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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNASEN
Full Name:
Ribonuclease 3
Alias:
EC 3.1.26.3; P241; RANSE3L; Ribonuclease III; RNase III; RNASE3L; RNC
Type:
Enzyme, Rnase for micorRNA
Mass (Da):
159316
Number AA:
1374
UniProt ID:
Q9NRR4
International Prot ID:
IPI00300956
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0003725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0006996
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
G
G
H
G
A
R
P
S
A
P
S
F
R
P
Q
Site 2
S33
G
A
R
P
S
A
P
S
F
R
P
Q
N
L
R
Site 3
Y51
P
Q
Q
P
P
V
Q
Y
Q
Y
E
P
P
S
A
Site 4
Y53
Q
P
P
V
Q
Y
Q
Y
E
P
P
S
A
P
S
Site 5
S57
Q
Y
Q
Y
E
P
P
S
A
P
S
T
T
F
S
Site 6
S60
Y
E
P
P
S
A
P
S
T
T
F
S
N
S
P
Site 7
T61
E
P
P
S
A
P
S
T
T
F
S
N
S
P
A
Site 8
T62
P
P
S
A
P
S
T
T
F
S
N
S
P
A
P
Site 9
S64
S
A
P
S
T
T
F
S
N
S
P
A
P
N
F
Site 10
S66
P
S
T
T
F
S
N
S
P
A
P
N
F
L
P
Site 11
S88
F
P
P
P
M
P
P
S
A
Q
G
P
L
P
P
Site 12
T141
G
A
P
P
G
Q
G
T
F
P
F
M
M
P
P
Site 13
S150
P
F
M
M
P
P
P
S
M
P
H
P
P
P
P
Site 14
Y166
V
M
P
Q
Q
V
N
Y
Q
Y
P
P
G
Y
S
Site 15
Y168
P
Q
Q
V
N
Y
Q
Y
P
P
G
Y
S
H
H
Site 16
S184
F
P
P
P
S
F
N
S
F
Q
N
N
P
S
S
Site 17
S191
S
F
Q
N
N
P
S
S
F
L
P
S
A
N
N
Site 18
S195
N
P
S
S
F
L
P
S
A
N
N
S
S
S
P
Site 19
S199
F
L
P
S
A
N
N
S
S
S
P
H
F
R
H
Site 20
S200
L
P
S
A
N
N
S
S
S
P
H
F
R
H
L
Site 21
S201
P
S
A
N
N
S
S
S
P
H
F
R
H
L
P
Site 22
Y210
H
F
R
H
L
P
P
Y
P
L
P
K
A
P
S
Site 23
S217
Y
P
L
P
K
A
P
S
E
R
R
S
P
E
R
Site 24
S221
K
A
P
S
E
R
R
S
P
E
R
L
K
H
Y
Site 25
Y228
S
P
E
R
L
K
H
Y
D
D
H
R
H
R
D
Site 26
S237
D
H
R
H
R
D
H
S
H
G
R
G
E
R
H
Site 27
S246
G
R
G
E
R
H
R
S
L
D
R
R
E
R
G
Site 28
S255
D
R
R
E
R
G
R
S
P
D
R
R
R
Q
D
Site 29
S263
P
D
R
R
R
Q
D
S
R
Y
R
S
D
Y
D
Site 30
Y265
R
R
R
Q
D
S
R
Y
R
S
D
Y
D
R
G
Site 31
S267
R
Q
D
S
R
Y
R
S
D
Y
D
R
G
R
T
Site 32
Y269
D
S
R
Y
R
S
D
Y
D
R
G
R
T
P
S
Site 33
T274
S
D
Y
D
R
G
R
T
P
S
R
H
R
S
Y
Site 34
S276
Y
D
R
G
R
T
P
S
R
H
R
S
Y
E
R
Site 35
S280
R
T
P
S
R
H
R
S
Y
E
R
S
R
E
R
Site 36
Y281
T
P
S
R
H
R
S
Y
E
R
S
R
E
R
E
Site 37
S284
R
H
R
S
Y
E
R
S
R
E
R
E
R
E
R
Site 38
S300
R
H
R
D
N
R
R
S
P
S
L
E
R
S
Y
Site 39
S302
R
D
N
R
R
S
P
S
L
E
R
S
Y
K
K
Site 40
S306
R
S
P
S
L
E
R
S
Y
K
K
E
Y
K
R
Site 41
Y307
S
P
S
L
E
R
S
Y
K
K
E
Y
K
R
S
Site 42
Y311
E
R
S
Y
K
K
E
Y
K
R
S
G
R
S
Y
Site 43
S314
Y
K
K
E
Y
K
R
S
G
R
S
Y
G
L
S
Site 44
Y318
Y
K
R
S
G
R
S
Y
G
L
S
V
V
P
E
Site 45
S321
S
G
R
S
Y
G
L
S
V
V
P
E
P
A
G
Site 46
T330
V
P
E
P
A
G
C
T
P
E
L
P
G
E
I
Site 47
T341
P
G
E
I
I
K
N
T
D
S
W
A
P
P
L
Site 48
S343
E
I
I
K
N
T
D
S
W
A
P
P
L
E
I
Site 49
S355
L
E
I
V
N
H
R
S
P
S
R
E
K
K
R
Site 50
S357
I
V
N
H
R
S
P
S
R
E
K
K
R
A
R
Site 51
S373
E
E
E
K
D
R
W
S
D
N
Q
S
S
G
K
Site 52
S377
D
R
W
S
D
N
Q
S
S
G
K
D
K
N
Y
Site 53
Y384
S
S
G
K
D
K
N
Y
T
S
I
K
E
K
E
Site 54
S386
G
K
D
K
N
Y
T
S
I
K
E
K
E
P
E
Site 55
T395
K
E
K
E
P
E
E
T
M
P
D
K
N
E
E
Site 56
Y421
R
C
T
H
S
E
N
Y
Y
S
S
D
P
M
D
Site 57
Y422
C
T
H
S
E
N
Y
Y
S
S
D
P
M
D
Q
Site 58
S423
T
H
S
E
N
Y
Y
S
S
D
P
M
D
Q
V
Site 59
S424
H
S
E
N
Y
Y
S
S
D
P
M
D
Q
V
G
Site 60
S433
P
M
D
Q
V
G
D
S
T
V
V
G
T
S
R
Site 61
T434
M
D
Q
V
G
D
S
T
V
V
G
T
S
R
L
Site 62
Y445
T
S
R
L
R
D
L
Y
D
K
F
E
E
E
L
Site 63
S454
K
F
E
E
E
L
G
S
R
Q
E
K
A
K
A
Site 64
T471
P
P
W
E
P
P
K
T
K
L
D
E
D
L
E
Site 65
S479
K
L
D
E
D
L
E
S
S
S
E
S
E
C
E
Site 66
S480
L
D
E
D
L
E
S
S
S
E
S
E
C
E
S
Site 67
S481
D
E
D
L
E
S
S
S
E
S
E
C
E
S
D
Site 68
S483
D
L
E
S
S
S
E
S
E
C
E
S
D
E
D
Site 69
S487
S
S
E
S
E
C
E
S
D
E
D
S
T
C
S
Site 70
S491
E
C
E
S
D
E
D
S
T
C
S
S
S
S
D
Site 71
T492
C
E
S
D
E
D
S
T
C
S
S
S
S
D
S
Site 72
S494
S
D
E
D
S
T
C
S
S
S
S
D
S
E
V
Site 73
S495
D
E
D
S
T
C
S
S
S
S
D
S
E
V
F
Site 74
S496
E
D
S
T
C
S
S
S
S
D
S
E
V
F
D
Site 75
S497
D
S
T
C
S
S
S
S
D
S
E
V
F
D
V
Site 76
Y524
R
L
H
D
E
L
W
Y
N
D
P
G
Q
M
N
Site 77
S539
D
G
P
L
C
K
C
S
A
K
A
R
R
T
G
Site 78
T545
C
S
A
K
A
R
R
T
G
I
R
H
S
I
Y
Site 79
S550
R
R
T
G
I
R
H
S
I
Y
P
G
E
E
A
Site 80
Y552
T
G
I
R
H
S
I
Y
P
G
E
E
A
I
K
Site 81
T565
I
K
P
C
R
P
M
T
N
N
A
G
R
L
F
Site 82
T577
R
L
F
H
Y
R
I
T
V
S
P
P
T
N
F
Site 83
S579
F
H
Y
R
I
T
V
S
P
P
T
N
F
L
T
Site 84
T586
S
P
P
T
N
F
L
T
D
R
P
T
V
I
E
Site 85
T590
N
F
L
T
D
R
P
T
V
I
E
Y
D
D
H
Site 86
Y594
D
R
P
T
V
I
E
Y
D
D
H
E
Y
I
F
Site 87
Y599
I
E
Y
D
D
H
E
Y
I
F
E
G
F
S
M
Site 88
Y660
F
R
D
I
L
E
L
Y
D
W
N
L
K
G
P
Site 89
S672
K
G
P
L
F
E
D
S
P
P
C
C
P
R
F
Site 90
S698
D
G
G
K
E
V
L
S
M
H
Q
I
L
L
Y
Site 91
Y705
S
M
H
Q
I
L
L
Y
L
L
R
C
S
K
A
Site 92
Y733
E
E
L
E
W
Q
K
Y
A
E
E
C
K
G
M
Site 93
T747
M
I
V
T
N
P
G
T
K
P
S
S
V
R
I
Site 94
S750
T
N
P
G
T
K
P
S
S
V
R
I
D
Q
L
Site 95
S751
N
P
G
T
K
P
S
S
V
R
I
D
Q
L
D
Site 96
S783
G
I
R
P
A
Q
L
S
Y
A
G
D
P
Q
Y
Site 97
Y790
S
Y
A
G
D
P
Q
Y
Q
K
L
W
K
S
Y
Site 98
S796
Q
Y
Q
K
L
W
K
S
Y
V
K
L
R
H
L
Site 99
Y797
Y
Q
K
L
W
K
S
Y
V
K
L
R
H
L
L
Site 100
S807
L
R
H
L
L
A
N
S
P
K
V
K
Q
T
D
Site 101
T833
Q
K
I
R
Q
K
N
T
M
R
R
E
V
T
V
Site 102
T839
N
T
M
R
R
E
V
T
V
E
L
S
S
Q
G
Site 103
T850
S
S
Q
G
F
W
K
T
G
I
R
S
D
V
C
Site 104
S916
N
P
D
H
A
R
N
S
L
S
N
C
G
I
R
Site 105
S918
D
H
A
R
N
S
L
S
N
C
G
I
R
Q
P
Site 106
Y927
C
G
I
R
Q
P
K
Y
G
D
R
K
V
H
H
Site 107
T944
M
R
K
K
G
I
N
T
L
I
N
I
M
S
R
Site 108
T958
R
L
G
Q
D
D
P
T
P
S
R
I
N
H
N
Site 109
Y1024
E
L
D
R
F
M
L
Y
A
H
G
P
D
L
C
Site 110
S1034
G
P
D
L
C
R
E
S
D
L
R
H
A
M
A
Site 111
S1056
G
A
V
Y
L
E
G
S
L
E
E
A
K
Q
L
Site 112
Y1081
L
R
E
V
W
L
N
Y
P
L
H
P
L
Q
L
Site 113
T1093
L
Q
L
Q
E
P
N
T
D
R
Q
L
I
E
T
Site 114
T1100
T
D
R
Q
L
I
E
T
S
P
V
L
Q
K
L
Site 115
S1101
D
R
Q
L
I
E
T
S
P
V
L
Q
K
L
T
Site 116
T1175
D
H
H
E
G
H
L
T
L
L
R
S
S
L
V
Site 117
S1179
G
H
L
T
L
L
R
S
S
L
V
N
N
R
T
Site 118
S1180
H
L
T
L
L
R
S
S
L
V
N
N
R
T
Q
Site 119
T1186
S
S
L
V
N
N
R
T
Q
A
K
V
A
E
E
Site 120
T1202
G
M
Q
E
Y
A
I
T
N
D
K
T
K
R
P
Site 121
T1206
Y
A
I
T
N
D
K
T
K
R
P
V
A
L
R
Site 122
Y1236
Y
I
D
K
D
L
E
Y
V
H
T
F
M
N
V
Site 123
T1271
Q
L
Q
Q
C
C
L
T
L
R
T
E
G
K
E
Site 124
Y1284
K
E
P
D
I
P
L
Y
K
T
L
Q
T
V
G
Site 125
T1286
P
D
I
P
L
Y
K
T
L
Q
T
V
G
P
S
Site 126
T1289
P
L
Y
K
T
L
Q
T
V
G
P
S
H
A
R
Site 127
S1293
T
L
Q
T
V
G
P
S
H
A
R
T
Y
T
V
Site 128
Y1298
G
P
S
H
A
R
T
Y
T
V
A
V
Y
F
K
Site 129
T1299
P
S
H
A
R
T
Y
T
V
A
V
Y
F
K
G
Site 130
Y1303
R
T
Y
T
V
A
V
Y
F
K
G
E
R
I
G
Site 131
S1316
I
G
C
G
K
G
P
S
I
Q
Q
A
E
M
G
Site 132
Y1332
A
M
D
A
L
E
K
Y
N
F
P
Q
M
A
H
Site 133
Y1348
K
R
F
I
E
R
K
Y
R
Q
E
L
K
E
M
Site 134
T1369
Q
E
R
E
P
D
E
T
E
D
I
K
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation