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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PNPLA3
Full Name:
Patatin-like phospholipase domain-containing protein 3
Alias:
Acylglycerol O-acyltransferase;Adiponutrin;Calcium-independent phospholipase A2-epsilon
Type:
Mass (Da):
52865
Number AA:
481
UniProt ID:
Q9NST1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
Y
D
A
E
R
G
W
S
L
S
F
A
G
C
G
Site 2
Y21
G
C
G
F
L
G
F
Y
H
V
G
A
T
R
C
Site 3
S70
E
Q
T
L
Q
V
L
S
D
L
V
R
K
A
R
Site 4
S91
F
H
P
S
F
N
L
S
K
F
L
R
Q
G
L
Site 5
T119
G
K
I
G
I
S
L
T
R
V
S
D
G
E
N
Site 6
S122
G
I
S
L
T
R
V
S
D
G
E
N
V
L
V
Site 7
S130
D
G
E
N
V
L
V
S
D
F
R
S
K
D
E
Site 8
S134
V
L
V
S
D
F
R
S
K
D
E
V
V
D
A
Site 9
Y164
P
S
F
R
G
V
R
Y
V
D
G
G
V
S
D
Site 10
T183
I
D
A
K
T
T
I
T
V
S
P
F
Y
G
E
Site 11
S185
A
K
T
T
I
T
V
S
P
F
Y
G
E
Y
D
Site 12
S211
H
V
D
I
T
K
L
S
L
R
L
C
T
G
N
Site 13
S264
R
P
Q
P
G
L
K
S
S
S
E
G
M
D
P
Site 14
S265
P
Q
P
G
L
K
S
S
S
E
G
M
D
P
E
Site 15
S266
Q
P
G
L
K
S
S
S
E
G
M
D
P
E
V
Site 16
S282
M
P
S
W
A
N
M
S
L
D
S
S
P
E
S
Site 17
S285
W
A
N
M
S
L
D
S
S
P
E
S
A
A
L
Site 18
S286
A
N
M
S
L
D
S
S
P
E
S
A
A
L
A
Site 19
S308
L
L
D
H
L
R
L
S
I
L
P
W
D
E
S
Site 20
S315
S
I
L
P
W
D
E
S
I
L
D
T
L
S
P
Site 21
T319
W
D
E
S
I
L
D
T
L
S
P
R
L
A
T
Site 22
T326
T
L
S
P
R
L
A
T
A
L
S
E
E
M
K
Site 23
S329
P
R
L
A
T
A
L
S
E
E
M
K
D
K
G
Site 24
Y338
E
M
K
D
K
G
G
Y
M
S
K
I
C
N
L
Site 25
S340
K
D
K
G
G
Y
M
S
K
I
C
N
L
L
P
Site 26
S407
C
L
L
P
A
S
R
S
Q
M
P
V
S
S
Q
Site 27
S412
S
R
S
Q
M
P
V
S
S
Q
Q
A
S
P
C
Site 28
S413
R
S
Q
M
P
V
S
S
Q
Q
A
S
P
C
T
Site 29
S417
P
V
S
S
Q
Q
A
S
P
C
T
P
E
Q
D
Site 30
T420
S
Q
Q
A
S
P
C
T
P
E
Q
D
W
P
C
Site 31
T445
A
E
T
K
A
E
A
T
P
R
S
I
L
R
S
Site 32
S448
K
A
E
A
T
P
R
S
I
L
R
S
S
L
N
Site 33
S453
P
R
S
I
L
R
S
S
L
N
F
F
L
G
N
Site 34
S474
E
G
L
S
T
F
P
S
F
S
L
E
K
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation