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Updated November 2019
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Protein Info
Short Name:
KCNH7
Full Name:
Potassium voltage-gated channel subfamily H member 7
Alias:
Ether-a-go-go-related gene potassium channel 3;Voltage-gated potassium channel subunit Kv11.3
Type:
Mass (Da):
135000
Number AA:
1196
UniProt ID:
Q9NS40
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T74
D
F
L
H
G
P
E
T
K
R
H
D
I
A
Q
Site 2
T97
E
E
R
K
V
E
V
T
Y
Y
H
K
N
G
S
Site 3
Y98
E
R
K
V
E
V
T
Y
Y
H
K
N
G
S
T
Site 4
Y99
R
K
V
E
V
T
Y
Y
H
K
N
G
S
T
F
Site 5
Y131
M
F
I
I
N
F
E
Y
V
T
D
N
E
N
A
Site 6
T140
T
D
N
E
N
A
A
T
P
E
R
V
N
P
I
Site 7
T152
N
P
I
L
P
I
K
T
V
N
R
K
F
F
G
Site 8
T169
F
P
G
L
R
V
L
T
Y
R
K
Q
S
L
P
Site 9
Y170
P
G
L
R
V
L
T
Y
R
K
Q
S
L
P
Q
Site 10
S174
V
L
T
Y
R
K
Q
S
L
P
Q
E
D
P
D
Site 11
S187
P
D
V
V
V
I
D
S
S
K
H
S
D
D
S
Site 12
S188
D
V
V
V
I
D
S
S
K
H
S
D
D
S
V
Site 13
S191
V
I
D
S
S
K
H
S
D
D
S
V
A
M
K
Site 14
S194
S
S
K
H
S
D
D
S
V
A
M
K
H
F
K
Site 15
S202
V
A
M
K
H
F
K
S
P
T
K
E
S
C
S
Site 16
T204
M
K
H
F
K
S
P
T
K
E
S
C
S
P
S
Site 17
S207
F
K
S
P
T
K
E
S
C
S
P
S
E
A
D
Site 18
S209
S
P
T
K
E
S
C
S
P
S
E
A
D
D
T
Site 19
S211
T
K
E
S
C
S
P
S
E
A
D
D
T
K
A
Site 20
T216
S
P
S
E
A
D
D
T
K
A
L
I
Q
P
S
Site 21
S223
T
K
A
L
I
Q
P
S
K
C
S
P
L
V
N
Site 22
S232
C
S
P
L
V
N
I
S
G
P
L
D
H
S
S
Site 23
S238
I
S
G
P
L
D
H
S
S
P
K
R
Q
W
D
Site 24
S239
S
G
P
L
D
H
S
S
P
K
R
Q
W
D
R
Site 25
Y248
K
R
Q
W
D
R
L
Y
P
D
M
L
Q
S
S
Site 26
S254
L
Y
P
D
M
L
Q
S
S
S
Q
L
S
H
S
Site 27
S255
Y
P
D
M
L
Q
S
S
S
Q
L
S
H
S
R
Site 28
S256
P
D
M
L
Q
S
S
S
Q
L
S
H
S
R
S
Site 29
S259
L
Q
S
S
S
Q
L
S
H
S
R
S
R
E
S
Site 30
S261
S
S
S
Q
L
S
H
S
R
S
R
E
S
L
C
Site 31
S263
S
Q
L
S
H
S
R
S
R
E
S
L
C
S
I
Site 32
S266
S
H
S
R
S
R
E
S
L
C
S
I
R
R
A
Site 33
S269
R
S
R
E
S
L
C
S
I
R
R
A
S
S
V
Site 34
S274
L
C
S
I
R
R
A
S
S
V
H
D
I
E
G
Site 35
S275
C
S
I
R
R
A
S
S
V
H
D
I
E
G
F
Site 36
S296
I
F
R
D
R
H
A
S
E
D
N
G
R
N
V
Site 37
S312
G
P
F
N
H
I
K
S
S
L
L
G
S
T
S
Site 38
S313
P
F
N
H
I
K
S
S
L
L
G
S
T
S
D
Site 39
S317
I
K
S
S
L
L
G
S
T
S
D
S
N
L
N
Site 40
S319
S
S
L
L
G
S
T
S
D
S
N
L
N
K
Y
Site 41
S321
L
L
G
S
T
S
D
S
N
L
N
K
Y
S
T
Site 42
Y326
S
D
S
N
L
N
K
Y
S
T
I
N
K
I
P
Site 43
T328
S
N
L
N
K
Y
S
T
I
N
K
I
P
Q
L
Site 44
T336
I
N
K
I
P
Q
L
T
L
N
F
S
E
V
K
Site 45
S340
P
Q
L
T
L
N
F
S
E
V
K
T
E
K
K
Site 46
T344
L
N
F
S
E
V
K
T
E
K
K
N
S
S
P
Site 47
S349
V
K
T
E
K
K
N
S
S
P
P
S
S
D
K
Site 48
S350
K
T
E
K
K
N
S
S
P
P
S
S
D
K
T
Site 49
S353
K
K
N
S
S
P
P
S
S
D
K
T
I
I
A
Site 50
S354
K
N
S
S
P
P
S
S
D
K
T
I
I
A
P
Site 51
T357
S
P
P
S
S
D
K
T
I
I
A
P
K
V
K
Site 52
T367
A
P
K
V
K
D
R
T
H
N
V
T
E
K
V
Site 53
T371
K
D
R
T
H
N
V
T
E
K
V
T
Q
V
L
Site 54
Y388
G
A
D
V
L
P
E
Y
K
L
Q
T
P
R
I
Site 55
T392
L
P
E
Y
K
L
Q
T
P
R
I
N
K
F
T
Site 56
T399
T
P
R
I
N
K
F
T
I
L
H
Y
S
P
F
Site 57
Y446
Q
K
R
R
E
C
G
Y
S
C
S
P
L
N
V
Site 58
S447
K
R
R
E
C
G
Y
S
C
S
P
L
N
V
V
Site 59
S449
R
E
C
G
Y
S
C
S
P
L
N
V
V
D
L
Site 60
T473
I
L
I
N
F
R
T
T
Y
V
N
Q
N
E
E
Site 61
Y474
L
I
N
F
R
T
T
Y
V
N
Q
N
E
E
V
Site 62
S483
N
Q
N
E
E
V
V
S
D
P
A
K
I
A
I
Site 63
T520
G
S
G
S
D
E
T
T
T
L
I
G
L
L
K
Site 64
T521
S
G
S
D
E
T
T
T
L
I
G
L
L
K
T
Site 65
Y544
V
A
R
K
L
D
R
Y
S
E
Y
G
A
A
V
Site 66
S545
A
R
K
L
D
R
Y
S
E
Y
G
A
A
V
L
Site 67
Y580
I
G
N
V
E
R
P
Y
L
T
D
K
I
G
W
Site 68
S590
D
K
I
G
W
L
D
S
L
G
Q
Q
I
G
K
Site 69
Y599
G
Q
Q
I
G
K
R
Y
N
D
S
D
S
S
S
Site 70
S602
I
G
K
R
Y
N
D
S
D
S
S
S
G
P
S
Site 71
S604
K
R
Y
N
D
S
D
S
S
S
G
P
S
I
K
Site 72
S605
R
Y
N
D
S
D
S
S
S
G
P
S
I
K
D
Site 73
S606
Y
N
D
S
D
S
S
S
G
P
S
I
K
D
K
Site 74
S609
S
D
S
S
S
G
P
S
I
K
D
K
Y
V
T
Site 75
Y614
G
P
S
I
K
D
K
Y
V
T
A
L
Y
F
T
Site 76
S634
S
V
G
F
G
N
V
S
P
N
T
N
S
E
K
Site 77
T637
F
G
N
V
S
P
N
T
N
S
E
K
I
F
S
Site 78
S639
N
V
S
P
N
T
N
S
E
K
I
F
S
I
C
Site 79
Y670
S
A
I
I
Q
R
L
Y
S
G
T
A
R
Y
H
Site 80
S671
A
I
I
Q
R
L
Y
S
G
T
A
R
Y
H
M
Site 81
Y703
L
R
Q
R
L
E
E
Y
F
Q
H
A
W
T
Y
Site 82
T763
A
L
A
M
K
F
K
T
T
H
A
P
P
G
D
Site 83
T771
T
H
A
P
P
G
D
T
L
V
H
C
G
D
V
Site 84
S789
L
Y
F
L
S
R
G
S
I
E
I
L
K
D
D
Site 85
Y815
F
G
E
M
V
H
L
Y
A
K
P
G
K
S
N
Site 86
S821
L
Y
A
K
P
G
K
S
N
A
D
V
R
A
L
Site 87
T829
N
A
D
V
R
A
L
T
Y
C
D
L
H
K
I
Site 88
T862
F
L
T
N
L
E
L
T
F
N
L
R
H
E
S
Site 89
S869
T
F
N
L
R
H
E
S
A
K
A
D
L
L
R
Site 90
S877
A
K
A
D
L
L
R
S
Q
S
M
N
D
S
E
Site 91
S879
A
D
L
L
R
S
Q
S
M
N
D
S
E
G
D
Site 92
S883
R
S
Q
S
M
N
D
S
E
G
D
N
C
K
L
Site 93
S896
K
L
R
R
R
K
L
S
F
E
S
E
G
E
K
Site 94
S906
S
E
G
E
K
E
N
S
T
N
D
P
E
D
S
Site 95
T907
E
G
E
K
E
N
S
T
N
D
P
E
D
S
A
Site 96
S913
S
T
N
D
P
E
D
S
A
D
T
I
R
H
Y
Site 97
T916
D
P
E
D
S
A
D
T
I
R
H
Y
Q
S
S
Site 98
Y920
S
A
D
T
I
R
H
Y
Q
S
S
K
R
H
F
Site 99
S922
D
T
I
R
H
Y
Q
S
S
K
R
H
F
E
E
Site 100
S923
T
I
R
H
Y
Q
S
S
K
R
H
F
E
E
K
Site 101
S932
R
H
F
E
E
K
K
S
R
S
S
S
F
I
S
Site 102
S934
F
E
E
K
K
S
R
S
S
S
F
I
S
S
I
Site 103
S935
E
E
K
K
S
R
S
S
S
F
I
S
S
I
D
Site 104
S936
E
K
K
S
R
S
S
S
F
I
S
S
I
D
D
Site 105
S939
S
R
S
S
S
F
I
S
S
I
D
D
E
Q
K
Site 106
S940
R
S
S
S
F
I
S
S
I
D
D
E
Q
K
P
Site 107
S950
D
E
Q
K
P
L
F
S
G
I
V
D
S
S
P
Site 108
T970
S
G
L
D
F
E
E
T
V
P
T
S
G
R
M
Site 109
T973
D
F
E
E
T
V
P
T
S
G
R
M
H
I
D
Site 110
S974
F
E
E
T
V
P
T
S
G
R
M
H
I
D
K
Site 111
S985
H
I
D
K
R
S
H
S
C
K
D
I
T
D
M
Site 112
S994
K
D
I
T
D
M
R
S
W
E
R
E
N
A
H
Site 113
S1007
A
H
P
Q
P
E
D
S
S
P
S
A
L
Q
R
Site 114
S1008
H
P
Q
P
E
D
S
S
P
S
A
L
Q
R
A
Site 115
S1020
Q
R
A
A
W
G
I
S
E
T
E
S
D
L
T
Site 116
T1022
A
A
W
G
I
S
E
T
E
S
D
L
T
Y
G
Site 117
S1024
W
G
I
S
E
T
E
S
D
L
T
Y
G
E
V
Site 118
T1027
S
E
T
E
S
D
L
T
Y
G
E
V
E
Q
R
Site 119
Y1028
E
T
E
S
D
L
T
Y
G
E
V
E
Q
R
L
Site 120
S1047
E
Q
L
N
R
L
E
S
Q
M
T
T
D
I
Q
Site 121
T1050
N
R
L
E
S
Q
M
T
T
D
I
Q
T
I
L
Site 122
T1051
R
L
E
S
Q
M
T
T
D
I
Q
T
I
L
Q
Site 123
T1065
Q
L
L
Q
K
Q
T
T
V
V
P
P
A
Y
S
Site 124
Y1080
M
V
T
A
G
S
E
Y
Q
R
P
I
I
Q
L
Site 125
S1091
I
I
Q
L
M
R
T
S
Q
P
E
A
S
I
K
Site 126
T1099
Q
P
E
A
S
I
K
T
D
R
S
F
S
P
S
Site 127
S1102
A
S
I
K
T
D
R
S
F
S
P
S
S
Q
C
Site 128
S1104
I
K
T
D
R
S
F
S
P
S
S
Q
C
P
E
Site 129
S1106
T
D
R
S
F
S
P
S
S
Q
C
P
E
F
L
Site 130
S1107
D
R
S
F
S
P
S
S
Q
C
P
E
F
L
D
Site 131
S1118
E
F
L
D
L
E
K
S
K
L
K
S
K
E
S
Site 132
S1122
L
E
K
S
K
L
K
S
K
E
S
L
S
S
G
Site 133
S1125
S
K
L
K
S
K
E
S
L
S
S
G
V
H
L
Site 134
S1127
L
K
S
K
E
S
L
S
S
G
V
H
L
N
T
Site 135
S1128
K
S
K
E
S
L
S
S
G
V
H
L
N
T
A
Site 136
S1136
G
V
H
L
N
T
A
S
E
D
N
L
T
S
L
Site 137
T1141
T
A
S
E
D
N
L
T
S
L
L
K
Q
D
S
Site 138
S1142
A
S
E
D
N
L
T
S
L
L
K
Q
D
S
D
Site 139
S1148
T
S
L
L
K
Q
D
S
D
L
S
L
E
L
H
Site 140
S1151
L
K
Q
D
S
D
L
S
L
E
L
H
L
R
Q
Site 141
T1161
L
H
L
R
Q
R
K
T
Y
V
H
P
I
R
H
Site 142
Y1162
H
L
R
Q
R
K
T
Y
V
H
P
I
R
H
P
Site 143
S1170
V
H
P
I
R
H
P
S
L
P
D
S
S
L
S
Site 144
S1174
R
H
P
S
L
P
D
S
S
L
S
T
V
G
I
Site 145
S1189
V
G
L
H
R
H
V
S
D
P
G
L
P
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation