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Updated November 2019
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Protein Info
Short Name:
TOPORS
Full Name:
E3 ubiquitin-protein ligase Topors
Alias:
LUN; LUN-1; RP31; SUMO1-protein E3 ligase Topors; Topoisomerase I binding arginine/serine-rich; Topoisomerase I binding, arginine/serine-rich; TOPRS; TP53BPL; Tumor protein p53-binding protein
Type:
EC 6.3.2.-; Cell cycle regulation; Ubiquitin conjugating system; Ligase; Ubiquitin ligase
Mass (Da):
119198
Number AA:
1045
UniProt ID:
Q9NS56
International Prot ID:
IPI00396077
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0016604
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003823
PhosphoSite+
KinaseNET
Biological Process:
GO:0003008
GO:0006139
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
S
Q
P
P
L
G
S
P
L
S
R
E
E
G
Site 2
S12
P
P
L
G
S
P
L
S
R
E
E
G
E
A
P
Site 3
S25
A
P
P
P
A
P
A
S
E
G
R
R
R
S
R
Site 4
S31
A
S
E
G
R
R
R
S
R
R
V
R
L
R
G
Site 5
S39
R
R
V
R
L
R
G
S
C
R
H
R
P
S
F
Site 6
S45
G
S
C
R
H
R
P
S
F
L
G
C
R
E
L
Site 7
S55
G
C
R
E
L
A
A
S
A
P
A
R
P
A
P
Site 8
S64
P
A
R
P
A
P
A
S
S
E
I
M
A
S
A
Site 9
S70
A
S
S
E
I
M
A
S
A
A
K
E
F
K
M
Site 10
S81
E
F
K
M
D
N
F
S
P
K
A
G
T
S
K
Site 11
T92
G
T
S
K
L
Q
Q
T
V
P
A
D
A
S
P
Site 12
S98
Q
T
V
P
A
D
A
S
P
D
S
K
C
P
I
Site 13
S101
P
A
D
A
S
P
D
S
K
C
P
I
C
L
D
Site 14
Y115
D
R
F
D
N
V
S
Y
L
D
R
C
L
H
K
Site 15
S147
L
C
K
Q
P
F
D
S
I
F
H
S
V
R
A
Site 16
S151
P
F
D
S
I
F
H
S
V
R
A
E
D
D
F
Site 17
Y161
A
E
D
D
F
K
E
Y
V
L
R
P
S
Y
N
Site 18
S166
K
E
Y
V
L
R
P
S
Y
N
G
S
F
V
T
Site 19
Y167
E
Y
V
L
R
P
S
Y
N
G
S
F
V
T
P
Site 20
S170
L
R
P
S
Y
N
G
S
F
V
T
P
D
R
R
Site 21
T173
S
Y
N
G
S
F
V
T
P
D
R
R
F
R
Y
Site 22
Y180
T
P
D
R
R
F
R
Y
R
T
T
L
T
R
E
Site 23
T182
D
R
R
F
R
Y
R
T
T
L
T
R
E
R
N
Site 24
T183
R
R
F
R
Y
R
T
T
L
T
R
E
R
N
A
Site 25
T185
F
R
Y
R
T
T
L
T
R
E
R
N
A
S
V
Site 26
S191
L
T
R
E
R
N
A
S
V
Y
S
P
S
G
P
Site 27
Y193
R
E
R
N
A
S
V
Y
S
P
S
G
P
V
N
Site 28
S194
E
R
N
A
S
V
Y
S
P
S
G
P
V
N
R
Site 29
S196
N
A
S
V
Y
S
P
S
G
P
V
N
R
R
T
Site 30
T203
S
G
P
V
N
R
R
T
T
T
P
P
D
S
G
Site 31
T204
G
P
V
N
R
R
T
T
T
P
P
D
S
G
V
Site 32
T205
P
V
N
R
R
T
T
T
P
P
D
S
G
V
L
Site 33
S209
R
T
T
T
P
P
D
S
G
V
L
F
E
G
L
Site 34
S219
L
F
E
G
L
G
I
S
T
R
P
R
D
V
E
Site 35
T240
Q
I
A
V
R
R
P
T
T
A
D
E
R
S
L
Site 36
T241
I
A
V
R
R
P
T
T
A
D
E
R
S
L
R
Site 37
S246
P
T
T
A
D
E
R
S
L
R
K
I
Q
E
Q
Site 38
T261
D
I
I
N
F
R
R
T
L
Y
R
A
G
A
R
Site 39
Y263
I
N
F
R
R
T
L
Y
R
A
G
A
R
V
R
Site 40
S282
G
G
R
Y
R
D
I
S
A
E
F
F
R
R
N
Site 41
Y329
I
M
S
N
V
T
R
Y
D
L
E
S
Q
A
F
Site 42
S333
V
T
R
Y
D
L
E
S
Q
A
F
V
S
D
L
Site 43
Y374
A
F
D
Q
H
A
N
Y
D
C
P
A
P
S
Y
Site 44
S380
N
Y
D
C
P
A
P
S
Y
E
E
G
S
H
S
Site 45
Y381
Y
D
C
P
A
P
S
Y
E
E
G
S
H
S
D
Site 46
S385
A
P
S
Y
E
E
G
S
H
S
D
S
S
V
I
Site 47
S387
S
Y
E
E
G
S
H
S
D
S
S
V
I
T
I
Site 48
S389
E
E
G
S
H
S
D
S
S
V
I
T
I
S
P
Site 49
S390
E
G
S
H
S
D
S
S
V
I
T
I
S
P
D
Site 50
T393
H
S
D
S
S
V
I
T
I
S
P
D
E
A
E
Site 51
S395
D
S
S
V
I
T
I
S
P
D
E
A
E
T
Q
Site 52
T410
E
L
D
I
N
V
A
T
V
S
Q
A
P
W
D
Site 53
S412
D
I
N
V
A
T
V
S
Q
A
P
W
D
D
E
Site 54
T420
Q
A
P
W
D
D
E
T
P
G
P
S
Y
S
S
Site 55
S424
D
D
E
T
P
G
P
S
Y
S
S
S
E
Q
V
Site 56
Y425
D
E
T
P
G
P
S
Y
S
S
S
E
Q
V
H
Site 57
S426
E
T
P
G
P
S
Y
S
S
S
E
Q
V
H
V
Site 58
S428
P
G
P
S
Y
S
S
S
E
Q
V
H
V
T
M
Site 59
T434
S
S
E
Q
V
H
V
T
M
S
S
L
L
N
T
Site 60
S437
Q
V
H
V
T
M
S
S
L
L
N
T
S
D
S
Site 61
T441
T
M
S
S
L
L
N
T
S
D
S
S
D
E
E
Site 62
S442
M
S
S
L
L
N
T
S
D
S
S
D
E
E
L
Site 63
S444
S
L
L
N
T
S
D
S
S
D
E
E
L
V
T
Site 64
S445
L
L
N
T
S
D
S
S
D
E
E
L
V
T
G
Site 65
T451
S
S
D
E
E
L
V
T
G
G
A
T
S
Q
I
Site 66
S471
N
D
D
L
N
N
D
S
D
D
S
S
D
N
C
Site 67
S475
N
N
D
S
D
D
S
S
D
N
C
V
I
V
G
Site 68
T491
V
K
P
L
A
E
R
T
P
E
L
V
E
L
S
Site 69
S498
T
P
E
L
V
E
L
S
S
D
S
E
D
L
G
Site 70
S499
P
E
L
V
E
L
S
S
D
S
E
D
L
G
S
Site 71
S501
L
V
E
L
S
S
D
S
E
D
L
G
S
Y
E
Site 72
S506
S
D
S
E
D
L
G
S
Y
E
K
M
E
T
V
Site 73
T512
G
S
Y
E
K
M
E
T
V
K
T
Q
E
Q
E
Site 74
T515
E
K
M
E
T
V
K
T
Q
E
Q
E
Q
S
Y
Site 75
S521
K
T
Q
E
Q
E
Q
S
Y
S
S
G
D
S
D
Site 76
S523
Q
E
Q
E
Q
S
Y
S
S
G
D
S
D
V
S
Site 77
S524
E
Q
E
Q
S
Y
S
S
G
D
S
D
V
S
R
Site 78
S527
Q
S
Y
S
S
G
D
S
D
V
S
R
C
S
S
Site 79
S530
S
S
G
D
S
D
V
S
R
C
S
S
P
H
S
Site 80
S533
D
S
D
V
S
R
C
S
S
P
H
S
V
L
G
Site 81
S534
S
D
V
S
R
C
S
S
P
H
S
V
L
G
K
Site 82
S537
S
R
C
S
S
P
H
S
V
L
G
K
D
E
Q
Site 83
S552
I
N
K
G
H
C
D
S
S
T
R
I
K
S
K
Site 84
S553
N
K
G
H
C
D
S
S
T
R
I
K
S
K
K
Site 85
T554
K
G
H
C
D
S
S
T
R
I
K
S
K
K
E
Site 86
S558
D
S
S
T
R
I
K
S
K
K
E
E
K
R
S
Site 87
S565
S
K
K
E
E
K
R
S
T
S
L
S
S
P
R
Site 88
T566
K
K
E
E
K
R
S
T
S
L
S
S
P
R
N
Site 89
S567
K
E
E
K
R
S
T
S
L
S
S
P
R
N
L
Site 90
S569
E
K
R
S
T
S
L
S
S
P
R
N
L
N
S
Site 91
S570
K
R
S
T
S
L
S
S
P
R
N
L
N
S
S
Site 92
S577
S
P
R
N
L
N
S
S
V
R
G
D
R
V
Y
Site 93
Y584
S
V
R
G
D
R
V
Y
S
P
Y
N
H
R
H
Site 94
S585
V
R
G
D
R
V
Y
S
P
Y
N
H
R
H
R
Site 95
Y587
G
D
R
V
Y
S
P
Y
N
H
R
H
R
K
R
Site 96
S597
R
H
R
K
R
G
R
S
R
S
S
D
S
R
S
Site 97
S599
R
K
R
G
R
S
R
S
S
D
S
R
S
Q
S
Site 98
S600
K
R
G
R
S
R
S
S
D
S
R
S
Q
S
R
Site 99
S602
G
R
S
R
S
S
D
S
R
S
Q
S
R
S
G
Site 100
S604
S
R
S
S
D
S
R
S
Q
S
R
S
G
H
D
Site 101
S606
S
S
D
S
R
S
Q
S
R
S
G
H
D
Q
K
Site 102
S608
D
S
R
S
Q
S
R
S
G
H
D
Q
K
N
H
Site 103
S626
H
G
K
K
R
M
K
S
K
R
S
R
S
R
E
Site 104
S629
K
R
M
K
S
K
R
S
R
S
R
E
S
S
R
Site 105
S631
M
K
S
K
R
S
R
S
R
E
S
S
R
P
R
Site 106
S634
K
R
S
R
S
R
E
S
S
R
P
R
G
R
R
Site 107
S635
R
S
R
S
R
E
S
S
R
P
R
G
R
R
D
Site 108
S646
G
R
R
D
K
K
R
S
R
T
R
D
S
S
W
Site 109
T648
R
D
K
K
R
S
R
T
R
D
S
S
W
S
R
Site 110
S651
K
R
S
R
T
R
D
S
S
W
S
R
R
S
Q
Site 111
S652
R
S
R
T
R
D
S
S
W
S
R
R
S
Q
T
Site 112
S654
R
T
R
D
S
S
W
S
R
R
S
Q
T
L
S
Site 113
S657
D
S
S
W
S
R
R
S
Q
T
L
S
L
S
S
Site 114
T659
S
W
S
R
R
S
Q
T
L
S
L
S
S
E
S
Site 115
S661
S
R
R
S
Q
T
L
S
L
S
S
E
S
T
S
Site 116
S663
R
S
Q
T
L
S
L
S
S
E
S
T
S
R
S
Site 117
S664
S
Q
T
L
S
L
S
S
E
S
T
S
R
S
R
Site 118
S666
T
L
S
L
S
S
E
S
T
S
R
S
R
S
R
Site 119
T667
L
S
L
S
S
E
S
T
S
R
S
R
S
R
S
Site 120
S668
S
L
S
S
E
S
T
S
R
S
R
S
R
S
S
Site 121
S670
S
S
E
S
T
S
R
S
R
S
R
S
S
D
H
Site 122
S672
E
S
T
S
R
S
R
S
R
S
S
D
H
G
K
Site 123
S674
T
S
R
S
R
S
R
S
S
D
H
G
K
R
R
Site 124
S675
S
R
S
R
S
R
S
S
D
H
G
K
R
R
S
Site 125
S682
S
D
H
G
K
R
R
S
R
S
R
N
R
D
R
Site 126
S684
H
G
K
R
R
S
R
S
R
N
R
D
R
Y
Y
Site 127
Y690
R
S
R
N
R
D
R
Y
Y
L
R
N
N
Y
G
Site 128
Y691
S
R
N
R
D
R
Y
Y
L
R
N
N
Y
G
S
Site 129
Y696
R
Y
Y
L
R
N
N
Y
G
S
R
Y
K
W
E
Site 130
Y704
G
S
R
Y
K
W
E
Y
T
Y
Y
S
R
N
K
Site 131
Y706
R
Y
K
W
E
Y
T
Y
Y
S
R
N
K
D
R
Site 132
Y707
Y
K
W
E
Y
T
Y
Y
S
R
N
K
D
R
D
Site 133
Y716
R
N
K
D
R
D
G
Y
E
S
S
Y
R
R
R
Site 134
S718
K
D
R
D
G
Y
E
S
S
Y
R
R
R
T
L
Site 135
S719
D
R
D
G
Y
E
S
S
Y
R
R
R
T
L
S
Site 136
Y720
R
D
G
Y
E
S
S
Y
R
R
R
T
L
S
R
Site 137
T724
E
S
S
Y
R
R
R
T
L
S
R
A
H
Y
S
Site 138
S726
S
Y
R
R
R
T
L
S
R
A
H
Y
S
R
Q
Site 139
Y730
R
T
L
S
R
A
H
Y
S
R
Q
S
S
S
P
Site 140
S731
T
L
S
R
A
H
Y
S
R
Q
S
S
S
P
E
Site 141
S734
R
A
H
Y
S
R
Q
S
S
S
P
E
F
R
V
Site 142
S735
A
H
Y
S
R
Q
S
S
S
P
E
F
R
V
Q
Site 143
S736
H
Y
S
R
Q
S
S
S
P
E
F
R
V
Q
S
Site 144
S743
S
P
E
F
R
V
Q
S
F
S
E
R
T
N
A
Site 145
S745
E
F
R
V
Q
S
F
S
E
R
T
N
A
R
K
Site 146
Y761
N
N
H
S
E
R
K
Y
Y
Y
Y
E
R
H
R
Site 147
Y762
N
H
S
E
R
K
Y
Y
Y
Y
E
R
H
R
S
Site 148
Y763
H
S
E
R
K
Y
Y
Y
Y
E
R
H
R
S
R
Site 149
Y764
S
E
R
K
Y
Y
Y
Y
E
R
H
R
S
R
S
Site 150
S769
Y
Y
Y
E
R
H
R
S
R
S
L
S
S
N
R
Site 151
S771
Y
E
R
H
R
S
R
S
L
S
S
N
R
S
R
Site 152
S773
R
H
R
S
R
S
L
S
S
N
R
S
R
T
A
Site 153
S774
H
R
S
R
S
L
S
S
N
R
S
R
T
A
S
Site 154
S777
R
S
L
S
S
N
R
S
R
T
A
S
T
G
T
Site 155
T779
L
S
S
N
R
S
R
T
A
S
T
G
T
D
R
Site 156
S781
S
N
R
S
R
T
A
S
T
G
T
D
R
V
R
Site 157
T784
S
R
T
A
S
T
G
T
D
R
V
R
N
E
K
Site 158
Y798
K
P
G
G
K
R
K
Y
K
T
R
H
L
E
G
Site 159
T800
G
G
K
R
K
Y
K
T
R
H
L
E
G
T
N
Site 160
T806
K
T
R
H
L
E
G
T
N
E
V
A
Q
P
S
Site 161
S818
Q
P
S
R
E
F
A
S
K
A
K
D
S
H
Y
Site 162
S823
F
A
S
K
A
K
D
S
H
Y
Q
K
S
S
S
Site 163
Y825
S
K
A
K
D
S
H
Y
Q
K
S
S
S
K
L
Site 164
S828
K
D
S
H
Y
Q
K
S
S
S
K
L
D
G
N
Site 165
S830
S
H
Y
Q
K
S
S
S
K
L
D
G
N
Y
K
Site 166
Y836
S
S
K
L
D
G
N
Y
K
N
E
S
D
T
F
Site 167
S840
D
G
N
Y
K
N
E
S
D
T
F
S
D
S
R
Site 168
T842
N
Y
K
N
E
S
D
T
F
S
D
S
R
S
S
Site 169
S844
K
N
E
S
D
T
F
S
D
S
R
S
S
D
R
Site 170
S846
E
S
D
T
F
S
D
S
R
S
S
D
R
E
T
Site 171
S848
D
T
F
S
D
S
R
S
S
D
R
E
T
K
H
Site 172
S849
T
F
S
D
S
R
S
S
D
R
E
T
K
H
K
Site 173
T853
S
R
S
S
D
R
E
T
K
H
K
R
R
K
R
Site 174
T862
H
K
R
R
K
R
K
T
R
S
L
S
V
E
I
Site 175
S864
R
R
K
R
K
T
R
S
L
S
V
E
I
V
Y
Site 176
S866
K
R
K
T
R
S
L
S
V
E
I
V
Y
E
G
Site 177
T876
I
V
Y
E
G
K
A
T
D
T
T
K
H
H
K
Site 178
T879
E
G
K
A
T
D
T
T
K
H
H
K
K
K
K
Site 179
S902
K
H
H
G
D
N
A
S
R
S
P
V
V
I
T
Site 180
S904
H
G
D
N
A
S
R
S
P
V
V
I
T
I
D
Site 181
S912
P
V
V
I
T
I
D
S
D
S
D
K
D
S
E
Site 182
S914
V
I
T
I
D
S
D
S
D
K
D
S
E
V
K
Site 183
S918
D
S
D
S
D
K
D
S
E
V
K
E
D
T
E
Site 184
T924
D
S
E
V
K
E
D
T
E
C
D
N
S
G
P
Site 185
S929
E
D
T
E
C
D
N
S
G
P
Q
D
P
L
Q
Site 186
S943
Q
N
E
F
L
A
P
S
L
E
P
F
E
T
K
Site 187
T949
P
S
L
E
P
F
E
T
K
D
V
V
T
I
E
Site 188
T970
D
K
E
C
D
I
A
T
L
S
N
N
L
N
N
Site 189
T981
N
L
N
N
A
N
K
T
V
D
N
I
P
P
L
Site 190
T995
L
A
A
S
V
E
Q
T
L
D
V
R
E
E
S
Site 191
S1002
T
L
D
V
R
E
E
S
T
F
V
S
D
L
E
Site 192
T1003
L
D
V
R
E
E
S
T
F
V
S
D
L
E
N
Site 193
S1006
R
E
E
S
T
F
V
S
D
L
E
N
Q
P
S
Site 194
S1013
S
D
L
E
N
Q
P
S
N
I
V
S
L
Q
T
Site 195
S1017
N
Q
P
S
N
I
V
S
L
Q
T
E
P
S
R
Site 196
S1023
V
S
L
Q
T
E
P
S
R
Q
L
P
S
P
R
Site 197
S1028
E
P
S
R
Q
L
P
S
P
R
T
S
L
M
S
Site 198
T1031
R
Q
L
P
S
P
R
T
S
L
M
S
V
C
L
Site 199
S1035
S
P
R
T
S
L
M
S
V
C
L
G
R
D
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation