68
S851
L
V
V
F
M
K
G
S
P
E
E
K
S
R
L
Site 69
S856
K
G
S
P
E
E
K
S
R
L
M
F
R
M
Y
Site 70
Y863
S
R
L
M
F
R
M
Y
D
F
D
G
N
G
L
Site 71
S872
F
D
G
N
G
L
I
S
K
D
E
F
I
R
M
Site 72
S882
E
F
I
R
M
L
R
S
F
I
E
I
S
N
N
Site 73
S902
Q
L
A
E
V
V
E
S
M
F
R
E
S
G
F
Site 74
S907
V
E
S
M
F
R
E
S
G
F
Q
D
K
E
E
Site 75
S929
F
M
L
R
D
H
N
S
E
L
R
F
T
Q
L
Site 76
T934
H
N
S
E
L
R
F
T
Q
L
C
V
K
G
V
Site 77
S955
K
D
L
C
R
R
A
S
Y
I
S
Q
D
M
I
Site 78
Y956
D
L
C
R
R
A
S
Y
I
S
Q
D
M
I
C
Site 79
S958
C
R
R
A
S
Y
I
S
Q
D
M
I
C
P
S
Site 80
S965
S
Q
D
M
I
C
P
S
P
R
V
S
A
R
C
Site 81
S969
I
C
P
S
P
R
V
S
A
R
C
S
R
S
D
Site 82
S973
P
R
V
S
A
R
C
S
R
S
D
I
E
T
E
Site 83
S975
V
S
A
R
C
S
R
S
D
I
E
T
E
L
T
Site 84
T979
C
S
R
S
D
I
E
T
E
L
T
P
Q
R
L
Site 85
T982
S
D
I
E
T
E
L
T
P
Q
R
L
Q
C
P
Site 86
T992
R
L
Q
C
P
M
D
T
D
P
P
Q
E
I
R
Site 87
S1008
R
F
G
K
K
V
T
S
F
Q
P
L
L
F
T
Site 88
T1030
Q
R
S
C
L
H
Q
T
V
Q
Q
F
K
R
F
Site 89
Y1041
F
K
R
F
I
E
N
Y
R
R
H
I
G
C
V
Site 90
Y1064
G
L
F
L
E
R
A
Y
Y
Y
A
F
A
A
H
Site 91
S1086
T
R
V
G
I
I
L
S
R
G
T
A
A
S
I
Site 92
Y1120
R
E
T
F
L
N
R
Y
V
P
F
D
A
A
V
Site 93
S1176
G
L
F
H
D
D
G
S
E
L
P
Q
K
Y
Y
Site 94
S1217
S
H
H
F
R
R
R
S
F
R
G
F
W
L
T
Site 95
S1267
Y
G
G
D
K
L
V
S
L
S
R
K
K
V
E
Site 96
S1269
G
D
K
L
V
S
L
S
R
K
K
V
E
I
S
Site 97
S1276
S
R
K
K
V
E
I
S
V
V
K
A
E
L
L
Site 98
Y1300
Q
R
P
Q
G
F
E
Y
K
S
G
Q
W
V
R
Site 99
T1322
T
T
E
Y
H
P
F
T
L
T
S
A
P
H
E
Site 100
T1324
E
Y
H
P
F
T
L
T
S
A
P
H
E
D
T
Site 101
T1331
T
S
A
P
H
E
D
T
L
S
L
H
I
R
A
Site 102
S1333
A
P
H
E
D
T
L
S
L
H
I
R
A
A
G
Site 103
T1343
I
R
A
A
G
P
W
T
T
R
L
R
E
I
Y
Site 104
Y1350
T
T
R
L
R
E
I
Y
S
A
P
T
G
D
R
Site 105
S1351
T
R
L
R
E
I
Y
S
A
P
T
G
D
R
C
Site 106
Y1361
T
G
D
R
C
A
R
Y
P
K
L
Y
L
D
G
Site 107
Y1365
C
A
R
Y
P
K
L
Y
L
D
G
P
F
G
E
Site 108
S1397
I
G
V
T
P
F
A
S
I
L
K
D
L
V
F
Site 109
T1466
E
K
F
D
L
R
T
T
M
L
Y
I
C
E
R
Site 110
Y1469
D
L
R
T
T
M
L
Y
I
C
E
R
H
F
Q
Site 111
S1489
S
L
F
T
G
L
R
S
I
T
H
F
G
R
P
Site 112
T1491
F
T
G
L
R
S
I
T
H
F
G
R
P
P
F
Site 113
S1504
P
F
E
P
F
F
N
S
L
Q
E
V
H
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation