PhosphoNET

           
Protein Info 
   
Short Name:  TREX1
Full Name:  Three prime repair exonuclease 1
Alias:  3'-5' exonuclease TREX1; DNase III; EC 3.1.11.2
Type:  Enzyme - Nuclease; nucleus
Mass (Da):  38923
Number AA:  369
UniProt ID:  Q9NSU2
International Prot ID:  IPI00220019
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005635     Uniprot OncoNet
Molecular Function:  GO:0008296  GO:0032405  GO:0032407 PhosphoSite+ KinaseNET
Biological Process:  GO:0006310  GO:0006260  GO:0008219 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T39ILTLGTHTPTPCSSP
Site 2T41TLGTHTPTPCSSPGS
Site 3S44THTPTPCSSPGSAAG
Site 4S45HTPTPCSSPGSAAGT
Site 5S48TPCSSPGSAAGTYPT
Site 6T52SPGSAAGTYPTMGSQ
Site 7Y53PGSAAGTYPTMGSQA
Site 8S58GTYPTMGSQALPPGP
Site 9S82EATGLPFSQPKVTEL
Site 10S101VHRCALESPPTSQGP
Site 11T104CALESPPTSQGPPPT
Site 12S105ALESPPTSQGPPPTV
Site 13T111TSQGPPPTVPPPPRV
Site 14S133VAPGKACSPAASEIT
Site 15Y184VAHNGDRYDFPLLQA
Site 16S221LKALERASSPSEHGP
Site 17S222KALERASSPSEHGPR
Site 18S224LERASSPSEHGPRKS
Site 19S231SEHGPRKSYSLGSIY
Site 20Y232EHGPRKSYSLGSIYT
Site 21S233HGPRKSYSLGSIYTR
Site 22S236RKSYSLGSIYTRLYG
Site 23Y238SYSLGSIYTRLYGQS
Site 24Y242GSIYTRLYGQSPPDS
Site 25S245YTRLYGQSPPDSHTA
Site 26S249YGQSPPDSHTAEGDV
Site 27T283AHARPFGTIRPMYGV
Site 28S293PMYGVTASARTKPRP
Site 29S301ARTKPRPSAVTTTAH
Site 30T304KPRPSAVTTTAHLAT
Site 31T305PRPSAVTTTAHLATT
Site 32T311TTTAHLATTRNTSPS
Site 33T312TTAHLATTRNTSPSL
Site 34T315HLATTRNTSPSLGES
Site 35S316LATTRNTSPSLGESR
Site 36S318TTRNTSPSLGESRGT
Site 37S322TSPSLGESRGTKDLP
Site 38T325SLGESRGTKDLPPVK
Site 39S338VKDPGALSREGLLAP
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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