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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS45
Full Name:
Vacuolar protein sorting-associated protein 45
Alias:
VPS45A; VPS45B
Type:
Golgi apparatus membrane, Peripheral membrane, Endosome membrane protein
Mass (Da):
65077
Number AA:
570
UniProt ID:
Q9NRW7
International Prot ID:
IPI00090327
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005768
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0006904
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
V
V
F
A
V
K
Q
Y
I
S
K
M
I
E
D
Site 2
S18
I
S
K
M
I
E
D
S
G
P
G
M
K
V
L
Site 3
T31
V
L
L
M
D
K
E
T
T
G
I
V
S
M
V
Site 4
T32
L
L
M
D
K
E
T
T
G
I
V
S
M
V
Y
Site 5
S42
V
S
M
V
Y
T
Q
S
E
I
L
Q
K
E
V
Site 6
Y50
E
I
L
Q
K
E
V
Y
L
F
E
R
I
D
S
Site 7
S57
Y
L
F
E
R
I
D
S
Q
N
R
E
I
M
K
Site 8
Y81
P
T
K
E
N
V
D
Y
I
I
Q
E
L
R
R
Site 9
Y91
Q
E
L
R
R
P
K
Y
T
I
Y
F
I
Y
F
Site 10
T92
E
L
R
R
P
K
Y
T
I
Y
F
I
Y
F
S
Site 11
Y94
R
R
P
K
Y
T
I
Y
F
I
Y
F
S
N
V
Site 12
S105
F
S
N
V
I
S
K
S
D
V
K
S
L
A
E
Site 13
S109
I
S
K
S
D
V
K
S
L
A
E
A
D
E
Q
Site 14
Y129
V
Q
E
F
Y
G
D
Y
I
A
V
N
P
H
L
Site 15
S156
N
W
D
P
A
Q
L
S
R
T
T
Q
G
L
T
Site 16
Y177
K
K
C
P
M
I
R
Y
Q
L
S
S
E
A
A
Site 17
S181
M
I
R
Y
Q
L
S
S
E
A
A
K
R
L
A
Site 18
T224
D
R
C
D
D
A
I
T
P
L
L
N
Q
W
T
Site 19
Y232
P
L
L
N
Q
W
T
Y
Q
A
M
V
H
E
L
Site 20
S250
N
N
N
R
I
D
L
S
R
V
P
G
I
S
K
Site 21
S256
L
S
R
V
P
G
I
S
K
D
L
R
E
V
V
Site 22
S265
D
L
R
E
V
V
L
S
A
E
N
D
E
F
Y
Site 23
Y272
S
A
E
N
D
E
F
Y
A
N
N
M
Y
L
N
Site 24
Y277
E
F
Y
A
N
N
M
Y
L
N
F
A
E
I
G
Site 25
Y318
M
K
A
F
V
E
N
Y
P
Q
F
K
K
M
S
Site 26
S325
Y
P
Q
F
K
K
M
S
G
T
V
S
K
H
V
Site 27
T327
Q
F
K
K
M
S
G
T
V
S
K
H
V
T
V
Site 28
S329
K
K
M
S
G
T
V
S
K
H
V
T
V
V
G
Site 29
T333
G
T
V
S
K
H
V
T
V
V
G
E
L
S
R
Site 30
S339
V
T
V
V
G
E
L
S
R
L
V
S
E
R
N
Site 31
S343
G
E
L
S
R
L
V
S
E
R
N
L
L
E
V
Site 32
S365
A
C
Q
N
D
H
S
S
A
L
Q
N
I
K
R
Site 33
Y395
V
M
L
Y
A
L
H
Y
E
R
H
S
S
N
S
Site 34
S399
A
L
H
Y
E
R
H
S
S
N
S
L
P
G
L
Site 35
S400
L
H
Y
E
R
H
S
S
N
S
L
P
G
L
M
Site 36
S402
Y
E
R
H
S
S
N
S
L
P
G
L
M
M
D
Site 37
S416
D
L
R
N
K
G
V
S
E
K
Y
R
K
L
V
Site 38
S424
E
K
Y
R
K
L
V
S
A
V
V
E
Y
G
G
Site 39
S437
G
G
K
R
V
R
G
S
D
L
F
S
P
K
D
Site 40
S441
V
R
G
S
D
L
F
S
P
K
D
A
V
A
I
Site 41
Y463
L
K
G
V
E
N
V
Y
T
Q
H
Q
P
F
L
Site 42
T464
K
G
V
E
N
V
Y
T
Q
H
Q
P
F
L
H
Site 43
Y487
G
R
L
K
E
N
L
Y
P
Y
L
G
P
S
T
Site 44
Y489
L
K
E
N
L
Y
P
Y
L
G
P
S
T
L
R
Site 45
T494
Y
P
Y
L
G
P
S
T
L
R
D
R
P
Q
D
Site 46
T517
A
T
Y
E
E
A
L
T
V
Y
N
L
N
R
T
Site 47
S542
T
T
V
H
N
T
K
S
F
L
E
E
V
L
A
Site 48
S550
F
L
E
E
V
L
A
S
G
L
H
S
R
S
K
Site 49
S554
V
L
A
S
G
L
H
S
R
S
K
E
S
S
Q
Site 50
S556
A
S
G
L
H
S
R
S
K
E
S
S
Q
V
T
Site 51
S559
L
H
S
R
S
K
E
S
S
Q
V
T
S
R
S
Site 52
S560
H
S
R
S
K
E
S
S
Q
V
T
S
R
S
A
Site 53
T563
S
K
E
S
S
Q
V
T
S
R
S
A
S
R
R
Site 54
S564
K
E
S
S
Q
V
T
S
R
S
A
S
R
R
_
Site 55
S566
S
S
Q
V
T
S
R
S
A
S
R
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation