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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
K84
Full Name:
Keratin, type II cuticular Hb4
Alias:
Hair keratin, type II Hb4; Hard keratin type II 4; Hard keratin, type II, 4; HB4; Hb-4; Keratin 84; Keratin, hair, basic, 4; KRHB4; KRT84; KRTHB4; Type II hair keratin 4
Type:
Cytoskeletal protein
Mass (Da):
64895
Number AA:
600
UniProt ID:
Q9NSB2
International Prot ID:
IPI00300052
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0045095
Uniprot
OncoNet
Molecular Function:
GO:0030280
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
C
R
S
Y
R
V
S
Site 2
S9
S
C
R
S
Y
R
V
S
S
G
H
R
V
G
N
Site 3
S10
C
R
S
Y
R
V
S
S
G
H
R
V
G
N
F
Site 4
S18
G
H
R
V
G
N
F
S
S
C
S
A
M
T
P
Site 5
S19
H
R
V
G
N
F
S
S
C
S
A
M
T
P
Q
Site 6
T24
F
S
S
C
S
A
M
T
P
Q
N
L
N
R
F
Site 7
S35
L
N
R
F
R
A
N
S
V
S
C
W
S
G
P
Site 8
S37
R
F
R
A
N
S
V
S
C
W
S
G
P
G
F
Site 9
S40
A
N
S
V
S
C
W
S
G
P
G
F
R
G
L
Site 10
T57
F
G
S
R
S
V
I
T
F
G
S
Y
S
P
R
Site 11
T171
D
E
K
E
Q
I
K
T
L
N
N
K
F
A
S
Site 12
S178
T
L
N
N
K
F
A
S
F
I
D
K
V
R
F
Site 13
S198
K
L
L
E
T
K
W
S
F
L
Q
E
Q
K
C
Site 14
T219
P
L
F
E
S
Y
I
T
N
L
R
R
Q
L
E
Site 15
S230
R
Q
L
E
V
L
V
S
D
Q
A
R
L
Q
A
Site 16
Y253
L
E
G
F
K
K
K
Y
E
E
E
V
V
C
R
Site 17
S282
D
A
A
F
M
N
K
S
D
L
E
A
N
V
D
Site 18
T292
E
A
N
V
D
T
L
T
Q
E
I
D
F
L
K
Site 19
T300
Q
E
I
D
F
L
K
T
L
Y
M
E
E
I
Q
Site 20
S311
E
E
I
Q
L
L
Q
S
H
I
S
E
T
S
V
Site 21
S317
Q
S
H
I
S
E
T
S
V
I
V
K
M
D
N
Site 22
S325
V
I
V
K
M
D
N
S
R
D
L
N
L
D
G
Site 23
Y341
I
A
E
V
K
A
Q
Y
E
E
V
A
R
R
S
Site 24
S348
Y
E
E
V
A
R
R
S
R
A
D
A
E
A
W
Site 25
Y356
R
A
D
A
E
A
W
Y
Q
T
K
Y
E
E
M
Site 26
Y360
E
A
W
Y
Q
T
K
Y
E
E
M
Q
V
T
A
Site 27
S421
Q
Q
G
E
A
T
L
S
D
A
K
C
K
L
A
Site 28
Y448
M
A
R
Q
L
R
E
Y
Q
E
L
M
N
A
K
Site 29
T464
G
L
D
I
E
I
A
T
Y
R
R
L
L
E
G
Site 30
Y465
L
D
I
E
I
A
T
Y
R
R
L
L
E
G
E
Site 31
S474
R
L
L
E
G
E
E
S
R
L
C
E
G
V
G
Site 32
S486
G
V
G
P
V
N
I
S
V
S
S
S
R
G
G
Site 33
T513
T
L
S
R
G
G
V
T
F
S
G
S
S
S
V
Site 34
S548
P
A
T
G
D
L
L
S
T
G
T
R
S
G
S
Site 35
T549
A
T
G
D
L
L
S
T
G
T
R
S
G
S
M
Site 36
S555
S
T
G
T
R
S
G
S
M
L
I
S
E
A
C
Site 37
S577
L
P
T
Q
G
G
F
S
S
C
S
G
G
R
S
Site 38
S578
P
T
Q
G
G
F
S
S
C
S
G
G
R
S
S
Site 39
S580
Q
G
G
F
S
S
C
S
G
G
R
S
S
S
V
Site 40
S584
S
S
C
S
G
G
R
S
S
S
V
R
F
V
S
Site 41
S585
S
C
S
G
G
R
S
S
S
V
R
F
V
S
T
Site 42
S586
C
S
G
G
R
S
S
S
V
R
F
V
S
T
T
Site 43
S591
S
S
S
V
R
F
V
S
T
T
T
S
C
R
T
Site 44
T593
S
V
R
F
V
S
T
T
T
S
C
R
T
K
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation