KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IARS2
Full Name:
Isoleucyl-tRNA synthetase, mitochondrial
Alias:
FLJ10326; IleRS; Isoleucine tRNA ligase 2, mitochondrial; Isoleucine-tRNA ligase; Isoleucine--tRNA ligase; Isoleucine-tRNA synthetase 2, mitochondrial; Isoleucyl-tRNA synthetase 2, mitochondrial; SYIM
Type:
EC 6.1.1.5; Ligase; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis
Mass (Da):
113792
Number AA:
1012
UniProt ID:
Q9NSE4
International Prot ID:
IPI00017283
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0005739
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004822
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006428
GO:0006139
GO:0006399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
T
A
R
S
L
W
G
T
P
R
L
P
C
S
P
Site 2
S30
G
T
P
R
L
P
C
S
P
G
W
Q
G
A
T
Site 3
S44
T
K
R
L
L
V
R
S
V
S
G
A
S
N
H
Site 4
S46
R
L
L
V
R
S
V
S
G
A
S
N
H
Q
P
Site 5
S55
A
S
N
H
Q
P
N
S
N
S
G
R
Y
R
D
Site 6
S57
N
H
Q
P
N
S
N
S
G
R
Y
R
D
T
V
Site 7
Y60
P
N
S
N
S
G
R
Y
R
D
T
V
L
L
P
Site 8
T63
N
S
G
R
Y
R
D
T
V
L
L
P
Q
T
S
Site 9
T83
L
G
R
Q
Q
P
D
T
E
L
E
I
Q
Q
K
Site 10
Y97
K
C
G
F
S
E
L
Y
S
W
Q
R
E
R
K
Site 11
S98
C
G
F
S
E
L
Y
S
W
Q
R
E
R
K
V
Site 12
Y117
C
L
H
D
G
P
P
Y
A
N
G
D
P
H
V
Site 13
S166
P
I
E
I
K
V
L
S
E
L
G
R
E
A
Q
Site 14
S176
G
R
E
A
Q
N
L
S
A
M
E
I
R
K
K
Site 15
S186
E
I
R
K
K
A
R
S
F
A
K
A
A
I
E
Site 16
Y219
Y
Y
T
F
D
G
K
Y
E
A
K
Q
L
R
T
Site 17
T226
Y
E
A
K
Q
L
R
T
F
Y
Q
M
Y
D
K
Site 18
Y228
A
K
Q
L
R
T
F
Y
Q
M
Y
D
K
G
L
Site 19
Y231
L
R
T
F
Y
Q
M
Y
D
K
G
L
V
Y
R
Site 20
Y237
M
Y
D
K
G
L
V
Y
R
S
Y
K
P
V
F
Site 21
S239
D
K
G
L
V
Y
R
S
Y
K
P
V
F
W
S
Site 22
Y240
K
G
L
V
Y
R
S
Y
K
P
V
F
W
S
P
Site 23
S246
S
Y
K
P
V
F
W
S
P
S
S
R
T
A
L
Site 24
S248
K
P
V
F
W
S
P
S
S
R
T
A
L
A
E
Site 25
S249
P
V
F
W
S
P
S
S
R
T
A
L
A
E
A
Site 26
T251
F
W
S
P
S
S
R
T
A
L
A
E
A
E
L
Site 27
Y270
E
H
V
S
R
S
I
Y
V
K
F
P
L
L
K
Site 28
S284
K
P
S
P
K
L
A
S
L
I
D
G
S
S
P
Site 29
Y312
P
A
N
E
A
V
C
Y
M
P
E
S
K
Y
A
Site 30
Y318
C
Y
M
P
E
S
K
Y
A
V
V
K
C
S
K
Site 31
S355
F
E
T
I
S
T
L
S
G
V
D
L
E
N
G
Site 32
S365
D
L
E
N
G
T
C
S
H
P
L
I
P
D
K
Site 33
S374
P
L
I
P
D
K
A
S
P
L
L
P
A
N
H
Site 34
Y402
P
A
H
G
M
E
D
Y
G
V
A
S
Q
H
N
Site 35
Y463
E
E
K
L
V
H
S
Y
P
Y
D
W
R
T
K
Site 36
T469
S
Y
P
Y
D
W
R
T
K
K
P
V
V
I
R
Site 37
T490
I
N
I
T
D
I
K
T
A
A
K
E
L
L
K
Site 38
Y519
E
M
M
D
R
R
P
Y
W
C
I
S
R
Q
R
Site 39
Y543
H
H
K
T
K
D
E
Y
L
I
N
S
Q
T
T
Site 40
S547
K
D
E
Y
L
I
N
S
Q
T
T
E
H
I
V
Site 41
T567
H
G
S
D
I
W
W
T
L
P
P
E
Q
L
L
Site 42
Y590
G
G
P
D
A
L
E
Y
V
P
G
Q
D
I
L
Site 43
S608
F
D
S
G
T
S
W
S
Y
V
L
P
G
P
D
Site 44
Y609
D
S
G
T
S
W
S
Y
V
L
P
G
P
D
Q
Site 45
Y621
P
D
Q
R
A
D
L
Y
L
E
G
K
D
Q
L
Site 46
T638
W
F
Q
S
S
L
L
T
S
V
A
A
R
K
R
Site 47
S639
F
Q
S
S
L
L
T
S
V
A
A
R
K
R
A
Site 48
Y648
A
A
R
K
R
A
P
Y
K
T
V
I
V
H
G
Site 49
T650
R
K
R
A
P
Y
K
T
V
I
V
H
G
F
T
Site 50
S668
K
G
E
K
M
S
K
S
L
G
N
V
I
H
P
Site 51
S686
V
N
G
G
Q
D
Q
S
K
E
P
P
Y
G
A
Site 52
Y691
D
Q
S
K
E
P
P
Y
G
A
D
V
L
R
W
Site 53
S724
N
A
A
R
D
D
I
S
K
L
R
N
T
L
R
Site 54
T729
D
I
S
K
L
R
N
T
L
R
F
L
L
G
N
Site 55
T744
V
A
D
F
N
P
E
T
D
S
I
P
V
N
D
Site 56
Y774
A
N
K
I
T
E
L
Y
K
Q
Y
D
F
G
K
Site 57
T788
K
V
V
R
L
L
R
T
F
Y
T
R
E
L
S
Site 58
Y790
V
R
L
L
R
T
F
Y
T
R
E
L
S
N
F
Site 59
T791
R
L
L
R
T
F
Y
T
R
E
L
S
N
F
Y
Site 60
Y798
T
R
E
L
S
N
F
Y
F
S
I
I
K
D
R
Site 61
Y807
S
I
I
K
D
R
L
Y
C
E
K
E
N
D
P
Site 62
S818
E
N
D
P
K
R
R
S
C
Q
T
A
L
V
E
Site 63
T821
P
K
R
R
S
C
Q
T
A
L
V
E
I
L
D
Site 64
T861
E
P
K
S
V
F
R
T
G
W
I
S
T
S
S
Site 65
S867
R
T
G
W
I
S
T
S
S
I
W
K
K
P
G
Site 66
S868
T
G
W
I
S
T
S
S
I
W
K
K
P
G
L
Site 67
S881
G
L
E
E
A
V
E
S
A
C
A
M
R
D
S
Site 68
S892
M
R
D
S
F
L
G
S
I
P
G
K
N
A
A
Site 69
Y901
P
G
K
N
A
A
E
Y
K
V
I
T
V
I
E
Site 70
S921
E
I
I
E
M
L
Q
S
E
E
T
S
S
T
S
Site 71
T924
E
M
L
Q
S
E
E
T
S
S
T
S
Q
L
N
Site 72
S925
M
L
Q
S
E
E
T
S
S
T
S
Q
L
N
E
Site 73
S926
L
Q
S
E
E
T
S
S
T
S
Q
L
N
E
L
Site 74
S928
S
E
E
T
S
S
T
S
Q
L
N
E
L
M
M
Site 75
T950
A
Q
E
P
R
E
M
T
A
D
V
I
E
L
K
Site 76
S973
G
G
D
I
R
E
E
S
S
Y
K
V
I
V
M
Site 77
Y975
D
I
R
E
E
S
S
Y
K
V
I
V
M
P
T
Site 78
T982
Y
K
V
I
V
M
P
T
T
K
E
K
C
P
R
Site 79
T983
K
V
I
V
M
P
T
T
K
E
K
C
P
R
C
Site 80
Y993
K
C
P
R
C
W
K
Y
T
A
E
S
S
D
T
Site 81
T994
C
P
R
C
W
K
Y
T
A
E
S
S
D
T
L
Site 82
T1000
Y
T
A
E
S
S
D
T
L
C
P
R
C
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation