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Updated November 2019
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Protein Info
Short Name:
BRWD1
Full Name:
Bromodomain and WD repeat-containing protein 1
Alias:
Bromodomain and WD repeat domain containing 1; Bromodomain and WD repeat-containing 1; C21orf107; FLJ11315; N143; WDR9; WD-repeat 9
Type:
Uncharacterized protein
Mass (Da):
262920
Number AA:
2320
UniProt ID:
Q9NSI6
International Prot ID:
IPI00250716
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0030528
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
E
P
S
S
A
R
R
P
V
P
Site 2
S6
_
_
M
A
E
P
S
S
A
R
R
P
V
P
L
Site 3
Y19
P
L
I
E
S
E
L
Y
F
L
I
A
R
Y
L
Site 4
Y45
L
V
Q
E
L
E
Q
Y
Q
L
L
P
K
R
L
Site 5
S62
E
G
N
E
H
N
R
S
Y
E
E
L
V
L
S
Site 6
Y63
G
N
E
H
N
R
S
Y
E
E
L
V
L
S
N
Site 7
S69
S
Y
E
E
L
V
L
S
N
K
H
V
A
P
D
Site 8
S96
L
D
K
E
I
P
P
S
I
S
R
V
T
S
L
Site 9
S98
K
E
I
P
P
S
I
S
R
V
T
S
L
L
G
Site 10
T101
P
P
S
I
S
R
V
T
S
L
L
G
A
G
R
Site 11
S102
P
S
I
S
R
V
T
S
L
L
G
A
G
R
Q
Site 12
S110
L
L
G
A
G
R
Q
S
L
L
R
T
A
K
D
Site 13
T114
G
R
Q
S
L
L
R
T
A
K
D
C
R
H
T
Site 14
T121
T
A
K
D
C
R
H
T
V
W
K
G
S
A
F
Site 15
Y143
P
P
E
M
P
V
N
Y
G
S
P
P
N
L
V
Site 16
S145
E
M
P
V
N
Y
G
S
P
P
N
L
V
E
I
Site 17
T159
I
H
R
G
K
Q
L
T
G
C
S
T
F
S
T
Site 18
S162
G
K
Q
L
T
G
C
S
T
F
S
T
A
F
P
Site 19
T163
K
Q
L
T
G
C
S
T
F
S
T
A
F
P
G
Site 20
T203
R
T
G
H
R
I
F
T
G
S
D
D
C
L
V
Site 21
S222
T
H
N
G
R
L
L
S
T
L
R
G
H
S
A
Site 22
T223
H
N
G
R
L
L
S
T
L
R
G
H
S
A
E
Site 23
S228
L
S
T
L
R
G
H
S
A
E
I
S
D
M
A
Site 24
S232
R
G
H
S
A
E
I
S
D
M
A
V
N
Y
E
Site 25
T274
Q
G
H
T
G
S
I
T
S
L
Q
F
S
P
M
Site 26
S275
G
H
T
G
S
I
T
S
L
Q
F
S
P
M
A
Site 27
S279
S
I
T
S
L
Q
F
S
P
M
A
K
G
S
Q
Site 28
S285
F
S
P
M
A
K
G
S
Q
R
Y
M
V
S
T
Site 29
S291
G
S
Q
R
Y
M
V
S
T
G
A
D
G
T
V
Site 30
T292
S
Q
R
Y
M
V
S
T
G
A
D
G
T
V
C
Site 31
S311
D
L
E
S
L
K
F
S
P
R
P
L
K
F
T
Site 32
T318
S
P
R
P
L
K
F
T
E
K
P
R
P
G
V
Site 33
S366
E
K
I
A
E
L
E
S
H
T
D
K
V
D
S
Site 34
S385
N
N
G
D
R
F
L
S
G
S
R
D
G
T
A
Site 35
S387
G
D
R
F
L
S
G
S
R
D
G
T
A
R
I
Site 36
T391
L
S
G
S
R
D
G
T
A
R
I
W
R
F
E
Site 37
S414
L
D
M
A
T
R
I
S
G
D
L
S
S
E
E
Site 38
S418
T
R
I
S
G
D
L
S
S
E
E
E
R
F
M
Site 39
S419
R
I
S
G
D
L
S
S
E
E
E
R
F
M
K
Site 40
S481
L
E
T
H
P
F
D
S
R
I
M
L
S
A
G
Site 41
S486
F
D
S
R
I
M
L
S
A
G
H
D
G
S
I
Site 42
Y507
K
G
T
K
M
K
H
Y
F
N
M
I
E
G
Q
Site 43
Y551
G
F
G
C
S
K
P
Y
E
K
I
P
D
Q
M
Site 44
T562
P
D
Q
M
F
F
H
T
D
Y
R
P
L
I
R
Site 45
Y564
Q
M
F
F
H
T
D
Y
R
P
L
I
R
D
S
Site 46
S571
Y
R
P
L
I
R
D
S
N
N
Y
V
L
D
E
Site 47
Y574
L
I
R
D
S
N
N
Y
V
L
D
E
Q
T
Q
Site 48
Y604
G
N
P
H
P
T
K
Y
Q
R
L
V
P
G
R
Site 49
S614
L
V
P
G
R
E
N
S
A
D
E
H
L
I
P
Site 50
Y625
H
L
I
P
Q
L
G
Y
V
A
T
S
D
G
E
Site 51
S639
E
V
I
E
Q
I
I
S
L
Q
T
N
D
N
D
Site 52
S649
T
N
D
N
D
E
R
S
P
E
S
S
I
L
D
Site 53
S653
D
E
R
S
P
E
S
S
I
L
D
G
M
I
R
Site 54
T676
R
M
G
A
D
Q
D
T
I
P
R
G
L
S
N
Site 55
S682
D
T
I
P
R
G
L
S
N
G
E
E
T
P
R
Site 56
T687
G
L
S
N
G
E
E
T
P
R
R
G
F
R
R
Site 57
S696
R
R
G
F
R
R
L
S
L
D
I
Q
S
P
P
Site 58
S701
R
L
S
L
D
I
Q
S
P
P
N
I
G
L
R
Site 59
S710
P
N
I
G
L
R
R
S
G
Q
V
E
G
V
R
Site 60
S726
M
H
Q
N
A
P
R
S
Q
I
A
T
E
R
D
Site 61
T730
A
P
R
S
Q
I
A
T
E
R
D
L
Q
A
W
Site 62
Y769
G
E
E
E
R
N
L
Y
I
I
G
R
K
R
K
Site 63
T777
I
I
G
R
K
R
K
T
L
Q
L
S
H
K
S
Site 64
S781
K
R
K
T
L
Q
L
S
H
K
S
D
S
V
V
Site 65
S786
Q
L
S
H
K
S
D
S
V
V
L
V
S
Q
S
Site 66
S791
S
D
S
V
V
L
V
S
Q
S
R
Q
R
T
C
Site 67
S793
S
V
V
L
V
S
Q
S
R
Q
R
T
C
R
R
Site 68
T797
V
S
Q
S
R
Q
R
T
C
R
R
K
Y
P
N
Site 69
Y802
Q
R
T
C
R
R
K
Y
P
N
Y
G
R
R
N
Site 70
Y805
C
R
R
K
Y
P
N
Y
G
R
R
N
R
S
W
Site 71
S811
N
Y
G
R
R
N
R
S
W
R
E
L
S
S
G
Site 72
S816
N
R
S
W
R
E
L
S
S
G
N
E
S
S
S
Site 73
S817
R
S
W
R
E
L
S
S
G
N
E
S
S
S
S
Site 74
S821
E
L
S
S
G
N
E
S
S
S
S
V
R
H
E
Site 75
S822
L
S
S
G
N
E
S
S
S
S
V
R
H
E
T
Site 76
S823
S
S
G
N
E
S
S
S
S
V
R
H
E
T
S
Site 77
S824
S
G
N
E
S
S
S
S
V
R
H
E
T
S
C
Site 78
T829
S
S
S
V
R
H
E
T
S
C
D
Q
S
E
G
Site 79
S830
S
S
V
R
H
E
T
S
C
D
Q
S
E
G
S
Site 80
S834
H
E
T
S
C
D
Q
S
E
G
S
G
S
S
E
Site 81
S837
S
C
D
Q
S
E
G
S
G
S
S
E
E
D
E
Site 82
S839
D
Q
S
E
G
S
G
S
S
E
E
D
E
W
R
Site 83
S847
S
E
E
D
E
W
R
S
D
R
K
S
E
S
Y
Site 84
S851
E
W
R
S
D
R
K
S
E
S
Y
S
E
S
S
Site 85
S853
R
S
D
R
K
S
E
S
Y
S
E
S
S
S
D
Site 86
Y854
S
D
R
K
S
E
S
Y
S
E
S
S
S
D
S
Site 87
S855
D
R
K
S
E
S
Y
S
E
S
S
S
D
S
S
Site 88
S857
K
S
E
S
Y
S
E
S
S
S
D
S
S
S
R
Site 89
S858
S
E
S
Y
S
E
S
S
S
D
S
S
S
R
Y
Site 90
S859
E
S
Y
S
E
S
S
S
D
S
S
S
R
Y
S
Site 91
S861
Y
S
E
S
S
S
D
S
S
S
R
Y
S
D
W
Site 92
S862
S
E
S
S
S
D
S
S
S
R
Y
S
D
W
T
Site 93
S863
E
S
S
S
D
S
S
S
R
Y
S
D
W
T
A
Site 94
Y865
S
S
D
S
S
S
R
Y
S
D
W
T
A
D
A
Site 95
S866
S
D
S
S
S
R
Y
S
D
W
T
A
D
A
G
Site 96
T869
S
S
R
Y
S
D
W
T
A
D
A
G
I
N
L
Site 97
S883
L
Q
P
P
L
R
T
S
C
R
R
R
I
T
R
Site 98
T889
T
S
C
R
R
R
I
T
R
F
C
S
S
S
E
Site 99
S893
R
R
I
T
R
F
C
S
S
S
E
D
E
I
S
Site 100
S895
I
T
R
F
C
S
S
S
E
D
E
I
S
T
E
Site 101
S900
S
S
S
E
D
E
I
S
T
E
N
L
S
P
P
Site 102
T901
S
S
E
D
E
I
S
T
E
N
L
S
P
P
K
Site 103
S905
E
I
S
T
E
N
L
S
P
P
K
R
R
R
K
Site 104
T928
K
E
N
L
R
R
M
T
P
A
E
L
A
N
M
Site 105
Y939
L
A
N
M
E
H
L
Y
E
F
H
P
P
V
W
Site 106
T950
P
P
V
W
I
T
D
T
T
L
R
K
S
P
F
Site 107
T951
P
V
W
I
T
D
T
T
L
R
K
S
P
F
V
Site 108
S955
T
D
T
T
L
R
K
S
P
F
V
P
Q
M
G
Site 109
Y967
Q
M
G
D
E
V
I
Y
F
R
Q
G
H
E
A
Site 110
Y985
A
V
R
R
N
N
I
Y
E
L
N
P
N
K
E
Site 111
S1038
T
G
K
L
M
D
K
S
F
S
I
R
Y
H
D
Site 112
S1040
K
L
M
D
K
S
F
S
I
R
Y
H
D
M
P
Site 113
Y1059
F
L
V
L
R
Q
F
Y
D
E
A
R
Q
R
N
Site 114
Y1092
T
V
L
S
Q
E
P
Y
Q
P
Q
Y
P
D
S
Site 115
Y1096
Q
E
P
Y
Q
P
Q
Y
P
D
S
H
F
Q
C
Site 116
T1111
Y
I
V
R
W
D
N
T
E
I
E
K
L
S
P
Site 117
S1117
N
T
E
I
E
K
L
S
P
W
D
M
E
P
I
Site 118
S1137
P
P
E
E
L
G
A
S
I
S
V
T
T
D
E
Site 119
S1139
E
E
L
G
A
S
I
S
V
T
T
D
E
L
E
Site 120
Y1150
D
E
L
E
K
L
L
Y
K
P
Q
A
G
E
W
Site 121
S1161
A
G
E
W
G
Q
K
S
R
D
E
E
C
D
R
Site 122
S1171
E
E
C
D
R
I
I
S
G
I
D
Q
L
L
N
Site 123
T1209
A
Y
P
T
D
L
Y
T
I
R
M
R
L
V
N
Site 124
S1223
N
R
F
Y
R
R
L
S
A
L
V
W
E
V
R
Site 125
T1238
Y
I
E
H
N
A
R
T
F
N
E
P
E
S
V
Site 126
S1244
R
T
F
N
E
P
E
S
V
I
A
R
S
A
K
Site 127
T1275
N
I
S
E
L
S
N
T
S
E
N
D
E
Q
N
Site 128
S1289
N
A
E
D
L
D
D
S
D
L
P
K
T
S
S
Site 129
T1294
D
D
S
D
L
P
K
T
S
S
G
R
R
R
V
Site 130
S1296
S
D
L
P
K
T
S
S
G
R
R
R
V
H
D
Site 131
S1307
R
V
H
D
G
K
K
S
I
R
A
T
N
Y
V
Site 132
T1311
G
K
K
S
I
R
A
T
N
Y
V
E
S
N
W
Site 133
Y1313
K
S
I
R
A
T
N
Y
V
E
S
N
W
K
K
Site 134
Y1347
Q
P
V
D
L
V
E
Y
P
D
Y
R
D
I
I
Site 135
Y1350
D
L
V
E
Y
P
D
Y
R
D
I
I
D
T
P
Site 136
T1356
D
Y
R
D
I
I
D
T
P
M
D
F
G
T
V
Site 137
T1362
D
T
P
M
D
F
G
T
V
R
E
T
L
D
A
Site 138
T1366
D
F
G
T
V
R
E
T
L
D
A
G
N
Y
D
Site 139
Y1372
E
T
L
D
A
G
N
Y
D
S
P
L
E
F
C
Site 140
S1374
L
D
A
G
N
Y
D
S
P
L
E
F
C
K
D
Site 141
T1393
F
S
N
A
K
A
Y
T
P
N
K
R
S
K
I
Site 142
S1398
A
Y
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I
D
Site 294
T2164
S
S
D
L
G
S
V
T
E
S
D
I
D
C
T
Site 295
S2166
D
L
G
S
V
T
E
S
D
I
D
C
T
D
N
Site 296
T2171
T
E
S
D
I
D
C
T
D
N
T
K
T
K
R
Site 297
T2174
D
I
D
C
T
D
N
T
K
T
K
R
R
K
T
Site 298
T2176
D
C
T
D
N
T
K
T
K
R
R
K
T
K
G
Site 299
T2181
T
K
T
K
R
R
K
T
K
G
K
A
K
V
V
Site 300
T2201
P
R
D
R
E
P
N
T
K
V
R
T
C
M
H
Site 301
S2218
K
D
A
V
Q
M
P
S
E
T
L
K
A
K
M
Site 302
T2236
K
V
P
R
R
C
A
T
V
A
A
N
K
I
K
Site 303
S2253
S
N
L
K
E
T
I
S
G
P
E
N
V
W
I
Site 304
S2263
E
N
V
W
I
R
K
S
S
R
K
L
P
H
R
Site 305
S2264
N
V
W
I
R
K
S
S
R
K
L
P
H
R
N
Site 306
S2273
K
L
P
H
R
N
A
S
A
A
A
K
K
K
L
Site 307
T2289
N
V
Y
K
E
D
D
T
T
I
N
S
E
S
E
Site 308
T2290
V
Y
K
E
D
D
T
T
I
N
S
E
S
E
K
Site 309
S2293
E
D
D
T
T
I
N
S
E
S
E
K
E
L
E
Site 310
S2314
L
F
L
R
G
F
R
S
W
K
E
N
A
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation