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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rad18
Full Name:
E3 ubiquitin-protein ligase RAD18
Alias:
HHR18; HRAD18; MRAD18Sc; Postreplication repair protein RAD18; RA18; RAD18; RAD18SC; RNF73
Type:
EC 6.3.2.-; DNA repair; Ligase
Mass (Da):
56195
Number AA:
495
UniProt ID:
Q9NS91
International Prot ID:
IPI00024579
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005657
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0000403
GO:0003684
GO:0016874
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0019941
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
S
L
A
E
S
R
W
P
P
G
L
A
Site 2
Y56
C
I
R
K
F
L
S
Y
K
T
Q
C
P
T
C
Site 3
S84
I
L
D
E
L
V
K
S
L
N
F
A
R
N
H
Site 4
S99
L
L
Q
F
A
L
E
S
P
A
K
S
P
A
S
Site 5
S103
A
L
E
S
P
A
K
S
P
A
S
S
S
S
K
Site 6
S106
S
P
A
K
S
P
A
S
S
S
S
K
N
L
A
Site 7
S107
P
A
K
S
P
A
S
S
S
S
K
N
L
A
V
Site 8
S108
A
K
S
P
A
S
S
S
S
K
N
L
A
V
K
Site 9
S109
K
S
P
A
S
S
S
S
K
N
L
A
V
K
V
Site 10
Y117
K
N
L
A
V
K
V
Y
T
P
V
A
S
R
Q
Site 11
T118
N
L
A
V
K
V
Y
T
P
V
A
S
R
Q
S
Site 12
S125
T
P
V
A
S
R
Q
S
L
K
Q
G
S
R
L
Site 13
S142
N
F
L
I
R
E
M
S
G
S
T
S
E
L
L
Site 14
S146
R
E
M
S
G
S
T
S
E
L
L
I
K
E
N
Site 15
S158
K
E
N
K
S
K
F
S
P
Q
K
E
A
S
P
Site 16
S164
F
S
P
Q
K
E
A
S
P
A
A
K
T
K
E
Site 17
S174
A
K
T
K
E
T
R
S
V
E
E
I
A
P
D
Site 18
S183
E
E
I
A
P
D
P
S
E
A
K
R
P
E
P
Site 19
S192
A
K
R
P
E
P
P
S
T
S
T
L
K
Q
V
Site 20
T193
K
R
P
E
P
P
S
T
S
T
L
K
Q
V
T
Site 21
S194
R
P
E
P
P
S
T
S
T
L
K
Q
V
T
K
Site 22
S222
H
I
N
K
H
L
D
S
C
L
S
R
E
E
K
Site 23
S225
K
H
L
D
S
C
L
S
R
E
E
K
K
E
S
Site 24
S232
S
R
E
E
K
K
E
S
L
R
S
S
V
H
K
Site 25
S236
K
K
E
S
L
R
S
S
V
H
K
R
K
P
L
Site 26
T246
K
R
K
P
L
P
K
T
V
Y
N
L
L
S
D
Site 27
Y248
K
P
L
P
K
T
V
Y
N
L
L
S
D
R
D
Site 28
S252
K
T
V
Y
N
L
L
S
D
R
D
L
K
K
K
Site 29
S266
K
L
K
E
H
G
L
S
I
Q
G
N
K
Q
Q
Site 30
S296
C
D
A
L
H
P
K
S
A
A
E
I
V
Q
E
Site 31
T310
E
I
E
N
I
E
K
T
R
M
R
L
E
A
S
Site 32
S317
T
R
M
R
L
E
A
S
K
L
N
E
S
V
M
Site 33
S322
E
A
S
K
L
N
E
S
V
M
V
F
T
K
D
Site 34
S340
K
E
I
D
E
I
H
S
K
Y
R
K
K
H
K
Site 35
S348
K
Y
R
K
K
H
K
S
E
F
Q
L
L
V
D
Site 36
Y361
V
D
Q
A
R
K
G
Y
K
K
I
A
G
M
S
Site 37
S368
Y
K
K
I
A
G
M
S
Q
K
T
V
T
I
T
Site 38
T371
I
A
G
M
S
Q
K
T
V
T
I
T
K
E
D
Site 39
S380
T
I
T
K
E
D
E
S
T
E
K
L
S
S
V
Site 40
T381
I
T
K
E
D
E
S
T
E
K
L
S
S
V
C
Site 41
S385
D
E
S
T
E
K
L
S
S
V
C
M
G
Q
E
Site 42
S386
E
S
T
E
K
L
S
S
V
C
M
G
Q
E
D
Site 43
T399
E
D
N
M
T
S
V
T
N
H
F
S
Q
S
K
Site 44
S403
T
S
V
T
N
H
F
S
Q
S
K
L
D
S
P
Site 45
S405
V
T
N
H
F
S
Q
S
K
L
D
S
P
E
E
Site 46
S409
F
S
Q
S
K
L
D
S
P
E
E
L
E
P
D
Site 47
S421
E
P
D
R
E
E
D
S
S
S
C
I
D
I
Q
Site 48
S422
P
D
R
E
E
D
S
S
S
C
I
D
I
Q
E
Site 49
S423
D
R
E
E
D
S
S
S
C
I
D
I
Q
E
V
Site 50
S432
I
D
I
Q
E
V
L
S
S
S
E
S
D
S
C
Site 51
S433
D
I
Q
E
V
L
S
S
S
E
S
D
S
C
N
Site 52
S434
I
Q
E
V
L
S
S
S
E
S
D
S
C
N
S
Site 53
S436
E
V
L
S
S
S
E
S
D
S
C
N
S
S
S
Site 54
S438
L
S
S
S
E
S
D
S
C
N
S
S
S
S
D
Site 55
S441
S
E
S
D
S
C
N
S
S
S
S
D
I
I
R
Site 56
S442
E
S
D
S
C
N
S
S
S
S
D
I
I
R
D
Site 57
S444
D
S
C
N
S
S
S
S
D
I
I
R
D
L
L
Site 58
T468
H
K
N
D
L
Q
D
T
E
I
S
P
R
Q
N
Site 59
S471
D
L
Q
D
T
E
I
S
P
R
Q
N
R
R
T
Site 60
T478
S
P
R
Q
N
R
R
T
R
A
A
E
S
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation