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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DIAPH3
Full Name:
Protein diaphanous homolog 3
Alias:
Diap3; Diaphanous 3; Diaphanous-related formin-3; DKFZP434C0931; DKFZp686A13178; DRF3; FLJ34705
Type:
Uncharacterized protein
Mass (Da):
136926
Number AA:
1193
UniProt ID:
Q9NSV4
International Prot ID:
IPI00655865
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0017048
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
L
H
H
P
A
Q
G
S
A
A
G
T
P
Y
P
Site 2
T19
A
Q
G
S
A
A
G
T
P
Y
P
S
S
A
S
Site 3
Y21
G
S
A
A
G
T
P
Y
P
S
S
A
S
L
R
Site 4
S23
A
A
G
T
P
Y
P
S
S
A
S
L
R
G
C
Site 5
S24
A
G
T
P
Y
P
S
S
A
S
L
R
G
C
R
Site 6
S26
T
P
Y
P
S
S
A
S
L
R
G
C
R
E
S
Site 7
S33
S
L
R
G
C
R
E
S
K
M
P
R
R
K
G
Site 8
S48
P
Q
H
P
P
P
P
S
G
P
E
E
P
G
E
Site 9
T66
K
F
H
L
N
I
R
T
L
T
D
D
M
L
D
Site 10
T68
H
L
N
I
R
T
L
T
D
D
M
L
D
K
F
Site 11
S77
D
M
L
D
K
F
A
S
I
R
I
P
G
S
K
Site 12
S83
A
S
I
R
I
P
G
S
K
K
E
R
P
P
L
Site 13
T95
P
P
L
P
N
L
K
T
A
F
A
S
S
D
C
Site 14
S99
N
L
K
T
A
F
A
S
S
D
C
S
A
A
P
Site 15
S118
E
N
F
P
K
P
L
S
E
N
E
L
L
E
L
Site 16
S149
P
L
R
E
K
D
F
S
I
K
K
E
M
V
M
Site 17
Y158
K
K
E
M
V
M
Q
Y
I
N
T
A
S
K
T
Site 18
S163
M
Q
Y
I
N
T
A
S
K
T
G
S
L
K
R
Site 19
S167
N
T
A
S
K
T
G
S
L
K
R
S
R
Q
I
Site 20
S171
K
T
G
S
L
K
R
S
R
Q
I
S
P
Q
E
Site 21
S175
L
K
R
S
R
Q
I
S
P
Q
E
F
I
H
E
Site 22
T204
E
S
L
R
V
S
L
T
S
N
P
V
S
W
V
Site 23
S205
S
L
R
V
S
L
T
S
N
P
V
S
W
V
E
Site 24
S209
S
L
T
S
N
P
V
S
W
V
E
S
F
G
H
Site 25
S213
N
P
V
S
W
V
E
S
F
G
H
E
G
L
G
Site 26
S231
D
I
L
E
K
L
I
S
G
K
I
Q
E
K
V
Site 27
Y258
K
A
L
M
N
T
Q
Y
G
L
E
R
I
M
S
Site 28
S265
Y
G
L
E
R
I
M
S
E
E
R
S
L
S
L
Site 29
S269
R
I
M
S
E
E
R
S
L
S
L
L
A
K
A
Site 30
S271
M
S
E
E
R
S
L
S
L
L
A
K
A
V
D
Site 31
T286
P
R
H
P
N
M
M
T
D
V
V
K
L
L
S
Site 32
S313
E
V
L
E
A
L
T
S
A
G
E
E
K
K
I
Site 33
S404
E
E
D
L
F
E
L
S
H
R
L
E
D
I
R
Site 34
Y418
R
A
E
L
D
E
A
Y
D
V
Y
N
M
V
W
Site 35
Y421
L
D
E
A
Y
D
V
Y
N
M
V
W
S
T
V
Site 36
Y436
K
E
T
R
A
E
G
Y
F
I
S
I
L
Q
H
Site 37
Y451
L
L
L
I
R
N
D
Y
F
I
R
Q
Q
Y
F
Site 38
Y457
D
Y
F
I
R
Q
Q
Y
F
K
L
I
D
E
C
Site 39
S466
K
L
I
D
E
C
V
S
Q
I
V
L
H
R
D
Site 40
T480
D
G
M
D
P
D
F
T
Y
R
K
R
L
D
L
Site 41
Y481
G
M
D
P
D
F
T
Y
R
K
R
L
D
L
D
Site 42
T521
K
K
F
E
K
E
F
T
D
H
Q
E
T
Q
A
Site 43
S565
C
N
I
P
L
P
P
S
K
E
G
G
T
G
H
Site 44
S573
K
E
G
G
T
G
H
S
A
L
P
P
P
P
P
Site 45
S583
P
P
P
P
P
L
P
S
G
G
G
V
P
P
P
Site 46
S607
P
G
M
R
M
P
F
S
G
P
V
P
P
P
P
Site 47
S624
G
F
L
G
G
Q
N
S
P
P
L
P
I
L
P
Site 48
S645
K
E
F
K
P
E
I
S
M
R
R
L
N
W
L
Site 49
Y673
I
K
V
N
E
N
K
Y
E
N
V
D
L
L
C
Site 50
S704
E
D
I
E
E
K
K
S
I
K
K
K
I
K
E
Site 51
S717
K
E
L
K
F
L
D
S
K
I
A
Q
N
L
S
Site 52
S728
Q
N
L
S
I
F
L
S
S
F
R
V
P
Y
E
Site 53
S729
N
L
S
I
F
L
S
S
F
R
V
P
Y
E
E
Site 54
S769
P
D
Q
E
Q
L
N
S
L
S
Q
F
K
S
E
Site 55
S771
Q
E
Q
L
N
S
L
S
Q
F
K
S
E
Y
S
Site 56
S775
N
S
L
S
Q
F
K
S
E
Y
S
N
L
C
E
Site 57
S801
K
R
L
R
P
R
L
S
A
I
L
F
K
L
Q
Site 58
S824
K
P
D
I
M
A
V
S
T
A
C
E
E
I
K
Site 59
S833
A
C
E
E
I
K
K
S
K
S
F
S
K
L
L
Site 60
S835
E
E
I
K
K
S
K
S
F
S
K
L
L
E
L
Site 61
T859
A
G
S
R
N
A
Q
T
F
G
F
N
L
S
S
Site 62
S865
Q
T
F
G
F
N
L
S
S
L
C
K
L
K
D
Site 63
S866
T
F
G
F
N
L
S
S
L
C
K
L
K
D
T
Site 64
S875
C
K
L
K
D
T
K
S
A
D
Q
K
T
T
L
Site 65
S911
L
E
P
L
D
K
A
S
K
V
S
V
E
T
L
Site 66
S954
D
K
F
V
T
K
M
S
R
F
V
I
S
A
K
Site 67
T966
S
A
K
E
Q
Y
E
T
L
S
K
L
H
E
N
Site 68
Y978
H
E
N
M
E
K
L
Y
Q
S
I
I
G
Y
Y
Site 69
T999
V
S
V
E
D
F
L
T
D
L
N
N
F
R
T
Site 70
T1007
D
L
N
N
F
R
T
T
F
M
Q
A
I
K
E
Site 71
T1054
K
R
L
L
E
M
K
T
E
G
D
E
T
G
V
Site 72
T1059
M
K
T
E
G
D
E
T
G
V
M
D
N
L
L
Site 73
S1071
N
L
L
E
A
L
Q
S
G
A
A
F
R
D
R
Site 74
T1082
F
R
D
R
R
K
R
T
P
M
P
K
D
V
R
Site 75
S1091
M
P
K
D
V
R
Q
S
L
S
P
M
S
Q
R
Site 76
S1093
K
D
V
R
Q
S
L
S
P
M
S
Q
R
P
V
Site 77
S1096
R
Q
S
L
S
P
M
S
Q
R
P
V
L
K
V
Site 78
T1114
E
N
Q
K
V
Q
L
T
E
G
S
R
S
H
Y
Site 79
Y1121
T
E
G
S
R
S
H
Y
N
I
N
C
N
S
T
Site 80
T1130
I
N
C
N
S
T
R
T
P
V
A
K
E
L
N
Site 81
T1142
E
L
N
Y
N
L
D
T
H
T
S
T
G
R
I
Site 82
S1145
Y
N
L
D
T
H
T
S
T
G
R
I
K
A
A
Site 83
S1162
K
E
A
C
N
V
E
S
N
R
K
K
E
T
E
Site 84
S1173
K
E
T
E
L
L
G
S
F
S
K
N
E
S
V
Site 85
S1175
T
E
L
L
G
S
F
S
K
N
E
S
V
P
E
Site 86
S1179
G
S
F
S
K
N
E
S
V
P
E
V
E
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation