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Updated November 2019
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Protein Info
Short Name:
TULP4
Full Name:
Tubby-related protein 4
Alias:
KIAA1397; Tubby like protein 4; Tubby-like 4; TUSP
Type:
Ubiquitin conjugating system
Mass (Da):
169174
Number AA:
1544
UniProt ID:
Q9NRJ4
International Prot ID:
IPI00024994
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0019941
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
D
S
N
I
L
C
L
S
W
K
G
R
V
P
K
Site 2
S29
W
K
G
R
V
P
K
S
E
K
E
K
P
V
C
Site 3
Y40
K
P
V
C
R
R
R
Y
Y
E
E
G
W
L
A
Site 4
Y41
P
V
C
R
R
R
Y
Y
E
E
G
W
L
A
T
Site 5
T58
G
R
G
V
V
G
V
T
F
T
S
S
H
C
R
Site 6
S62
V
G
V
T
F
T
S
S
H
C
R
R
D
R
S
Site 7
S69
S
H
C
R
R
D
R
S
T
P
Q
R
I
N
F
Site 8
T70
H
C
R
R
D
R
S
T
P
Q
R
I
N
F
N
Site 9
S83
F
N
L
R
G
H
N
S
E
V
V
L
V
R
W
Site 10
Y94
L
V
R
W
N
E
P
Y
Q
K
L
A
T
C
D
Site 11
Y112
G
I
F
V
W
I
Q
Y
E
G
R
W
S
V
E
Site 12
S117
I
Q
Y
E
G
R
W
S
V
E
L
V
N
D
R
Site 13
S129
N
D
R
G
A
Q
V
S
D
F
T
W
S
H
D
Site 14
T132
G
A
Q
V
S
D
F
T
W
S
H
D
G
T
Q
Site 15
S134
Q
V
S
D
F
T
W
S
H
D
G
T
Q
A
L
Site 16
T138
F
T
W
S
H
D
G
T
Q
A
L
I
S
Y
R
Site 17
S153
D
G
F
V
L
V
G
S
V
S
G
Q
R
H
W
Site 18
S155
F
V
L
V
G
S
V
S
G
Q
R
H
W
S
S
Site 19
S161
V
S
G
Q
R
H
W
S
S
E
I
N
L
E
S
Site 20
S162
S
G
Q
R
H
W
S
S
E
I
N
L
E
S
Q
Site 21
T176
Q
I
T
C
G
I
W
T
P
D
D
Q
Q
V
L
Site 22
S227
P
I
F
L
V
E
D
S
S
E
S
D
T
D
S
Site 23
S228
I
F
L
V
E
D
S
S
E
S
D
T
D
S
D
Site 24
S230
L
V
E
D
S
S
E
S
D
T
D
S
D
D
Y
Site 25
T232
E
D
S
S
E
S
D
T
D
S
D
D
Y
A
P
Site 26
S234
S
S
E
S
D
T
D
S
D
D
Y
A
P
P
Q
Site 27
Y237
S
D
T
D
S
D
D
Y
A
P
P
Q
D
G
P
Site 28
Y247
P
Q
D
G
P
A
A
Y
P
I
P
V
Q
N
I
Site 29
T259
Q
N
I
K
P
L
L
T
V
S
F
T
S
G
D
Site 30
S268
S
F
T
S
G
D
I
S
L
M
N
N
Y
D
D
Site 31
Y273
D
I
S
L
M
N
N
Y
D
D
L
S
P
T
V
Site 32
S277
M
N
N
Y
D
D
L
S
P
T
V
I
R
S
G
Site 33
T279
N
Y
D
D
L
S
P
T
V
I
R
S
G
L
K
Site 34
T308
V
A
G
M
E
R
Q
T
Q
L
G
E
L
P
N
Site 35
S321
P
N
G
P
L
L
K
S
A
M
V
K
F
Y
N
Site 36
Y327
K
S
A
M
V
K
F
Y
N
V
R
G
E
H
I
Site 37
T336
V
R
G
E
H
I
F
T
L
D
T
L
V
Q
R
Site 38
Y366
M
A
S
G
P
A
L
Y
V
V
R
V
E
H
R
Site 39
S376
R
V
E
H
R
V
S
S
L
Q
L
L
C
Q
Q
Site 40
S387
L
C
Q
Q
A
I
A
S
T
L
R
E
D
K
D
Site 41
S396
L
R
E
D
K
D
V
S
K
L
T
L
P
P
R
Site 42
T399
D
K
D
V
S
K
L
T
L
P
P
R
L
C
S
Site 43
S431
N
N
M
R
D
F
V
S
Y
P
S
A
G
N
E
Site 44
Y432
N
M
R
D
F
V
S
Y
P
S
A
G
N
E
R
Site 45
S478
I
L
K
G
R
R
I
S
K
L
R
P
E
F
V
Site 46
T491
F
V
I
M
D
P
R
T
D
S
K
P
D
E
I
Site 47
S493
I
M
D
P
R
T
D
S
K
P
D
E
I
Y
G
Site 48
Y499
D
S
K
P
D
E
I
Y
G
N
S
L
I
S
T
Site 49
S502
P
D
E
I
Y
G
N
S
L
I
S
T
V
I
D
Site 50
S514
V
I
D
S
C
N
C
S
D
S
S
D
I
E
L
Site 51
S516
D
S
C
N
C
S
D
S
S
D
I
E
L
S
D
Site 52
S517
S
C
N
C
S
D
S
S
D
I
E
L
S
D
D
Site 53
S522
D
S
S
D
I
E
L
S
D
D
W
A
A
K
K
Site 54
S530
D
D
W
A
A
K
K
S
P
K
I
S
R
A
S
Site 55
S534
A
K
K
S
P
K
I
S
R
A
S
K
S
P
K
Site 56
S537
S
P
K
I
S
R
A
S
K
S
P
K
L
P
R
Site 57
S539
K
I
S
R
A
S
K
S
P
K
L
P
R
I
S
Site 58
S546
S
P
K
L
P
R
I
S
I
E
A
R
K
S
P
Site 59
S552
I
S
I
E
A
R
K
S
P
K
L
P
R
A
A
Site 60
S563
P
R
A
A
Q
E
L
S
R
S
P
R
L
P
L
Site 61
S565
A
A
Q
E
L
S
R
S
P
R
L
P
L
R
K
Site 62
S574
R
L
P
L
R
K
P
S
V
G
S
P
S
L
T
Site 63
S577
L
R
K
P
S
V
G
S
P
S
L
T
R
R
E
Site 64
S579
K
P
S
V
G
S
P
S
L
T
R
R
E
F
P
Site 65
T581
S
V
G
S
P
S
L
T
R
R
E
F
P
F
E
Site 66
Y595
E
D
I
T
Q
H
N
Y
L
A
Q
V
T
S
N
Site 67
Y626
T
N
L
G
A
V
I
Y
K
T
S
L
L
H
L
Site 68
T639
H
L
Q
P
R
Q
M
T
I
Y
L
P
E
V
R
Site 69
Y641
Q
P
R
Q
M
T
I
Y
L
P
E
V
R
K
I
Site 70
S649
L
P
E
V
R
K
I
S
M
D
Y
I
N
L
P
Site 71
S676
D
L
P
V
T
G
A
S
G
V
P
E
N
S
P
Site 72
S682
A
S
G
V
P
E
N
S
P
P
C
T
V
N
I
Site 73
T686
P
E
N
S
P
P
C
T
V
N
I
P
I
A
P
Site 74
S697
P
I
A
P
I
H
S
S
A
Q
A
M
S
P
T
Site 75
S702
H
S
S
A
Q
A
M
S
P
T
Q
S
I
G
L
Site 76
T704
S
A
Q
A
M
S
P
T
Q
S
I
G
L
V
Q
Site 77
T742
E
H
A
G
D
S
A
T
Q
Y
P
V
S
N
R
Site 78
Y744
A
G
D
S
A
T
Q
Y
P
V
S
N
R
Y
S
Site 79
S747
S
A
T
Q
Y
P
V
S
N
R
Y
S
N
P
G
Site 80
Y750
Q
Y
P
V
S
N
R
Y
S
N
P
G
Q
V
I
Site 81
S751
Y
P
V
S
N
R
Y
S
N
P
G
Q
V
I
F
Site 82
S774
I
Q
N
P
P
P
L
S
L
P
P
P
P
Q
G
Site 83
S786
P
Q
G
P
M
Q
L
S
T
V
G
H
G
D
R
Site 84
T787
Q
G
P
M
Q
L
S
T
V
G
H
G
D
R
D
Site 85
T808
S
A
K
A
L
R
P
T
P
Q
L
A
A
E
G
Site 86
T829
A
P
Q
E
V
Q
V
T
K
I
N
P
P
P
P
Site 87
Y837
K
I
N
P
P
P
P
Y
P
G
T
I
P
A
A
Site 88
T840
P
P
P
P
Y
P
G
T
I
P
A
A
P
T
T
Site 89
S871
C
L
K
K
G
D
F
S
L
Y
P
T
S
V
H
Site 90
Y873
K
K
G
D
F
S
L
Y
P
T
S
V
H
Y
Q
Site 91
T875
G
D
F
S
L
Y
P
T
S
V
H
Y
Q
T
P
Site 92
S876
D
F
S
L
Y
P
T
S
V
H
Y
Q
T
P
L
Site 93
Y879
L
Y
P
T
S
V
H
Y
Q
T
P
L
G
Y
E
Site 94
T881
P
T
S
V
H
Y
Q
T
P
L
G
Y
E
R
I
Site 95
Y885
H
Y
Q
T
P
L
G
Y
E
R
I
T
T
F
D
Site 96
T889
P
L
G
Y
E
R
I
T
T
F
D
S
S
G
N
Site 97
T890
L
G
Y
E
R
I
T
T
F
D
S
S
G
N
V
Site 98
S894
R
I
T
T
F
D
S
S
G
N
V
E
E
V
C
Site 99
T905
E
E
V
C
R
P
R
T
R
M
L
C
S
Q
N
Site 100
S910
P
R
T
R
M
L
C
S
Q
N
T
Y
T
L
P
Site 101
Y914
M
L
C
S
Q
N
T
Y
T
L
P
G
P
G
S
Site 102
T915
L
C
S
Q
N
T
Y
T
L
P
G
P
G
S
S
Site 103
S921
Y
T
L
P
G
P
G
S
S
A
T
L
R
L
T
Site 104
T924
P
G
P
G
S
S
A
T
L
R
L
T
A
T
E
Site 105
T928
S
S
A
T
L
R
L
T
A
T
E
K
K
V
P
Site 106
T930
A
T
L
R
L
T
A
T
E
K
K
V
P
Q
P
Site 107
S939
K
K
V
P
Q
P
C
S
S
A
T
L
N
R
L
Site 108
T942
P
Q
P
C
S
S
A
T
L
N
R
L
T
V
P
Site 109
T947
S
A
T
L
N
R
L
T
V
P
R
Y
S
I
P
Site 110
Y951
N
R
L
T
V
P
R
Y
S
I
P
T
G
D
P
Site 111
S952
R
L
T
V
P
R
Y
S
I
P
T
G
D
P
P
Site 112
T955
V
P
R
Y
S
I
P
T
G
D
P
P
P
Y
P
Site 113
Y961
P
T
G
D
P
P
P
Y
P
E
I
A
S
Q
L
Site 114
S966
P
P
Y
P
E
I
A
S
Q
L
A
Q
G
R
G
Site 115
S978
G
R
G
A
A
Q
R
S
D
N
S
L
I
H
A
Site 116
T986
D
N
S
L
I
H
A
T
L
R
R
N
N
R
E
Site 117
T995
R
R
N
N
R
E
A
T
L
K
M
A
Q
L
A
Site 118
S1004
K
M
A
Q
L
A
D
S
P
R
A
P
L
Q
P
Site 119
S1015
P
L
Q
P
L
A
K
S
K
G
G
P
G
G
V
Site 120
T1024
G
G
P
G
G
V
V
T
Q
L
P
A
R
P
P
Site 121
Y1035
A
R
P
P
P
A
L
Y
T
C
S
Q
C
S
G
Site 122
T1036
R
P
P
P
A
L
Y
T
C
S
Q
C
S
G
T
Site 123
S1038
P
P
A
L
Y
T
C
S
Q
C
S
G
T
G
P
Site 124
S1041
L
Y
T
C
S
Q
C
S
G
T
G
P
S
S
Q
Site 125
T1043
T
C
S
Q
C
S
G
T
G
P
S
S
Q
P
G
Site 126
S1046
Q
C
S
G
T
G
P
S
S
Q
P
G
A
S
L
Site 127
S1047
C
S
G
T
G
P
S
S
Q
P
G
A
S
L
A
Site 128
S1052
P
S
S
Q
P
G
A
S
L
A
H
T
A
S
A
Site 129
S1060
L
A
H
T
A
S
A
S
P
L
A
S
Q
S
S
Site 130
S1066
A
S
P
L
A
S
Q
S
S
Y
S
L
L
S
P
Site 131
S1067
S
P
L
A
S
Q
S
S
Y
S
L
L
S
P
P
Site 132
Y1068
P
L
A
S
Q
S
S
Y
S
L
L
S
P
P
D
Site 133
S1069
L
A
S
Q
S
S
Y
S
L
L
S
P
P
D
S
Site 134
S1072
Q
S
S
Y
S
L
L
S
P
P
D
S
A
R
D
Site 135
S1076
S
L
L
S
P
P
D
S
A
R
D
R
T
D
Y
Site 136
T1081
P
D
S
A
R
D
R
T
D
Y
V
N
S
A
F
Site 137
Y1083
S
A
R
D
R
T
D
Y
V
N
S
A
F
T
E
Site 138
S1095
F
T
E
D
E
A
L
S
Q
H
C
Q
L
E
K
Site 139
T1115
P
L
P
E
A
A
V
T
L
K
R
P
P
P
Y
Site 140
Y1122
T
L
K
R
P
P
P
Y
Q
W
D
P
M
L
G
Site 141
T1142
P
Q
E
R
T
A
Q
T
S
G
P
N
P
L
K
Site 142
S1143
Q
E
R
T
A
Q
T
S
G
P
N
P
L
K
L
Site 143
S1151
G
P
N
P
L
K
L
S
S
L
M
L
S
Q
G
Site 144
S1152
P
N
P
L
K
L
S
S
L
M
L
S
Q
G
Q
Site 145
S1156
K
L
S
S
L
M
L
S
Q
G
Q
H
L
D
V
Site 146
S1164
Q
G
Q
H
L
D
V
S
R
L
P
F
I
S
P
Site 147
S1170
V
S
R
L
P
F
I
S
P
K
S
P
A
S
P
Site 148
S1173
L
P
F
I
S
P
K
S
P
A
S
P
T
A
T
Site 149
S1176
I
S
P
K
S
P
A
S
P
T
A
T
F
Q
T
Site 150
T1180
S
P
A
S
P
T
A
T
F
Q
T
G
Y
G
M
Site 151
Y1185
T
A
T
F
Q
T
G
Y
G
M
G
V
P
Y
P
Site 152
Y1191
G
Y
G
M
G
V
P
Y
P
G
S
Y
N
N
P
Site 153
S1194
M
G
V
P
Y
P
G
S
Y
N
N
P
P
L
P
Site 154
Y1195
G
V
P
Y
P
G
S
Y
N
N
P
P
L
P
G
Site 155
S1208
P
G
V
Q
A
P
C
S
P
K
D
A
L
S
P
Site 156
S1214
C
S
P
K
D
A
L
S
P
T
Q
F
A
Q
Q
Site 157
T1239
P
P
S
L
S
Y
C
T
L
P
P
M
Y
P
G
Site 158
Y1244
Y
C
T
L
P
P
M
Y
P
G
S
S
T
C
S
Site 159
S1247
L
P
P
M
Y
P
G
S
S
T
C
S
S
L
Q
Site 160
S1248
P
P
M
Y
P
G
S
S
T
C
S
S
L
Q
L
Site 161
T1249
P
M
Y
P
G
S
S
T
C
S
S
L
Q
L
P
Site 162
S1251
Y
P
G
S
S
T
C
S
S
L
Q
L
P
P
V
Site 163
S1252
P
G
S
S
T
C
S
S
L
Q
L
P
P
V
A
Site 164
S1264
P
V
A
L
H
P
W
S
S
Y
S
A
C
P
P
Site 165
T1278
P
M
Q
N
P
Q
G
T
L
P
P
K
P
H
L
Site 166
S1293
V
V
E
K
P
L
V
S
P
P
P
A
D
L
Q
Site 167
S1301
P
P
P
A
D
L
Q
S
H
L
G
T
E
V
M
Site 168
T1305
D
L
Q
S
H
L
G
T
E
V
M
V
E
T
A
Site 169
S1320
D
N
F
Q
E
V
L
S
L
T
E
S
P
V
P
Site 170
T1322
F
Q
E
V
L
S
L
T
E
S
P
V
P
Q
R
Site 171
S1324
E
V
L
S
L
T
E
S
P
V
P
Q
R
T
E
Site 172
S1343
K
N
R
K
R
L
D
S
R
A
E
E
G
S
V
Site 173
S1349
D
S
R
A
E
E
G
S
V
Q
A
I
T
E
G
Site 174
T1364
K
V
K
K
E
A
R
T
L
S
D
F
N
S
L
Site 175
S1366
K
K
E
A
R
T
L
S
D
F
N
S
L
I
S
Site 176
S1370
R
T
L
S
D
F
N
S
L
I
S
S
P
H
L
Site 177
S1374
D
F
N
S
L
I
S
S
P
H
L
G
R
E
K
Site 178
S1386
R
E
K
K
K
V
K
S
Q
K
D
Q
L
K
S
Site 179
S1393
S
Q
K
D
Q
L
K
S
K
K
L
N
K
T
N
Site 180
T1399
K
S
K
K
L
N
K
T
N
E
F
Q
D
S
S
Site 181
S1405
K
T
N
E
F
Q
D
S
S
E
S
E
P
E
L
Site 182
S1406
T
N
E
F
Q
D
S
S
E
S
E
P
E
L
F
Site 183
S1408
E
F
Q
D
S
S
E
S
E
P
E
L
F
I
S
Site 184
S1415
S
E
P
E
L
F
I
S
G
D
E
L
M
N
Q
Site 185
S1423
G
D
E
L
M
N
Q
S
Q
G
S
R
K
G
W
Site 186
S1432
G
S
R
K
G
W
K
S
K
R
S
P
R
A
A
Site 187
S1435
K
G
W
K
S
K
R
S
P
R
A
A
G
E
L
Site 188
S1451
E
A
K
C
R
R
A
S
E
K
E
D
G
R
L
Site 189
S1460
K
E
D
G
R
L
G
S
Q
G
F
V
Y
V
M
Site 190
Y1465
L
G
S
Q
G
F
V
Y
V
M
A
N
K
Q
P
Site 191
Y1481
W
N
E
A
T
Q
V
Y
Q
L
D
F
G
G
R
Site 192
T1490
L
D
F
G
G
R
V
T
Q
E
S
A
K
N
F
Site 193
S1493
G
G
R
V
T
Q
E
S
A
K
N
F
Q
I
E
Site 194
S1515
Q
F
G
R
I
D
G
S
A
Y
I
L
D
F
Q
Site 195
Y1517
G
R
I
D
G
S
A
Y
I
L
D
F
Q
Y
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation