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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BMP2K
Full Name:
BMP-2-inducible protein kinase
Alias:
BIKe; BM2K; BMP2 inducible kinase; DKFZp434K0614; EC 2.7.11.1; HRIHFB2017; Kinase BIKE
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; NAK family
Mass (Da):
129172
Number AA:
1161
UniProt ID:
Q9NSY1
International Prot ID:
IPI00337426
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
K
F
S
R
M
P
K
S
E
G
G
S
G
G
G
Site 2
S14
M
P
K
S
E
G
G
S
G
G
G
A
A
G
G
Site 3
T52
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
Site 4
S56
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
Site 5
Y82
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
Site 6
T97
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
Site 7
Y111
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
Site 8
T174
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
Site 9
Y224
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
Site 10
T225
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
Site 11
T226
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
Site 12
S228
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
Site 13
Y229
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
Site 14
Y238
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
Site 15
Y257
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
Site 16
Y286
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
Site 17
S326
A
K
K
D
C
P
V
S
N
I
N
N
S
S
I
Site 18
S331
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
Site 19
S332
V
S
N
I
N
N
S
S
I
P
S
A
L
P
E
Site 20
S335
I
N
N
S
S
I
P
S
A
L
P
E
P
M
T
Site 21
T342
S
A
L
P
E
P
M
T
A
S
E
A
A
A
R
Site 22
S351
S
E
A
A
A
R
K
S
Q
I
K
A
R
I
T
Site 23
T358
S
Q
I
K
A
R
I
T
D
T
I
G
P
T
E
Site 24
T360
I
K
A
R
I
T
D
T
I
G
P
T
E
T
S
Site 25
S378
R
Q
R
P
K
A
N
S
A
T
T
A
T
P
S
Site 26
T381
P
K
A
N
S
A
T
T
A
T
P
S
V
L
T
Site 27
T383
A
N
S
A
T
T
A
T
P
S
V
L
T
I
Q
Site 28
Y500
H
H
L
L
Q
D
A
Y
M
Q
Q
Y
Q
H
A
Site 29
S522
Q
Q
Q
F
L
M
H
S
V
Y
Q
P
Q
P
S
Site 30
Y524
Q
F
L
M
H
S
V
Y
Q
P
Q
P
S
A
S
Site 31
S529
S
V
Y
Q
P
Q
P
S
A
S
Q
Y
P
T
M
Site 32
S531
Y
Q
P
Q
P
S
A
S
Q
Y
P
T
M
M
P
Site 33
Y533
P
Q
P
S
A
S
Q
Y
P
T
M
M
P
Q
Y
Site 34
T535
P
S
A
S
Q
Y
P
T
M
M
P
Q
Y
Q
Q
Site 35
S556
M
L
A
Q
H
Q
P
S
Q
Q
Q
A
S
P
E
Site 36
S561
Q
P
S
Q
Q
Q
A
S
P
E
Y
L
T
S
P
Site 37
Y564
Q
Q
Q
A
S
P
E
Y
L
T
S
P
Q
E
F
Site 38
S567
A
S
P
E
Y
L
T
S
P
Q
E
F
S
P
A
Site 39
S572
L
T
S
P
Q
E
F
S
P
A
L
V
S
Y
T
Site 40
T588
S
L
P
A
Q
V
G
T
I
M
D
S
S
Y
S
Site 41
S593
V
G
T
I
M
D
S
S
Y
S
A
N
R
S
V
Site 42
Y594
G
T
I
M
D
S
S
Y
S
A
N
R
S
V
A
Site 43
S595
T
I
M
D
S
S
Y
S
A
N
R
S
V
A
D
Site 44
S599
S
S
Y
S
A
N
R
S
V
A
D
K
E
A
I
Site 45
S616
F
T
N
Q
K
N
I
S
N
P
P
D
M
S
G
Site 46
S633
P
F
G
E
D
N
F
S
K
L
T
E
E
E
L
Site 47
S658
N
R
L
E
E
R
A
S
S
D
K
N
V
D
S
Site 48
S659
R
L
E
E
R
A
S
S
D
K
N
V
D
S
L
Site 49
S665
S
S
D
K
N
V
D
S
L
S
A
P
H
N
H
Site 50
S667
D
K
N
V
D
S
L
S
A
P
H
N
H
P
P
Site 51
S680
P
P
E
D
P
F
G
S
V
P
F
I
S
H
S
Site 52
S685
F
G
S
V
P
F
I
S
H
S
G
S
P
E
K
Site 53
S687
S
V
P
F
I
S
H
S
G
S
P
E
K
K
A
Site 54
S689
P
F
I
S
H
S
G
S
P
E
K
K
A
E
H
Site 55
S697
P
E
K
K
A
E
H
S
S
I
N
Q
E
N
G
Site 56
S698
E
K
K
A
E
H
S
S
I
N
Q
E
N
G
T
Site 57
T705
S
I
N
Q
E
N
G
T
A
N
P
I
K
N
G
Site 58
T714
N
P
I
K
N
G
K
T
S
P
A
S
K
D
Q
Site 59
S715
P
I
K
N
G
K
T
S
P
A
S
K
D
Q
R
Site 60
S718
N
G
K
T
S
P
A
S
K
D
Q
R
T
G
K
Site 61
T723
P
A
S
K
D
Q
R
T
G
K
K
T
S
V
Q
Site 62
T727
D
Q
R
T
G
K
K
T
S
V
Q
G
Q
V
Q
Site 63
S728
Q
R
T
G
K
K
T
S
V
Q
G
Q
V
Q
K
Site 64
S740
V
Q
K
G
N
D
E
S
E
S
D
F
E
S
D
Site 65
S742
K
G
N
D
E
S
E
S
D
F
E
S
D
P
P
Site 66
S746
E
S
E
S
D
F
E
S
D
P
P
S
P
K
S
Site 67
S750
D
F
E
S
D
P
P
S
P
K
S
S
E
E
E
Site 68
S753
S
D
P
P
S
P
K
S
S
E
E
E
E
Q
D
Site 69
S754
D
P
P
S
P
K
S
S
E
E
E
E
Q
D
D
Site 70
T777
G
D
F
N
D
D
D
T
E
P
E
N
L
G
H
Site 71
S791
H
R
P
L
L
M
D
S
E
D
E
E
E
E
E
Site 72
S801
E
E
E
E
E
K
H
S
S
D
S
D
Y
E
Q
Site 73
S802
E
E
E
E
K
H
S
S
D
S
D
Y
E
Q
A
Site 74
S804
E
E
K
H
S
S
D
S
D
Y
E
Q
A
K
A
Site 75
Y806
K
H
S
S
D
S
D
Y
E
Q
A
K
A
K
Y
Site 76
Y813
Y
E
Q
A
K
A
K
Y
S
D
M
S
S
V
Y
Site 77
S814
E
Q
A
K
A
K
Y
S
D
M
S
S
V
Y
R
Site 78
S818
A
K
Y
S
D
M
S
S
V
Y
R
D
R
S
G
Site 79
Y820
Y
S
D
M
S
S
V
Y
R
D
R
S
G
S
G
Site 80
S824
S
S
V
Y
R
D
R
S
G
S
G
P
T
Q
D
Site 81
S826
V
Y
R
D
R
S
G
S
G
P
T
Q
D
L
N
Site 82
T829
D
R
S
G
S
G
P
T
Q
D
L
N
T
I
L
Site 83
T834
G
P
T
Q
D
L
N
T
I
L
L
T
S
A
Q
Site 84
T838
D
L
N
T
I
L
L
T
S
A
Q
L
S
S
D
Site 85
S839
L
N
T
I
L
L
T
S
A
Q
L
S
S
D
V
Site 86
S843
L
L
T
S
A
Q
L
S
S
D
V
A
V
E
T
Site 87
T850
S
S
D
V
A
V
E
T
P
K
Q
E
F
D
V
Site 88
T899
Q
E
E
F
D
V
F
T
K
A
P
F
S
K
K
Site 89
S904
V
F
T
K
A
P
F
S
K
K
V
N
V
Q
E
Site 90
Y925
E
A
H
T
I
P
G
Y
P
K
S
V
D
V
F
Site 91
S928
T
I
P
G
Y
P
K
S
V
D
V
F
G
S
T
Site 92
T942
T
P
F
Q
P
F
L
T
S
T
S
K
S
E
S
Site 93
S943
P
F
Q
P
F
L
T
S
T
S
K
S
E
S
N
Site 94
S945
Q
P
F
L
T
S
T
S
K
S
E
S
N
E
D
Site 95
S947
F
L
T
S
T
S
K
S
E
S
N
E
D
L
F
Site 96
S949
T
S
T
S
K
S
E
S
N
E
D
L
F
G
L
Site 97
T963
L
V
P
F
D
E
I
T
G
S
Q
Q
Q
K
V
Site 98
S965
P
F
D
E
I
T
G
S
Q
Q
Q
K
V
K
Q
Site 99
S974
Q
Q
K
V
K
Q
R
S
L
Q
K
L
S
S
R
Site 100
S979
Q
R
S
L
Q
K
L
S
S
R
Q
R
R
T
K
Site 101
S980
R
S
L
Q
K
L
S
S
R
Q
R
R
T
K
Q
Site 102
T985
L
S
S
R
Q
R
R
T
K
Q
D
M
S
K
S
Site 103
S990
R
R
T
K
Q
D
M
S
K
S
N
G
K
R
H
Site 104
S992
T
K
Q
D
M
S
K
S
N
G
K
R
H
H
G
Site 105
T1000
N
G
K
R
H
H
G
T
P
T
S
T
K
K
T
Site 106
T1002
K
R
H
H
G
T
P
T
S
T
K
K
T
L
K
Site 107
S1003
R
H
H
G
T
P
T
S
T
K
K
T
L
K
P
Site 108
T1004
H
H
G
T
P
T
S
T
K
K
T
L
K
P
T
Site 109
T1007
T
P
T
S
T
K
K
T
L
K
P
T
Y
R
T
Site 110
T1011
T
K
K
T
L
K
P
T
Y
R
T
P
E
R
A
Site 111
Y1012
K
K
T
L
K
P
T
Y
R
T
P
E
R
A
R
Site 112
T1014
T
L
K
P
T
Y
R
T
P
E
R
A
R
R
H
Site 113
S1029
K
K
V
G
R
R
D
S
Q
S
S
N
E
F
L
Site 114
S1031
V
G
R
R
D
S
Q
S
S
N
E
F
L
T
I
Site 115
S1032
G
R
R
D
S
Q
S
S
N
E
F
L
T
I
S
Site 116
T1037
Q
S
S
N
E
F
L
T
I
S
D
S
K
E
N
Site 117
S1039
S
N
E
F
L
T
I
S
D
S
K
E
N
I
S
Site 118
S1041
E
F
L
T
I
S
D
S
K
E
N
I
S
V
A
Site 119
S1046
S
D
S
K
E
N
I
S
V
A
L
T
D
G
K
Site 120
T1050
E
N
I
S
V
A
L
T
D
G
K
D
R
G
N
Site 121
S1064
N
V
L
Q
P
E
E
S
L
L
D
P
F
G
A
Site 122
S1076
F
G
A
K
P
F
H
S
P
D
L
S
W
H
P
Site 123
S1080
P
F
H
S
P
D
L
S
W
H
P
P
H
Q
G
Site 124
S1089
H
P
P
H
Q
G
L
S
D
I
R
A
D
H
N
Site 125
T1097
D
I
R
A
D
H
N
T
V
L
P
G
R
P
R
Site 126
S1107
P
G
R
P
R
Q
N
S
L
H
G
S
F
H
S
Site 127
S1111
R
Q
N
S
L
H
G
S
F
H
S
A
D
V
L
Site 128
S1114
S
L
H
G
S
F
H
S
A
D
V
L
K
M
D
Site 129
S1135
F
T
E
L
V
V
Q
S
I
T
P
H
Q
S
Q
Site 130
T1137
E
L
V
V
Q
S
I
T
P
H
Q
S
Q
Q
S
Site 131
S1141
Q
S
I
T
P
H
Q
S
Q
Q
S
Q
P
V
E
Site 132
S1144
T
P
H
Q
S
Q
Q
S
Q
P
V
E
L
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation