KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
INPP5E
Full Name:
72 kDa inositol polyphosphate 5-phosphatase
Alias:
5ptase IV; EC 3.1.3.36; Inositol polyphosphate-5-phosphatase, 72 kDa; INP5E; Phosphatidylinositol polyphosphate 5-phosphatase type IV; PPI5PIV
Type:
Phosphatase (non-protein); Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36
Mass (Da):
70150
Number AA:
644
UniProt ID:
Q9NRR6
International Prot ID:
IPI00181799
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009898
Uniprot
OncoNet
Molecular Function:
GO:0004445
GO:0004439
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
K
A
E
N
L
R
P
S
E
P
A
P
Q
P
P
Site 2
S38
P
P
A
Q
R
A
G
S
P
P
D
A
P
G
S
Site 3
S45
S
P
P
D
A
P
G
S
E
S
P
A
L
A
C
Site 4
S47
P
D
A
P
G
S
E
S
P
A
L
A
C
S
T
Site 5
S53
E
S
P
A
L
A
C
S
T
P
A
T
P
S
G
Site 6
T54
S
P
A
L
A
C
S
T
P
A
T
P
S
G
E
Site 7
T57
L
A
C
S
T
P
A
T
P
S
G
E
D
P
P
Site 8
S59
C
S
T
P
A
T
P
S
G
E
D
P
P
A
R
Site 9
S85
P
R
L
E
R
A
L
S
L
D
D
K
G
W
R
Site 10
S99
R
R
R
R
F
R
G
S
Q
E
D
L
E
A
R
Site 11
T109
D
L
E
A
R
N
G
T
S
P
S
R
G
S
V
Site 12
S110
L
E
A
R
N
G
T
S
P
S
R
G
S
V
Q
Site 13
S112
A
R
N
G
T
S
P
S
R
G
S
V
Q
S
E
Site 14
S115
G
T
S
P
S
R
G
S
V
Q
S
E
G
P
G
Site 15
S118
P
S
R
G
S
V
Q
S
E
G
P
G
A
P
A
Site 16
S127
G
P
G
A
P
A
H
S
C
S
P
P
C
L
S
Site 17
S129
G
A
P
A
H
S
C
S
P
P
C
L
S
T
S
Site 18
S134
S
C
S
P
P
C
L
S
T
S
L
Q
E
I
P
Site 19
S136
S
P
P
C
L
S
T
S
L
Q
E
I
P
K
S
Site 20
S143
S
L
Q
E
I
P
K
S
R
G
V
L
S
S
E
Site 21
S148
P
K
S
R
G
V
L
S
S
E
R
G
S
P
S
Site 22
S149
K
S
R
G
V
L
S
S
E
R
G
S
P
S
S
Site 23
S153
V
L
S
S
E
R
G
S
P
S
S
G
G
N
P
Site 24
S155
S
S
E
R
G
S
P
S
S
G
G
N
P
L
S
Site 25
S156
S
E
R
G
S
P
S
S
G
G
N
P
L
S
G
Site 26
S162
S
S
G
G
N
P
L
S
G
V
A
S
S
S
P
Site 27
S166
N
P
L
S
G
V
A
S
S
S
P
N
L
P
H
Site 28
S167
P
L
S
G
V
A
S
S
S
P
N
L
P
H
R
Site 29
S168
L
S
G
V
A
S
S
S
P
N
L
P
H
R
D
Site 30
S181
R
D
A
A
V
A
G
S
S
P
R
L
P
S
L
Site 31
S187
G
S
S
P
R
L
P
S
L
L
P
P
R
P
P
Site 32
S198
P
R
P
P
P
A
L
S
L
D
I
A
S
D
S
Site 33
S205
S
L
D
I
A
S
D
S
L
R
T
A
N
K
V
Site 34
Y219
V
D
S
D
L
A
D
Y
K
L
R
A
Q
P
L
Site 35
S232
P
L
L
V
R
A
H
S
S
L
G
P
G
R
P
Site 36
S233
L
L
V
R
A
H
S
S
L
G
P
G
R
P
R
Site 37
S241
L
G
P
G
R
P
R
S
P
L
A
C
D
D
C
Site 38
S249
P
L
A
C
D
D
C
S
L
R
S
A
K
S
S
Site 39
S252
C
D
D
C
S
L
R
S
A
K
S
S
F
S
L
Site 40
S258
R
S
A
K
S
S
F
S
L
L
A
P
I
R
S
Site 41
S265
S
L
L
A
P
I
R
S
K
D
V
R
S
R
S
Site 42
S270
I
R
S
K
D
V
R
S
R
S
Y
L
E
G
S
Site 43
S272
S
K
D
V
R
S
R
S
Y
L
E
G
S
L
L
Site 44
Y273
K
D
V
R
S
R
S
Y
L
E
G
S
L
L
A
Site 45
Y293
G
A
D
E
L
A
R
Y
F
P
D
R
N
V
A
Site 46
S317
G
Q
K
E
L
P
P
S
L
D
E
F
L
L
P
Site 47
Y334
A
D
Y
A
Q
D
L
Y
V
I
G
V
Q
E
G
Site 48
S343
I
G
V
Q
E
G
C
S
D
R
R
E
W
E
T
Site 49
T350
S
D
R
R
E
W
E
T
R
L
Q
E
T
L
G
Site 50
S399
T
V
T
T
R
I
V
S
Q
I
K
T
K
G
A
Site 51
S427
F
I
T
S
H
F
T
S
G
D
G
K
V
A
E
Site 52
Y439
V
A
E
R
L
L
D
Y
T
R
T
V
Q
A
L
Site 53
T440
A
E
R
L
L
D
Y
T
R
T
V
Q
A
L
V
Site 54
T455
L
P
R
N
V
P
D
T
N
P
Y
R
S
S
A
Site 55
S461
D
T
N
P
Y
R
S
S
A
A
D
V
T
T
R
Site 56
T466
R
S
S
A
A
D
V
T
T
R
F
D
E
V
F
Site 57
S483
G
D
F
N
F
R
L
S
G
G
R
T
V
V
D
Site 58
S518
I
R
E
M
R
K
G
S
I
F
K
G
F
Q
E
Site 59
Y534
D
I
H
F
L
P
S
Y
K
F
D
I
G
K
D
Site 60
T542
K
F
D
I
G
K
D
T
Y
D
S
T
S
K
Q
Site 61
Y543
F
D
I
G
K
D
T
Y
D
S
T
S
K
Q
R
Site 62
S545
I
G
K
D
T
Y
D
S
T
S
K
Q
R
T
P
Site 63
T546
G
K
D
T
Y
D
S
T
S
K
Q
R
T
P
S
Site 64
S547
K
D
T
Y
D
S
T
S
K
Q
R
T
P
S
Y
Site 65
T551
D
S
T
S
K
Q
R
T
P
S
Y
T
D
R
V
Site 66
S553
T
S
K
Q
R
T
P
S
Y
T
D
R
V
L
Y
Site 67
Y554
S
K
Q
R
T
P
S
Y
T
D
R
V
L
Y
R
Site 68
T555
K
Q
R
T
P
S
Y
T
D
R
V
L
Y
R
S
Site 69
Y560
S
Y
T
D
R
V
L
Y
R
S
R
H
K
G
D
Site 70
S562
T
D
R
V
L
Y
R
S
R
H
K
G
D
I
C
Site 71
S574
D
I
C
P
V
S
Y
S
S
C
P
G
I
K
T
Site 72
T581
S
S
C
P
G
I
K
T
S
D
H
R
P
V
Y
Site 73
S582
S
C
P
G
I
K
T
S
D
H
R
P
V
Y
G
Site 74
Y588
T
S
D
H
R
P
V
Y
G
L
F
R
V
K
V
Site 75
Y614
G
K
F
D
R
E
L
Y
L
L
G
I
K
R
R
Site 76
S623
L
G
I
K
R
R
I
S
K
E
I
Q
R
Q
Q
Site 77
S634
Q
R
Q
Q
A
L
Q
S
Q
N
S
S
T
I
C
Site 78
S637
Q
A
L
Q
S
Q
N
S
S
T
I
C
S
V
S
Site 79
S638
A
L
Q
S
Q
N
S
S
T
I
C
S
V
S
_
Site 80
T639
L
Q
S
Q
N
S
S
T
I
C
S
V
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation