PhosphoNET

           
Protein Info 
   
Short Name:  SIRT3
Full Name:  NAD-dependent deacetylase sirtuin-3, mitochondrial
Alias:  SIR2-like protein 3
Type: 
Mass (Da):  43555
Number AA:  399
UniProt ID:  Q9NTG7
International Prot ID:  IPI00183171
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005677  GO:0005739  GO:0005759 Uniprot OncoNet
Molecular Function:  GO:0003676  GO:0003677  GO:0003824 PhosphoSite+ KinaseNET
Biological Process:  GO:0006325  GO:0006333  GO:0006338 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S47LGGRDDVSAGLRGSH
Site 2S53VSAGLRGSHGARGEP
Site 3S89QPRAAAPSFFFSSIK
Site 4S93AAPSFFFSSIKGGRR
Site 5S94APSFFFSSIKGGRRS
Site 6S101SIKGGRRSISFSVGA
Site 7S103KGGRRSISFSVGASS
Site 8S105GRRSISFSVGASSVV
Site 9S114GASSVVGSGGSSDKG
Site 10S117SVVGSGGSSDKGKLS
Site 11S118VVGSGGSSDKGKLSL
Site 12S124SSDKGKLSLQDVAEL
Site 13S159SGIPDFRSPGSGLYS
Site 14S162PDFRSPGSGLYSNLQ
Site 15Y165RSPGSGLYSNLQQYD
Site 16S166SPGSGLYSNLQQYDL
Site 17Y171LYSNLQQYDLPYPEA
Site 18Y175LQQYDLPYPEAIFEL
Site 19T194HNPKPFFTLAKELYP
Site 20Y200FTLAKELYPGNYKPN
Site 21Y204KELYPGNYKPNVTHY
Site 22Y211YKPNVTHYFLRLLHD
Site 23S242RVSGIPASKLVEAHG
Site 24T284VPRCPVCTGVVKPDI
Site 25S357PLAWHPRSRDVAQLG
Site 26T391RDLVQRETGKLDGPD
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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