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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THSD1
Full Name:
Thrombospondin type-1 domain-containing protein 1
Alias:
Transmembrane molecule with thrombospondin module
Type:
Mass (Da):
94584
Number AA:
852
UniProt ID:
Q9NS62
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T229
L
G
R
D
S
V
I
T
S
T
G
P
I
D
L
Site 2
S446
F
G
R
P
A
K
C
S
T
P
A
R
H
N
S
Site 3
T447
G
R
P
A
K
C
S
T
P
A
R
H
N
S
I
Site 4
S453
S
T
P
A
R
H
N
S
I
H
S
P
S
F
R
Site 5
S456
A
R
H
N
S
I
H
S
P
S
F
R
K
N
S
Site 6
S458
H
N
S
I
H
S
P
S
F
R
K
N
S
D
E
Site 7
S463
S
P
S
F
R
K
N
S
D
E
E
N
I
C
E
Site 8
S472
E
E
N
I
C
E
L
S
E
Q
R
G
S
F
S
Site 9
S477
E
L
S
E
Q
R
G
S
F
S
D
G
G
D
G
Site 10
S479
S
E
Q
R
G
S
F
S
D
G
G
D
G
P
T
Site 11
T486
S
D
G
G
D
G
P
T
G
S
P
G
D
T
G
Site 12
S488
G
G
D
G
P
T
G
S
P
G
D
T
G
I
P
Site 13
T492
P
T
G
S
P
G
D
T
G
I
P
L
T
Y
R
Site 14
T497
G
D
T
G
I
P
L
T
Y
R
R
S
G
P
V
Site 15
Y498
D
T
G
I
P
L
T
Y
R
R
S
G
P
V
P
Site 16
S501
I
P
L
T
Y
R
R
S
G
P
V
P
P
E
D
Site 17
S511
V
P
P
E
D
D
A
S
G
S
E
S
F
Q
S
Site 18
S513
P
E
D
D
A
S
G
S
E
S
F
Q
S
N
A
Site 19
S515
D
D
A
S
G
S
E
S
F
Q
S
N
A
Q
K
Site 20
S518
S
G
S
E
S
F
Q
S
N
A
Q
K
I
I
P
Site 21
S529
K
I
I
P
P
L
F
S
Y
R
L
A
Q
Q
Q
Site 22
Y552
L
T
E
T
T
K
V
Y
H
V
S
Q
S
P
L
Site 23
S555
T
T
K
V
Y
H
V
S
Q
S
P
L
T
D
T
Site 24
S557
K
V
Y
H
V
S
Q
S
P
L
T
D
T
A
I
Site 25
T562
S
Q
S
P
L
T
D
T
A
I
D
A
A
P
S
Site 26
S576
S
A
P
L
D
L
E
S
P
E
E
A
A
A
N
Site 27
S589
A
N
K
F
R
I
K
S
P
F
P
E
Q
P
A
Site 28
S598
F
P
E
Q
P
A
V
S
A
G
E
R
P
P
S
Site 29
S605
S
A
G
E
R
P
P
S
R
L
D
L
N
V
T
Site 30
S615
D
L
N
V
T
Q
A
S
C
A
I
S
P
S
Q
Site 31
S619
T
Q
A
S
C
A
I
S
P
S
Q
T
L
I
R
Site 32
S621
A
S
C
A
I
S
P
S
Q
T
L
I
R
K
S
Site 33
T623
C
A
I
S
P
S
Q
T
L
I
R
K
S
Q
A
Site 34
S628
S
Q
T
L
I
R
K
S
Q
A
R
H
V
G
S
Site 35
S635
S
Q
A
R
H
V
G
S
R
G
G
P
S
E
R
Site 36
S640
V
G
S
R
G
G
P
S
E
R
S
H
A
R
N
Site 37
S643
R
G
G
P
S
E
R
S
H
A
R
N
A
H
F
Site 38
T653
R
N
A
H
F
R
R
T
A
S
F
H
E
A
R
Site 39
S655
A
H
F
R
R
T
A
S
F
H
E
A
R
Q
A
Site 40
S669
A
R
P
F
R
E
R
S
M
S
T
L
T
P
R
Site 41
S671
P
F
R
E
R
S
M
S
T
L
T
P
R
Q
A
Site 42
T674
E
R
S
M
S
T
L
T
P
R
Q
A
P
A
Y
Site 43
Y681
T
P
R
Q
A
P
A
Y
S
S
R
T
R
T
C
Site 44
S682
P
R
Q
A
P
A
Y
S
S
R
T
R
T
C
E
Site 45
T687
A
Y
S
S
R
T
R
T
C
E
Q
A
E
D
R
Site 46
S699
E
D
R
F
R
P
Q
S
R
G
A
H
L
F
P
Site 47
T718
H
F
Q
E
A
S
G
T
R
G
P
L
N
P
L
Site 48
S728
P
L
N
P
L
P
K
S
Y
T
L
G
Q
P
L
Site 49
T730
N
P
L
P
K
S
Y
T
L
G
Q
P
L
R
K
Site 50
S764
H
R
A
R
R
G
P
S
P
S
H
K
S
V
S
Site 51
S766
A
R
R
G
P
S
P
S
H
K
S
V
S
R
K
Site 52
S769
G
P
S
P
S
H
K
S
V
S
R
K
Q
S
S
Site 53
S771
S
P
S
H
K
S
V
S
R
K
Q
S
S
P
I
Site 54
S775
K
S
V
S
R
K
Q
S
S
P
I
S
P
K
D
Site 55
S776
S
V
S
R
K
Q
S
S
P
I
S
P
K
D
N
Site 56
S779
R
K
Q
S
S
P
I
S
P
K
D
N
Y
Q
R
Site 57
Y784
P
I
S
P
K
D
N
Y
Q
R
V
S
S
L
S
Site 58
S788
K
D
N
Y
Q
R
V
S
S
L
S
P
S
Q
C
Site 59
S789
D
N
Y
Q
R
V
S
S
L
S
P
S
Q
C
R
Site 60
S791
Y
Q
R
V
S
S
L
S
P
S
Q
C
R
K
D
Site 61
S793
R
V
S
S
L
S
P
S
Q
C
R
K
D
K
C
Site 62
Y812
T
H
P
E
F
A
F
Y
D
N
T
S
F
G
L
Site 63
T815
E
F
A
F
Y
D
N
T
S
F
G
L
T
E
A
Site 64
S816
F
A
F
Y
D
N
T
S
F
G
L
T
E
A
E
Site 65
T820
D
N
T
S
F
G
L
T
E
A
E
Q
R
M
L
Site 66
Y832
R
M
L
D
L
P
G
Y
F
G
S
N
E
E
D
Site 67
S835
D
L
P
G
Y
F
G
S
N
E
E
D
E
T
T
Site 68
T841
G
S
N
E
E
D
E
T
T
S
T
L
S
V
E
Site 69
T842
S
N
E
E
D
E
T
T
S
T
L
S
V
E
K
Site 70
T844
E
E
D
E
T
T
S
T
L
S
V
E
K
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation