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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRLF1
Full Name:
Glucocorticoid receptor DNA-binding factor 1
Alias:
GAP-associated protein p190; Glucocorticoid receptor DNA binding factor 1; Glucocorticoid receptor repression factor 1; GRF1; GRF-1; GRLF; KIAA1722; P190-A; Rho GAP p190A
Type:
Transcription factor; GTPase activating protein, Rac/Rho
Mass (Da):
172229
Number AA:
1513
UniProt ID:
Q9NRY4
International Prot ID:
IPI00334715
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005100
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0016481
GO:0007165
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
K
Q
D
V
R
I
P
T
Y
N
I
S
V
V
G
Site 2
S46
C
N
R
F
V
R
P
S
A
D
E
F
H
L
D
Site 3
T55
D
E
F
H
L
D
H
T
S
V
L
S
T
S
D
Site 4
S56
E
F
H
L
D
H
T
S
V
L
S
T
S
D
F
Site 5
S59
L
D
H
T
S
V
L
S
T
S
D
F
G
G
R
Site 6
T60
D
H
T
S
V
L
S
T
S
D
F
G
G
R
V
Site 7
Y75
V
N
N
D
H
F
L
Y
W
G
E
V
S
R
S
Site 8
S82
Y
W
G
E
V
S
R
S
L
E
D
C
V
E
C
Site 9
T104
T
E
F
I
D
D
Q
T
F
Q
P
H
R
S
T
Site 10
T111
T
F
Q
P
H
R
S
T
A
L
Q
P
Y
I
K
Site 11
Y133
A
S
A
E
K
L
M
Y
F
C
T
D
Q
L
G
Site 12
T136
E
K
L
M
Y
F
C
T
D
Q
L
G
L
E
Q
Site 13
Y209
C
D
E
G
V
E
R
Y
I
R
D
A
H
T
F
Site 14
T215
R
Y
I
R
D
A
H
T
F
A
L
S
K
K
N
Site 15
T228
K
N
L
Q
V
V
E
T
S
A
R
S
N
V
N
Site 16
S229
N
L
Q
V
V
E
T
S
A
R
S
N
V
N
V
Site 17
S250
L
V
Q
L
I
D
K
S
R
G
K
T
K
I
I
Site 18
T254
I
D
K
S
R
G
K
T
K
I
I
P
Y
F
E
Site 19
Y259
G
K
T
K
I
I
P
Y
F
E
A
L
K
Q
Q
Site 20
Y277
I
A
T
A
K
D
K
Y
E
W
L
V
S
R
I
Site 21
S296
N
E
N
W
L
S
V
S
R
K
M
Q
A
S
P
Site 22
S302
V
S
R
K
M
Q
A
S
P
E
Y
Q
D
Y
V
Site 23
Y305
K
M
Q
A
S
P
E
Y
Q
D
Y
V
Y
L
E
Site 24
Y308
A
S
P
E
Y
Q
D
Y
V
Y
L
E
G
T
Q
Site 25
Y310
P
E
Y
Q
D
Y
V
Y
L
E
G
T
Q
K
A
Site 26
S362
L
D
E
I
D
H
L
S
C
I
K
A
K
K
L
Site 27
Y416
T
V
P
A
E
Q
L
Y
E
A
H
L
E
K
L
Site 28
T442
A
F
K
E
N
L
E
T
S
P
F
I
T
P
G
Site 29
S443
F
K
E
N
L
E
T
S
P
F
I
T
P
G
K
Site 30
T447
L
E
T
S
P
F
I
T
P
G
K
P
W
E
E
Site 31
Y465
F
I
M
N
E
D
F
Y
Q
W
L
E
E
S
V
Site 32
Y473
Q
W
L
E
E
S
V
Y
M
D
I
Y
G
K
H
Site 33
Y477
E
S
V
Y
M
D
I
Y
G
K
H
Q
K
Q
I
Site 34
S500
Q
E
L
L
L
E
Y
S
E
L
F
Y
E
L
E
Site 35
Y504
L
E
Y
S
E
L
F
Y
E
L
E
L
D
A
K
Site 36
S513
L
E
L
D
A
K
P
S
K
E
K
M
G
V
I
Site 37
Y552
L
K
H
I
H
F
V
Y
H
P
T
K
E
T
C
Site 38
S561
P
T
K
E
T
C
P
S
C
P
A
C
V
D
A
Site 39
S575
A
K
I
E
H
L
I
S
S
R
F
I
R
P
S
Site 40
S576
K
I
E
H
L
I
S
S
R
F
I
R
P
S
D
Site 41
S582
S
S
R
F
I
R
P
S
D
R
N
Q
K
N
S
Site 42
S589
S
D
R
N
Q
K
N
S
L
S
D
P
N
I
D
Site 43
S591
R
N
Q
K
N
S
L
S
D
P
N
I
D
R
I
Site 44
Y626
L
C
T
N
D
D
K
Y
V
I
D
G
K
M
Y
Site 45
S636
D
G
K
M
Y
E
L
S
L
R
P
I
E
G
N
Site 46
S650
N
V
R
L
P
V
N
S
F
Q
T
P
T
F
Q
Site 47
T653
L
P
V
N
S
F
Q
T
P
T
F
Q
P
H
G
Site 48
T655
V
N
S
F
Q
T
P
T
F
Q
P
H
G
C
L
Site 49
Y665
P
H
G
C
L
C
L
Y
N
S
K
E
S
L
S
Site 50
S670
C
L
Y
N
S
K
E
S
L
S
Y
V
V
E
S
Site 51
S672
Y
N
S
K
E
S
L
S
Y
V
V
E
S
I
E
Site 52
Y673
N
S
K
E
S
L
S
Y
V
V
E
S
I
E
K
Site 53
S677
S
L
S
Y
V
V
E
S
I
E
K
S
R
E
S
Site 54
S681
V
V
E
S
I
E
K
S
R
E
S
T
L
G
R
Site 55
S684
S
I
E
K
S
R
E
S
T
L
G
R
R
D
N
Site 56
T685
I
E
K
S
R
E
S
T
L
G
R
R
D
N
H
Site 57
T709
L
V
N
K
R
G
D
T
S
G
E
T
L
H
S
Site 58
S710
V
N
K
R
G
D
T
S
G
E
T
L
H
S
L
Site 59
S716
T
S
G
E
T
L
H
S
L
I
Q
Q
G
Q
Q
Site 60
Y742
P
A
S
A
G
I
G
Y
G
R
N
I
N
E
K
Site 61
S752
N
I
N
E
K
Q
I
S
Q
V
L
K
G
L
L
Site 62
S769
K
R
N
L
N
L
V
S
S
T
A
S
I
K
D
Site 63
S770
R
N
L
N
L
V
S
S
T
A
S
I
K
D
L
Site 64
T771
N
L
N
L
V
S
S
T
A
S
I
K
D
L
A
Site 65
S773
N
L
V
S
S
T
A
S
I
K
D
L
A
D
V
Site 66
S806
I
L
F
P
V
L
Q
S
Q
T
C
K
S
S
H
Site 67
S811
L
Q
S
Q
T
C
K
S
S
H
C
G
S
N
N
Site 68
S812
Q
S
Q
T
C
K
S
S
H
C
G
S
N
N
S
Site 69
S816
C
K
S
S
H
C
G
S
N
N
S
V
L
L
E
Site 70
S836
H
K
K
R
I
E
L
S
V
L
S
Y
H
S
S
Site 71
S843
S
V
L
S
Y
H
S
S
F
S
I
R
K
S
R
Site 72
S845
L
S
Y
H
S
S
F
S
I
R
K
S
R
L
V
Site 73
S849
S
S
F
S
I
R
K
S
R
L
V
H
G
Y
I
Site 74
Y855
K
S
R
L
V
H
G
Y
I
V
F
Y
S
A
K
Site 75
S860
H
G
Y
I
V
F
Y
S
A
K
R
K
A
S
L
Site 76
S866
Y
S
A
K
R
K
A
S
L
A
M
L
R
A
F
Site 77
S901
D
V
L
D
N
D
L
S
R
E
Q
L
T
E
G
Site 78
T920
Q
E
I
D
G
R
F
T
S
I
P
C
S
Q
P
Site 79
S921
E
I
D
G
R
F
T
S
I
P
C
S
Q
P
Q
Site 80
S925
R
F
T
S
I
P
C
S
Q
P
Q
H
K
L
E
Site 81
T963
N
A
A
E
A
C
S
T
T
E
E
V
F
N
S
Site 82
S970
T
T
E
E
V
F
N
S
P
R
A
G
S
P
L
Site 83
S975
F
N
S
P
R
A
G
S
P
L
C
N
S
N
L
Site 84
S980
A
G
S
P
L
C
N
S
N
L
Q
D
S
E
E
Site 85
S985
C
N
S
N
L
Q
D
S
E
E
D
I
E
P
S
Site 86
S992
S
E
E
D
I
E
P
S
Y
S
L
F
R
E
D
Site 87
Y993
E
E
D
I
E
P
S
Y
S
L
F
R
E
D
T
Site 88
S994
E
D
I
E
P
S
Y
S
L
F
R
E
D
T
S
Site 89
T1000
Y
S
L
F
R
E
D
T
S
L
P
S
L
S
K
Site 90
S1001
S
L
F
R
E
D
T
S
L
P
S
L
S
K
D
Site 91
S1004
R
E
D
T
S
L
P
S
L
S
K
D
H
S
K
Site 92
S1006
D
T
S
L
P
S
L
S
K
D
H
S
K
L
S
Site 93
S1010
P
S
L
S
K
D
H
S
K
L
S
M
E
L
E
Site 94
S1013
S
K
D
H
S
K
L
S
M
E
L
E
G
N
D
Site 95
S1023
L
E
G
N
D
G
L
S
F
I
M
S
N
F
E
Site 96
S1027
D
G
L
S
F
I
M
S
N
F
E
S
K
L
N
Site 97
S1031
F
I
M
S
N
F
E
S
K
L
N
N
K
V
P
Site 98
S1057
E
I
T
K
G
D
L
S
Y
L
D
Q
G
H
R
Site 99
Y1058
I
T
K
G
D
L
S
Y
L
D
Q
G
H
R
D
Site 100
S1070
H
R
D
G
Q
R
K
S
V
S
S
S
P
W
L
Site 101
S1072
D
G
Q
R
K
S
V
S
S
S
P
W
L
P
Q
Site 102
S1073
G
Q
R
K
S
V
S
S
S
P
W
L
P
Q
D
Site 103
S1074
Q
R
K
S
V
S
S
S
P
W
L
P
Q
D
G
Site 104
S1085
P
Q
D
G
F
D
P
S
D
Y
A
E
P
M
D
Site 105
Y1087
D
G
F
D
P
S
D
Y
A
E
P
M
D
A
V
Site 106
Y1105
R
N
E
E
E
N
I
Y
S
V
P
H
D
S
T
Site 107
S1106
N
E
E
E
N
I
Y
S
V
P
H
D
S
T
Q
Site 108
S1111
I
Y
S
V
P
H
D
S
T
Q
G
K
I
I
T
Site 109
T1118
S
T
Q
G
K
I
I
T
I
R
N
I
N
K
A
Site 110
S1127
R
N
I
N
K
A
Q
S
N
G
S
G
N
G
S
Site 111
S1130
N
K
A
Q
S
N
G
S
G
N
G
S
D
S
E
Site 112
S1134
S
N
G
S
G
N
G
S
D
S
E
M
D
T
S
Site 113
S1136
G
S
G
N
G
S
D
S
E
M
D
T
S
S
L
Site 114
T1140
G
S
D
S
E
M
D
T
S
S
L
E
R
G
R
Site 115
S1141
S
D
S
E
M
D
T
S
S
L
E
R
G
R
K
Site 116
S1142
D
S
E
M
D
T
S
S
L
E
R
G
R
K
V
Site 117
S1150
L
E
R
G
R
K
V
S
I
V
S
K
P
V
L
Site 118
S1153
G
R
K
V
S
I
V
S
K
P
V
L
Y
R
T
Site 119
Y1158
I
V
S
K
P
V
L
Y
R
T
R
C
T
R
L
Site 120
T1160
S
K
P
V
L
Y
R
T
R
C
T
R
L
G
R
Site 121
T1163
V
L
Y
R
T
R
C
T
R
L
G
R
F
A
S
Site 122
S1170
T
R
L
G
R
F
A
S
Y
R
T
S
F
S
V
Site 123
T1173
G
R
F
A
S
Y
R
T
S
F
S
V
G
S
D
Site 124
S1174
R
F
A
S
Y
R
T
S
F
S
V
G
S
D
D
Site 125
S1176
A
S
Y
R
T
S
F
S
V
G
S
D
D
E
L
Site 126
S1179
R
T
S
F
S
V
G
S
D
D
E
L
G
P
I
Site 127
S1195
K
K
E
E
D
Q
A
S
Q
G
Y
K
G
D
N
Site 128
Y1198
E
D
Q
A
S
Q
G
Y
K
G
D
N
A
V
I
Site 129
Y1207
G
D
N
A
V
I
P
Y
E
T
D
E
D
P
R
Site 130
S1221
R
R
R
N
I
L
R
S
L
R
R
N
T
K
K
Site 131
T1226
L
R
S
L
R
R
N
T
K
K
P
K
P
K
P
Site 132
S1236
P
K
P
K
P
R
P
S
I
T
K
A
T
W
E
Site 133
Y1246
K
A
T
W
E
S
N
Y
F
G
V
P
L
T
T
Site 134
S1286
T
E
G
I
Y
R
V
S
G
N
K
S
E
M
E
Site 135
S1290
Y
R
V
S
G
N
K
S
E
M
E
S
L
Q
R
Site 136
S1294
G
N
K
S
E
M
E
S
L
Q
R
Q
F
D
Q
Site 137
T1316
E
K
D
F
T
V
N
T
V
A
G
A
M
K
S
Site 138
Y1374
E
N
H
E
V
F
K
Y
V
I
S
H
L
N
K
Site 139
T1416
F
S
T
M
D
A
L
T
A
T
R
T
Y
Q
T
Site 140
T1442
F
F
Y
N
R
P
I
T
E
P
P
G
A
R
P
Site 141
S1450
E
P
P
G
A
R
P
S
S
P
S
A
V
A
S
Site 142
S1451
P
P
G
A
R
P
S
S
P
S
A
V
A
S
T
Site 143
S1453
G
A
R
P
S
S
P
S
A
V
A
S
T
V
P
Site 144
S1464
S
T
V
P
F
L
T
S
T
P
V
T
S
Q
P
Site 145
T1465
T
V
P
F
L
T
S
T
P
V
T
S
Q
P
S
Site 146
T1468
F
L
T
S
T
P
V
T
S
Q
P
S
P
P
Q
Site 147
S1469
L
T
S
T
P
V
T
S
Q
P
S
P
P
Q
S
Site 148
S1472
T
P
V
T
S
Q
P
S
P
P
Q
S
P
P
P
Site 149
S1476
S
Q
P
S
P
P
Q
S
P
P
P
T
P
Q
S
Site 150
T1480
P
P
Q
S
P
P
P
T
P
Q
S
P
M
Q
P
Site 151
S1483
S
P
P
P
T
P
Q
S
P
M
Q
P
L
L
P
Site 152
S1491
P
M
Q
P
L
L
P
S
P
L
H
P
H
R
P
Site 153
T1499
P
L
H
P
H
R
P
T
P
Q
P
S
R
N
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation