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Updated November 2019
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Protein Info
Short Name:
DISC1
Full Name:
Disrupted in schizophrenia 1 protein
Alias:
Type:
Mass (Da):
93611
Number AA:
854
UniProt ID:
Q9NRI5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
A
A
G
G
G
G
V
S
H
R
A
G
S
R
D
Site 2
S24
G
V
S
H
R
A
G
S
R
D
C
L
P
P
A
Site 3
Y45
R
L
A
R
R
P
G
Y
M
R
S
S
T
G
P
Site 4
S48
R
R
P
G
Y
M
R
S
S
T
G
P
G
I
G
Site 5
S49
R
P
G
Y
M
R
S
S
T
G
P
G
I
G
F
Site 6
T50
P
G
Y
M
R
S
S
T
G
P
G
I
G
F
L
Site 7
S58
G
P
G
I
G
F
L
S
P
A
V
G
T
L
F
Site 8
S72
F
R
F
P
G
G
V
S
G
E
E
S
H
H
S
Site 9
S76
G
G
V
S
G
E
E
S
H
H
S
E
S
R
A
Site 10
S79
S
G
E
E
S
H
H
S
E
S
R
A
R
Q
C
Site 11
S97
S
R
G
L
L
V
R
S
P
V
S
K
S
A
A
Site 12
S102
V
R
S
P
V
S
K
S
A
A
A
P
T
V
T
Site 13
T107
S
K
S
A
A
A
P
T
V
T
S
V
R
G
T
Site 14
S110
A
A
A
P
T
V
T
S
V
R
G
T
S
A
H
Site 15
T114
T
V
T
S
V
R
G
T
S
A
H
F
G
I
Q
Site 16
T126
G
I
Q
L
R
G
G
T
R
L
P
D
R
L
S
Site 17
S133
T
R
L
P
D
R
L
S
W
P
C
G
P
G
S
Site 18
S159
S
S
E
T
L
D
A
S
W
E
A
A
C
S
D
Site 19
S165
A
S
W
E
A
A
C
S
D
G
A
R
R
V
R
Site 20
S176
R
R
V
R
A
A
G
S
L
P
S
A
E
L
S
Site 21
S179
R
A
A
G
S
L
P
S
A
E
L
S
S
N
S
Site 22
S183
S
L
P
S
A
E
L
S
S
N
S
C
S
P
G
Site 23
S184
L
P
S
A
E
L
S
S
N
S
C
S
P
G
C
Site 24
S186
S
A
E
L
S
S
N
S
C
S
P
G
C
G
P
Site 25
S188
E
L
S
S
N
S
C
S
P
G
C
G
P
E
V
Site 26
T198
C
G
P
E
V
P
P
T
P
P
G
S
H
S
A
Site 27
S202
V
P
P
T
P
P
G
S
H
S
A
F
T
S
S
Site 28
S204
P
T
P
P
G
S
H
S
A
F
T
S
S
F
S
Site 29
T207
P
G
S
H
S
A
F
T
S
S
F
S
F
I
R
Site 30
S209
S
H
S
A
F
T
S
S
F
S
F
I
R
L
S
Site 31
S216
S
F
S
F
I
R
L
S
L
G
S
A
G
E
R
Site 32
S219
F
I
R
L
S
L
G
S
A
G
E
R
G
E
A
Site 33
S232
E
A
E
G
C
P
P
S
R
E
A
E
S
H
C
Site 34
S237
P
P
S
R
E
A
E
S
H
C
Q
S
P
Q
E
Site 35
S241
E
A
E
S
H
C
Q
S
P
Q
E
M
G
A
K
Site 36
S251
E
M
G
A
K
A
A
S
L
D
G
P
H
E
D
Site 37
S263
H
E
D
P
R
C
L
S
R
P
F
S
L
L
A
Site 38
S284
L
A
Q
A
A
R
N
S
S
R
P
E
R
D
M
Site 39
S285
A
Q
A
A
R
N
S
S
R
P
E
R
D
M
H
Site 40
S293
R
P
E
R
D
M
H
S
L
P
D
M
D
P
G
Site 41
S301
L
P
D
M
D
P
G
S
S
S
S
L
D
P
S
Site 42
S302
P
D
M
D
P
G
S
S
S
S
L
D
P
S
L
Site 43
S303
D
M
D
P
G
S
S
S
S
L
D
P
S
L
A
Site 44
S304
M
D
P
G
S
S
S
S
L
D
P
S
L
A
G
Site 45
S308
S
S
S
S
L
D
P
S
L
A
G
C
G
G
D
Site 46
S317
A
G
C
G
G
D
G
S
S
G
S
G
D
A
H
Site 47
S318
G
C
G
G
D
G
S
S
G
S
G
D
A
H
S
Site 48
S320
G
G
D
G
S
S
G
S
G
D
A
H
S
W
D
Site 49
S325
S
G
S
G
D
A
H
S
W
D
T
L
L
R
K
Site 50
T328
G
D
A
H
S
W
D
T
L
L
R
K
W
E
P
Site 51
S352
R
R
Q
M
E
V
I
S
L
R
L
K
L
Q
K
Site 52
Y370
D
A
V
E
N
D
D
Y
D
K
A
E
T
L
Q
Site 53
S389
D
L
E
Q
E
K
I
S
L
H
F
Q
L
P
S
Site 54
S396
S
L
H
F
Q
L
P
S
R
Q
P
A
L
S
S
Site 55
S402
P
S
R
Q
P
A
L
S
S
F
L
G
H
L
A
Site 56
T421
A
A
L
R
R
G
A
T
Q
Q
A
S
G
D
D
Site 57
T429
Q
Q
A
S
G
D
D
T
H
T
P
L
R
M
E
Site 58
T431
A
S
G
D
D
T
H
T
P
L
R
M
E
P
R
Site 59
T443
E
P
R
L
L
E
P
T
A
Q
D
S
L
H
V
Site 60
S447
L
E
P
T
A
Q
D
S
L
H
V
S
I
T
R
Site 61
S451
A
Q
D
S
L
H
V
S
I
T
R
R
D
W
L
Site 62
T453
D
S
L
H
V
S
I
T
R
R
D
W
L
L
Q
Site 63
T505
Q
W
Q
G
C
D
L
T
P
L
V
G
Q
L
S
Site 64
T542
F
H
A
E
P
P
E
T
I
R
S
L
Q
E
R
Site 65
S545
E
P
P
E
T
I
R
S
L
Q
E
R
I
K
S
Site 66
S552
S
L
Q
E
R
I
K
S
L
N
L
S
L
K
E
Site 67
S556
R
I
K
S
L
N
L
S
L
K
E
I
T
T
K
Site 68
T573
M
S
E
K
F
C
S
T
L
R
K
K
V
N
D
Site 69
T583
K
K
V
N
D
I
E
T
Q
L
P
A
L
L
E
Site 70
T608
F
W
T
A
K
D
L
T
E
E
I
R
S
L
T
Site 71
S613
D
L
T
E
E
I
R
S
L
T
S
E
R
E
G
Site 72
T615
T
E
E
I
R
S
L
T
S
E
R
E
G
L
E
Site 73
S616
E
E
I
R
S
L
T
S
E
R
E
G
L
E
G
Site 74
S633
S
K
L
L
V
L
S
S
R
N
V
K
K
L
G
Site 75
Y646
L
G
S
V
K
E
D
Y
N
R
L
R
R
E
V
Site 76
T658
R
E
V
E
H
Q
E
T
A
Y
E
T
S
V
K
Site 77
Y671
V
K
E
N
T
M
K
Y
M
E
T
L
K
N
K
Site 78
T674
N
T
M
K
Y
M
E
T
L
K
N
K
L
C
S
Site 79
S713
Q
L
Q
E
A
R
G
S
L
S
V
E
D
E
R
Site 80
S715
Q
E
A
R
G
S
L
S
V
E
D
E
R
Q
M
Site 81
S738
P
I
P
P
R
L
H
S
E
D
K
R
K
T
P
Site 82
T744
H
S
E
D
K
R
K
T
P
L
K
V
L
E
E
Site 83
T754
K
V
L
E
E
W
K
T
H
L
I
P
S
L
H
Site 84
S775
K
E
E
S
Y
I
L
S
A
E
L
G
E
K
C
Site 85
Y791
D
I
G
K
K
L
L
Y
L
E
D
Q
L
H
T
Site 86
S802
Q
L
H
T
A
I
H
S
H
D
E
D
L
I
Q
Site 87
S810
H
D
E
D
L
I
Q
S
L
R
R
E
L
Q
M
Site 88
S843
G
E
R
E
A
A
A
S
C
M
T
A
G
V
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation