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Updated November 2019
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Protein Info
Short Name:
TSHZ2
Full Name:
Teashirt homolog 2
Alias:
Ovarian cancer-related protein 10-2;Zinc finger protein 218
Type:
Mass (Da):
115005
Number AA:
1034
UniProt ID:
Q9NRE2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
E
E
E
E
E
E
D
S
G
S
V
A
Q
L
Q
Site 2
S38
E
E
E
E
D
S
G
S
V
A
Q
L
Q
G
G
Site 3
T50
Q
G
G
N
D
T
G
T
D
E
E
L
E
T
G
Site 4
T56
G
T
D
E
E
L
E
T
G
P
E
Q
K
G
C
Site 5
S65
P
E
Q
K
G
C
F
S
Y
Q
N
S
P
G
S
Site 6
Y66
E
Q
K
G
C
F
S
Y
Q
N
S
P
G
S
H
Site 7
S69
G
C
F
S
Y
Q
N
S
P
G
S
H
L
S
N
Site 8
S72
S
Y
Q
N
S
P
G
S
H
L
S
N
Q
D
A
Site 9
S75
N
S
P
G
S
H
L
S
N
Q
D
A
E
N
E
Site 10
S83
N
Q
D
A
E
N
E
S
L
L
S
D
A
S
D
Site 11
S86
A
E
N
E
S
L
L
S
D
A
S
D
Q
V
S
Site 12
S89
E
S
L
L
S
D
A
S
D
Q
V
S
D
I
K
Site 13
S93
S
D
A
S
D
Q
V
S
D
I
K
S
V
C
G
Site 14
S97
D
Q
V
S
D
I
K
S
V
C
G
R
D
A
S
Site 15
S104
S
V
C
G
R
D
A
S
D
K
K
A
H
T
H
Site 16
T110
A
S
D
K
K
A
H
T
H
V
R
L
P
N
E
Site 17
S148
L
G
L
G
F
K
L
S
N
S
E
R
R
N
C
Site 18
S150
L
G
F
K
L
S
N
S
E
R
R
N
C
D
T
Site 19
T157
S
E
R
R
N
C
D
T
R
N
G
S
N
K
S
Site 20
S174
D
W
H
Q
D
A
L
S
K
S
L
Q
Q
N
L
Site 21
S176
H
Q
D
A
L
S
K
S
L
Q
Q
N
L
P
S
Site 22
S183
S
L
Q
Q
N
L
P
S
R
S
V
S
K
P
S
Site 23
S185
Q
Q
N
L
P
S
R
S
V
S
K
P
S
L
F
Site 24
S187
N
L
P
S
R
S
V
S
K
P
S
L
F
S
S
Site 25
S190
S
R
S
V
S
K
P
S
L
F
S
S
V
Q
L
Site 26
S194
S
K
P
S
L
F
S
S
V
Q
L
Y
R
Q
S
Site 27
Y198
L
F
S
S
V
Q
L
Y
R
Q
S
S
K
M
C
Site 28
S201
S
V
Q
L
Y
R
Q
S
S
K
M
C
G
T
V
Site 29
S202
V
Q
L
Y
R
Q
S
S
K
M
C
G
T
V
F
Site 30
S221
R
F
R
C
R
Q
C
S
A
A
Y
D
T
L
V
Site 31
T231
Y
D
T
L
V
E
L
T
V
H
M
N
E
T
G
Site 32
Y240
H
M
N
E
T
G
H
Y
Q
D
D
N
R
K
K
Site 33
T253
K
K
D
K
L
R
P
T
S
Y
S
K
P
R
K
Site 34
S254
K
D
K
L
R
P
T
S
Y
S
K
P
R
K
R
Site 35
Y255
D
K
L
R
P
T
S
Y
S
K
P
R
K
R
A
Site 36
S256
K
L
R
P
T
S
Y
S
K
P
R
K
R
A
F
Site 37
S283
K
C
M
F
C
G
D
S
F
D
S
L
Q
D
L
Site 38
S286
F
C
G
D
S
F
D
S
L
Q
D
L
S
V
H
Site 39
S291
F
D
S
L
Q
D
L
S
V
H
M
I
K
T
K
Site 40
T311
P
L
K
E
P
V
P
T
I
S
S
K
M
V
T
Site 41
S314
E
P
V
P
T
I
S
S
K
M
V
T
P
A
K
Site 42
T318
T
I
S
S
K
M
V
T
P
A
K
K
R
V
F
Site 43
S332
F
D
V
N
R
P
C
S
P
D
S
T
T
G
S
Site 44
S335
N
R
P
C
S
P
D
S
T
T
G
S
F
A
D
Site 45
T336
R
P
C
S
P
D
S
T
T
G
S
F
A
D
S
Site 46
T337
P
C
S
P
D
S
T
T
G
S
F
A
D
S
F
Site 47
S339
S
P
D
S
T
T
G
S
F
A
D
S
F
S
S
Site 48
S343
T
T
G
S
F
A
D
S
F
S
S
Q
K
N
A
Site 49
S345
G
S
F
A
D
S
F
S
S
Q
K
N
A
N
L
Site 50
S346
S
F
A
D
S
F
S
S
Q
K
N
A
N
L
Q
Site 51
S355
K
N
A
N
L
Q
L
S
S
N
N
R
Y
G
Y
Site 52
S356
N
A
N
L
Q
L
S
S
N
N
R
Y
G
Y
Q
Site 53
Y360
Q
L
S
S
N
N
R
Y
G
Y
Q
N
G
A
S
Site 54
Y362
S
S
N
N
R
Y
G
Y
Q
N
G
A
S
Y
T
Site 55
Y368
G
Y
Q
N
G
A
S
Y
T
W
Q
F
E
A
C
Site 56
S387
L
K
C
M
E
C
G
S
S
H
D
T
L
Q
Q
Site 57
T391
E
C
G
S
S
H
D
T
L
Q
Q
L
T
T
H
Site 58
T409
T
G
H
F
L
K
V
T
S
S
A
S
K
K
G
Site 59
S411
H
F
L
K
V
T
S
S
A
S
K
K
G
K
Q
Site 60
S413
L
K
V
T
S
S
A
S
K
K
G
K
Q
L
V
Site 61
S431
L
A
V
E
K
M
Q
S
L
S
E
A
P
N
S
Site 62
S433
V
E
K
M
Q
S
L
S
E
A
P
N
S
D
S
Site 63
S438
S
L
S
E
A
P
N
S
D
S
L
A
P
K
P
Site 64
S440
S
E
A
P
N
S
D
S
L
A
P
K
P
S
S
Site 65
S446
D
S
L
A
P
K
P
S
S
N
S
A
S
D
C
Site 66
S447
S
L
A
P
K
P
S
S
N
S
A
S
D
C
T
Site 67
S449
A
P
K
P
S
S
N
S
A
S
D
C
T
A
S
Site 68
S451
K
P
S
S
N
S
A
S
D
C
T
A
S
T
T
Site 69
T454
S
N
S
A
S
D
C
T
A
S
T
T
E
L
K
Site 70
S473
K
E
R
P
E
E
T
S
K
D
E
K
V
V
K
Site 71
S481
K
D
E
K
V
V
K
S
E
D
Y
E
D
P
L
Site 72
Y484
K
V
V
K
S
E
D
Y
E
D
P
L
Q
K
P
Site 73
T495
L
Q
K
P
L
D
P
T
I
K
Y
Q
Y
L
R
Site 74
Y498
P
L
D
P
T
I
K
Y
Q
Y
L
R
E
E
D
Site 75
Y500
D
P
T
I
K
Y
Q
Y
L
R
E
E
D
L
E
Site 76
S510
E
E
D
L
E
D
G
S
K
G
G
G
D
I
L
Site 77
S519
G
G
G
D
I
L
K
S
L
E
N
T
V
T
T
Site 78
T525
K
S
L
E
N
T
V
T
T
A
I
N
K
A
Q
Site 79
S537
K
A
Q
N
G
A
P
S
W
S
A
Y
P
S
I
Site 80
S539
Q
N
G
A
P
S
W
S
A
Y
P
S
I
H
A
Site 81
Y541
G
A
P
S
W
S
A
Y
P
S
I
H
A
A
Y
Site 82
S543
P
S
W
S
A
Y
P
S
I
H
A
A
Y
Q
L
Site 83
S562
K
P
P
L
P
M
G
S
Q
V
L
Q
I
R
P
Site 84
T598
P
T
H
L
A
P
Y
T
Q
V
K
K
E
S
E
Site 85
S618
V
K
E
C
G
K
E
S
P
H
E
E
A
S
S
Site 86
S624
E
S
P
H
E
E
A
S
S
F
S
H
S
E
G
Site 87
S625
S
P
H
E
E
A
S
S
F
S
H
S
E
G
D
Site 88
S627
H
E
E
A
S
S
F
S
H
S
E
G
D
S
F
Site 89
S629
E
A
S
S
F
S
H
S
E
G
D
S
F
R
K
Site 90
S633
F
S
H
S
E
G
D
S
F
R
K
S
E
T
P
Site 91
S637
E
G
D
S
F
R
K
S
E
T
P
P
E
A
K
Site 92
T639
D
S
F
R
K
S
E
T
P
P
E
A
K
K
T
Site 93
T646
T
P
P
E
A
K
K
T
E
L
G
P
L
K
E
Site 94
S662
E
K
L
M
K
E
G
S
E
K
E
K
P
Q
P
Site 95
S674
P
Q
P
L
E
P
T
S
A
L
S
N
G
C
A
Site 96
S700
N
P
L
S
A
L
Q
S
V
L
N
N
H
L
G
Site 97
S715
K
A
T
E
P
L
R
S
P
S
C
S
S
P
S
Site 98
S717
T
E
P
L
R
S
P
S
C
S
S
P
S
S
S
Site 99
S719
P
L
R
S
P
S
C
S
S
P
S
S
S
T
I
Site 100
S720
L
R
S
P
S
C
S
S
P
S
S
S
T
I
S
Site 101
S722
S
P
S
C
S
S
P
S
S
S
T
I
S
M
F
Site 102
S723
P
S
C
S
S
P
S
S
S
T
I
S
M
F
H
Site 103
S724
S
C
S
S
P
S
S
S
T
I
S
M
F
H
K
Site 104
S727
S
P
S
S
S
T
I
S
M
F
H
K
S
N
L
Site 105
S743
V
M
D
K
P
V
L
S
P
A
S
T
R
S
A
Site 106
S746
K
P
V
L
S
P
A
S
T
R
S
A
S
V
S
Site 107
T747
P
V
L
S
P
A
S
T
R
S
A
S
V
S
R
Site 108
S749
L
S
P
A
S
T
R
S
A
S
V
S
R
R
Y
Site 109
S751
P
A
S
T
R
S
A
S
V
S
R
R
Y
L
F
Site 110
S753
S
T
R
S
A
S
V
S
R
R
Y
L
F
E
N
Site 111
Y756
S
A
S
V
S
R
R
Y
L
F
E
N
S
D
Q
Site 112
S761
R
R
Y
L
F
E
N
S
D
Q
P
I
D
L
T
Site 113
T768
S
D
Q
P
I
D
L
T
K
S
K
S
K
K
A
Site 114
S770
Q
P
I
D
L
T
K
S
K
S
K
K
A
E
S
Site 115
S772
I
D
L
T
K
S
K
S
K
K
A
E
S
S
Q
Site 116
S777
S
K
S
K
K
A
E
S
S
Q
A
Q
S
C
M
Site 117
S778
K
S
K
K
A
E
S
S
Q
A
Q
S
C
M
S
Site 118
S782
A
E
S
S
Q
A
Q
S
C
M
S
P
P
Q
K
Site 119
S785
S
Q
A
Q
S
C
M
S
P
P
Q
K
H
A
L
Site 120
T807
K
V
L
P
K
A
T
T
P
K
P
A
S
S
S
Site 121
S812
A
T
T
P
K
P
A
S
S
S
R
V
P
P
M
Site 122
S813
T
T
P
K
P
A
S
S
S
R
V
P
P
M
K
Site 123
S814
T
P
K
P
A
S
S
S
R
V
P
P
M
K
L
Site 124
S832
V
R
R
F
E
D
V
S
S
E
V
S
T
L
H
Site 125
S833
R
R
F
E
D
V
S
S
E
V
S
T
L
H
K
Site 126
S836
E
D
V
S
S
E
V
S
T
L
H
K
R
K
G
Site 127
T837
D
V
S
S
E
V
S
T
L
H
K
R
K
G
R
Site 128
S863
L
Q
A
Q
F
A
S
S
L
F
Q
T
S
E
G
Site 129
S868
A
S
S
L
F
Q
T
S
E
G
K
Y
L
L
S
Site 130
Y872
F
Q
T
S
E
G
K
Y
L
L
S
D
L
G
P
Site 131
S875
S
E
G
K
Y
L
L
S
D
L
G
P
Q
E
R
Site 132
Y905
H
W
L
A
N
V
K
Y
Q
L
R
K
T
G
G
Site 133
T910
V
K
Y
Q
L
R
K
T
G
G
T
K
F
L
K
Site 134
T913
Q
L
R
K
T
G
G
T
K
F
L
K
N
M
D
Site 135
Y927
D
K
G
H
P
I
F
Y
C
S
D
C
A
S
Q
Site 136
S933
F
Y
C
S
D
C
A
S
Q
F
R
T
P
S
T
Site 137
T937
D
C
A
S
Q
F
R
T
P
S
T
Y
I
S
H
Site 138
S939
A
S
Q
F
R
T
P
S
T
Y
I
S
H
L
E
Site 139
T940
S
Q
F
R
T
P
S
T
Y
I
S
H
L
E
S
Site 140
Y941
Q
F
R
T
P
S
T
Y
I
S
H
L
E
S
H
Site 141
S943
R
T
P
S
T
Y
I
S
H
L
E
S
H
L
G
Site 142
S960
M
K
D
M
T
R
L
S
V
D
Q
Q
S
K
V
Site 143
S965
R
L
S
V
D
Q
Q
S
K
V
E
Q
E
I
S
Site 144
S972
S
K
V
E
Q
E
I
S
R
V
S
S
A
Q
R
Site 145
S975
E
Q
E
I
S
R
V
S
S
A
Q
R
S
P
E
Site 146
S976
Q
E
I
S
R
V
S
S
A
Q
R
S
P
E
T
Site 147
S980
R
V
S
S
A
Q
R
S
P
E
T
I
A
A
E
Site 148
T990
T
I
A
A
E
E
D
T
D
S
K
F
K
C
K
Site 149
S992
A
A
E
E
D
T
D
S
K
F
K
C
K
L
C
Site 150
S1014
H
A
V
K
L
H
L
S
K
T
H
S
K
S
P
Site 151
T1016
V
K
L
H
L
S
K
T
H
S
K
S
P
E
H
Site 152
S1018
L
H
L
S
K
T
H
S
K
S
P
E
H
H
S
Site 153
S1020
L
S
K
T
H
S
K
S
P
E
H
H
S
Q
F
Site 154
S1025
S
K
S
P
E
H
H
S
Q
F
V
T
D
V
D
Site 155
T1029
E
H
H
S
Q
F
V
T
D
V
D
E
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation