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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKDREJ
Full Name:
Polycystic kidney disease and receptor for egg jelly-related protein
Alias:
PKD and REJ homolog; PKDRE; polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly, sea urchin); polycystic kidney disease and receptor for egg jelly related protein
Type:
Unknown function
Mass (Da):
255450
Number AA:
UniProt ID:
Q9NTG1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005216
PhosphoSite+
KinaseNET
Biological Process:
GO:0007340
GO:0006811
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S58
R
G
G
R
A
L
L
S
L
R
P
S
A
V
R
Site 2
S62
A
L
L
S
L
R
P
S
A
V
R
A
G
G
A
Site 3
Y89
G
G
T
G
R
R
W
Y
C
L
D
L
R
V
L
Site 4
S98
L
D
L
R
V
L
L
S
A
Q
R
L
P
W
P
Site 5
S125
S
A
R
G
G
R
L
S
L
T
W
S
V
R
L
Site 6
T127
R
G
G
R
L
S
L
T
W
S
V
R
L
P
R
Site 7
S129
G
R
L
S
L
T
W
S
V
R
L
P
R
S
P
Site 8
S135
W
S
V
R
L
P
R
S
P
G
R
L
A
W
A
Site 9
S157
P
G
A
A
R
P
A
S
P
A
A
R
V
S
P
Site 10
S163
A
S
P
A
A
R
V
S
P
R
S
A
A
P
G
Site 11
S166
A
A
R
V
S
P
R
S
A
A
P
G
P
R
P
Site 12
T181
Q
Q
G
F
V
A
R
T
E
C
P
T
D
G
P
Site 13
T185
V
A
R
T
E
C
P
T
D
G
P
A
R
V
M
Site 14
S198
V
M
L
Q
A
V
N
S
S
S
H
R
A
V
E
Site 15
S200
L
Q
A
V
N
S
S
S
H
R
A
V
E
S
S
Site 16
S206
S
S
H
R
A
V
E
S
S
V
S
C
Q
I
N
Site 17
S207
S
H
R
A
V
E
S
S
V
S
C
Q
I
N
A
Site 18
T224
I
Q
R
V
R
I
N
T
D
Q
K
G
A
P
V
Site 19
S234
K
G
A
P
V
R
L
S
M
Q
A
E
A
T
I
Site 20
T274
V
G
Q
A
P
D
W
T
Q
P
L
D
L
P
Q
Site 21
S287
P
Q
L
E
I
R
N
S
P
L
F
I
H
I
P
Site 22
T313
N
F
T
V
S
I
T
T
G
N
P
K
M
P
E
Site 23
S359
E
Q
L
I
L
D
G
S
T
S
S
D
P
D
A
Site 24
S361
L
I
L
D
G
S
T
S
S
D
P
D
A
D
S
Site 25
S362
I
L
D
G
S
T
S
S
D
P
D
A
D
S
P
Site 26
S368
S
S
D
P
D
A
D
S
P
L
Q
G
L
Q
F
Site 27
Y386
C
T
T
D
P
R
N
Y
G
G
D
R
I
I
L
Site 28
S395
G
D
R
I
I
L
G
S
K
E
V
C
H
P
E
Site 29
S439
R
M
V
I
R
K
D
S
R
T
A
F
S
D
K
Site 30
T441
V
I
R
K
D
S
R
T
A
F
S
D
K
R
V
Site 31
S444
K
D
S
R
T
A
F
S
D
K
R
V
H
V
L
Site 32
Y491
N
C
A
S
R
D
F
Y
K
W
S
I
L
S
S
Site 33
S494
S
R
D
F
Y
K
W
S
I
L
S
S
S
G
G
Site 34
S497
F
Y
K
W
S
I
L
S
S
S
G
G
E
M
L
Site 35
S498
Y
K
W
S
I
L
S
S
S
G
G
E
M
L
F
Site 36
T511
L
F
D
W
M
G
E
T
V
T
G
R
N
G
A
Site 37
T513
D
W
M
G
E
T
V
T
G
R
N
G
A
Y
L
Site 38
S521
G
R
N
G
A
Y
L
S
I
K
A
F
A
F
R
Site 39
T595
R
D
K
H
V
P
L
T
Y
K
I
I
V
S
D
Site 40
S611
H
S
V
G
E
I
S
S
V
K
E
N
T
L
G
Site 41
Y648
S
Q
Y
G
L
K
I
Y
A
Q
V
Y
D
S
L
Site 42
T678
T
D
K
N
S
S
K
T
V
L
N
Q
L
L
S
Site 43
S692
S
F
T
V
G
P
S
S
L
L
S
T
L
I
Q
Site 44
S695
V
G
P
S
S
L
L
S
T
L
I
Q
K
K
D
Site 45
T696
G
P
S
S
L
L
S
T
L
I
Q
K
K
D
F
Site 46
Y708
K
D
F
L
P
A
G
Y
L
L
Y
I
V
A
S
Site 47
Y711
L
P
A
G
Y
L
L
Y
I
V
A
S
V
L
N
Site 48
T722
S
V
L
N
N
M
K
T
E
L
P
L
R
D
D
Site 49
S741
R
K
H
L
I
D
Q
S
F
L
L
P
V
S
T
Site 50
S747
Q
S
F
L
L
P
V
S
T
L
V
E
I
G
Q
Site 51
T748
S
F
L
L
P
V
S
T
L
V
E
I
G
Q
V
Site 52
T763
V
M
T
I
T
K
L
T
Q
K
P
S
E
F
T
Site 53
S767
T
K
L
T
Q
K
P
S
E
F
T
W
D
A
Q
Site 54
S800
Q
K
D
K
R
F
R
S
E
Q
I
E
I
V
S
Site 55
S822
S
N
I
L
K
M
T
S
P
H
Q
V
V
K
D
Site 56
Y832
Q
V
V
K
D
P
F
Y
V
I
E
S
L
S
D
Site 57
T851
N
K
V
P
G
N
K
T
T
S
M
R
T
P
N
Site 58
S853
V
P
G
N
K
T
T
S
M
R
T
P
N
F
N
Site 59
T856
N
K
T
T
S
M
R
T
P
N
F
N
M
Y
V
Site 60
Y862
R
T
P
N
F
N
M
Y
V
K
K
V
E
K
W
Site 61
Y886
K
H
C
R
N
C
F
Y
P
T
L
N
V
S
S
Site 62
S893
Y
P
T
L
N
V
S
S
V
P
G
L
S
A
N
Site 63
S925
L
N
D
Q
E
N
T
S
V
E
V
S
G
F
R
Site 64
S929
E
N
T
S
V
E
V
S
G
F
R
M
T
G
V
Site 65
T934
E
V
S
G
F
R
M
T
G
V
A
D
N
G
S
Site 66
S941
T
G
V
A
D
N
G
S
V
L
E
I
T
P
D
Site 67
Y953
T
P
D
V
A
E
V
Y
L
V
R
K
N
L
T
Site 68
S972
N
L
T
V
G
P
N
S
E
V
D
G
S
L
K
Site 69
S977
P
N
S
E
V
D
G
S
L
K
K
T
T
G
G
Site 70
T981
V
D
G
S
L
K
K
T
T
G
G
F
S
F
Q
Site 71
S986
K
K
T
T
G
G
F
S
F
Q
V
D
S
T
V
Site 72
S1039
H
D
I
P
P
F
A
S
Q
S
A
L
F
D
P
Site 73
S1070
L
Q
L
I
A
Q
H
S
H
S
P
H
C
T
V
Site 74
Y1108
S
V
Q
C
L
D
M
Y
G
I
Q
S
E
W
R
Site 75
Y1118
Q
S
E
W
R
E
G
Y
C
I
L
G
E
K
T
Site 76
Y1128
L
G
E
K
T
S
W
Y
E
V
H
C
I
C
K
Site 77
T1146
R
A
R
R
Q
L
G
T
I
G
L
T
G
I
H
Site 78
S1179
L
R
L
N
I
I
K
S
L
H
Q
N
P
V
T
Site 79
Y1227
V
L
P
D
N
D
P
Y
D
N
L
C
Y
L
V
Site 80
S1240
L
V
T
I
F
T
G
S
R
W
G
S
G
T
R
Site 81
S1244
F
T
G
S
R
W
G
S
G
T
R
A
N
V
F
Site 82
T1246
G
S
R
W
G
S
G
T
R
A
N
V
F
V
Q
Site 83
T1260
Q
L
R
G
T
V
S
T
S
D
V
H
C
L
S
Site 84
S1261
L
R
G
T
V
S
T
S
D
V
H
C
L
S
H
Site 85
T1273
L
S
H
P
H
F
T
T
L
Y
R
G
S
I
N
Site 86
Y1275
H
P
H
F
T
T
L
Y
R
G
S
I
N
T
F
Site 87
T1281
L
Y
R
G
S
I
N
T
F
L
L
T
T
K
S
Site 88
T1285
S
I
N
T
F
L
L
T
T
K
S
D
L
G
D
Site 89
S1288
T
F
L
L
T
T
K
S
D
L
G
D
I
H
S
Site 90
S1306
W
H
N
N
E
G
R
S
P
S
W
Y
L
S
R
Site 91
S1308
N
N
E
G
R
S
P
S
W
Y
L
S
R
I
K
Site 92
Y1310
E
G
R
S
P
S
W
Y
L
S
R
I
K
V
E
Site 93
S1312
R
S
P
S
W
Y
L
S
R
I
K
V
E
N
L
Site 94
T1338
K
W
L
S
V
D
T
T
L
D
R
T
F
H
V
Site 95
T1342
V
D
T
T
L
D
R
T
F
H
V
T
H
P
D
Site 96
T1346
L
D
R
T
F
H
V
T
H
P
D
E
R
L
T
Site 97
T1353
T
H
P
D
E
R
L
T
R
K
D
F
F
F
I
Site 98
S1374
R
K
N
H
M
W
F
S
I
F
A
S
V
V
A
Site 99
S1378
M
W
F
S
I
F
A
S
V
V
A
K
T
F
N
Site 100
T1383
F
A
S
V
V
A
K
T
F
N
R
L
Q
R
L
Site 101
S1418
N
R
Q
E
Q
T
E
S
R
E
R
K
Y
M
R
Site 102
Y1423
T
E
S
R
E
R
K
Y
M
R
S
M
M
I
G
Site 103
S1426
R
E
R
K
Y
M
R
S
M
M
I
G
I
E
S
Site 104
S1451
I
T
F
L
F
T
C
S
Q
R
K
P
Q
A
D
Site 105
S1463
Q
A
D
L
K
E
V
S
P
Q
K
H
P
L
M
Site 106
S1471
P
Q
K
H
P
L
M
S
E
A
S
E
H
W
E
Site 107
S1474
H
P
L
M
S
E
A
S
E
H
W
E
E
Y
L
Site 108
Y1480
A
S
E
H
W
E
E
Y
L
R
K
W
H
A
Y
Site 109
Y1487
Y
L
R
K
W
H
A
Y
E
T
A
K
V
H
P
Site 110
S1502
R
E
V
A
K
P
A
S
K
G
K
P
R
L
P
Site 111
S1512
K
P
R
L
P
K
A
S
P
K
A
T
S
K
P
Site 112
T1516
P
K
A
S
P
K
A
T
S
K
P
K
H
R
H
Site 113
S1517
K
A
S
P
K
A
T
S
K
P
K
H
R
H
R
Site 114
T1530
H
R
K
A
Q
I
K
T
P
E
T
L
G
P
N
Site 115
T1533
A
Q
I
K
T
P
E
T
L
G
P
N
T
N
S
Site 116
S1552
E
D
D
Q
D
V
H
S
E
Q
H
P
S
Q
K
Site 117
S1557
V
H
S
E
Q
H
P
S
Q
K
D
L
Q
Q
L
Site 118
S1634
P
S
K
I
I
L
L
S
G
F
R
T
N
K
P
Site 119
T1638
I
L
L
S
G
F
R
T
N
K
P
K
Y
C
K
Site 120
Y1643
F
R
T
N
K
P
K
Y
C
K
N
L
S
W
S
Site 121
Y1655
S
W
S
T
K
Y
K
Y
T
E
I
R
L
D
G
Site 122
T1683
Q
I
V
R
I
R
G
T
R
M
Y
Q
P
L
T
Site 123
Y1686
R
I
R
G
T
R
M
Y
Q
P
L
T
E
D
E
Site 124
T1690
T
R
M
Y
Q
P
L
T
E
D
E
I
R
I
F
Site 125
Y1738
L
R
H
T
D
C
F
Y
Y
N
Q
F
I
R
D
Site 126
Y1739
R
H
T
D
C
F
Y
Y
N
Q
F
I
R
D
R
Site 127
S1748
Q
F
I
R
D
R
F
S
M
D
L
A
T
V
T
Site 128
T1779
L
H
N
D
L
N
P
T
F
L
P
E
S
S
S
Site 129
S1784
N
P
T
F
L
P
E
S
S
S
K
I
L
G
L
Site 130
S1801
M
R
Q
V
R
A
K
S
S
E
K
M
C
L
P
Site 131
S1802
R
Q
V
R
A
K
S
S
E
K
M
C
L
P
A
Site 132
Y1827
E
I
H
C
H
P
K
Y
G
I
D
P
E
D
T
Site 133
T1834
Y
G
I
D
P
E
D
T
K
N
Y
S
G
F
W
Site 134
S1852
D
K
Q
A
I
D
E
S
T
N
G
F
T
Y
K
Site 135
T1857
D
E
S
T
N
G
F
T
Y
K
P
Q
G
T
Q
Site 136
Y1858
E
S
T
N
G
F
T
Y
K
P
Q
G
T
Q
W
Site 137
Y1867
P
Q
G
T
Q
W
L
Y
Y
S
Y
G
L
L
H
Site 138
Y1868
Q
G
T
Q
W
L
Y
Y
S
Y
G
L
L
H
T
Site 139
Y1884
G
S
G
G
Y
A
L
Y
F
F
P
E
Q
Q
R
Site 140
S1894
P
E
Q
Q
R
F
N
S
T
L
R
L
K
E
L
Site 141
T1895
E
Q
Q
R
F
N
S
T
L
R
L
K
E
L
Q
Site 142
S1904
R
L
K
E
L
Q
E
S
N
W
L
D
E
K
T
Site 143
T1911
S
N
W
L
D
E
K
T
W
A
V
V
L
E
L
Site 144
S1951
N
T
S
I
S
L
H
S
F
S
L
A
D
F
D
Site 145
S1953
S
I
S
L
H
S
F
S
L
A
D
F
D
R
K
Site 146
S1962
A
D
F
D
R
K
A
S
A
E
I
Y
L
Y
V
Site 147
S1992
I
I
M
Q
E
R
A
S
Y
V
R
S
V
Y
N
Site 148
Y1993
I
M
Q
E
R
A
S
Y
V
R
S
V
Y
N
L
Site 149
S1996
E
R
A
S
Y
V
R
S
V
Y
N
L
L
N
F
Site 150
Y2030
A
T
G
I
I
R
F
Y
L
S
N
P
E
D
F
Site 151
Y2068
T
I
L
K
T
L
R
Y
S
R
F
F
Y
D
V
Site 152
S2069
I
L
K
T
L
R
Y
S
R
F
F
Y
D
V
R
Site 153
Y2073
L
R
Y
S
R
F
F
Y
D
V
R
L
A
Q
R
Site 154
Y2118
F
G
Q
H
E
W
N
Y
S
N
L
I
H
S
T
Site 155
T2125
Y
S
N
L
I
H
S
T
Q
T
V
F
S
Y
C
Site 156
Y2131
S
T
Q
T
V
F
S
Y
C
V
S
A
F
Q
N
Site 157
S2142
A
F
Q
N
T
E
F
S
N
N
R
I
L
G
V
Site 158
S2173
L
F
Q
A
V
I
L
S
A
Y
E
E
M
K
Q
Site 159
Y2183
E
E
M
K
Q
P
V
Y
E
E
P
S
D
E
V
Site 160
S2187
Q
P
V
Y
E
E
P
S
D
E
V
E
A
M
T
Site 161
Y2195
D
E
V
E
A
M
T
Y
L
C
R
K
L
R
T
Site 162
S2205
R
K
L
R
T
M
F
S
F
L
T
S
Q
S
K
Site 163
S2209
T
M
F
S
F
L
T
S
Q
S
K
A
K
D
E
Site 164
Y2225
E
F
F
I
D
M
L
Y
G
Q
P
E
K
N
S
Site 165
S2232
Y
G
Q
P
E
K
N
S
H
R
Y
L
G
L
K
Site 166
Y2235
P
E
K
N
S
H
R
Y
L
G
L
K
T
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation