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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDS5B
Full Name:
Sister chromatid cohesion protein PDS5 homolog B
Alias:
Androgen-induced proliferation inhibitor; Androgen-induced shutoff 3; AS3; CG008; FLJ23236; KIAA0979; Sister chromatid cohesion protein PDS5 homolog B: Androgen-induced proliferation inhibitor: Androgen-induced prostate proliferative shutoff-associated protein AS3: Sister chromatid cohesion protein PDS5 homolog B: Androgen-induced proliferation inhibitor: Androgen-induced prostate proliferative shutoff-associated protein AS3
Type:
DNA binding protein
Mass (Da):
164667
Number AA:
1447
UniProt ID:
Q9NTI5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0008283
GO:0007064
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
H
S
K
T
R
T
N
D
G
K
I
T
Y
Site 2
T14
R
T
N
D
G
K
I
T
Y
P
P
G
V
K
E
Site 3
Y15
T
N
D
G
K
I
T
Y
P
P
G
V
K
E
I
Site 4
S23
P
P
G
V
K
E
I
S
D
K
I
S
K
E
E
Site 5
S27
K
E
I
S
D
K
I
S
K
E
E
M
V
R
R
Site 6
T41
R
L
K
M
V
V
K
T
F
M
D
M
D
Q
D
Site 7
S49
F
M
D
M
D
Q
D
S
E
E
E
K
E
L
Y
Site 8
Y56
S
E
E
E
K
E
L
Y
L
N
L
A
L
H
L
Site 9
Y97
I
Y
A
P
E
A
P
Y
T
S
P
D
K
L
K
Site 10
T98
Y
A
P
E
A
P
Y
T
S
P
D
K
L
K
D
Site 11
S99
A
P
E
A
P
Y
T
S
P
D
K
L
K
D
I
Site 12
T120
Q
L
K
G
L
E
D
T
K
S
P
Q
F
N
R
Site 13
S122
K
G
L
E
D
T
K
S
P
Q
F
N
R
Y
F
Site 14
Y128
K
S
P
Q
F
N
R
Y
F
Y
L
L
E
N
I
Site 15
Y130
P
Q
F
N
R
Y
F
Y
L
L
E
N
I
A
W
Site 16
S252
K
T
S
I
S
D
L
S
E
H
V
F
D
L
I
Site 17
S283
Q
L
E
F
K
L
K
S
N
D
N
E
E
R
L
Site 18
S305
K
M
F
G
A
K
D
S
E
L
A
S
Q
N
K
Site 19
S309
A
K
D
S
E
L
A
S
Q
N
K
P
L
W
Q
Site 20
Y318
N
K
P
L
W
Q
C
Y
L
G
R
F
N
D
I
Site 21
T352
P
D
L
A
K
D
L
T
E
Y
L
K
V
R
S
Site 22
Y354
L
A
K
D
L
T
E
Y
L
K
V
R
S
H
D
Site 23
S359
T
E
Y
L
K
V
R
S
H
D
P
E
E
A
I
Site 24
T397
L
N
F
V
R
E
R
T
L
D
K
R
W
R
V
Site 25
Y419
L
A
Q
I
Y
K
K
Y
A
L
Q
S
A
A
G
Site 26
Y444
K
D
K
L
L
H
I
Y
Y
Q
N
S
I
D
D
Site 27
Y445
D
K
L
L
H
I
Y
Y
Q
N
S
I
D
D
R
Site 28
Y462
V
E
R
I
F
A
Q
Y
M
V
P
H
N
L
E
Site 29
T471
V
P
H
N
L
E
T
T
E
R
M
K
C
L
Y
Site 30
Y478
T
E
R
M
K
C
L
Y
Y
L
Y
A
T
L
D
Site 31
T518
D
L
I
K
Q
P
K
T
D
A
S
V
K
A
I
Site 32
S521
K
Q
P
K
T
D
A
S
V
K
A
I
F
S
K
Site 33
S568
K
Q
L
E
V
L
V
S
P
T
C
S
C
K
Q
Site 34
T584
E
G
C
V
R
E
I
T
K
K
L
G
N
P
K
Site 35
S617
P
V
H
I
D
T
E
S
I
S
A
L
I
K
Q
Site 36
S628
L
I
K
Q
V
N
K
S
I
D
G
T
A
D
D
Site 37
T632
V
N
K
S
I
D
G
T
A
D
D
E
D
E
G
Site 38
T642
D
E
D
E
G
V
P
T
D
Q
A
I
R
A
G
Site 39
S718
L
P
V
L
H
H
K
S
K
K
G
P
P
R
Q
Site 40
Y728
G
P
P
R
Q
A
K
Y
A
I
H
C
I
H
A
Site 41
S754
I
F
E
P
L
H
K
S
L
D
P
S
N
L
E
Site 42
S758
L
H
K
S
L
D
P
S
N
L
E
H
L
I
T
Site 43
T808
D
R
L
P
G
K
K
T
T
K
L
W
V
P
D
Site 44
S819
W
V
P
D
E
E
V
S
P
E
T
M
V
K
I
Site 45
S844
L
G
M
K
N
N
H
S
K
S
G
T
S
T
L
Site 46
S846
M
K
N
N
H
S
K
S
G
T
S
T
L
R
L
Site 47
T848
N
N
H
S
K
S
G
T
S
T
L
R
L
L
T
Site 48
T850
H
S
K
S
G
T
S
T
L
R
L
L
T
T
I
Site 49
T856
S
T
L
R
L
L
T
T
I
L
H
S
D
G
D
Site 50
S860
L
L
T
T
I
L
H
S
D
G
D
L
T
E
Q
Site 51
T865
L
H
S
D
G
D
L
T
E
Q
G
K
I
S
K
Site 52
Y895
K
L
A
Q
E
P
C
Y
H
E
I
I
T
L
E
Site 53
S931
Q
K
L
H
K
G
L
S
R
L
R
L
P
L
E
Site 54
Y972
N
I
N
V
R
R
E
Y
L
K
Q
H
A
A
V
Site 55
Y1005
L
L
A
H
D
P
D
Y
V
K
V
Q
D
I
E
Site 56
S1080
M
N
I
I
M
S
K
S
T
T
Y
S
L
E
S
Site 57
T1082
I
I
M
S
K
S
T
T
Y
S
L
E
S
P
K
Site 58
S1084
M
S
K
S
T
T
Y
S
L
E
S
P
K
D
P
Site 59
S1087
S
T
T
Y
S
L
E
S
P
K
D
P
V
L
P
Site 60
T1099
V
L
P
A
R
F
F
T
Q
P
D
K
N
F
S
Site 61
Y1111
N
F
S
N
T
K
N
Y
L
P
P
E
M
K
S
Site 62
S1118
Y
L
P
P
E
M
K
S
F
F
T
P
G
K
P
Site 63
T1121
P
E
M
K
S
F
F
T
P
G
K
P
K
T
T
Site 64
T1127
F
T
P
G
K
P
K
T
T
N
V
L
G
A
V
Site 65
S1139
G
A
V
N
K
P
L
S
S
A
G
K
Q
S
Q
Site 66
S1140
A
V
N
K
P
L
S
S
A
G
K
Q
S
Q
T
Site 67
S1145
L
S
S
A
G
K
Q
S
Q
T
K
S
S
R
M
Site 68
T1147
S
A
G
K
Q
S
Q
T
K
S
S
R
M
E
T
Site 69
S1149
G
K
Q
S
Q
T
K
S
S
R
M
E
T
V
S
Site 70
T1154
T
K
S
S
R
M
E
T
V
S
N
A
S
S
S
Site 71
S1156
S
S
R
M
E
T
V
S
N
A
S
S
S
S
N
Site 72
S1159
M
E
T
V
S
N
A
S
S
S
S
N
P
S
S
Site 73
S1160
E
T
V
S
N
A
S
S
S
S
N
P
S
S
P
Site 74
S1161
T
V
S
N
A
S
S
S
S
N
P
S
S
P
G
Site 75
S1162
V
S
N
A
S
S
S
S
N
P
S
S
P
G
R
Site 76
S1165
A
S
S
S
S
N
P
S
S
P
G
R
I
K
G
Site 77
S1166
S
S
S
S
N
P
S
S
P
G
R
I
K
G
R
Site 78
S1176
R
I
K
G
R
L
D
S
S
E
M
D
H
S
E
Site 79
S1177
I
K
G
R
L
D
S
S
E
M
D
H
S
E
N
Site 80
S1182
D
S
S
E
M
D
H
S
E
N
E
D
Y
T
M
Site 81
Y1187
D
H
S
E
N
E
D
Y
T
M
S
S
P
L
P
Site 82
T1188
H
S
E
N
E
D
Y
T
M
S
S
P
L
P
G
Site 83
S1190
E
N
E
D
Y
T
M
S
S
P
L
P
G
K
K
Site 84
S1191
N
E
D
Y
T
M
S
S
P
L
P
G
K
K
S
Site 85
S1198
V
S
N
A
S
S
S
S
N
P
S
S
P
G
R
Site 86
S1204
K
S
D
K
R
D
D
S
D
L
V
R
S
E
L
Site 87
S1209
D
D
S
D
L
V
R
S
E
L
E
K
P
R
G
Site 88
T1220
K
P
R
G
R
K
K
T
P
V
T
E
Q
E
E
Site 89
T1235
K
L
G
M
D
D
L
T
K
L
V
Q
E
Q
K
Site 90
S1246
Q
E
Q
K
P
K
G
S
Q
R
S
R
K
R
G
Site 91
T1255
R
S
R
K
R
G
H
T
A
S
E
S
D
E
Q
Site 92
S1257
R
K
R
G
H
T
A
S
E
S
D
E
Q
Q
W
Site 93
S1259
R
K
R
G
H
T
A
S
E
S
D
E
Q
Q
W
Site 94
S1283
E
N
E
D
E
Q
N
S
P
P
K
K
G
K
R
Site 95
T1301
P
K
P
L
G
G
G
T
P
K
E
E
P
T
M
Site 96
S1311
E
E
P
T
M
K
T
S
K
K
G
S
K
K
K
Site 97
S1315
M
K
T
S
K
K
G
S
K
K
K
S
G
P
P
Site 98
S1319
E
N
E
D
E
Q
N
S
P
P
K
K
G
K
R
Site 99
S1334
E
E
E
E
E
R
Q
S
G
N
T
E
Q
K
S
Site 100
T1337
P
K
P
L
G
G
G
T
P
K
E
E
P
T
M
Site 101
S1341
S
G
N
T
E
Q
K
S
K
S
K
Q
H
R
V
Site 102
S1343
N
T
E
Q
K
S
K
S
K
Q
H
R
V
S
R
Site 103
S1349
K
S
K
Q
H
R
V
S
R
R
A
Q
Q
R
A
Site 104
S1358
R
A
Q
Q
R
A
E
S
P
E
S
S
A
I
E
Site 105
S1361
Q
R
A
E
S
P
E
S
S
A
I
E
S
T
Q
Site 106
S1362
R
A
E
S
P
E
S
S
A
I
E
S
T
Q
S
Site 107
S1366
P
E
S
S
A
I
E
S
T
Q
S
T
P
Q
K
Site 108
T1367
E
S
S
A
I
E
S
T
Q
S
T
P
Q
K
G
Site 109
S1369
E
E
E
E
E
R
Q
S
G
N
T
E
Q
K
S
Site 110
T1370
A
I
E
S
T
Q
S
T
P
Q
K
G
R
G
R
Site 111
S1379
Q
K
G
R
G
R
P
S
K
T
P
S
P
S
Q
Site 112
T1381
G
R
G
R
P
S
K
T
P
S
P
S
Q
P
K
Site 113
S1383
G
R
P
S
K
T
P
S
P
S
Q
P
K
K
N
Site 114
S1385
P
S
K
T
P
S
P
S
Q
P
K
K
N
V
R
Site 115
S1406
A
A
T
K
E
N
D
S
S
E
E
V
D
V
F
Site 116
S1407
A
T
K
E
N
D
S
S
E
E
V
D
V
F
Q
Site 117
S1417
V
D
V
F
Q
G
S
S
P
V
D
D
I
P
Q
Site 118
S1433
E
T
E
E
E
E
V
S
T
V
N
V
R
R
R
Site 119
T1434
T
E
E
E
E
V
S
T
V
N
V
R
R
R
S
Site 120
S1441
T
V
N
V
R
R
R
S
A
K
R
E
R
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation